Search clinical trials for: Proteolytic enzymes

Total 47829 results

Chromaderm, Inc.

Completed

Protein Kinase C (PKC) Inhibitor-Diabetic Retinopathy Phase 3 Study

Diabetic Retinopathy

United States
Chromaderm, Inc.

Completed

Treatment for Completers of the Study B7A-MC-MBCM

Diabetic Retinopathy

United States
Bayer

Completed

Relative Bioavailability and Food Effect Study

Pharmacology, Clinical

Germany
Chroma Therapeutics

Unknown

Extension Study With Tosedostat in Relapsed/Refractory Acute Myeloid Leukemia

Acute Myeloid Leukemia

United States
Sanofi

Recruiting

Study to Evaluate the Efficacy and Safety of Venglustat in Adult and Pediatric Patients With Gaucher Disease Type 3 (LEAP2MONO)

Gaucher's Disease Type III

United States, Germany, Hungary, France, China, Japan, Canada, Argentina, Italy, Turkey
Icahn School of Medicine at Mount Sinai

Recruiting

JAK Inhibition in Food Allergy

Food Allergy

United States
Novartis Pharmaceuticals

Available

Global Managed Access Program Cohort for Remibrutinib in Adult Patients With Chronic Spontaneous Urticaria

Chronic Spontaneous Urticaria
Pfizer

Completed

Efficacy and Safety of Tofacitinib in Subjects With Active Ankylosing Spondylitis (AS)

Ankylosing Spondylitis

United States, Poland, Bulgaria, Korea, Republic of, Czechia, China, Israel, Australia, Turkey, Canada, Hungary, Russian Federation, France, Ukraine
Xiangya Hospital of Central South University

Active, not recruiting

The Effect of Early Use of Methylene Blue on Hemodynamics in Septic Shock

Septic Shock

China
GlaxoSmithKline

Completed

Safety, Pharmacokinetic (PK) and Pharmacodynamic (PD) Study of Repeat Doses of Inhaled Nemiralisib in Patients With APDS/PASLI

Activated PI3K-delta Syndrome

United Kingdom
University of California, San Diego

Completed

Nitisinone (NTBC) In Different Age Groups Of Patients With Alkaptonuria

Alkaptonuria

United States
Saptalis Pharmaceuticals LLC
bioRASI, LLC

Completed

A Bioequivalence Study With Clinical Endpoints to Evaluate the Safety and Therapeutic Equivalence of Permethrin Cream 5% & Elimite™ in Subjects With Scabies

Scabies

United States
Gilead Sciences

Completed

Study to Evaluate Safety, Tolerability, and Efficacy of GS-0976 in Adults With Nonalcoholic Steatohepatitis

Nonalcoholic Steatohepatitis (NASH)

United States
Dinesh Khanna, MD, MS
Bayer

Completed

Riociguat in Scleroderma Associated Digital Ulcers (RESCUE)

Scleroderma | Digital Ulcers

United States
Eisai Inc.

Completed

Evaluating the Efficacy and Safety of Oral Ranirestat (40 and 80 mg) in Mild to Moderate Diabetic Sensorimotor Polyneuropathy

Mild to Moderate Diabetic Sensorimotor Polyneuropathy

United States
Globe Pharmaceuticals Limited
Globe pharmaceuticals Ltd, Dhaka, Bangladesh

Unknown

Safety and Efficacy of Tofacitinib in the Treatment of NSAID Refractory Axial Spondyloarthritis:A Clinical Trial

Axial Spondyloarthritis

Bangladesh
M.D. Anderson Cancer Center
Schering-Plough

Completed

A Phase IB Study Of Oral SCH 66336 Preoperatively In Patients With Head And Neck Squamous Cell Cancer

Carcinoma, Squamous Cell | Cancer of Head and Neck

United States
Janssen Research & Development, LLC

Completed

A Single and Multiple Dose Study to Investigate Safety, Tolerability and Pharmacokinetics of JNJ-42165279 in Healthy Japanese Male Participants

Healthy

United States
Hoffmann-La Roche

Completed

A Study to Assess the Efficacy of RO5459072 in Participants With Primary Sjogren's Syndrome

Sjogren's Syndrome

United States, United Kingdom, Poland, Germany, Portugal, France
Bristol-Myers Squibb

Completed

Pharmacokinetics and Metabolism Study in Healthy Male Participants

Cancer

United States
Takeda

Completed

Phase I Open-label Study to Evaluate Pharmacokinetics of TAK-272 in Participants With Renal or Hepatic Impairment

Renal Impairment | Hepatic Impairment

Japan
Genzyme, a Sanofi Company

Completed

A Study of the Effects of Hepatic Impairment on the Pharmacokinetics and Tolerability of Eliglustat Tartrate

Gaucher Disease

United States
Hoffmann-La Roche

Completed

An Exploratory Study of RO4929097 in Patients With Recurrent or Refractory Non-Small Cell Lung Cancer

Non-Squamous Non-Small Cell Lung Cancer

Netherlands
UNC Lineberger Comprehensive Cancer Center
National Cancer Institute (NCI)

Completed

Biomarkers Related to Thrombosis in Patients With Newly Diagnosed Multiple Myeloma Receiving Chemotherapy

Multiple Myeloma | Thromboembolism | Plasma Cell Neoplasm

United States
Chromaderm, Inc.

Completed

Treatment for Symptomatic Peripheral Neuropathy in Patients With Diabetes

Diabetic Neuropathies | Diabetes Mellitus, Non-Insulin-Dependent | Diabetes Mellitus, Insulin-Dependent

Canada, United States, Croatia, Finland, India, Lithuania, Netherlands, United Kingdom
University of Florida

Completed

Lowering Serum Uric Acid to Prevent Acute Kidney Injury (RasbAKI)

Hyperuricemia

United States
Chroma Therapeutics
Institute of Cancer Research, United Kingdom

Completed

Safety Study to Evaluate CHR-2797 in Patients With Advanced Tumours

Advanced Solid Tumors
National University of Malaysia

Completed

Efficacy of Natural Enzymes Mouthwash: a Randomised Controlled Trial

Xerostomia | Dry Mouth

Malaysia
University College, London
National Institute for Health Research, United Kingdom

Recruiting

CiproPAL (Ciprofloxacin Prophylaxis in Acute Leukaemia) (CiproPAL)

Acute Lymphoblastic Leukaemia - Category

United Kingdom
Sherief Abd-Elsalam

Recruiting

Effect of Some Drugs on Liver Fibrosis

Liver Fibroses

Egypt
Vanderbilt University Medical Center
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Brigham... and other collaborators

Suspended

Optimal Management of HIV Infected Adults at Risk for Kidney Complications in Nigeria

Kidney Diseases | HIV/AIDS | Albuminuria | Genetic Predisposition

Nigeria
Brigham and Women's Hospital

Completed

Replication of the ONTARGET Antihypertensive Trial in Healthcare Claims Data

Hypertension

United States
Pharmtechnology LLC
Ligand Research, LLC

Completed

Bioequivalence Study of Two Formulations of Tablets Ramipril 10 mg in Healthy Volunteers Under Fasting Conditions

Bioequivalence

Russian Federation
Mazandaran University of Medical Sciences

Completed

Ciprofloxacin in Drug-resistant Epilepsy (CIDRE)

Epilepsy Intractable

Iran, Islamic Republic of
University Children's Hospital, Zurich
University Children's Hospital Basel; Ostschweizer Kinderspital

Unknown

Diagnosis of Mycoplasma Pneumoniae Infection With Detection of Specific Antibody-secreting Cells in Community-acquired Pneumonia (CAP) Patients of the Randomised Placebo-controlled Multi-centre Effectiveness Trial of Adjunct Betamethasone Therapy (myKIDS-STEP)

Community-acquired Pneumonia

Switzerland
Institute of Liver and Biliary Sciences, India

Completed

Comparison of the Efficacy of Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) and Norfloxacin in Secondary Prophylaxis for Spontaneous Bacterial Peritonitis

Spontaneous Bacterial Peritonitis

India
University Hospital Padova
DMG Paris Descartes

Unknown

Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA) (MAPA)

Hyperaldosteronism

Italy
Mario Negri Institute for Pharmacological Research
Agenzia Italiana del Farmaco

Completed

Preventing ESRD in Overt Nephropathy of Type 2 Diabetes (VALID)

Diabetes

Italy, Slovenia
Boehringer Ingelheim

Completed

Relative Bioavailability of Empagliflozin (BI 10773) and Ramipril Administered Together Compared to Empagliflozin (BI 10773) and Ramipril Alone in Healthy Volunteers

Healthy

Germany
Bayer

Completed

Ciprofloxacin Special Drug Use Investigation - To Investigate the Safety and Efficacy in Patients With Ciprofloxacin iv Administration Without Dilution

Infection

Japan
Samsung Medical Center

Not yet recruiting

Lazertinib 160mg in EGFR T790M NSCLC

Lung Cancer Stage IV | EGFR T790M

Korea, Republic of
Beijing Chest Hospital
Jiangsu HengRui Medicine Co., Ltd.

Not yet recruiting

A Real-World Study of Pyrotinib Maleate in the Treatment of Advanced/Metastatic Non-Small Cell Lung Cancer With Rare Mutations in HER2

HER2 Mutant Non-small Cell Lung Cancer
Xynomic Pharmaceuticals, Inc.

Recruiting

A Multi-Center Phase 2 Study to Evaluate Efficacy and Safety of Oral Abexinostat as Monotherapy in Patients With Relapsed or Refractory Follicular Lymphoma

Lymphoma, Follicular

China
Boehringer Ingelheim

Completed

Pharmacokinetics of BI 409306 After a High Fat, High Caloric Meal and After a Single Oral Dose Given at Bed Time in Healthy Volunteers

Healthy

Germany
Dana-Farber Cancer Institute
AstraZeneca

Active, not recruiting

AZD1775 in Women With Recurrent or Persistent Uterine Serous Carcinoma or Uterine Carcinosarcoma

Uterine Cancer

United States
Genzyme, a Sanofi Company

Completed

A Study of Mitoguazone Dihydrochloride in Patients With AIDS-Related Non-Hodgkin's Lymphoma

HIV Infections | Lymphoma, Non-Hodgkin

United States
BioCryst Pharmaceuticals

Approved for marketing

Oral Berotralstat Expanded Access Program

Hereditary Angioedema | Prophylaxis | HAE
Monica E. Kleinman
Schering-Plough

Completed

Phase II Trial of Lonafarnib (a Farnesyltransferase Inhibitor) for Progeria

Progeria | Hutchinson-Gilford Syndrome

United States
Bristol-Myers Squibb

Completed

A Study to Assess the Absorption of a Single Dose of BMS-986205 in Healthy Volunteers When Administered as a Crushed Tablet Orally or Crushed Tablet Suspension Via Nasogastric Tube, as Compared to a Tablet

Healthy Volunteers

United States
American Regent, Inc.

Completed

Safety, Tolerability, and Pharmacokinetic Study of Methylene Blue Following a 1 mg/kg Intravenous Dose in Healthy Adults

Methemoglobinemia | Congenital Methemoglobinemia

3

Subscribe