Search clinical trials for: cytochrome P450 (CYP450) probe drugs or BCRP transporter substrate

Total 1401 results

Columbia University
University of Pennsylvania; Washington University School of Medicine; National... and other collaborators

Completed

Comparison of Depression Interventions After Acute Coronary Syndrome (CODIACS)

Depression | Acute Coronary Syndrome

United States
Noven Therapeutics

Completed

Eight-Week Efficacy & Safety Study of Brisdelle™ (Formerly Known as Mesafem) in the Treatment of Vasomotor Symptoms Associated With Menopause

Hot Flashes

United States
Cairo University

Completed

Efficacy of Phenytoin Phonophoresis on Pressure Ulcer Healing

Pressure Ulcer

Egypt
Supernus Pharmaceuticals, Inc.

Completed

Safety and Tolerability of OXC XR as Adjunctive Therapy in Subjects With Refractory Partial Epilepsy

Partial Epilepsy

United States, Poland, Bulgaria, Romania, Canada, Russian Federation, Mexico, Croatia
Alexion Pharmaceuticals, Inc.

Recruiting

A Study to Evaluate Potential Drug Interactions Between ALXN2080 and Itraconazole, Fluconazole & Carbamazepine in Healthy Adults

Healthy

United Kingdom
Nantes University Hospital

Recruiting

Prospective Multicenter Randomized and Controlled Study Evaluating the Benefit of Early Pulmonary Vein Isolation Compared to Usual Treatment in Patients Aged Over 75 Years and Presenting With Atrial Fibrillation (EDearly AF)

Atrial Fibrillation

France
David J. Kopsky
Princess Beatrix Muscle Foundation; Dr. C.J. Vaillant Fonds

Completed

Phenytoin Cream for the Treatment of Neuropathic Pain (EPHENE)

Chronic Idiopathic Axonal Polyneuropathy

Netherlands
University of Iowa

Completed

Phenytoin and Driving Safety: A Randomized, Controlled Cross-Over Study

Cognitive Measures | Driving Simulator Performance

United States
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

A Study to Assess if Epanutin Infatabs 50 mg From Germany Are Similar to Dilantin Infatabs 50 mg From Australia

Healthy

Singapore
National Institute on Drug Abuse (NIDA)
University of Minnesota

Completed

Effects of Phenytoin on Cocaine Use in Humans - 2

Cocaine-Related Disorders

United States
Duke University
Duke Clinical Research Institute

Terminated

Pilot Study of Catheter Ablation for Ventricular Tachycardia in Patients With an Implantable Cardioverter Defibrillator (CALYPSO)

Ventricular Tachycardia

United States
Hoffmann-La Roche

Completed

A Study of the Effect of Fluvoxamine on the Pharmacokinetics of RO4917523 in Healthy Volunteers

Healthy Volunteer

France
National Institute of Mental Health (NIMH)

Completed

Treatment for Anxiety in Children

Obsessive-Compulsive Disorder | Anxiety Disorders | Generalized Anxiety Disorder | Social Phobia | Separation Anxiety
ANRS, Emerging Infectious Diseases

Completed

First-Line Treatment for HIV-2 (FIT-2)

HIV-2 Infection

Côte D'Ivoire, Burkina Faso, Senegal, Togo
Bill & Melinda Gates Medical Research Institute
Global Alliance for TB Drug Development; Janssen Pharmaceutica; Otsuka Pharmaceutical...

Recruiting

Efficacy and Safety Evaluation of Two to Four Months of Treatment With the Combination Regimens of DBOS and PBOS in Adults With Pulmonary Tuberculosis

Pulmonary Tuberculosis

Philippines, South Africa
University of Maryland, Baltimore
Food and Drug Administration (FDA)

Completed

Class 3 Biowaivers

Healthy

United States
Theracos

Completed

Study to Evaluate Effects of Probenecid, Rifampin and Verapamil on Bexagliflozin in Healthy Subjects

Type 2 Diabetes Mellitus

United States
Indiana University
National Institute of General Medical Sciences (NIGMS)

Completed

CYP2B6 Genetics and Drug Interactions in Healthy Volunteers

Healthy

United States
Agency for Healthcare Research and Quality (AHRQ)

Completed

Management of Vaginal Complaints: A Pilot Study Within a Practice-Based Research Network (VCAT)

Vaginitis

United States
Pfizer

Completed

Comparative Randomized Study of the Efficacy, Safety, and Toleration of Fluconazole Oral Suspension or Nystatin Oral Suspension in the Treatment of Patients With Oropharyngeal Candidiasis in Association With the Acquired Immunodeficiency Syndrome

HIV Infections | Candidiasis, Oral

United States
Mayo Clinic
Abbott Medical Devices; Duke Clinical Research Institute

Completed

Ablation vs Drug Therapy for Atrial Fibrillation - Pilot Trial (CABANA)

Atrial Fibrillation | Arrhythmia

United States
Cambridge University Hospitals NHS Foundation Trust
University of Cambridge

Not yet recruiting

Pharmacological Management of Seizures Post Traumatic Brain Injury (MAST)

Traumatic Brain Injury | Post Traumatic Seizures
Shaheed Zulfiqar Ali Bhutto Medical University

Completed

Efficacy of Phenytoin vs Levetiracetam in Status Epilepticus at Institute of Child Health,Faisalabad

Status Epilepticus

Pakistan
Children's Surgical Center, Cambodia

Unknown

Phenytoin in the Healing of Clean Surgical Wounds

Wound | Re-Epithelialization

Cambodia
Eisai Inc.

Completed

A 2-Part Study to Assess Potential Metabolism-Based Drug-Drug Interactions of E2006 When Coadministered With Itraconazole, Rifampin, Midazolam, or Bupropion

Healthy Subjects

United States
Institute of Cardiology, Warsaw, Poland

Unknown

Cardiac Resynchronization in Atrial Fibrillation Trial - a Pilot Study (Pilot-CRAfT)

Heart Failure | Atrial Fibrillation

Poland
Ottawa Heart Institute Research Corporation

Terminated

Anti-arrhythmic Therapy vs Catheter Ablation as First Line Treatment for AICD Shock Prevention (AVATAR)

Ventricular Tachycardia | Ventricular Arrhythmia

Canada
Mackay Memorial Hospital

Completed

ILTHPI - Comparison of Medicament Containing Tetracycline, Metronidazole, Bismuth Versus Amoxicillin, Metronidazole, Clarithromycin

Helicobacter Pylori Infection

Taiwan
Kaohsiung Medical University Chung-Ho Memorial...

Completed

Adding Bismuth to Rabeprazole-based First-line Triple Therapy Does Not Improve the Eradication of Helicobacter Pylori

Helicobacter Pylori Infection
IRCCS Policlinico S. Matteo

Terminated

Epigallocatechingallate (EGCG) in Cardiac AL Amyloidosis (EpiCardiAL)

Primary Amyloidosis of Light Chain Type

Italy
Supernus Pharmaceuticals, Inc.

Approved for marketing

Long Term Study of the Safety of OXC XR as in Pediatric Epilepsy Subjects

Epilepsy

United States
University College, London
National Multiple Sclerosis Society; Multiple Sclerosis Society of Great Britain...

Completed

Neuroprotection With Phenytoin in Optic Neuritis

Multiple Sclerosis | Optic Neuritis

United Kingdom
Penn State University

Terminated

Dilantin Levels With Continuous Delivery of Enteral Feedings - A Pilot Study

Seizures
Arrevus Inc.

Terminated

Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infection

Prosthetic Joint Infections of Hip | Prosthetic Joint Infections of Knee | Infected Spacers

United States
Lingjiang Li

Recruiting

A Clinical Trial of Fluvoxamine for Melancholia

Depressive Disorder | Melancholia | Endogenous Depression

China
Susanna Naggie, MD
Vanderbilt University Medical Center; National Center for Advancing Translational...

Completed

ACTIV-6: COVID-19 Study of Repurposed Medications - Arm E (Fluvoxamine 100)

Covid19

United States
Guang Dong Provincial Mental Health Institute

Unknown

The Effect of Fluvoxamine on Polysonogram in Depressed Patients With Insomnia

Depression

China
Vanda Pharmaceuticals

Completed

Pharmacokinetics of Tasimelteon Alone and in Combination With CYP1A2 Inhibitor, Fluvoxamine

Healthy Volunteers

United States
Solvay Pharmaceuticals

Terminated

Fluvoxamine Maleate in the Treatment of Obsessive-Compulsive Disorder: A Post-marketing Clinical Study in Children and Adolescents

Obsessive Compulsive Disorder

Japan
McMaster University
Hamilton Health Sciences Corporation

Completed

The Gut Microbiota in Obsessive-Compulsive Disorder

Obsessive-Compulsive Disorder

Canada
Asceneuron S.A.

Recruiting

Drug-Drug Interaction of ASN51 With Fluvoxamine, Itraconazole and Paroxetine in Healthy Subjects

Drug Drug Interaction

Netherlands
Corcept Therapeutics

Completed

Study to Evaluate the Effects of a Cytochrome P450 2C19 Inhibitor on the Pharmacokinetics of Miricorilant

Non-alcoholic Steatohepatitis (NASH) | Antipsychotic Induced Weight Gain

United States
Washington University School of Medicine
Cures Within Reach; Covid-19 Early Treatment Fund; McGill University Health Centre...

Completed

Fluvoxamine for Early Treatment of Covid-19 (Stop Covid 2)

Covid19 | Coronavirus

United States, Canada
Washington University School of Medicine

Withdrawn

Fluvoxamine to Augment Olfactory Recovery For Long COVID-19 Parosmia (FluCOP)

COVID-19 | Olfactory Disorder | Parosmia

United States
Washington University School of Medicine

Completed

A Double-blind, Placebo-controlled Clinical Trial of Fluvoxamine for Symptomatic Individuals With COVID-19 Infection (STOP COVID)

COVID 19 | Coronavirus

United States
Novartis Pharmaceuticals

Completed

Pharmacokinetic Drug-drug Interaction Study of Dovitinib (TKI258) in Patients With Advanced Solid Tumors. (CTKI258A2120)

Advanced Solid Tumors, Excluding Breast Cancer

Netherlands, Switzerland, Denmark, United States
Moscow Research Institute of Psychiatry
Abbott

Completed

Study to Evaluate Cognitive Functioning in Remitted Depression During Treatment With Fluvoxamine

Recurrent Depressive Disorder

Russian Federation
Sha'ar Menashe Mental Health Center

Unknown

Effect of Fluvoxamine on Cognition, Behavior, Symptoms and mRNA and Protein Expression in Schizophrenia Patients

SCHIZOPHRENIA 1 (Disorder)

Israel
Sha'ar Menashe Mental Health Center

Unknown

Genetic Expression in Schizophrenics Treated With SSRI Augmentation: Relationship to Clinical and Cognitive Function

Schizophrenia

Israel
Northwell Health

Terminated

Fluoxetine vs Aripiprazole Comparative Trial (FACT) (FACT)

Attenuated Psychosis Syndrome

United States

Search clinical trials for: cytochrome P450 (CYP450) probe drugs or BCRP transporter substrate

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