Search clinical trials for: Prostaglandin Antagonists

Total 32892 results

Assistance Publique - Hôpitaux de Paris

Unknown

Evaluating Efficacy and Safety of Danazol in Severe Hematologic or Pulmonary Disease Related to Telomeropathy (ANDROTELO)

Telomere Length, Mean Leukocyte | Telomere Shortening
Takeda

Completed

Efficacy and Safety of TAK-385 in the Treatment of Uterine Fibroids

Uterine Fibroids

Japan
BeiGene

Recruiting

A Study to Examine the Safety of Different Doses of BG-68501 Given to Participants With Advanced-Stage Tumors

Breast Cancer | Small Cell Lung Cancer | Gastric Cancer | Ovarian Cancer | Prostate Cancer | Advanced Solid Tumor | Endometrial Cancer | Hormone Receptor Positive HER-2 Negative Breast Cancer | Hormone-receptor-positive Breast Cancer

United States, Australia
UNICANCER
Novartis; Breast Cancer Research Foundation

Recruiting

Detection of Tumor DNA in the Blood of Patients Receiving Standard Therapy for Hormone Receptor-positive (HR+) Non-HER2 Expressing (HER2-) Metastatic Breast Cancer as a Tool to Select Those Who May Benefit From the Next Course of Fulvestrant in Combination With Alpelisib or Ribociclib (SAFIR 03)

Breast Cancer Stage IV

France
Blueprint Medicines Corporation

Recruiting

(VELA) Study of BLU-222 in Advanced Solid Tumors

Gastric Cancer | Ovarian Cancer | Carcinosarcoma | Advanced Solid Tumors | Endometrial Cancer | Esophageal Adenocarcinoma | HER2-negative Breast Cancer | CCNE1 Amplification | HR+ Breast Cancer

United States, Italy, United Kingdom
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Recruiting

A Study of TQB3616 Capsules Combined With Fulvestrant Injection in Subjects With Advanced Breast Cancer

HR-positive, HER2-negative Advanced Breast Cancer

China
University of California, Irvine
Eli Lilly and Company

Terminated

Neo-Adjuvant Abemaciclib With Fulvestrant in Patients With ER/PR +HER Negative Breast Cancer

Breast Neoplasm | Hormone Receptor Positive Breast Carcinoma

United States
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Unknown

A Study of TQ-B3525 Tablets Combined With Fulvestrant Injection in Subjects With HR-positive, HER2-negative and PIK3CA Mutation Advanced Breast Cancer

HR-positive, HER2-negative and PIK3CA Mutation Advanced Breast Cancer

China
Ontario Clinical Oncology Group (OCOG)
AstraZeneca

Completed

Trial to Evaluate the Therapeutic Benefit of Fulvestrant in Combination With ZACTIMA in Postmenopausal Women With Bone Predominant, Hormone Receptor Positive Metastatic Breast Cancer (ZAMBONEY)

Metastatic Breast Cancer

Canada
Merck Sharp & Dohme LLC

Not yet recruiting

Sacituzumab Tirumotecan (MK-2870) Versus Pemetrexed and Carboplatin Combination Therapy in Participants With Epidermal Growth Factor (EGFR)-Mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) and Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors (MK-2870-009)

Non-small Cell Lung Cancer (NSCLC)
Centre hospitalier de l'Université de Montréal...
Quebec Researchnetwork on aging

Recruiting

Mirtazapine for Chronic Insomnia in Older Adults (MIRAGE)

Chronic Insomnia

Canada
OnKure, Inc.

Recruiting

First-in-Human Study of OKI-219 in Advanced Solid Tumors and Advanced Breast Cancer (PIKture-01)

Breast Cancer | Advanced Cancer

United States
Organon and Co

Completed

Evaluation of Desloratadine When Used in Patients With Either Allergic Rhinitis or Chronic Idiopathic Urticaria (Aerius)

Rhinitis | Urticaria
Novartis Pharmaceuticals

Terminated

A Phase III Study of BKM120 With Fulvestrant in Patients With HR+,HER2-, AI Treated, Locally Advanced or Metastatic Breast Cancer Who Progressed on or After mTORi (BELLE-3)

Metastatic Breast Cancer

United States, Germany, Belgium, Canada, France, Italy, Spain, United Kingdom, Austria, Argentina, Sweden, Hungary, Korea, Republic of, Lebanon, Bulgaria, Greece, Thailand, Netherlands, Colombia, Norway, Finland, Poland
Shanghai Mental Health Center

Completed

a Pilot Study of Pramipexole to Treat Extrapyramidal Symptoms Induced by Antipsychotics

Extrapyramidal Syndrome

China
Centre de Recherche de l'Institut Universitaire...

Completed

Aspirin Versus Aspirin+Clopidogrel as Antithrombotic Treatment Following TAVI (ARTE)

Myocardial Infarction | Stroke | Bleeding | Aortic Valve Disease

Canada, Chile, Spain
National Institute of Mental Health (NIMH)

Terminated

Treatment of Menstrually Related Disorders With Continuous v. Interrupted Oral Contraceptives

Depression | Premenstrual Dysphoric Disorder | Premenstrual Syndrome | PMS | PMDD

United States
Treadwell Therapeutics, Inc

Recruiting

CFI-402257, a Potent and Selective TTK Inhibitor, in Solid Tumors and With Fulvestrant in Breast Cancer

Breast Cancer | Advanced Solid Tumor

United States
Kyoto Breast Cancer Research Network

Terminated

Anti PD-L1 Antibody + Anti CTLA-4 Antibody in Combination With Hormone Therapy in Patients With Hormone Receptor Positive HER2-negative Recurrent or Metastatic Breast Cancer

Breast Cancer

Japan
Novartis Pharmaceuticals

Completed

An Open Label Multi-center Extension Study to Evaluate Long-term Safety/ Tolerability of Dovitinib in Patients With Solid Tumors Who Continue to Receive Treatment With Dovitinib (TKI258) in Novartis-sponsored Single Agent Dovitinib Studies Which Fulfilled the Requirements for the Primary Objective

Solid Tumors

Austria, Belgium, United States, Italy, Denmark, Spain, Japan
University of Wisconsin, Madison
AstraZeneca; University of Pittsburgh

Withdrawn

Trial of ZD6474 and Faslodex in Non-Small Cell Lung Cancer

Carcinoma, Non Small Cell Lung
NeuroRx, Inc.
Prevail Infoworks, Inc

Active, not recruiting

NRX-101 for Bipolar Depression With Subacute Suicidal Ideation

Bipolar Depression | Suicidal Ideation and Behavior

United States
NeuroRx, Inc.
Target Health Inc.

Active, not recruiting

NRX-101 for Maintenance of Remission From Severe Bipolar Depression in Patients With Suicidal Ideation (SBD-ASIB)

Suicidal Ideation | Bipolar Depression

United States
Sumitomo Pharma Co., Ltd.

Completed

A Phase III Study of SM-13496 in Patients With Bipolar I Depression.

Bipolar Depression

Lithuania, Malaysia, Russian Federation, Slovakia, Ukraine, Japan, Philippines, Taiwan
Sunovion

Completed

A Study Evaluating Lurasidone for The Treatment of Schizophrenia or Schizoaffective Disorder in Subjects Switched From Other Antipsychotic Agents (SWITCHCore)

Schizophrenia | Schizoaffective Disorder

United States
Sunovion

Completed

Rifampin Drug-Drug Interaction Study With Lurasidone HCl

Male, Healthy Normal Subjects

United States
Sunovion

Completed

Digoxin Drug-Drug Interaction With Lurasidone HCl

Schizophrenia

United States
University of Saskatchewan

Completed

Airway Responses to Montelukast and Desloratadine.

Asthma

Canada
Kinnov Therapeutics

Not yet recruiting

A Study to Assess the Pharmacokinetic Profile of Prazosin and Cyproheptadine

Alcohol Use Disorder
UCB S.A. - Pharma Sector

Completed

Compare the Efficacy of Levocetirizine and Montelukast to Placebo in Reducing Seasonal Allergic Rhinitis (SAR) Symptoms in Ragweed Sensitive Subjects

Rhinitis, Allergic, Seasonal

Canada
Jeil Pharmaceutical Co., Ltd.

Completed

The PK Study of the JLP-1207 and Solifenacin/Tamsulosin in Healthy Male Volunteers.

Overactive Bladder | Benign Prostatic Hyperplasia | LUTS(Lower Urinary Tract Symptoms)
Astellas Pharma Europe B.V.

Completed

A Study to Evaluate How Tamsulosin (at 1 Dose) and Solifenacin (at 2 Different Doses) Are Taken up From the Intestine, Distributed Through the Body and Eliminated From the Body When Administered in Combination as a Single Tablet (Called EC905)

Healthy Subjects | Pharmacokinetics | EC905 | Multiple Dose

United Kingdom
Northwestern University

Recruiting

Cognitive Effects of Androgen Receptor Directed Therapies for Advanced Prostate Cancer

Metastatic Prostate Carcinoma | Recurrent Prostate Carcinoma | Stage IV Prostate Cancer | Hormone-Refractory Prostate Cancer | Castration-Resistant Prostatic Cancer

United States
Peking University People's Hospital
Peking University First Hospital; Beijing Friendship Hospital; Chinese PLA General... and other collaborators

Recruiting

Low-dose Baricitinib Plus Danazol for Steroid-resistant/Relapse Immune Thrombocytopenia

Immune Thrombocytopenia

China
IVI Madrid

Completed

Effects of Telomerase Reactivation With Danazol in Ovarian Function.

Ovarian Reserve

Spain
Ain Shams University

Recruiting

Mirtazapine Versus Dexamethasone in Preventing Postoperative Nausea and Vomiting

Post Operative Nausea and Vomiting

Egypt
Organon and Co

Completed

An Efficacy and Safety Study of Desloratadine (MK-4117) in Japanese Participants With Chronic Urticaria (MK-4117-201)

Urticaria
Eagle Pharmaceuticals, Inc.

Completed

Study to Evaluate the Safety, Tolerability, and PK of Fulvestrant After IM Administration

Pharmacokinetics

United States
AstraZeneca

Completed

Study to Compare the Effects of AZD9496 vs Fulvestrant in Breast Cancer. (D6090C00002)

Postmenopausal Women With ER+ HER2- Primary Breast Cancer

Germany, United Kingdom
Tigris Pharmaceuticals

Terminated

Study of AFP464 +/- Faslodex in ER + Breast Cancer

Breast Neoplasm

United States
University of Wisconsin, Madison

Completed

Treatment of Symptoms After Stent Placement for Urinary Tract Obstruction

Ureteral Obstruction

United States
Astellas Pharma Inc

Completed

A Study With Combination Treatment (Tamsulosin Hydrochloride and Solifenacin Succinate) in Male Patients With LUTS/BPH (SATURN)

Lower Urinary Tract Symptoms | Prostatic Hyperplasia

France, Poland, Germany, Spain, Finland, Netherlands, Russian Federation, Czech Republic, Hungary, Norway, Denmark, Slovakia, Sweden, Austria, Portugal, United Kingdom
Actelion

Completed

A Study to Evaluate Whether Macitentan is an Effective and Safe Treatment for Patients With Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease (SERENADE)

Heart Failure With Preserved Ejection Fraction

United States, Spain, United Kingdom, Poland, Germany, Israel, Austria, Czechia, Russian Federation, Denmark, Bulgaria, Hungary, France, Argentina, Brazil, Romania, Sweden
Viramal Limited

Completed

Study to Determine Intraperitoneal,Tissue, Serum Concentrations of VML-0501 Following Five Days of Daily Vaginal Single Dose of VML-0501 (100 mg Danazol), in Comparison to Oral Danazol Capsules Daily 600 mg), in Women With Signs and Symptoms of Endometriosis Undergoing Laparoscopy

Endometriosis

Italy
Actelion

Completed

Extension of the Psychometric Validation Study ORCHESTRA in Patients With PAH

Pulmonary Arterial Hypertension

Spain, France, Italy
NeuroRx, Inc.
Target Health Inc.

Completed

NRX101 Glx Biomarker Validation Study (NRX-GLX)

Suicidal Ideation | Bipolar Depression

United States
Sunovion

Completed

Lurasidone HCL - A 6-week Phase 3 Study of Patients With Acute Schizophrenia. (PEARL 3)

Schizophrenia

United States, Russian Federation, India, Romania, Ukraine
Dana-Farber Cancer Institute

Active, not recruiting

Fulvestrant With or Without Ganetespib in HR+ Breast Cancer

Breast Cancer

United States
Fudan University

Active, not recruiting

Dalpiciclib, Fulvestrant, Trastuzumab and Pertuzumab in HR Positive, HER2 Positive Metastatic Breast Cancer

Breast Cancer

China
Organon and Co

Completed

Comparison of the Effects of Desloratadine and Placebo in the Relief of Nasal Symptom Scores in Subjects With Seasonal Allergic Rhinitis to Cypress Pollen (Study P02836)

Seasonal Allergic Rhinitis

3

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