Search clinical trials for: ziv-aflibercept

Total 8662 results

Clover Biopharmaceuticals AUS Pty Ltd

Withdrawn

Study of SCB-420 in Subjects With Neovascular Age-related Macular Degeneration

Wet Age-related Macular Degeneration
Mabwell (Shanghai) Bioscience Co., Ltd.

Completed

Safety and Efficacy of 9MW0813 in Subjects With Diabetic Macular Edema

Diabetic Macular Edema

China
Greater Houston Retina Research
Regeneron Pharmaceuticals

Completed

Long-Term Efficacy & Safety of Aflibercept IVT for the Treatment of DME in Subjects Who Completed the VISTA-DME Trial

Diabetic Macular Edema

United States
Tennessee Retina
Regeneron Pharmaceuticals

Unknown

On-label tReatment With Intravitreal Aflibercept injectiOn for Patients With Persistent Pigment epitheliaL Detachments in Neovascular Age Related Macular Degeneration (AMD) (ROLL)

Age Related Macular Degeneration | Pigment Epithelial Detachment

United States
Sam Chun Dang Pharm. Co. Ltd.

Completed

A Study to Comparing SCD411 and Eylea® in Subjects With Wet Age-related Macular Degeneration (AMD)

Neovascular Age-related Macular Degeneration | Wet Age-related Macular Degeneration

United States, Australia, Bulgaria, Czechia, Hungary, India, Israel, Japan, Korea, Republic of, Latvia, Poland, Russian Federation, Slovakia, Spain
PT Bio Farma

Completed

Protectivity and Safety of Quadrivalent Influenza HA Vaccine in Indonesian Population

Safety Issues

Indonesia
Lpath, Inc.

Completed

Efficacy and Safety Study of iSONEP With & Without Lucentis/Avastin/Eylea to Treat Wet AMD (Nexus)

Exudative Age-related Macular Degeneration

United States
Johns Hopkins University

Withdrawn

Safety and Efficacy of IV Diazoxide as an Additive to Hyperkalemic Cardioplegia in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass

Myocardial Stunning

United States
Clearside Biomedical, Inc.

Completed

Suprachoroidal Injection of CLS-TA Alone or With Aflibercept in Subjects With Diabetic Macular Edema (HULK)

Diabetic Macular Edema

United States
University Hospital, Caen

Unknown

Anticancer Vigilance Of Cardiac Events (AVOCETTE) in Metastatic Colorectal Cancer (AVOCETTE)

Colorectal Cancer Metastatic

France
King's College Hospital NHS Trust
King's College London; Fight for Sight (Funder)

Recruiting

Vitrectomy, Subretinal Tissue Plasminogen Activator (TPA) and Intravitreal Gas for Submacular Haemorrhage Secondary to Exudative (Wet) Age-related Macular Degeneration (TIGER). (TIGER)

Eye Diseases | Macular Degeneration, Wet | Sub-Macular Hemorrhage

United Kingdom
Amgen
Parexel

Completed

A Study to Understand Effectiveness and Safety of ABP 938 Compared to Aflibercept (Eylea®) in Patients Suffering With Neovascular Age-related Macular Degeneration [Neovascular (Wet) AMD]

Neovascular (Wet) Age-related Macular Degeneration (AMD)

Spain, United States, Czechia, Serbia, Israel, Canada, Germany, Japan, Hungary, Poland, Korea, Republic of, Estonia, Hong Kong, Italy, Latvia, Lithuania, Mexico, Slovakia
Novartis Pharmaceuticals

Completed

Study of Efficacy and Safety of Brolucizumab vs. Aflibercept in Patients With Visual Impairment Due to Diabetic Macular Edema (KESTREL)

Diabetic Macular Edema

United States, Austria, Japan, Australia, Spain, Canada, Israel, Netherlands, Italy, United Kingdom, Portugal, Colombia, Puerto Rico, Argentina
Associated Retinal Consultants, Michigan
Genentech, Inc.

Completed

Genetic Analysis of Patients Responsive to Ranibizumab But Resistant to Aflibercept

Age-Related Macular Degeneration

United States
Vitreous -Retina- Macula Consultants of New York
Regeneron Pharmaceuticals

No longer available

Use of Eylea for the Treatment of an Optic Nerve Hemangioma

Retinal Hemangioma

United States
RemeGen Co., Ltd.

Recruiting

Efficacy and Safety of RC28-E Versus Aflibercept in Diabetic Macular Edema

Diabetic Macular Edema

China
Novartis Pharmaceuticals

Completed

Efficacy and Safety of Brolucizumab vs Aflibercept in Patients With Visual Impairment Due to Diabetic Macular Edema (KINGFISHER)

Diabetic Macular Edema

United States, Hungary, Israel, Slovakia, Puerto Rico
Anders Kvanta

Completed

Comparing Injection Frequency Between Aflibercept and Ranibizumab in Patients With CRVO With a Treat& Extend Regimen

Central Retinal Vein Occlusion

Sweden
Novartis Pharmaceuticals

Withdrawn

24 Week Study to Compare Systemic VEGF-levels of Ranibizumab and Aflibercept in DME. (TIDE DME)

Visual Impairment Due to Diabetic Macular Edema
Unity Biotechnology, Inc.

Recruiting

Assess the Efficacy and Safety of Repeat Intravitreal Injections of Foselutoclax (UBX1325) in Patients With DME (ASPIRE) (ASPIRE)

Eye Diseases | Diabetes Mellitus | Retinal Degeneration | Retinal Diseases | Edema | Diabetic Retinopathy | Diabetic Macular Edema | Macular Edema | Retinal Disease

United States
Wenbin Wei

Recruiting

Anti-VEGF in Real-world

Diabetic Macular Edema | Retinal Vein Occlusion | Proliferative Diabetic Retinopathy | Non-proliferative Diabetic Retinopathy | Choroidal Neovascular Membrane | Neovascular Age-related Macular Edema

China
Amgen

Completed

A Study to Evaluate ABP 938 and Aflibercept (Eylea®) in Participants With Chorioretinal Vascular Disease (CVD)

Chorioretinal Vascular Disease

United States
Novartis Pharmaceuticals

Completed

To Compare Brolucizumab to Aflibercept in Chinese Patients With Visual Impairment Due to Diabetic Macular Edema (KINGLET)

Diabetic Macular Edema

China
Novartis Pharmaceuticals

Withdrawn

Efficacy and Safety of Brolucizumab vs. Aflibercept in Patients With Visual Impairment Due to Diabetic Macular Edema (BUZZARD)

Diabetic Macula Edema
Novartis Pharmaceuticals

Withdrawn

Systemic VEGF Protein Dynamics Following Intravitreal Injections of Ranibizumab Versus Aflibercept in Patients With Visual Impairment Due to Diabetic Macular Edema (TIDE DME)

Visual Impairment Due to Diabetic Macular Edema

Germany
Regeneron Pharmaceuticals

Completed

Phase 1 Study of VEGF Trap in Patients With Diabetic Macular Edema

Diabetic Macular Edema

United States
Novartis Pharmaceuticals

Completed

A Study of the Efficacy and Safety of Brolucizumab vs. Aflibercept in Patients With Visual Impairment Due to Diabetic Macular Edema (KITE)

Diabetic Macular Edema

Czechia, India, Russian Federation, Taiwan, Turkey, Lebanon, Denmark, Estonia, France, Germany, Hungary, Korea, Republic of, Latvia, Lithuania, Bulgaria, Norway, Belgium, Malaysia, Sweden, Slovakia, Singapore, Poland, Switzerland
King's College Hospital NHS Trust
King's College London

Completed

A Pharmacokinetic Study: Ranibizumab, Aflibercept and the Effect of Vitrectomy. (VITCLEAR)

Age Related Macular Degeneration

United Kingdom
Instituto de Olhos de Goiania

Completed

Intravitreal Aflibercept or Ranibizumab for Rubeosis Iridis

Glaucoma | Rubeosis Iridis

Brazil
Palmetto Retina Center, LLC

Unknown

Treat and Extend Therapy Study Using Intravitreal Aflibercept for Patients Exited From Protocol VGFT-OD 0910 (RANGE)

Exudative Age-related Macular Degeneration

United States
Minia University

Completed

Comparison of Aflibercept Versus Ranibizumab in Management of Diabetic Macular Edema (DME) (DME)

Diabetic Macular Edema

Egypt
RemeGen Co., Ltd.

Recruiting

Efficacy and Safety of RC28-E Versus Aflibercept

Wet Age-related Macular Degeneration

China
Novartis Pharmaceuticals

Terminated

Study of Safety and Efficacy of Brolucizumab 6 mg Dosed Every 4 Weeks Compared to Aflibercept 2 mg Dosed Every 4 Weeks in Patients With Retinal Fluid Despite Frequent Anti-VEGF Injections (MERLIN)

Age-Related Macular Degeneration

United States, Puerto Rico
University of Sydney
Center for Eye Research Australia

Completed

Laser Therapy Combined With Intravitreal Aflibercept vs Intravitreal Aflibercept Monotherapy (LADAMO) (LADAMO)

Diabetic Retinopathy

Australia
Regeneron Pharmaceuticals
Bayer

Completed

Randomized, Single-Masked, Long-Term, Safety and Tolerability Study of VEGF Trap-Eye in AMD

Macular Degeneration

United States
Regeneron Pharmaceuticals
Bayer

Completed

Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Central Retinal Vein Occlusion (CRVO)

Macular Edema Secondary to Central Retinal Vein Occlusion

United States, Canada, Colombia, Israel, India
Clearside Biomedical, Inc.

Terminated

Suprachoroidal Injection of Triamcinolone Acetonide With IVT Aflibercept in Subjects With Macular Edema Following RVO (SAPPHIRE)

Macular Edema | Retinal Vein Occlusion

Spain, United States, Taiwan, Canada, Hungary, Israel, Portugal, Australia, Poland, United Kingdom, Austria, Denmark, India, Italy, Philippines, Slovakia
California Retina Consultants
Allergan

Completed

Dexamethasone Intravitreal Implant for the Treatment of Persistent Diabetic Macular Edema (DIME)

Diabetic Macular Edema

United States
Sanofi
Regeneron Pharmaceuticals

Completed

Colorectal Cancer Metastatic (AFEQT)

Colorectal Cancer Metastatic

France
Sanofi
Regeneron Pharmaceuticals

Completed

A Phase I Study of Aflibercept Plus FOLFIRI (Irinotecan, 5-Fluorouracil, and Leucovorin) in Chinese Patients With Advanced Solid Malignancies

Neoplasm Malignant

China
Janssen Research & Development, LLC

Completed

AAVCAGsCD59 for the Treatment of Wet AMD

Wet Age-related Macular Degeneration

United States
Clearside Biomedical, Inc.

Completed

Suprachoroidal CLS-TA With Intravitreal Aflibercept Versus Aflibercept Alone in Subject With Diabetic Macular Edema (TYBEE)

Diabetic Macular Edema

United States
Innovent Biologics (Suzhou) Co. Ltd.

Active, not recruiting

A Study of Longer Interval of IVT IBI302 in Subjects With nAMD

Neovascular Age-related Macular Degeneration

China
Innovent Biologics (Suzhou) Co. Ltd.

Active, not recruiting

A Study of IBI302 in Patients With nAMD

Neovascular Age-related Macular Degeneration

China
Opthea Limited

Completed

A Dose Ranging Study of OPT-302 With Aflibercept for Persistent Diabetic Macular Edema

Diabetic Macular Edema

United States, Israel, Australia, Latvia
Sanofi
Regeneron Pharmaceuticals

Completed

A Study of Aflibercept Versus Placebo With FOLFIRI in Patients With Metastatic Colorectal Cancer Previously Treated With an Oxaliplatin Chemotherapy (AFLAME)

Colorectal Cancer Metastatic

Taiwan, China, Hong Kong, Japan, Singapore
Alcon Research

Completed

Efficacy and Safety Study of ESBA1008 Versus EYLEA®

Exudative Age-Related Macular Degeneration
Novartis Pharmaceuticals

Completed

Efficacy of Ranibizumab Prn Treatment Compared to Aflibercept Bimonthly Intravitreal Injections on Retinal Thickness Stability in Patients With Wet AMD (SALT)

Neovascular Age-related Macular Degeneration

Germany, Austria, Belgium, Denmark, Switzerland, France, Netherlands, Portugal, Sweden, Norway
Santen Inc.

Completed

A Safety and Efficacy Study of DE-120 Injectable Solution for Age-related Macular Degeneration (VAPOR1)

Age-Related Macular Degeneration

United States
Ulucanlar Eye Training and Research Hospital

Completed

Effect of Aflibercept on Human Corneal Endothelial Cells in Neovascular Age-Related Macular Degeneration

Age Related Macular Degeneration

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