Search clinical trials for: Phospholipase A2 Inhibitors

Total 64492 results

Mayo Clinic
National Heart, Lung, and Blood Institute (NHLBI); GlaxoSmithKline; National...

Completed

Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Progenitor Cells and Coronary Atherosclerosis in Humans

Endothelial Dysfunction

United States
GlaxoSmithKline

Completed

A Phase 2 Clinical Study to Investigate Effects of Darapladib in Subjects With Diabetic Macular Edema

Retinopathy, Diabetic

Australia, Netherlands, Italy, Germany, Denmark
Kanuni Sultan Suleyman Training and Research Hospital

Completed

Preeclamptic Patients and Pentraxin 3 & Lipoprotein-associated Phospholipase A2

Pre-Eclampsia

Turkey
GlaxoSmithKline

Completed

Study to Evaluate Darapladib in Moderately Hepatically Impaired Subjects

Atherosclerosis

United States
GlaxoSmithKline

Completed

A Healthy Volunteer Pharmacokinetic Study of Single and Repeat Doses of SB-480848

Atherosclerosis

United States
GlaxoSmithKline

Completed

A Study to Assess the Pharmacokinetics, Safety and Tolerability of Repeat Oral Doses of Darapladib (SB-480848) in Subjects With Severe Renal Impairment

Atherosclerosis

United States
GlaxoSmithKline

Completed

Effect of Darapladib on Cantharidin-Induced Inflammatory Blisters in Subjects With Type 2 Diabetes Mellitus (T2DM)

Atherosclerosis

United Kingdom
GlaxoSmithKline

Completed

Darapladib China PK

Atherosclerosis

China
GlaxoSmithKline

Completed

Phase I Study of SB-480848(Darapladib) -Repeat Dose Study in Healthy Japanese Male Subjects-

Atherosclerosis

Japan
GlaxoSmithKline

Completed

SB-480848 in Major Adverse Cardiovascular Events - Integrated Summary of Efficacy and Safety From the STABILITY Trial (LPL100601) and the SOLID-TIMI-52 Trial (SB-480848/033)

Coronary Heart Disease
GlaxoSmithKline

Completed

A Study With Darapladib to Collect Tolerability Information

Atherosclerosis

United States
GlaxoSmithKline

Completed

A Study Investigating the Concentrations of Darapladib in Blood and the Safety of This Compound in Healthy Japanese Men

Atherosclerosis

United States
Anthera Pharmaceuticals

Terminated

A Study of the Pharmacokinetics and Safety of Varespladib in Subjects With Normal or Impaired Renal Function

Renal Impairment

United States
GlaxoSmithKline

Completed

The Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy Trial (STABILITY)

Atherosclerosis

United States, Argentina, Australia, France, Germany, Netherlands, Taiwan, Bulgaria, Estonia, Poland, Russian Federation, Spain, Belgium, Canada, Peru, Philippines, Sweden, Thailand, Korea, Republic of, Hong Kong, Hungary, Slovakia, Ukrain... and more
Anthera Pharmaceuticals

Completed

Study to Assess the Metabolism and Elimination of [14C]-Labeled Varespladib Methyl in Healthy Male Subjects

Healthy Volunteers

United States
HK inno.N Corporation

Recruiting

A Study to Investigate the Effect of Food on the Pharmacokinetics of IN-A002 Capsule in Healthy Male Subjects

Healthy

Korea, Republic of
University Health Network, Toronto
Anthera Pharmaceuticals

Completed

sPLA2 Inhibition to Decrease Enzyme Release After PCI Trial (SPIDER-PCI)

Coronary Artery Disease

Canada
Anthera Pharmaceuticals

Terminated

A Study of Varespladib Infusion in Subjects With Sickle Cell Disease. (IMPACTS-2)

Sickle Cell Disease | Vaso-occlusive Crisis

United States
Ophirex, Inc.
Premier Research Group plc

Completed

Broad-spectrum Rapid Antidote: Varespladib Oral for Snakebite (BRAVO)

Snakebites | Envenoming | Envenoming, Snake | Envenomation, Snake

United States, India
GlaxoSmithKline

Completed

Study Of The Effects Of SB 480848 (Darapladib) On The Electrical Conduction Of The Heart

Atherosclerosis

United States
Anthera Pharmaceuticals

Terminated

VISTA-16 Trial: Evaluation of Safety and Efficacy of Short-term A-002 Treatment in Subjects With Acute Coronary Syndrome (VISTA-16)

Acute Coronary Syndrome

United States, Australia, Canada, Czech Republic, Georgia, Germany, Hungary, India, Italy, Korea, Republic of, Lebanon, Netherlands, New Zealand, Poland, Russian Federation, Spain, Ukraine
Ophirex, Inc.
Premier Research Group plc

Terminated

Study of Varespladib in Patients Hospitalized With Severe COVID-19 (STAIRS)

Coronavirus Disease 2019 | Disease Caused by Severe Acute Respiratory Syndrome Coronavirus 2

United States
GlaxoSmithKline
The TIMI Study Group

Completed

The Stabilization Of pLaques usIng Darapladib-Thrombolysis In Myocardial Infarction 52 Trial (SOLID-TIMI 52)

Acute Coronary Syndrome

United States, France, Netherlands, Ukraine, Germany, Taiwan, Bulgaria, Hungary, Poland, Russian Federation, Argentina, Belgium, Peru, Philippines, Sweden, Thailand, Israel, Spain, Korea, Republic of, Australia, Czechia, Japan, New... and more
GlaxoSmithKline

Completed

A Phase II Clinical Study of SB-480848 in Dyslipidemic Patients

Atherosclerosis

Japan
Ophirex, Inc.

Recruiting

Broad-spectrum Rapid Antidote: Varespladib IV to Oral Trial for Snakebite (BRAVIO) (BRAVIO)

Snakebite | Envenoming, Snake

United States
Anthera Pharmaceuticals

Completed

FRANCIS-ACS Trial: A Study of the Safety and Efficacy of A 002 in Subjects With Acute Coronary Syndromes (FRANCIS-ACS)

Acute Coronary Syndrome

Russian Federation, Georgia, Ukraine
University of Reading

Completed

Effects of A2 Milk on Gastrointestinal Function in Non-lactose Milk Intolerance

Milk Intolerance

United Kingdom
GlaxoSmithKline

Completed

To Estimate the Potential Effects of Repeat Doses of Darapladib on the Pharmacokinetics (PK) of Rosuvastatin as Well as Evaluating Safety and Tolerability in Healthy Volunteers

Atherosclerosis

United States
GlaxoSmithKline

Completed

Study to Determine the Effect of Repeated Administration of Diltiazem on the Pharmacokinetics of Darapladib (Sb-480848).

Atherosclerosis

United States
GlaxoSmithKline

Completed

Pharmacokinetic Interaction of Darapladib and CYP 3A4 in Healthy Subjects

Atherosclerosis

United States
Seoul National University Bundang Hospital

Active, not recruiting

Evaluation of the Efficacy and Safety of A2 Milk on Digestion

Digestive Discomfort

Korea, Republic of
Institut Pasteur de Lille

Completed

Milk Consumption on Digestive Comfort. (A2-DIGEST)

Healthy Volunteers

France
Athenex, Inc.

Withdrawn

Evaluate TCRT-ESO-A2 Autologous T Cells Expressing TCR Specific for NY-ESO-1 in Subjects With Advanced Solid Tumors

Advanced Solid Tumor
National Institute of Allergy and Infectious Diseases...

Completed

Challenge Infection of Healthy Adult Volunteers With RSV A2

Upper Respiratory Tract Infections

United States
SynergEyes, Inc.

Unknown

Study to Evaluate the Clinical Performance of SynergEyes A2 Hybrid Contact Lenses

Refractive Errors | Astigmatism

United States
Royal College of Surgeons, Ireland
Jagmed Limited

Unknown

A Study Measuring the Effectiveness of Combined Modulated Ultrasound and Electric Current Stimulation as an Adjunctive Treatment in Treating Diabetic Foot Ulcers

Diabetic Foot Ulcer
Purdue University

Completed

Comparing the Gastric Transit of Commercial Milk and A2 Milk

Lactose Intolerance, Adult Type

United States
Sorrento Therapeutics, Inc.

Completed

Study to Evaluate the Safety and Efficacy of Anti-CD38 CAR-T in Relapsed or Refractory Multiple Myeloma Patients

Relapsed or Refractory Multiple Myeloma

United States
National Institute of Allergy and Infectious Diseases...

Completed

Respiratory Syncytial Virus Human Challenge in Healthy Adult Volunteers

Upper Respiratory Tract Infection

United States
Purdue University

Recruiting

Comparing the Adaptation of Commercial Milk and A2 Milk in Lactose Maldigesters

Lactose Intolerance

United States
Purdue University

Recruiting

Comparing the Inflammation, Maldigestion and Symptoms Due to Commercial Milk and A2 Milk

Lactose Intolerance

United States
Auburn University

Recruiting

Double Crossover Casein Type Tolerance Trial

Healthy Adults | Dairy Intolerance

United States
a2 Milk Company Ltd.

Completed

Incidence of Lactose Intolerance Among Self-reported Lactose Intolerant People

Lactose Intolerance
Thuasne

Recruiting

Contribution of an Off-the-shelf Carbon Ankle Foot Orthosis (AFO) in the Management of Walking Functional Impairment (DEFISTEP)

Neuropathy (Disorder)

France
Maastricht University Medical Center

Completed

Impact of A2 Milk Versus Conventional Milk on Intestinal Health: a Proof-of-concept Study in IBS-patients

Irritable Bowel Syndrome

Netherlands
University of Pittsburgh

Completed

Effects of an 8-day Advanced Meditation, Samyama on Physical, Psychological and Spiritual Wellbeing ,and Associated Neural Mechanisms

Depression | Stress | Inflammatory Bowel Diseases | Dietary Habits | Mental Health Wellness 1 | Happiness | Consciousness, Level Altered | Ecstasy

United States
Northumbria University
ESPA Research; a2 Milk Company Ltd.

Completed

a2 Milk for Autism and Attention-deficit Hyperactivity Disorder (ADHD) (A2MT)

Autism Spectrum Disorder | Attention Deficit Hyperactivity Disorder | Autism

United Kingdom
Bakirkoy Dr. Sadi Konuk Research and Training Hospital

Completed

Serum Caspase 3, Annexin a2 and Soluble Fas Levels and Endometriosis

Endometriosis | Apoptotic Pathway Deregulation

Turkey
Cevriye Mülkoğlu

Completed

Effect of Oral Isotretinoin on Muscle Strength in Patients With Acne Vulgaris: A Prospective Controlled Study

Muscle Strength

Turkey
Quell Therapeutics Limited

Recruiting

Safety and Clinical Activity of QEL-001 in A2-mismatch Liver Transplant Patients (LIBERATE)

Liver Diseases | Liver Failure | Rejection; Transplant, Liver

Belgium, United Kingdom, Spain

Search clinical trials for: Phospholipase A2 Inhibitors

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