Search clinical trials for: ribociclib ET

Total 308 results

Nationwide Children's Hospital
Novartis

Not yet recruiting

Study of Ribociclib and Everolimus in HGG and DIPG

Glioblastoma | Glioblastoma Multiforme | High Grade Glioma | Anaplastic Astrocytoma | Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma, H3 K27M-Mutant | WHO Grade III Glioma | Metastatic Brain Tumor | WHO Grade IV Glioma

United States, Australia, United Kingdom, Canada, Germany, Netherlands
St. Joseph's Hospital and Medical Center, Phoenix
Barrow Neurological Institute; Ivy Brain Tumor Center

Completed

A Phase 0 /II Study of Ribociclib (LEE011) in Combination With Everolimus in Preoperative Recurrent High-Grade Glioma Patients Scheduled for Resection

Glioblastoma Multiforme | Glioma of Brain

United States
Samsung Medical Center
AstraZeneca

Unknown

Evaluation of EGFR TKI Resistance Mechanism Using Plasma DNA Analysis

EGFR Mutation Positive Non-small Cell Lung Cancer

Korea, Republic of
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Withdrawn

Trabectedin and Venetoclax in Treating Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Resistant or Intolerant to a BTK Inhibitor

Refractory Chronic Lymphocytic Leukemia | Refractory Small Lymphocytic Lymphoma

United States
Assiut University

Unknown

Progesterone and Doppler in Recurrent Abortion

Abortion in First Trimester

Egypt
NYU Langone Health

Completed

Comparison of Medical and Surgical Treatment of Uncomplicated Acute Appendicitis in Children

Appendicitis

United States
Bogomolets National Medical University

Completed

The Influence of the Volume of Injuries and Surgical Operations on the Results of Pain Treatment in Patients With Gunshot and Mine-explosive Wounds at the Stages of Treatment (IVaSORPTP)

Chronic Pain

Ukraine
Bogomolets National Medical University

Completed

The Influence of Therapeutic Tactics of Analgesia on the Long-term Results of Pain Treatment in Patients With Gunshot and Mine-explosive Wounds (ITTAL-TRPT)

Chronic Pain

Ukraine
Bogomolets National Medical University

Completed

The Concept of Pain Treatment in Patients With Gunshot and Mine-explosive Wounds and to Develop an Algorithm for Analgesia at the Stages of Treatment (CPTGaM-EW)

Chronic Pain

Ukraine
Gynecologic Oncology Group
Novartis

Active, not recruiting

Ribociclib and Letrozole Treatment in Ovarian Cancer

Low Grade Serous Carcinoma

United States
UNICANCER
National Cancer Institute, France

Recruiting

Evaluation of Lymphadenectomy and Chemotherapy TIP on Inguinal Lymph Nodes in Squamous Cell Carcinoma of the Penis (MEGACEP)

Penile Cancer | Squamous Carcinoma

France
Fox Chase Cancer Center

Active, not recruiting

Phase II Trial of Ribociclib and Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS)

Soft Tissue Sarcoma

United States
Italian Sarcoma Group
AstraZeneca; PharmaMar; Istituto Di Ricerche Farmacologiche Mario Negri

Completed

Trabectedin Plus Olaparib in Metastatic or Advanced Sarcomas (TOMAS) (TOMAS)

Soft Tissue Sarcoma | Bone Tumor

Italy
Centre Leon Berard

Recruiting

A Study Evaluating the Activity of Anti-cancer Treatments Targeting Tumor Molecular Alterations/Characteristics in Advanced / Metastatic Tumors. (MegaMOST)

Malignant Solid Tumor

France
Novartis Pharmaceuticals
Innovative Therapies For Children with Cancer Consortium

Recruiting

Study of Efficacy and Safety of Ribociclib (LEE011) in Combination With Topotecan and Temozolomide (TOTEM) in Pediatric Patients With Relapsed or Refractory Neuroblastoma and Other Solid Tumors

Neuroblastoma

Germany, Italy, Singapore, Spain, United States, Australia, France
Brigham and Women's Hospital
EMD Serono

Completed

Comparison of Crinone 8% Intravaginal Gel and IM Progesterone Supplementation for In Vitro Fertilization (IVF)

Infertility

United States
Novartis Pharmaceuticals

Terminated

A Companion Sample Collection Protocol to Support the Discovery of Breast Cancer Aberrations With Treatment of CDK4/6 Therapy/LEE011/Ribociclib

Breast Cancer

United States
Hospices Civils de Lyon

Completed

Efficacy of Prazosin in Preventing Post-traumatic Stress Disorder (PRAZOSTRESS)

Acute Stress Disorder

France
AstraZeneca

Recruiting

Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292) (CAPItello-292)

Locally Advanced (Inoperable) or Metastatic Breast Cancer

Spain, Denmark, United States, Korea, Republic of, Germany, Belgium, Vietnam, United Kingdom, France, Japan, Brazil, Canada, China, India, Malaysia, Taiwan, Thailand, Australia, Turkey, Argentina, Poland, Sweden, Italy
Qamar Khan
Novartis Pharmaceuticals

Active, not recruiting

Letrozole Plus Ribociclib or Placebo as Neo-adjuvant Therapy in ER-positive, HER2-negative Early Breast Cancer (FELINE)

Breast Cancer

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

Ribociclib and Everolimus in Treating Children With Recurrent or Refractory Malignant Brain Tumors

Malignant Glioma | Recurrent Childhood Ependymoma | Recurrent Medulloblastoma | Recurrent Diffuse Intrinsic Pontine Glioma | Recurrent Atypical Teratoid/Rhabdoid Tumor | Refractory Diffuse Intrinsic Pontine Glioma | CNS Embryonal Tumor, Not Otherwise Specified

United States
Novartis Pharmaceuticals

Completed

Study of Ribociclib With Everolimus + Exemestane in HR+ HER2- Locally Advanced/Metastatic Breast Cancer Post Progression on CDK 4/6 Inhibitor. (TRINITI-1)

Breast Cancer

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); EMD Serono

Terminated

Avelumab and Trabectedin in Treating Patients With Liposarcoma or Leiomyosarcoma That is Metastatic or Cannot Be Removed by Surgery

Metastatic Leiomyosarcoma | Unresectable Leiomyosarcoma | Metastatic Liposarcoma | Unresectable Liposarcoma

United States
Borstkanker Onderzoek Groep
Novartis; Philips Healthcare

Active, not recruiting

Tailoring NEOadjuvant Therapy in Hormone Receptor Positive, HER2 Negative, Luminal Breast Cancer. (NEOLBC)

Breast Neoplasms

Netherlands
Novartis Pharmaceuticals

Completed

Study to Compare the Combination of Ribociclib Plus Goserelin Acetate With Hormonal Therapy Versus Combination Chemotherapy in Premenopausal or Perimenopausal Patients With Advanced or Metastatic Breast Cancer (RIGHT Choice)

Breast Cancer

India, Malaysia, Saudi Arabia, Taiwan, Russian Federation, Lebanon, South Africa, Thailand, Jordan, Turkey, Egypt, Vietnam, Singapore
Novartis Pharmaceuticals

Active, not recruiting

Study of 2 Ribociclib Doses in Combination With Aromatase Inhibitors in Women With HR+, HER2- Advanced Breast Cancer (AMALEE)

Breast Cancer

United States, South Africa, Austria, Hungary, Germany, Czechia, France, Russian Federation, Thailand, Belgium, Bulgaria, Lithuania, Jordan, Sweden, Finland, Peru, Colombia, Portugal, Canada, Brazil, India, Argentina, Costa Rica
Dana-Farber Cancer Institute
Novartis

Completed

An Open-Label, Phase Ib/II Clinical Trial Of Cdk 4/6 Inhibitor, Ribociclib (Lee011), In Combination With Trastuzumab Or T-Dm1 For Advanced/Metastatic Her2-Positive Breast Cancer.

Breast Cancer

United States
Merck Sharp & Dohme LLC

Completed

ZOSTAVAX™ Administered Concomitantly With PNEUMOVAX™ 23 (V211-012)(COMPLETED)

Herpes Zoster | Pneumococcal Infection
Bogomolets National Medical University

Completed

Predictors of Treatment Failure Pain Among Patients With Mine-explosive Wounds (PTFPAPM-EW)

Chronic Pain

Ukraine
Mayo Clinic
National Cancer Institute (NCI)

Completed

Ribociclib and Letrozole in Treating Patients With Relapsed ER Positive Ovarian, Fallopian Tube, Primary Peritoneal, or Endometrial Cancer

Recurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Recurrent Uterine Corpus Carcinoma | Estrogen Receptor Positive | Postmenopausal

United States
Novartis Pharmaceuticals

Completed

Study for Women and Men With Hormone-receptor Positive Locally Advanced or Metastatic Breast Cancer

Advanced Metastatic Breast Cancer

Germany
National Taiwan University Hospital

Recruiting

A Randomized Study Comparing the Immune Modulation Effect of Ribociclib, Palbociclib, and Abemaciclib in ER+/HER2- EBC (ORACLE-RIPA)

Breast Cancer | Hormone Receptor-positive Breast Cancer | Hormone Therapy

Taiwan
Stemline Therapeutics, Inc.

Recruiting

Open-Label Umbrella Study To Evaluate Safety And Efficacy Of Elacestrant In Various Combination In Patients With Metastatic Breast Cancer (ELEVATE)

Breast Cancer | Metastatic Breast Cancer

United States
Melissa K Accordino
Novartis Pharmaceuticals

Active, not recruiting

Study of Efficacy of Ribociclib After Progression on CDK4/6 Inhibition in Patients With HR+ HER2- Advanced Breast Cancer (MAINTAIN)

Metastatic Breast Cancer | Breast Carcinoma

United States
Peking University
Hangzhou DIAN Medical Diagnostic Center Co., Ltd., China

Recruiting

Targeted Agent Evaluation in Digestive Cancers in China Based on Molecular Characteristics (VISIONARY)

Gastric Cancer | Colorectal Cancer | Pancreatic Cancer | Gastrointestinal Stromal Tumors | Neuroendocrine Tumors | Esophageal Squamous Cell Carcinoma | Biliary Tract Neoplasms | Unknown Primary Cancer | Digestive Cancer

China
Bogomolets National Medical University

Completed

Predictors of Pain Chronicity in Patients With Gunshot and Mine-explosive Wounds (PPСPGM-EW)

Chronic Pain, Widespread

Ukraine
St. Jude Children's Research Hospital
Novartis Pharmaceuticals

Active, not recruiting

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Glioma | Neoplasms | Glioblastoma | Neoplasms, Neuroepithelial | Central Nervous System Neoplasms | Brain Cancer | Brain Tumor | Ependymoma | Medulloblastoma | Anaplastic Astrocytoma | Anaplastic Ganglioglioma | Anaplastic Ependymoma | Anaplastic Oligodendroglioma | Pineoblastoma | Recurrent Medulloblastoma | CNS Tumor | Pediatric... and other conditions

United States
Novartis Pharmaceuticals

Completed

Study of the Molecular Features of Postmenopausal Women With HR+ HER2-negative aBC on First-line Treatment With Ribociclib and Letrozole and, in Patients With a PIK3CA Mutation, on Second-line Treatment With Alpelisib Plus Fulvestrant (BioItaLEE)

Breast Cancer

Italy
Novartis Pharmaceuticals

Completed

Phase Ib Trial of LEE011 With Everolimus (RAD001) and Exemestane in the Treatment of Hormone Receptor Positive HER2 Negative Advanced Breast Cancer

Breast Cancer

United States, Spain, Belgium, Hong Kong, France
H. Lee Moffitt Cancer Center and Research Institute
Novartis

Completed

TEEL Study- Phase 1 Tamoxifen and Ribociclib (LEE011) in Advanced ER+ (HER2 Negative) Breast Cancer

Breast Cancer | Breast Cancer - Female | Breast Cancer - Male

United States
Addis Ababa University
University of Oslo; Ullevaal University Hospital; Sorlandet Hospital HF; University...

Unknown

Antioxidant Supplements in the Reversal of Schistosomal Peri-portal Fibrosis

Oxidative Stress | Liver Fibrosis | Schistosomiasis | Periportal Fibrosis

Ethiopia
Eirion Therapeutics Inc.

Completed

ET-01 in Subjects With Lateral Canthal Lines

Lateral Canthal Lines | Crow's Feet

United States
Yonsei University

Recruiting

Phase IB & II Study of Ribociclib With Trastuzumab Plus Letrozole in Postmenopausal HR+, HER2+ Advanced Breast Cancer Patients

Metastatic Breast Cancer | HER2-positive Breast Cancer | Postmenopausal

Korea, Republic of
Eirion Therapeutics Inc.

Completed

ET-01 in Subjects With Lateral Canthal Lines, LCL-208

Lateral Canthal Lines | Crow's Feet

United States
Eirion Therapeutics Inc.

Completed

ET-01 in Subjects With Lateral Canthal Lines, LCL-207

Lateral Canthal Lines | Crow's Feet

United States
Novartis Pharmaceuticals

Recruiting

[177Lu]Lu-NeoB in Combination With Ribociclib and Fulvestrant in Participants With ER+, HER2- and GRPR+ Advanced Breast Cancer

Breast Cancer

France, Germany, Spain, Portugal
Relay Therapeutics, Inc.

Active, not recruiting

First-in-Human Study of RLY-5836 in Advanced Breast Cancer and Other Solid Tumors

Breast Cancer | Advanced Breast Cancer | Metastatic Breast Cancer | Solid Tumor, Adult | HER2-negative Breast Cancer | Hormone Receptor Positive Tumor | Unresectable Solid Tumor | PIK3CA Mutation

United States
Novartis Pharmaceuticals

Completed

Study to Assess the Safety and Efficacy of Ribociclib (LEE011) in Combination With Letrozole for the Treatment of Men and Pre/Postmenopausal Women With HR+ HER2- aBC (COMPLEEMENT-1)

Breast Cancer

United States, Belgium, Canada, Italy, Spain, United Kingdom, Austria, Czechia, Hungary, Malaysia, Saudi Arabia, Taiwan, Argentina, France, Israel, Netherlands, Russian Federation, Hong Kong, Thailand, Lebanon, Bulgaria, Denmark, Po... and more
Mayo Clinic
National Cancer Institute (NCI)

Completed

Ribociclib and Gemcitabine Hydrochloride in Treating Patients With Advanced or Metastatic Solid Tumors

Advanced Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States
Dana-Farber Cancer Institute
Novartis

Terminated

Ribociclib + PDR001 in Breast Cancer and Ovarian Cancer

Metastatic Hormone-Receptor-Positive (HR+) Breast Cancer | HER2-Negative Breast Cancer | Metastatic Epithelial Ovarian Cancer

United States

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