Search clinical trials for: local anesthetic and dexmedetomidine

Total 15768 results

Merck Sharp & Dohme LLC

Completed

Safety of Sugammadex for the Reversal of Neuromuscular Blockade in American Society of Anesthesiologists (ASA) Class 3 or 4 Participants (MK-8616-145)

Reversal of Neuromuscular Blockade

United States, Austria, Denmark, Germany
Merck Sharp & Dohme LLC

Completed

Comparison of Sugammadex (MK-8616/Org 25969) With Neostigmine Administered at 1-2 Post-tetanic Counts (PTCs) After Administration of Rocuronium or Vecuronium (19.4.302/P05945/MK-8616-025)

Anesthesia, General
Merck Sharp & Dohme LLC

Withdrawn

Rocuronium + Sugammadex vs. Succinylcholine + Cisatracurium + Neostigmine/Atropine in Obese Participants (MK-8616-104) (BENN)

Neuromuscular Blockade
Novartis Pharmaceuticals

Completed

Efficacy of NVA237 Compared to Tiotropium in Patients With Chronic Obstructive Pulmonary Disease (COPD) (FAST)

Chronic Obstructive Pulmonary Disease

Germany
Novartis Pharmaceuticals

Completed

The Effect of QVA149 on Health Related Quality of Life in Patients With Chronic Obstructive Pulmonary Disease (COPD) (QUANTIFY)

Chronic Obstructive Pulmonary Disease (COPD)

Germany
Chiesi Farmaceutici S.p.A.

Completed

Triple in Asthma Dose Finding (Triskel)

Asthma

Bulgaria, Germany, Hungary, Italy, Poland, United Kingdom
Johns Hopkins University

Completed

Effects of Hallucinogens and Other Drugs on Mood and Performance

Healthy

United States
Merck Sharp & Dohme LLC

Completed

A Study to Evaluate Aprepitant for the Prevention of Post-Operative Nausea and Vomiting in Children (MK-0869-219)

Post-operative Nausea | Post-operative Vomiting
Pearl Therapeutics, Inc.

Completed

Multi-Center Study to Assess the Efficacy and Safety of PT003, PT005, and PT001 in Subjects With Moderate to Very Severe COPD (PINNACLE 2)

Chronic Obstructive Pulmonary Disease (COPD)

United States
Shandong University

Completed

Efficacies of Antimicrobial Susceptibility-Guided Versus Empirical Therapy for Rescue Treatment of Helicobacter Pylori Infection

Helicobacter Pylori Infection

China
Oriel Therapeutics

Completed

Clinical Efficacy Study of Salmeterol Xinafoate/Fluticasone Propionate in Asthma

Asthma

United States
University Hospital, Tours

Completed

Evaluation of the Effectiveness of the Nebulization Bronchodilators Under High Nasal Flow Humidified (AirvoNEB)

Chronic Obstructive Pulmonary Disease

France
Assiut University

Completed

Oral Hyoscine Butyl Bromide Versus Diclofenac Potassium Before Office Hysteroscopy

Endoscopy

Egypt
Assiut University

Completed

Oral Diclofenac Sodium Versus Oral Hyoscine Butyl Bromide During Intrauterine Device Insertion

Family Planning

Egypt
University of Missouri-Columbia
Kansas City Veteran Affairs Medical Center

Completed

Early Diagnosis of Diastolic Dysfunction and Reliability of DSE in Detecting Stress Diastolic Dysfunction

Diastolic Dysfunction

United States
Novartis Pharmaceuticals

Completed

Efficacy, Safety, and Tolerability of NVA237 Compared to Tiotropium in Patients With Chronic Obstructive Pulmonary Disease (COPD) (GLOW5)

Chronic Obstructive Pulmonary Disease

Germany, India, South Africa, Croatia, Estonia, Poland, Lithuania, Guatemala, Czech Republic, France, Philippines, Korea, Republic of, Taiwan, Canada, Latvia
Novartis Pharmaceuticals

Completed

The Effect of QVA149 on Patient Reported Dyspnea in Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) (BLAZE)

Chronic Obstructive Pulmonary Disease

Germany, Belgium, Spain, Canada, United Kingdom
New York State Psychiatric Institute

Completed

Treatment of Depression Following Multiple Brain Tests

Major Depression | Dysthymia

United States
Kavaklıdere Umut Hospital

Unknown

Intraoperative Use of Dexketoprofen Trometamol, Pethidine Hcl, Tramadol Hcl and Their Combinations for Postoperative Pain Management in Laparoscopic Nissen Fundoplication

Laparoscopic Nissen Fundoplication

Turkey
Eyegate Pharmaceuticals, Inc.

Completed

Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis

Anterior Uveitis

United States
Clinical Research Support Center Kyush

Unknown

Oral Steroids for Regorafenib-induced Fatigue/Malaise in Unresectable mCRC (KSCC1402/HGCSG1402)

Rectal Cancer

Japan
Chiesi SAS
Kappa Santé

Recruiting

Impact of Fixed TRIple Therapy With Beclometasone/Formoterol/Glycopyrronium DPI (Trimbow® in NEXThaler Device) in Chronic Obstructive PulmoNary Disease in rEal-world Settings: Health-related Quality of Life Patient' eXpectations and characterisTics: the TriNEXT Study (TriNEXT)

COPD

France
Tomsk National Research Medical Center of the Russian...

Completed

The EPIVER Randomized Controlled Trial (EPIVER)

ST Elevation Myocardial Infarction | Percutaneous Coronary Intervention | No-Reflow Phenomenon

Russian Federation
AstraZeneca
Iqvia Pty Ltd; Premier Inc.

Withdrawn

IKANOS: Breztri Maintenance Versus Any Non-Triple Inhaled Therapy After Hospitalization for a COPD Exacerbation in the US (IKANOS)

COPD

United States
University of Nottingham

Recruiting

Asthma: Phenotyping Exacerbations 3 (APEX3)

Asthma Attack

United Kingdom
Liaocheng People's Hospital

Recruiting

Susceptibility-Guided Sequential Therapy for Helicobacter Pylori Infection

Helicobacter Pylori Infection

China
PARZIBUT Gilles

Not yet recruiting

Non-inferiority Evaluation of Trimbow in Critically Ill Patients Admitted in ICU Compared to Standard of Care (TRIMICU)

COPD Exacerbation
Chiesi Farmaceutici S.p.A.

Recruiting

A Study Comparing Efficacy, Safety and Tolerability of the Fixed Dose Triple Combination CHF 5993 With the Fixed Dose Dual Combination CHF 1535 in Subjects With COPD (TRITON)

COPD | COPD Exacerbation

United States, Bulgaria, Hungary, Poland, Argentina, Czechia, Mexico, Canada, Puerto Rico, Romania
Assistance Publique - Hôpitaux de Paris

Completed

Postoperative Vomiting in Children: Comparison Tri - Versus bi -Prophylaxis (VPOP2)

Postoperative Vomiting

France
AstraZeneca

Completed

A Study to Assess the Pulmonary Distribution of Budesonide, Glycopyrronium and Formoterol Fumarate

Pulmonary Disease, Chronic Obstructive

United Kingdom
Pearl Therapeutics, Inc.

Completed

24-hour Lung Function in Subjects With Moderate to Very Severe COPD After Treatment With PT003, Open-Label Spiriva® Respimat® as an Active Control, and Placebo

COPD
Ohio State University

Completed

The Response to Atropine Drops (RAD) Study

Myopia

United States
Ghada Mohammed AboelFadl

Completed

Oral Amantadine Versus Gabapentin to Attenuate the Response to Laryngoscopy and Tracheal Intubation (15/5/2017)

Effect of Laryngoscopy and Tracheal Intubation

Egypt
Mahidol University
Siriraj Hospital

Unknown

Efficacy of Mefenamic Acid and Hyoscine for Pain Relief During Saline Infusion Sonohysterography in Infertile Women

Infertility

Thailand
Xijing Hospital of Digestive Diseases

Recruiting

Standard or Short-course Vonoprazan Non-bismuth Triple Therapy or High-dose Dual Therapy Versus Rabeprazole-bismuth Quadruple Therapy for Primary Helicobacter Pylori Eradication

the Eradication Rates of Helicobacter Pylori

China
Jinling Hospital, China

Recruiting

Clinical Study of Bowel Preparation Before Colonoscopy

Bowel Preparation

China
Yale University
National Institute on Drug Abuse (NIDA)

Recruiting

Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction

Smoking | Nicotine Dependence | Smoking Behaviors

United States
King Abdulaziz University

Completed

The Efficacy of Pre-procedural Mouth Rinses on COVID-19 Saliva Viral Load

COVID-19 | Covid19 | SARS-CoV-2 | Coronavirus | Saliva | Viral Load | Polymerase Chain Reaction | Mouthwashes

Saudi Arabia
Jie Chen

Active, not recruiting

Effect of Glycopyrrolate on Nausea and Vomiting After ERCP Operation

Nausea and Vomiting

China
Cairo University

Completed

Celecoxib Versus Hyoscine Butyl-bromide in Reducing Pain Associated With IUD.

IUD Insertion Pain

Egypt
Universitaire Ziekenhuizen KU Leuven

Completed

Effect of the Motilin Receptor Agonist, Erythromycin, on Hunger and Food Intake; Study of Role of Cholinergic Pathways

Healthy
Taizhou Hospital
First Affiliated Hospital of Zhejiang University; Taizhou First People's Hospital and other collaborators

Unknown

A Multi-center Study for Eradication of Refractory Helicobacter Pylori

Gastritis

China
Brno University Hospital
KDCHOT FN Brno

Completed

Depth of Neuromuscular Blockade and the Perioperative Conditions in Laparoscopic Surgery in Pediatric Population (PedLapBlock)

Neuromuscular Blockade

Czechia
Ziekenhuis Oost-Limburg
Merck Sharp & Dohme LLC

Completed

CURES: The Effect of Deep Curarisation and Reversal With Sugammadex on Surgical Conditions and Perioperative Morbidity (CURES)

Obesity | Surgical Conditions | Respiratory Function | Laparoscopic Gastric Bypass Surgery | Cerebral Tissue Oxygenation

Belgium
University Hospital, Angers

Completed

Mechanisms of Human Cutaneous Microcirculation in Healthy Volunteers

Healthy Volunteers

France
University Clinical Centre of Kosova
University of Ljubljana, Faculty of Medicine

Unknown

FM-SRP and Tooth Extraction Improve Type 2 Diabetes Mellitus in Periodontitis

Type 2 Diabetes Mellitus | Periodontitis

Kosovo
AstraZeneca

Recruiting

A Study to Investigate the Effect on Lung Function of an Approved COPD Treatment (BGF, With HFA Propellant) Compared to BGF Formulated With a New Propellant (HFO) in Participants 40 to 80 Years of Age With COPD

COPD (Chronic Obstructive Pulmonary Disease)

United States, Korea, Republic of, Argentina, Turkey, Vietnam, Malaysia, Philippines, Thailand, Hungary, Mexico, Bulgaria, Canada, India, Poland
Dar El Oyoun Hospital

Unknown

Subconjunctival Atropine and Intracameral Epinephrine for Pupil Dilation in Phacoemulsification

Cataract | Adverse Drug Event | Mydriasis

Egypt
Merck Sharp & Dohme LLC

Completed

Placebo-Controlled Crossover Study to Evaluate Donepezil and MK-3134 for Reversal of Cognitive Impairment Associated With Scopolamine Administration (3134-005)(COMPLETED)

Dementia
Vanderbilt University

Completed

Treatment of Orthostatic Hypotension in Autonomic Failure

Orthostatic Hypotension | Autonomic Failure

United States

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