Search clinical trials for: Tolvaptan or Samsca

Total 5659 results

Cardiovascular Clinical Science Foundation

Completed

Randomized, Double-Blind, Placebo Controlled Study of the Short Term Clinical Effects of Tolvaptan in Patients Hospitalized for Worsening Heart Failure With Challenging Volume Management (Secret of CHF)

Heart Failure

United States
NYU Langone Health

Withdrawn

Fractional Urate Excretion in Nonedematous Hyponatremia

SIADH | Cerebral Hyponatremia | Cerebral Salt-wasting Syndrome | Reset Hypothalamic Osmostat

United States
Otsuka Pharmaceutical Development & Commercialization...

Completed

A PK Study of 3 Dosages of Tolvaptan in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)

Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)

Germany, United Kingdom, Spain, Sweden, Hungary, Czech Republic, Denmark
University of North Carolina, Chapel Hill
Otsuka America Pharmaceutical

Completed

Pilot Study of Using Copeptin to Predict Response to Tolvaptan

Heart Diseases | Cardiovascular Diseases | Heart Failure

United States
Regional Hospital Holstebro
Aarhus University Hospital

Completed

Effect of the Aquaretic Tolvaptan on Nitric Oxide System. A Dose-response Study (DOVA) (DOVA)

Nephropathy

Denmark
Otsuka Beijing Research Institute

Completed

Multiple-dose Pharmacokinetics Study of Tolvaptan Tablets in Chinese Patients With Hepatocirrhosis

Ascites | Hepatic Cirrhosis

China
Otsuka Pharmaceutical Co., Ltd.

Recruiting

Samsca Post-marketing General Drug Use-results Survey in Patients With Hyponatremia in SIADH

Antidiuretic Hormone, Inappropriate Secretion

Japan
University of North Carolina, Chapel Hill
Otsuka America Pharmaceutical

Completed

Tolvaptan For Worsening Outpatient Heart Failure: Role of Copeptin In Identifying Responders (TROUPER)

Congestive Heart Failure

United States
Gia Dinh People Hospital
Otsuka Pharmaceutical Vietnam

Recruiting

Tolvaptan add-on Therapy to Overcome Loop Diuretic Resistance in Acute Heart Failure With Renal Dysfunction (DR-AHF)

Acute Heart Failure

Vietnam
Otsuka Pharmaceutical Development & Commercialization...

Terminated

Effects of Tolvaptan vs Fluid Restriction in Hospitalized Subjects With Dilutional Hyponatremia (SALACIA)

Hyponatremia | Inappropriate ADH Syndrome | Dilutional Hyponatremia

United States
Korea Otsuka Pharmaceutical Co., Ltd.

Recruiting

Samsca PMS in ADPKD Patients

Safety

Korea, Republic of
Otsuka Frankfurt Research Institute GmbH

Unknown

Post-Authorisation Safety Study of Samsca (Tolvaptan) Used in Routine Medical Practice

SIADH | Non-SIADH Hyponatremia | Non-Hyponatremia

Denmark, Germany, Italy, Norway, Spain, Sweden, United Kingdom
Hunter Holmes Mcguire Veteran Affairs Medical Center
Otsuka America Pharmaceutical

Completed

Effect of Tolvaptan on Cognitive Function in Cirrhosis

Hepatic Encephalopathy | Cirrhosis | Hyponatremia

United States
University of North Carolina, Chapel Hill
Otsuka America Pharmaceutical

Completed

Bioavailability Study Comparing Tolvaptan Administered Via Nasogastric Tube to Tolvaptan Tablets Swallowed Intact

Healthy

United States
Duke University

Completed

Targeting Acute Congestion With Tolvaptan in Congestive Heart Failure (TACTICS-HF)

Heart Failure | Dyspnea

United States
Korea Otsuka Pharmaceutical Co., Ltd.

Completed

Pharmacokinetics/Pharmacodynamics (PK/PD) Characteristics of Tolvaptan Tablet in Korean Healthy Male

Healthy

Korea, Republic of
Otsuka Pharmaceutical Development & Commercialization...
Syneos Health

Terminated

Study of the Safety and Effectiveness of SAMSCA® (Tolvaptan) in Children and Adolescents With Euvolemic or Hypervolemic Hyponatremia

Hyponatremia

United States, United Kingdom, Italy
Taiwan Otsuka Pharm. Co., Ltd

Completed

Efficacy and Safety of Tolvaptan in the Treatment of Cardiac-Induced Edema in Patients With Heart Failure

Cardiac-induced Edema

Taiwan
Maisel, Alan, M.D.
Otsuka Pharmaceutical Development & Commercialization, Inc.; Thermo Fisher...

Unknown

Acute Heart Failure Patients With High Copeptin Treated With Tolvaptan Targets Increased AVP Activation for Treatment (ACTIVATE) (ACTIVATE)

Acute Heart Failure
Korea Otsuka Pharmaceutical Co., Ltd.

Completed

Evaluating the Safety and effectivenesS in Adult KorEaN Patients Treated With Tolvaptan for Management of Autosomal domInAnt poLycystic Kidney Disease (ESSENTIAL)

Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Korea, Republic of
Otsuka Pharmaceutical Development & Commercialization...
Syneos Health

Terminated

An Extension Follow-up Trial to Evaluate the Long-term Safety of Children and Adolescent Participants With Euvolemic or Hypervolemic Hyponatremia

Hyponatremia

Belgium, Spain, United States, United Kingdom, Italy, Germany, Czechia, Romania
Otsuka Pharmaceutical Development & Commercialization...

Withdrawn

A Trial of Tolvaptan in Children and Adolescent Subjects With Euvolemic and Hypervolemic Hyponatremia

Hyponatremia
Otsuka Beijing Research Institute

Completed

Efficacy and Safety Study of Tolvaptan to Treat Patients With Cardiac Edema

Cardiac Edema

China
Korea Otsuka Pharmaceutical Co., Ltd.

Terminated

Outcome and Treatment Quality Study of Tolvaptan to Treat Hyponatremia in Patients With Heart Failure (AQUATIC)

Heart Failure With Hyponatremia

Korea, Republic of
University of Florida
Otsuka America Pharmaceutical

Completed

Tolvaptan for Ascites in Cirrhotic Patients

Cirrhosis | Ascites

United States
Polderman, Kees, H., MD, PhD
University of Pittsburgh

Terminated

Tolvaptan for Patients With Acute Neurological Injuries

Hyponatremia | SIADH

United States
Otsuka Beijing Research Institute

Completed

Dose Exploring and Setting Study for Tolvaptan to Treat Hepatic Cirrhosis With Ascites

Ascites | Hepatic Cirrhosis

China
Vanderbilt University

Completed

Comparison of Oral or Intravenous Thiazides vs Tolvaptan in Diuretic Resistant Decompensated Heart Failure

Heart Failure

United States
Otsuka Beijing Research Institute

Completed

Phase III Study of Tolvaptan Tablet to Treat Cirrhosis Ascites

Ascites | Hepatic Cirrhosis

China
M.D. Anderson Cancer Center
Otsuka Pharmaceutical Development & Commercialization, Inc.

Completed

Tolvaptan in Hyponatremic Cancer Patients

Advanced Cancers

United States
Kyorin University

Unknown

Efficacy of Tolvaptan on ADPKD Patients

Autosomal Dominant Polycystic Kidney Disease

Japan
Konkuk University Medical Center
Samsung Medical Center; Seoul St. Mary's Hospital; Korea University Anam Hospital and other collaborators

Unknown

Tolvaptan for Hyponatremia in Cirrhotic Patients With Ascites (TONIC)

Ascites | Hyponatremia

Korea, Republic of
Cardiology Research UBC

Unknown

Regional Tolvaptan Registry (Tolvaptan)

Hyponatremia | Decompensated Heart Failure

Canada
Mayo Clinic

Completed

Use of Tolvaptan to Reduce Urinary Supersaturation: a Pilot Proof of Principle Study

Nephrolithiasis, Calcium Oxalate | Nephrolithiasis, Calcium Phosphate

United States
University of Calgary

Terminated

Tolvaptan for Advanced or Refractory Heart Failure

Heart Failure | Hyponatremia

Canada
Northwestern University
Otsuka America Pharmaceutical

Completed

Effects of Tolvaptan in Healthy Adults

Healthy

United States
Emory University

Completed

AiDing Diuresis wIth Tolvaptan (ADD-IT) (ADD-IT)

Congestive Heart Failure | Cardiomyopathy

United States
Regional Hospital Holstebro
Aarhus University Hospital

Completed

Effect of the Aquaretic Tolvaptan on Nitric Oxide System (TOPO)

Autosomal Dominant Polycystic Kidney Disease

Denmark
Chinese Pulmonary Vascular Disease Research Group

Recruiting

Efficacy and Safety Evaluation of Tolvaptan in the Treatment of Patients With RHF Caused by PAH

Pulmonary Arterial Hypertension | Randomized Controlled Trial

China
University of Southern California
Otsuka America Pharmaceutical

Completed

Aquaresis Utility for Hyponatremic Acute Heart Failure Study (AQUA-AHF)

Heart Failure

United States
Regional Hospital Holstebro

Completed

Effect of the Aquaretic Tolvaptan on Nitric Oxide System (TORA)

Cardiovascular Diseases | Nephropathy

Denmark
Otsuka Pharmaceutical Development & Commercialization...

Recruiting

A Study to See if Tolvaptan is Safe in Infants and Children Who at Enrollment Are 28 Days to Less Than 18 Years Old With Autosomal Recessive Polycystic Kidney Disease (ARPKD)

Autosomal Recessive Polycystic Kidney (ARPKD)

United States, United Kingdom, Belgium, Poland, France, Germany, Italy
Otsuka Pharmaceutical Development & Commercialization...

Completed

8-Week Study of Tolvaptan Dose Forms in Autosomal Dominant Polycystic Kidney Disease (ADPKD) (NOCTURNE)

Autosomal Dominant Polycystic Kidney Disease

United States
Otsuka Pharmaceutical Development & Commercialization...

Completed

Dose-finding Study of New Tolvaptan Formulation in Subjects With ADPKD

Autosomal Dominant Polycystic Kidney Disease

United States
Eli Lilly and Company

Active, not recruiting

A Study of Ixekizumab (LY2439821) in Participants Aged ≥18 Years With Moderate-to-Severe Plaque or Active Psoriatic Arthritis in India

Plaque Psoriasis | Psoriatic Arthritis

India
Otsuka Pharmaceutical Co., Ltd.

Completed

Post-Marketing Surveillance Study of Tolvaptan in Patients With ADPKD

Polycystic Kidney, Autosomal Dominant

Japan
Otsuka Pharmaceutical Co., Ltd.

Completed

A Study to Investigate the Long-term Safety and Efficacy of Tolvaptan in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD) [Extension of Trial 156-04-251 in Japan]

Autosomal Dominant Polycystic Kidney Disease （ADPKD)

Japan
Otsuka Pharmaceutical Co., Ltd.

Completed

Effect of Tolvaptan on Mid- to Long-term Prognosis of Heart Failure Patients

Heart Failure

Japan
Otsuka Pharmaceutical Co., Ltd.

Completed

A Double-blind, Placebo-controlled Study of OPC-41061 in the Treatment of Cardiac Edema (Congestive Heart Failure)

Edema, Cardiac

Japan
Otsuka Pharmaceutical Development & Commercialization...
Otsuka Pharmaceutical Co., Ltd.

Completed

"SALT Trial" Study of Ascending Levels of Tolvaptan in Hyponatremia

Inappropriate ADH Syndrome | Water Intoxication | Hyponatremias | Water-Electrolyte Imbalances

United States

Search clinical trials for: Tolvaptan or Samsca

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