Search clinical trials for: Disease Modifying Treatments

Total 383836 results

Alzheimer's Disease Expert Lab (ADEL), Inc.
Oscotec Inc.

Recruiting

A Phase Ia/Ib, First-in-human (FIH) Study for Safety, Tolerability, Pharmacokinetics (PK), and Clinical Activity Evaluation of ADEL-Y01

Alzheimer Disease

United States
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

MAP THE SMA: a Machine-learning Based Algorithm to Predict THErapeutic Response in Spinal Muscular Atrophy (MAP_THE_SMA-01)

Spinal Muscular Atrophy

Italy
Fondazione Policlinico Universitario Agostino Gemelli...
Bambino Gesù Hospital and Research Institute; University of Messina; University... and other collaborators

Recruiting

Long Term Trajectories of SMA Patients Receiving or Not Disease-modifying Treatments

Spinal Muscular Atrophy

Italy
Washington University School of Medicine
National Institute on Aging (NIA); Alzheimer's Association; Eisai Inc.; Accelerating...

Recruiting

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU) (DIAN-TU)

Dementia | Alzheimers Disease | Alzheimers Disease, Familial

United States, Canada, Italy, Argentina, Australia, Colombia, Netherlands, Puerto Rico, Spain, United Kingdom, France, Ireland, Mexico, Brazil, Japan, Germany
Washington University School of Medicine
Eli Lilly and Company; Hoffmann-La Roche; Avid Radiopharmaceuticals; National Institute... and other collaborators

Recruiting

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001 (DIAN-TU)

Dementia | Alzheimers Disease | Alzheimers Disease, Familial

United States, Canada, Italy, Argentina, Australia, Colombia, France, Ireland, Mexico, Netherlands, Puerto Rico, Spain, United Kingdom, Brazil, Japan, Germany
Washington University School of Medicine
Hoffmann-La Roche; Genentech, Inc.; National Institute on Aging (NIA); Alzheimer...

Suspended

A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation (DIAN-TU)

Dementia | Alzheimers Disease | Alzheimers Disease, Familial

United States, Canada, Italy, France, Spain, Ireland, Argentina, Australia, Colombia, Germany, Mexico, Netherlands, Puerto Rico, United Kingdom
Washington University School of Medicine
Hoffmann-La Roche; National Institute on Aging (NIA); Alzheimer's Association

Terminated

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia: A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)

Dementia | Alzheimers Disease | Alzheimers Disease, Familial

United States, France, Spain, Ireland, Canada, Australia, Puerto Rico, United Kingdom
Hikma Pharmaceuticals LLC

Active, not recruiting

Safety and Effectiveness of Generic Fingolimod (Sphingomod®, Hikma) in Patients With Relapsing-Remitting Multiple Sclerosis in Egypt

Relapsing-Remitting Multiple Sclerosis

Egypt
Centre Hospitalier Universitaire de Saint Etienne

Completed

Smart Marker Annunciating Response to Rheumatologic Treatments SMART²T (SMART²T)

Rheumatoid Arthritis

France
Hikma Pharmaceuticals LLC

Completed

Effectiveness and Safety of Generic Delayed-Release Dimethyl Fumarate (Sclera® or Marovarex ®, Hikma) in Routine Medical Practice in the Treatment of Relapsing-Remitting Multiple Sclerosis in MENA Region

Relapsing Remitting Multiple Sclerosis

Algeria, Egypt, Jordan
University Hospital, Basel, Switzerland
Swiss Multiple Sclerosis Society; Bangerter-Rhyner Stiftung; Center for Chronic...

Active, not recruiting

Prospective Stratification of Infectious Risks in Multiple Sclerosis (InRIMS)

Multiple Sclerosis

Switzerland
Novartis Pharmaceuticals

Completed

Risk Perception in Multiple Sclerosis

Multiple Sclerosis

United States
Washington University School of Medicine
Eli Lilly and Company; Hoffmann-La Roche; Avid Radiopharmaceuticals; National Institute... and other collaborators

Completed

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. (DIAN-TU)

Dementia | Alzheimers Disease | Alzheimers Disease, Familial

United States, Canada, France, Spain, Ireland, Australia, Puerto Rico, United Kingdom
Hacettepe University

Active, not recruiting

Development and Evaluation of the Self-management Module in Patients With Multiple Sclerosis

Multiple Sclerosis

Turkey
Duke University
Patient-Centered Outcomes Research Institute; Beth Israel Deaconess Medical...

Completed

Disease-Modifying Treatments for Myasthenia Gravis (PROMISE-MG)

Autoimmune Diseases | Neurological Disorder

United States, Canada
University Hospital, Caen
Genzyme, a Sanofi Company; Ligue contre le cancer, France

Completed

Impact of the Arrival on the French Market of New First Line Oral Treatments on the Delay Between MS Onset and First Disease Modifying Treatment (DMTs) Administration (PREMISEP)

C10.114.375.500

France
Regeneron Pharmaceuticals
Sanofi

Completed

Study of Alirocumab (REGN727/SAR236553) added-on to Rosuvastatin Versus Other Lipid Modifying Treatments (LMT) (ODYSSEY OPTIONS II)

Hypercholesterolemia

United States, France, Italy, Germany, Spain, Canada, United Kingdom, Australia, Mexico
Radboud University Medical Center
Dutch Cancer Society

Completed

Patient Selection for Hypoxia Modifying Treatments in Larynx Carcinomas

Larynx Cancer

Netherlands
Regeneron Pharmaceuticals

Not yet recruiting

A Study of Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for Adult Patients With Operable Non-Small Cell Lung Cancer (NSCLC)

Non-Small Cell Lung Cancer
Memorial Sloan Kettering Cancer Center
TransThera Sciences

Recruiting

A Study of Tinengotinib (TT-00420) in Combination With Standard Treatments in People With Prostate Cancer

Prostate Cancer

United States
Ming Wei

Recruiting

Ischemic Post-conditioning in the Treatment of Acute Ischemic Stroke

Acute Ischemic Stroke | Large Vessel Occlusion | Intracranial Artery Occlusion With Cerebral Infarction | Endovascular Treatments

China
VA Office of Research and Development

Not yet recruiting

Personalized Exercise Treatments for Older Veterans With Motoric Cognitive Risk Syndrome

Motoric Cognitive Risk Syndrome

United States
Bristol-Myers Squibb

Not yet recruiting

Patient and Physician Preference Study in Resectable, Non-small Cell Lung Cancer Treatments

Non-small Cell Lung Cancer (NSCLC)

United Kingdom
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Efficacy and Safety of Bezafibrate 400 mg and Bezafibrate 200 mg as Adjunctive Treatments in Patients With Primary Biliary Cholangitis and Non-optimal Biochemical Response to Ursodeoxycholic Acid Therapy (BEZURSO 2)

BPC | Non Optimal Response to UDCA

France
Duke University
Temple University

Not yet recruiting

ROAR-DIGAP: A Widely Inclusive, Largely Virtual Pilot Trial Utilizing DIGAP (Deep Integrated Genomics Analysis Platform) To Personalize Treatments

Amyotrophic Lateral Sclerosis ALS

United States
Jorge Javier Osma López
Hospital General Universitario de Castellón; Hospital Universitario La Plana...

Not yet recruiting

Online Prevention of Emotional Disorders in Women Undergoing Fertility Treatments (RE-FER moodle)

Infertility | Emotional Disorder | Anxiety Depression

Spain
Umm Al-Qura University

Recruiting

Comparative Effectiveness of Different Drugs Used to tr€at Patients in Rheumatoid Arthritis Saudi Database (RASD)"

Rheumatoid Arthritis RA

Saudi Arabia
Universidad Complutense de Madrid

Recruiting

To Evaluate Postoperative Pain and Quality of Life After Taking a Deephethelized Gingival Graft and Covering it With Different Treatments

Quality of Life | Pain, Postoperative | Palate; Wound

Spain
Janssen-Cilag Ltd.

Recruiting

Transmural Healing and Disease-Modifying Effect of Guselkumab in Crohn's Disease Patients (REASON)

Crohn's Disease

Taiwan, Israel
European Organisation for Research and Treatment...

Not yet recruiting

Improvement of Quality of Life Through Supportive Treatments for Hormone Therapy - Related Symptoms in Women With Early Breast Cancer

Musculoskeletal Pain | Drug-Related Side Effects and Adverse Reactions | Breast Cancer Stage I | Breast Cancer Stage II | Breast Cancer Stage III | HER2-negative Breast Cancer | ER+ Breast Cancer
Beijing Chest Hospital
The First Affiliated Hospital with Nanjing Medical University; Anhui Chest... and other collaborators

Recruiting

Efficacy Safety BaiDiZiYin ShenQiYiFei Adjunctive Treatments Pulmonary Tuberculosis

Tuberculosis | Treatment | Adjuvant

China
TC Erciyes University

Recruiting

Effect of Different Irrigation Solutions on Postoperative Pain and Lesion Healing

Endodontic Disease

Turkey
Fresenius Medical Care Deutschland GmbH
KLIFO GmbH

Not yet recruiting

Clinical Performance of the New Plasma Filter PX2 in TPE Treatments (plasmaFlux)

Autoimmune Diseases

Germany
Novartis Pharmaceuticals

Not yet recruiting

Modifying PEST for Psoriatic Arthritis Screening (ScreenX)

Plaque Psoriasis | Psoriatic Arthritis
Northern Michigan University

Recruiting

Climbing Lifestyle Intervention for Modifying Physical Activity Behaviors: Pilot Study (CLIMB)

Quality of Life | Physical Inactivity | Lifestyle Factors

United States
Fondazione SISA (Societa Italiana per lo Studio...

Recruiting

Lipid Transport Disorder Italian Genetic Record (LIPIGEN) (LIPIGEN)

Familial Hypercholesterolemia | Genetic Disorder

Italy
Rennes University Hospital

Not yet recruiting

Medico-economic Evaluation of Robot-assisted Laparoscopy Compared With Conventional Laparoscopy in Hysterectomy for Endometrial Cancer. (ROBOT-ECO-GYN)

Hysterectomies for Low- or Intermediate-risk Endometrial Carcinoma

France
Memorial Sloan Kettering Cancer Center

Recruiting

A Study of 2141-V11 in Combination With Standard Treatments in People With Prostate Cancer

Prostate Cancer

United States
State University of New York at Buffalo
The Cure Parkinson's Trust

Not yet recruiting

Repurposing Lithium for Parkinson's Disease: a RCT

Parkinson Disease

United States
National Cancer Institute (NCI)

Not yet recruiting

Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma

Classic Follicular Lymphoma | Follicular Lymphoma With Unusual Cytological Features
Gilead Sciences

Not yet recruiting

A Study to Provide Continued Access to Study Drug to Children and Adolescents Who Have Completed Clinical Studies Involving Gilead HIV Treatments

HIV-1-infection
European Institute of Oncology

Recruiting

Radiotherapy Treatments for Neoplasms of the Limbs

Bone Neoplasms | Bone Metastases

Italy
European Institute of Oncology

Recruiting

Total Body Irradiation Treatments for Patients Treated at European Institute of Oncology

Lymphoma | Leukemia | Aplastic Anemia | Leukemia, Acute | Leukemia, Chronic

Italy
European Institute of Oncology

Recruiting

Minimally Invasive Treatments of the Thyroid (MIPA-MITT)

Papillary Thyroid Microcarcinoma

Italy
Durham VA Medical Center

Not yet recruiting

Veterans Enhanced Recovery Using Integrative Treatments Around Surgery (VERITAS)

Surgery | Anesthesia | Knee Arthropathy
Hospices Civils de Lyon

Not yet recruiting

Exploring Food Rejection Dispositions as Potential Risk Factors for Undernutrition in Hospitalized Children Aged 2 to 8 (MEDIALIME)

Undernutrition

France
H. Lundbeck A/S

Recruiting

A Dose-finding Trial With Lu-AG09222 in Adults With Migraine Who Have Not Been Helped by Prior Preventive Treatments (PROCEED)

Migraine

United States
University College, London
Novartis; Cancer Research UK; Janssen Pharmaceutica NV

Not yet recruiting

A Randomised Controlled Platform Trial Testing Treatments in Metastatic Hormone Sensitive Prostate Cancer (STAMPEDE2)

Prostate Cancer Metastatic
Tianjin Medical University Cancer Institute and...

Recruiting

Compare the Prognostic Differences Between SBRT and Surgery for NSCLC Patients With Interlobular Fissure Invasion.

NSCLC | Surgery | Radiotherapy

China
ImmuneMed, Inc.

Not yet recruiting

A Study to Assess the Efficacy and Safety of Burfiralimab (hzVSF-v13) and DMRD (Disease-modifying Antirheumatic Drug)

Moderate to Severe Rheumatoid Arthritis

Netherlands

Search clinical trials for: Disease Modifying Treatments

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