Search clinical trials for: Potassium Channel Blockers

Total 11785 results

University of Missouri-Columbia

Recruiting

ENAC Blockade and Arterial Stiffness

Insulin Resistance | Overweight and Obesity

United States
University of Southern Denmark
Odense University Hospital; Region of Southern Denmark

Completed

Increased Activity of ENaC in Proteinuric Kidney Transplant Recipients

Kidney Transplant; Complications

Denmark
University of Southern Denmark
Odense University Hospital; The Ministry of Science, Technology and Innovation... and other collaborators

Unknown

Increased Activity of a Renal Salt Transporter (ENaC) in Diabetic Kidney Disease

Hypertension | Diabetic Nephropathies

Denmark
Acorda Therapeutics

Completed

A Phase 2b Study of Dalfampridine 10mg Extended Release Tablet in Subjects With Chronic Deficits After Ischemic Stroke

Ischemic Stroke

United States
Coordinación de Investigación en Salud, Mexico

Active, not recruiting

High Doses of 4-aminopyridine in Clinically Complete Chronic Spinal Cord Injury Patients.

Spinal Cord Injuries | Chronic

Mexico
Coordinación de Investigación en Salud, Mexico

Completed

Efficacy and Safety of 4-aminopyridine on Cognitive Performance and Motor Function of Patients With Multiple Sclerosis

Multiple Sclerosis

Mexico
FDA Office of Orphan Products Development

Completed

Assessment of Chronic Guillain-Barre Syndrome Improvement With Use of 4-aminopyridine

Guillain-Barre Syndrome

United States
Acorda Therapeutics

Completed

Open-Label Extension Study to Evaluate the Safety, Tolerability and Activity of Oral Fampridine-SR in Patients With Multiple Sclerosis

Multiple Sclerosis

United States, Canada
Acorda Therapeutics
Prometrika, LLC; BCS Consulting, Inc.

Completed

An Open Label, Proof of Concept Study to Evaluate the Effects of Dalfampridine Withdrawal on Gait and Balance Parameters in Subjects With Multiple Sclerosis (MS)

Multiple Sclerosis

United States
Yale University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

Mechanisms of Diuretic Resistance in Heart Failure, Aim 2 (MsDR 2)

Heart Failure

United States
Guangdong Provincial People's Hospital

Completed

A New Application of Amiloride in the Treatment of Patient With Chronic Kidney Disease In Reducing Urinary PROtein (ANTI-UPRO)

Chronic Kidney Diseases

China
Boston Children's Hospital
Cystic Fibrosis Foundation

Completed

Amiloride Solution and Tobramycin Solution for Inhalation for the Eradication of Burkholderia Dolosa in Patients With Cystic Fibrosis

Cystic Fibrosis

United States
Milton S. Hershey Medical Center

Terminated

A Single Dose Pharmaco-Diagnostic for Peripheral Nerve Continuity After Trauma

Nerve Injury

United States
Washington University School of Medicine
Acorda Therapeutics

Completed

Ampyra for Optic Neuritis in Multiple Sclerosis

Multiple Sclerosis | Optic Neuritis

United States
Columbia University

Completed

Short and Long Term Treatment With 4-AP in Ambulatory SMA Patients

Spinal Muscular Atrophy

United States
University of Southern Denmark
Biogen; Region of Southern Denmark

Completed

FAME - Fampyra Outcome Measures Study: a Study of Different Outcome Measures on the Effect of Fampyra (FAME)

Multiple Sclerosis

Denmark
Acorda Therapeutics

Completed

A Study to Evaluate the Efficacy and Safety of Two Dose Strengths of Dalfampridine Extended Release Tablets. (MILESTONE℠)

Post-Ischemic Stroke

United States, Canada
University of California, San Francisco
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Diuretics, Hypertension, and Arrhythmias Clinical Trial

Heart Diseases | Cardiovascular Diseases | Hypertension | Heart Arrest | Death, Sudden, Cardiac
Ain Shams University

Recruiting

Comparative Study Between Nicorandil and Nifedipine for the Treatment of Preterm Labour

Preterm Labor With Preterm Delivery

Egypt
Radboud University Medical Center

Completed

The Influence of Rosiglitazone on the Diuretic Effect of Furosemide and Amiloride

Insulin Resistance

Netherlands
Biogen

Completed

A Safety and Efficacy Study of Oral Prolonged-Release Fampridine (BIIB041) in Japanese Participants With Multiple Sclerosis (MOTION - JAPAN)

Multiple Sclerosis | Relapsing-Remitting Multiple Sclerosis | Secondary Progressive Multiple Sclerosis | Multiple Sclerosis, Primary Progressive | Multiple Sclerosis, Remittent Progressive

Japan
Thryv Therapeutics, Inc.

Recruiting

Study of LQT-1213 on QTc-induced Prolongation in Healthy Adult Subjects (Part1) and on Congenital Long QT in Patients Diagnosed With Type 2 or 3 Long QT Syndrome (Part 2).

Long QT Syndrome

United States
Erasmus Medical Center

Recruiting

Treatment of Vascular Stiffness in ADPKD (TRAMPOLINE)

Autosomal Dominant Polycystic Kidney

Netherlands
State University of New York - Upstate Medical...

Terminated

Amiloride Hydrochloride as an Effective Treatment for ADHD

ADHD

United States
Ain Shams University

Recruiting

Dalfampridine in Egyptian Patients With Multiple Sclerosis

Multiple Sclerosis

Egypt
Brown, Theodore R., M.D., MPH
Acorda Therapeutics

Completed

A Placebo Controlled Trial of Dalfampridine ER for Ambulatory Activity in People With Multiple Sclerosis

Multiple Sclerosis

United States
Assistance Publique - Hôpitaux de Paris
URC-CIC Paris Descartes Necker Cochin

Withdrawn

Potassium Chloride in Out-of-hospital Cardiac Arrest Due to Refractory Ventricular Fibrillation (POTACREH)

Out-of-hospital Cardiac Arrest (OHCA)

France
Acorda Therapeutics

Completed

Study of Oral Fampridine-SR in Multiple Sclerosis

Multiple Sclerosis

United States, Canada
Acorda Therapeutics

Terminated

Study to Evaluate the Long-Term Safety, Tolerability and Efficacy of Dalfampridine. (MILESTONE℠)

Post-ischemic Stroke

United States, Canada
Acorda Therapeutics

Completed

Study of Fampridine-ER Tablets in Patients With Multiple Sclerosis

Multiple Sclerosis

United States
Biogen

Terminated

Fampridine Pregnancy Exposure Registry

Multiple Sclerosis | Pregnancy

France
Biogen
Acorda Therapeutics

Completed

A Pharmacokinetics (PK) and Safety Study of Oral Fampridine-PR 10 mg in Chinese, Japanese, and Caucasian Adult Healthy Volunteers

Healthy

Hong Kong, Australia
Erasmus Medical Center

Completed

DD-study: Diet or Diuretics for Salt-sensitivity in Chronic Kidney Disease (DD)

Chronic Kidney Disease

Netherlands
Centre Hospitalier Universitaire, Amiens

Completed

Pilot Study on the Usefulness of 3,4-diaminopyridine in the Treatment of Botulism

Botulism

France
FDA Office of Orphan Products Development
Duke University

Completed

Randomized Study of 3,4-Diaminopyridine for Lambert-Eaton Myasthenic Syndrome

Lambert-Eaton Myasthenic Syndrome
David Lacomis, MD
Jacobus Pharmaceutical

No longer available

Treatment of Lambert-Eaton Syndrome With 3,4 Diaminopyridine

Lambert-Eaton Myasthenic Syndrome
Sheba Medical Center

Unknown

Efficacy of Dalfampridine on Upper Extremity Function in Patients With MS

Multiple Sclerosis

Israel
Louis H. Weimer, MD

No longer available

Treatment of Lambert-Eaton Myasthenic Syndrome (LEMS) With 3, 4 DAP

Lambert Eaton Myasthenic Syndrome (LEMS)

United States
Augusta University

Recruiting

Firdapse for Post-BOTOX Vocal Weakness

Vocal Weakness(Post-BOTOX Injection)

United States
Biogen

Completed

Open-Label Study to Assess the Effect of Long-Term Prolonged-Release Fampridine (BIIB041) on Quality of Life as Reported by Participants With Multiple Sclerosis (ENABLE)

Multiple Sclerosis

France, Italy, United Kingdom, Germany, Australia, Belgium, Netherlands, Portugal, Denmark
Assistance Publique - Hôpitaux de Paris

Recruiting

AMIloride for the Treatment of Nephrogenic Diabetes Insipidus for Patients With Bipolar Disorder Treated With Lithium (AMIND)

Bipolar Disorder

France
University of Alabama at Birmingham
National Institutes of Health (NIH)

Completed

Vascular Effects of Mineralocorticoid Receptor Antagonism in Kidney Disease (VEMAKD)

Chronic Kidney Disease | Albuminuria

United States
University of New Mexico
University of Pittsburgh; Dialysis Clinic, Inc.

Terminated

Epithelial Sodium Channel (ENaC) as a Novel Mechanism for Hypertension and Volume Expansion in Type 2 Diabetes

Hypertension | Proteinuria | Type II Diabetes

United States
Yonsei University

Recruiting

Comparison of Spironolactone and Amiloride on Home Blood Pressure in Resistant Hypertension

Resistant Hypertension

Korea, Republic of
Regional Hospital Holstebro

Completed

The Effects of Amiloride and Spironolactone on Renophysiological and Cardiovascular Variables (hass)

Essential Hypertension

Denmark
Erling Bjerregaard Pedersen

Completed

The Effect of Amiloride and Spironolactone in Patients With Hypertension (hass)

Hypertension

Denmark
Wake Forest University Health Sciences

Recruiting

Effect of Amifampridine on Neuromuscular Transmission in Patients Treated With OnabotulinumtoxinA

Botulism | Iatrogenic Botulism

United States
The Cleveland Clinic

No longer available

Use Of 3,4-Diaminopyridine (3,4-DAP) In The Treatment Of Lambert Eaton Myasthenic Syndrome (34-DAP)

Lambert-Eaton Myasthenic Syndrome

United States
Biogen
Acorda Therapeutics

Completed

Open Label Extension Study to Evaluate the Safety and Tolerability of Oral Fampridine-Sustained Release (SR) in Canadian Participants With Multiple Sclerosis Who Participated in Acorda Extension Trials.

Multiple Sclerosis

Canada
Biogen

Completed

An Observational Study to Collect Information on Safety and to Document the Drug Utilization of Fampyra (BIIB041) When Used In Routine Medical Practice (LIBERATE)

Multiple Sclerosis

France, Spain, Germany, Netherlands, Argentina, Czechia, Israel, Portugal, United Arab Emirates, Canada, Norway, Lebanon, Ireland

Search clinical trials for: Potassium Channel Blockers

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