Search clinical trials for: Trametinib+Dimethyl+Sulfoxide

Total 1207 results

National Cancer Institute (NCI)

Completed

MPACT Study to Compare Effects of Targeted Drugs on Tumor Gene Variations

Advanced Malignant Solid Neoplasm

United States
GlaxoSmithKline

Completed

A 5-way Treatment Period Trial of Single Doses of Intranasal GSK256066 in Patients With Rhinitis

Rhinitis, Allergic, Seasonal

Germany
GlaxoSmithKline

Completed

Trial With Rhinitic Patients Taking GSK256066 Versus Placebo In A Pollen Challenge Chamber

Rhinitis, Allergic, Seasonal | Seasonal Allergic Rhinitis

Austria
GlaxoSmithKline

Completed

Trial With Allergic Rhinitis Patients Taking GSK256066 Versus Placebo In A Pollen Challenge Chamber

Rhinitis, Allergic, Seasonal | Seasonal Allergic Rhinitis

Austria
Kavita Sarin
National Institutes of Health (NIH); Medivir; American Skin Association

Completed

Topical Remetinostat in Treating Patient With Cutaneous Basal Cell Cancer

Skin Basal Cell Carcinoma

United States
GlaxoSmithKline

Completed

Study To Evaluate Safety And Tolerability Of GSK256066 In Chronic Obstructive Pulmonary Disease (COPD) Patients

Pulmonary Disease, Chronic Obstructive

Russian Federation, Estonia, Finland, Germany, Netherlands, Slovakia
Mayo Clinic
National Cancer Institute (NCI)

Recruiting

Acalabrutinib With or Without Obinutuzumab in Treating Patients With Early-Stage Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Chronic Lymphocytic Leukemia | Small Lymphocytic Lymphoma

United States
National Cancer Institute (NCI)

Terminated

Ipilimumab With or Without Dabrafenib, Trametinib, and/or Nivolumab in Treating Patients With Melanoma That Is Metastatic or Cannot Be Removed by Surgery

Metastatic Melanoma | Stage III Cutaneous Melanoma AJCC v7 | Stage IV Cutaneous Melanoma AJCC v6 and v7 | Stage IIIC Cutaneous Melanoma AJCC v7 | BRAF V600E Mutation Present | BRAF V600K Mutation Present | Stage IIIA Cutaneous Melanoma AJCC v7 | Stage IIIB Cutaneous Melanoma AJCC v7

United States
Amsterdam UMC, location VUmc

Recruiting

Discontinuing Disease-modifying Therapies in Stable Relapsing - Onset Multiple Sclerosis (DOT-MS). (DOT-MS)

Multiple Sclerosis | Multiple Sclerosis, Relapsing-Remitting | Multiple Sclerosis, Secondary Progressive

Netherlands
Karolinska Institutet
Patient-Centered Outcomes Research Institute; Kaiser Foundation Research Institute

Active, not recruiting

COMparison Between All immunoTherapies for Multiple Sclerosis. (COMBAT-MS)

Relapsing-remitting Multiple Sclerosis

Sweden
Promomed, LLC

Completed

Efficacy of the Therapy With BRAINMAX® Using fMRI for the Treatment of Patients With Asthenia After COVID-19

COVID-19 | Asthenia | Cognitive Impairment | Functional MRI

Russian Federation
Brigham and Women's Hospital

Active, not recruiting

Second-Line Uterotonics in Postpartum Hemorrhage: A Randomized Clinical Trial

Postpartum Hemorrhage | Uterine Atony

United States
Eisai Inc.

Completed

Study Evaluating the Safety and Efficacy of Eribulin Mesilate in Combination With Irinotecan Hydrochloride in Children With Refractory or Recurrent Solid Tumors

Ewing Sarcoma | Rhabdomyosarcoma | Refractory or Recurrent Solid Tumors | Non-Rhabdomyosarcoma Soft Tissue Sarcoma

Spain, United Kingdom, Italy, France, Germany, Greece, Poland, Switzerland
Washington University School of Medicine

Completed

Pharmacokinetics and Side Effects of the mGlu5 Antagonist Fenobam in Adult Healthy Volunteers

Healthy

United States
Mclean Hospital
Yale University; University of Lausanne

Not yet recruiting

MitoQ for Early-phase Schizophrenia-spectrum Disorder and Mitochondrial Dysfunction

Cognitive Impairment | Schizophrenia and Related Disorders | Mitochondrial Alteration

United States, Switzerland
GlaxoSmithKline

Completed

Endotoxin Challenge Study For Healthy Men and Women

Pulmonary Disease, Chronic Obstructive

Germany
Yingbing Wang

Completed

Multiparametric Imaging in Multiple Myeloma

Multiple Myeloma

United States
GlaxoSmithKline

Completed

Study To Evaluate GSK256066 In Subjects With Mild Bronchial Asthma

Asthma | Mild Asthma

United Kingdom
Suven Life Sciences Limited

Completed

SUVN-502 With Donepezil and Memantine for the Treatment of Moderate Alzheimer's Disease- Phase 2a Study

Alzheimer's Disease

United States
The University of Texas at Arlington

Completed

The Effect of Antioxidants on Skin Blood Flow-BH4

Cardiovascular Diseases | Cardiovascular Risk Factor | Vasoconstriction

United States
Eisai Inc.

Terminated

Phase 2 Study of the Poly(ADP-Ribose) Polymerase Inhibitor E7016 in Combination With Temozolomide in Subjects With Wild Type BRAF Stage IV or Unresectable Stage III Melanoma

Unresectable Stage III Melanoma | Wild Type BRAF Stage IV Melanoma

United States
Eisai Inc.

Completed

Study of Poly (ADP-Ribose) Polymerase (PARP) Inhibitor E7016 in Combination With Temozolomide in Subjects With Advanced Solid Tumors

Solid Tumors

United States
Bispebjerg Hospital

Completed

Laser-Mediated Photodynamic Therapy of Acne Vulgaris and Rosacea

Acne Vulgaris and Rosacea

Denmark
Harvard School of Public Health (HSPH)
Unity Health Toronto; University of Toronto

Completed

Air Pollution, Epigenetics and Cardiovascular Health: A Human Intervention Trial (EPI-Air)

Inflammation | Heart Rate Variability | Heart Rate

Canada
Princess Maxima Center for Pediatric Oncology
Innovative Therapies For Children with Cancer Consortium; IBFM; Fight Kids Cancer

Not yet recruiting

HEM iSMART-D: Trametinib + Dexamethasone + Chemotherapy in Children With Relapsed or Refractory Hematological Malignancies (HEM-iSMART D)

Acute Lymphoblastic Leukemia, in Relapse | Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent | Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent | Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory | Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Refractory

Netherlands
London School of Hygiene and Tropical Medicine

Completed

Evaluation of a Novel Long Lasting Insecticidal Net and Indoor Residual Spray Product

Malaria | Anaemia

Tanzania
Seoul National University Bundang Hospital
Korea United Pharm. Inc.

Recruiting

Atmeg (Atorvastatin and Omega-3 Combination) and Carotid Atherosclerosis in Patients With Type 2 Diabetes and Combined Dyslipidemia

Diabetes Mellitus, Type 2 | Atherosclerosis | Dyslipidemias

Korea, Republic of
Sidney Kimmel Comprehensive Cancer Center at Johns...
National Cancer Institute (NCI)

Terminated

Study of Metformin Plus Paclitaxel/Carboplatin/Bevacizumab in Patients With Adenocarcinoma.

Carcinoma, Non-Small-Cell Lung | Lung Adenocarcinoma

United States
Dwight Owen

Recruiting

All-Trans Retinoic Acid (ATRA) and Atezolizumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer

Metastatic Lung Non-Small Cell Carcinoma | Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Recurrent Lung Non-Small Cell Carcinoma

United States
The Netherlands Cancer Institute
Bristol-Myers Squibb; Eli Lilly and Company; Bayer; GlaxoSmithKline; Merck Sharp... and other collaborators

Recruiting

The Drug Rediscovery Protocol (DRUP Trial) (DRUP)

Cancer | Neoplasm | Tumors | Neoplasia

Netherlands
Juan Manuel Marquez Romero
Centenario Hospital Miguel Hidalgo; Universidad de Guanajuato

Completed

Capsaicin for Cerebral Perfusion Augmentation.

Stroke

Mexico
TorreyPines Therapeutics

Completed

Study of NGX267 Oral Capsules in Patients With Xerostomia Associated With Sjorgren's Syndrome

Sjogren's Syndrome | Xerostomia

United States
GlaxoSmithKline

Completed

Clinical Endpoint Trial Investigating Once Daily and Bronchodilator Dosing

Asthma

New Zealand, South Africa
National Cancer Institute (NCI)

Completed

Se-Methyl-Seleno-L- Cysteine (MSC) in Treating Healthy Patients

Healthy, no Evidence of Disease

United States
Donald Krogstad
University of the Sciences, Techniques and Technologies of Bamako

Completed

Studies of a Candidate Aminoquinoline Antimalarial (AQ-13)

Malaria

Mali
Anna Stanhewicz, PhD

Recruiting

Sex Differences in the Vascular Effects of E-cigarette Use

E-cigarette Use

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Enasidenib in Combination With Cobimetinib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

Recurrent Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia

United States
Teva Branded Pharmaceutical Products R&D, Inc.

Completed

Talampanel for Amyotrophic Lateral Sclerosis (ALS) (ALS)

ALS

United States, Netherlands, Canada, Italy, Spain, Belgium, France, Germany, Hungary, Israel
Kavita Sarin
Medivir

Terminated

Topical Remetinostat Gel as Neoadjuvant Therapy in Patients With Squamous Cell Carcinoma (SCC)

Squamous Cell Carcinoma

United States
National Cancer Institute (NCI)

Completed

Bortezomib in Treating Patients With Relapsed or Refractory AIDS-Related Kaposi Sarcoma

HIV Infection | Recurrent Kaposi Sarcoma | AIDS-Related Kaposi Sarcoma

United States
Jaime Moore, MD MPH
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); University... and other collaborators

Completed

Adjunct Phentermine + Topiramate After Bariatric Surgery in 12-24 Year Olds

Adolescent | Obesity, Morbid | Drug Therapy | Bariatric Surgery | Young Adult

United States
University Hospital, Grenoble

Completed

Role of Epoxy-eicosatrienoic Acids in Post-occlusive Hyperemia and Thermal Hyperemia (EETY)

Healthy Volunteers

France
Michael Wagner
Edgewood Oncology Inc.

Not yet recruiting

BTX-A51 in Patients With Liposarcoma

Liposarcoma | MDM2 Gene Amplification | Metastatic Liposarcoma | Unresectable Liposarcoma | Recurrent Liposarcoma

United States
University of Auckland, New Zealand
Counties Manukau Health; Waikato Hospital; Cancer Trials New Zealand

Active, not recruiting

Optimal Selenium for Bowel Polyps (OSCAR) (OSCAR)

Colorectal Adenoma

New Zealand
Regeneron Pharmaceuticals

Available

R3470-3471-3479 (REGN-EB3) Expanded Access Protocol (EAP) for Treatment of Ebola Virus Disease

Ebola Virus Disease
National Cancer Institute (NCI)

Completed

Tipifarnib and Bortezomib in Treating Patients With Acute Leukemia or Chronic Myelogenous Leukemia in Blast Phase

Recurrent Adult Acute Myeloid Leukemia | Untreated Adult Acute Myeloid Leukemia | Recurrent Disease | Recurrent Adult Acute Lymphoblastic Leukemia | Adult Acute Monoblastic Leukemia | Adult Acute Monocytic Leukemia | Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11 | Adult Acute Myeloid... and other conditions

United States
Isfahan University of Medical Sciences

Completed

Niacin Skin Flush Response in Patients With Schizophrenia

Schizophrenia
Fred Hutchinson Cancer Center
National Center for Complementary and Integrative Health (NCCIH)

Completed

Effects of Garlic Supplements on Drug Metabolism

Healthy

United States
Jonsson Comprehensive Cancer Center
Mirati Therapeutics Inc.; Phase One Foundation

Recruiting

Mocetinostat With Vinorelbine in Children, Adolescents & Young Adults With Refractory and/or Recurrent Rhabdomyosarcoma

Rhabdomyosarcoma

United States
The Cleveland Clinic
University of Nottingham

Active, not recruiting

Determining the Effectiveness of earLy Intensive Versus Escalation Approaches for RRMS (DELIVER-MS)

Multiple Sclerosis, Relapsing-Remitting

United States, United Kingdom

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