Search clinical trials for: Placebo-to-match GS-1427

Total 1576 results

Vertex Pharmaceuticals Incorporated

Completed

Study of VX-121 in Healthy Subjects and in Subjects With Cystic Fibrosis

Cystic Fibrosis

Netherlands, United Kingdom
Novartis Pharmaceuticals

Completed

Safety and Efficacy of DNK333 in Atopic Dermatitis Patients

Pruritus in Patients With Atopic Dermatitis

Germany
AstraZeneca

Completed

Trial to Assess the Anti-inflammatory Effects of Roflumilast in Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease | COPD

Poland, United Kingdom, Germany, Sweden, Denmark
Bayer

Terminated

A Study to Learn How Safe Study Drug BAY2413555 is, How it Affects the Body, and How it Moves Into, Through, and Out of the Body Over 4 Weeks of Use in Participants With Heart Failure and Implanted Cardiac Defibrillator or Cardiac Resynchronization Devices (ICD/CRT) (REMOTE-HF)

Chronic Heart Failure

United States, Spain, Denmark, Israel, Germany, Italy
Guangdong Hengrui Pharmaceutical Co., Ltd

Enrolling by invitation

A Study to Assess the Efficacy and Tolerance of HRS-2261 in Subjects With Refractory Chronic Cough

Refractory Chronic Cough

China
Intermountain Health Care, Inc.
University of Utah

Active, not recruiting

Family Procedural Presence

Patient and Family Engagement

United States
Crucell Holland BV

Completed

A Study to Evaluate the Immunogenicity, Safety and Tolerability of Ad26.ZEBOV and MVA-BN-Filo in Healthy Adult Participants

Healthy

United States
Jiangsu Hansoh Pharmaceutical Co., Ltd.
Nanjing Medical University

Unknown

Phase Ⅲ Trial for Combination Treatment of PEG-Tα1 and Adefovir for HBeAg-positive Chronic Hepatitis B (PEG-Tα1)

Hepatitis B, Chronic

China
Ono Pharmaceutical Co. Ltd

Terminated

A Four-Part Study to Assess the Safety, Tolerability, PK and PD of ONO-5788 in Healthy Adult Volunteers

Acromegaly

United States
Advanz Pharma

Completed

A Study of the Efficacy and Safety of Vernakalant Hydrochloride (MK-6621) in Patients With Atrial Fibrillation (MK-6621-010 AM4)

Atrial Fibrillation
Merck Sharp & Dohme LLC

Completed

A Study of a Bivalent Influenza Peptide Conjugate Vaccine in Healthy Adults

Influenza
Centre for Addiction and Mental Health
Ottawa Heart Institute Research Corporation; Canadian Cancer Society (CCS)

Completed

Personalized Dosing of Nicotine Replacement (NRT to Effect)

Tobacco Use Disorder | Nicotine Dependence

Canada
Purdue Pharma LP

Completed

Buprenorphine Accumulation and Description of Its Metabolites During Co-Medication of Buprenorphine Transdermal System (BTDS) and Ketoconazole

Healthy

United States
Murdoch Childrens Research Institute

Suspended

Can Vitamin D Treatment Help Treat Moderate to Severe Atopic Dermatitis in Young Children? The D-Vex Pilot Study (D-Vex)

Atopic Dermatitis

Australia
Brigham and Women's Hospital
National Cancer Institute (NCI); Mayo Clinic; Albert Einstein College of Medicine and other collaborators

Completed

KEEPS Mammographic Density And Breast Health Ancillary Study (KEEPS MDBHAS)

Mammographic Density | Abnormal Mammogram

United States
Hoffmann-La Roche

Completed

An Efficacy and Safety Study of Subcutaneous Tocilizumab in Combination With Methotrexate (MTX) and as Monotherapy Versus MTX in Participants With Moderate to Severe Rheumatoid Arthritis With Inadequate Response to Current Disease-Modifying Antirheumatic Drug (DMARD) Therapy

Rheumatoid Arthritis

China
Universidade Federal do Ceara

Completed

Effects of Auriculotherapy on Pain and Functional Capacity of Individuals With Chikungunya Fever

Chikungunya Fever

Brazil
Boehringer Ingelheim

Completed

Safety, Tolerability and Pharmacokinetics of Multiple Rising Doses of BI 113608 in Healthy Male Volunteers

Healthy

Germany
The Scripps Research Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Completed

Tobacco Dependence in Alcoholism Treatment (Nicotine Patch/Naltrexone)

Smoking | Alcoholism

United States
Shire

Terminated

Evaluation of Ecallantide for Treatment of Angiotensin Converting Enzyme (ACE) Inhibitor Induced Angioedema

ACE Inhibitor Induced Angioedema

United States
Gilead Sciences

Terminated

Study of Edecesertib in Participants With Cutaneous Lupus Erythematosus (CLE) (LYNX)

Cutaneous Lupus Erythematosus

United States
Gilead Sciences
Nimbus Apollo

Completed

Study to Evaluate the Pharmacodynamic Effects of a Single Oral Dose of GS-0976 (NDI-010976) in Healthy Adult Subjects

PD Effects of GS-0976 (NDI-010976) on Fractional DNL

United States
Gilead Sciences

Completed

Dose-Ranging Study of Sofosbuvir in Combination With Pegylated Interferon and Ribavirin in Treatment Naïve GT 1 HCV Patients

Hepatitis C

United States, Puerto Rico
ZARS Pharma Inc.

Terminated

Fentanyl Transdermal Patch With CHADD™ for Breakthrough Pain in Patients With Moderate to Severe Non-Malignant Pain

Pain

United States
Vibe G Frøkjær, MD, PhD
Hvidovre University Hospital; Herlev Hospital

Recruiting

Maternal Mental Health Trial (MAMA)

Postpartum Depression | Major Depressive Disorder

Denmark
University Hospital Heidelberg

Terminated

Gemtuzumab Ozogamicin in Induction and Glasdegib in Postremission Therapy in Patients With AML (Acute Myeloid Leukemia) (GnG)

Acute Myeloid Leukemia

Germany
ACELYRIN Inc.

Completed

Hidradenitis Suppurativa Phase 2b Pivotal Study of Izokibep

Hidradenitis Suppurativa

United States, Canada, Germany, Hungary, Poland, Spain
Theratocular Biotek Co.
Novotech (Australia) Pty Limited

Active, not recruiting

A Study to Investigate the Effect of IOP-lowering With TO-O-1001 Eye Drops in Healthy Subjects and in Patients With Open-Angle Glaucoma or Ocular Hypertension

Ocular Hypertension | Open Angle Glaucoma

Australia
Pennington Biomedical Research Center
THE C.B. AND IRENE PENNINGTON FOUNDATION

Completed

Postpartum Weight Loss and Exercise (PRIDE) (PRIDE)

Glucose Intolerance | Gestational Diabetes

United States
AstraZeneca

Completed

Esophageal Hypersensitivity Study in Patients With Gastroesophageal Reflux Disease (GERD)

Sensitivity in Esophagus

Denmark, Sweden
Merck Sharp & Dohme LLC

Completed

MK-0954E Phase III Long-Term Study in Participants With Hypertension (MK-0954E-356)

Hypertension
Gilead Sciences

Terminated

Magrolimab + Azacitidine Versus Azacitidine + Placebo in Untreated Participants With Myelodysplastic Syndrome (MDS) (ENHANCE)

Myelodysplastic Syndromes

United States, Spain, Belgium, Australia, France, Hong Kong, Hungary, Finland, New Zealand, Germany, Netherlands, United Kingdom, Italy, Switzerland, Portugal, Canada, Austria, Czechia, Norway, Poland, Turkey
ACELYRIN Inc.

Active, not recruiting

Psoriatic Arthritis Study of Izokibep

Psoriatic Arthritis

United States, Bulgaria, Canada, Czechia, Germany, Hungary, Poland, Spain
Novartis Pharmaceuticals

Completed

To Assess Safety, Tolerability and Efficacy of LJN452 in Patients With Primary Bile Acid Diarrhea.

Primary Bile Acid Diarrhea

United States, United Kingdom
AstraZeneca

Completed

Study to Investigate Multiple Ascending Oral Doses of AZD5213 in Healthy Male and Non Fertile Female Subjects

Healthy

United States
Aswan University Hospital

Unknown

Role of 200 mg Versus 400mg Vaginal Progesterone in Prevention of Preterm Labor in Twin Gestation

Twin; Pregnancy, Affecting Fetus or Newborn

Egypt
Columbia University
National Institute on Aging (NIA); Harvard School of Public Health (HSPH); National...

Completed

The Effect of De-Prescribing Antipsychotics on Health and Quality of Life for People With Dementia

Dementia | Alzheimer Disease | Prescribing, Off-Label

United States
University of Colorado, Denver
National Institute on Aging (NIA)

Recruiting

Bioenergetic Effects of Aging and Menopause (BEAM) (BEAM)

Menopause | Aging | Weight Gain | Obesity, Abdominal

United States
GlaxoSmithKline

Completed

Emotional Processing in Healthy Volunteers in the Presence of an Investigational Anxiolytic

Depressive Disorder and Anxiety Disorders

United Kingdom
Kessler Foundation

Recruiting

Evaluation of a Theory-Driven Manualized Approach to Improving New Learning and Memory in MS (STEM)

Multiple Sclerosis

United States
Gilead Sciences

Terminated

Study to Evaluate the Efficacy and Safety of Remdesivir in Participants With Severely Reduced Kidney Function Who Are Hospitalized for Coronavirus Disease 2019 (COVID-19) (REDPINE)

COVID-19

Spain, United States, United Kingdom, Portugal, Brazil, South Africa
Federal University of São Paulo

Completed

Non-Pharmacologic Interventions to Relief Pain in Healthy Newborns Submitted to Vaccination to Hepatitis B

Pain | Analgesia
Merck Sharp & Dohme LLC

Completed

A Study of Omarigliptin (MK-3102) in Participants With Type 2 Diabetes Mellitus With Chronic Kidney Disease or Kidney Failure on Dialysis (MK-3102-019)

Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC

Completed

Letermovir Versus Valganciclovir to Prevent Human Cytomegalovirus Disease in Kidney Transplant Recipients (MK-8228-002)

CMV Disease

United States, Argentina, Australia, Austria, Belgium, Canada, Colombia, France, Germany, Hungary, Italy, Mexico, New Zealand, Poland, Spain, United Kingdom
Gangnam Severance Hospital

Completed

Effect of Oral Carbohydrate on Serum S-100β Protein and Development of Postoperative Delirium in Elderly Patients

Inflammation | Delirium | Insulin Resistance
Vertex Pharmaceuticals Incorporated

Completed

Study of VX-661 Alone and in Combination With Ivacaftor in Subjects Homozygous or Heterozygous to the F508del-Cystic Fibrosis Transmembrane Conductance Regulator(CFTR) Mutation

Cystic Fibrosis

United States, Canada, Germany, United Kingdom
Memorial Sloan Kettering Cancer Center

Withdrawn

Transdermal Methylphenidate for Cancer-Related Fatigue

Head and Neck Cancer
EMS

Not yet recruiting

Efficacy and Safety of Toronto Association in the Treatment of Erectile Dysfunction and Premature Ejaculation

Erectile Dysfunction | Premature Ejaculation
Assembly Biosciences

Completed

A Study to Assess Safety, Tolerability, and Pharmacokinetics of ABI-H3733 in Healthy Adults

Chronic Hepatitis B

New Zealand
Vertex Pharmaceuticals Incorporated

Completed

Study to Evaluate Safety and Efficacy of VX-661 in Combination With Ivacaftor in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation With an Open-Label Expansion

Cystic Fibrosis

United States

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