Search clinical trials for: TTR cardiomyopathy

Total 1436 results

Alexion Pharmaceuticals, Inc.

Recruiting

Study of ALXN2220 Versus Placebo in Adults With ATTR-CM (DepleTTR-CM)

Transthyretin Amyloid Cardiomyopathy

United States, Spain, United Kingdom, Norway, Israel, China, Korea, Republic of, France, Germany, Italy, Japan, Belgium, Australia, Argentina, Austria, Taiwan, Switzerland, Canada, Sweden, Poland, Denmark, Turkey, Brazil, Netherlands, G... and more
Intellia Therapeutics
Regeneron Pharmaceuticals

Recruiting

MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)

Transthyretin Amyloidosis (ATTR) With Cardiomyopathy

United States, Australia, United Kingdom, New Zealand, Canada
University of Texas Southwestern Medical Center
National Heart, Lung, and Blood Institute (NHLBI); Columbia University; The Cleveland... and other collaborators

Recruiting

Subclinical Transthyretin Cardiac Amyloidosis in V122I TTR Carriers

Amyloidosis, Familial | Amyloidosis, Hereditary | Amyloidosis Cardiac | Transthyretin-Related (ATTR) Familial Amyloid Cardiomyopathy | Transthyretin Gene Mutation

United States
Oregon Health and Science University
Ionis Pharmaceuticals, Inc.

Recruiting

carDIo-ttranSSfOrm nucLEar Imaging Study (DISSOLvE)

Amyloidosis | Transthyretin Amyloid Cardiomyopathy

United States
Centre Hospitalier Régional d'Orléans

Recruiting

Amyloidosis TTR Flow Reserve Evaluation (AMYTRE)

Amyloid Cardiomyopathy

France
Brigham and Women's Hospital

Not yet recruiting

ION-682884 in Patients With TTR Amyloid Cardiomyopathy

Transthyretin Amyloid Cardiopathy

United States
Pfizer

Recruiting

Vyndaqel Capsules Special Investigation (ATTR-CM)

Transthyretin (TTR) Amyloid Cardiomyopathy

Japan
Mathew S. Maurer
National Heart, Lung, and Blood Institute (NHLBI); Yale University; Boston Medical... and other collaborators

Recruiting

Screening for Cardiac Amyloidosis With Nuclear Imaging for Minority Populations (SCAN-MP)

Amyloid Cardiomyopathy, Transthyretin-Related

United States
CENTOGENE GmbH Rostock
Alnylam Pharmaceuticals

Recruiting

TRAMmoniTTR Study Genetic Screening of an At-risk Population for hATTR and Monitoring of TTR Positive Subjects (TRAMmoniTTR)

Cardiomyopathies | Polyneuropathies | Transthyretin Amyloidosis | Transthyretin-Related (ATTR) Familial Amyloid Cardiomyopathy | Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy

Germany, Austria, Switzerland
Eidos Therapeutics, a BridgeBio company

Completed

Efficacy and Safety of AG10 in Subjects With Transthyretin Amyloid Cardiomyopathy (ATTRibute-CM)

Heart Diseases | Amyloidosis | Cardiomyopathies | Transthyretin Amyloidosis | Amyloid Cardiomyopathy

United States, Netherlands, Ireland, Canada, Italy, Spain, Belgium, New Zealand, Israel, Australia, Portugal, Brazil, Poland, Czechia, Denmark, Greece, Korea, Republic of, United Kingdom
Alnylam Pharmaceuticals

Active, not recruiting

APOLLO-B: A Study to Evaluate Patisiran in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR Amyloidosis With Cardiomyopathy)

Transthyretin Amyloidosis (ATTR) With Cardiomyopathy

United States, Australia, Brazil, Bulgaria, France, Italy, Japan, Mexico, Netherlands, Taiwan, United Kingdom, Belgium, Czechia, Denmark, New Zealand, Sweden, Korea, Republic of, Argentina, Chile, Hong Kong, Portugal
Novo Nordisk A/S

Active, not recruiting

A Research Study to Look at How a New Medicine Called NNC6019-0001 Works and How Safe it is for People Who Have Heart Disease Due to Transthyretin (TTR) Amyloidosis

Transthyretin Amyloid Cardiomyopathy (ATTR CM)

United States, Netherlands, Spain, Portugal, Canada, Czechia, France, Germany, Italy, Japan
Pfizer

Completed

Long-term Safety of Tafamidis in Subjects With Transthyretin Cardiomyopathy

Transthyretin (TTR) Amyloid Cardiomyopathy

United States, Taiwan, Canada, Belgium, Australia, Czechia, Sweden, Spain, Italy, Hong Kong, Germany, Netherlands, United Kingdom, France, Japan, Argentina, Brazil
Alnylam Pharmaceuticals

No longer available

Expanded Access Protocol to Provide Patisiran to Patients With Transthyretin-mediated Amyloidosis With Cardiomyopathy

Transthyretin-mediated Amyloidosis With Cardiomyopathy | ATTR Amyloidosis With Cardiomyopathy

United States
Alnylam Pharmaceuticals

Active, not recruiting

HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

Transthyretin Amyloidosis (ATTR) With Cardiomyopathy

United States, Poland, Argentina, Australia, Belgium, France, Germany, Japan, Netherlands, Portugal, Spain, Sweden, United Kingdom, Canada, Czechia, Denmark, Hungary, Ireland, Norway, Korea, Republic of, Austria, Croatia, Israel, Latvia, Lithuan... and more
Pfizer

Completed

Prevalence and Characteristics of Transthyretin Amyloidosis in Patients With Left Ventricular Hypertrophy of Unknown Etiology (TTRACK)

Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM)

Italy, Romania, France, Australia, Austria, Portugal, Slovakia, Slovenia, Spain, United Kingdom
Ionis Pharmaceuticals, Inc.

Active, not recruiting

CARDIO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Participants With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

United States, Australia, Spain, Canada, Germany, Japan, Italy, Israel, Argentina, France, Portugal, Austria, Brazil, Greece, United Kingdom, Czechia, Sweden, Belgium, Denmark, Poland, Puerto Rico
Ionis Pharmaceuticals, Inc.
AstraZeneca

Active, not recruiting

CARDIO-TTRansform Magnetic Resonance Imaging (MRI) Sub-study

Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)

United States, United Kingdom, Italy, Spain
Ionis Pharmaceuticals, Inc.
AstraZeneca

Active, not recruiting

The CARDIO-TTRansform Scintigraphy Sub-study

Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)

United States, Spain
Intellia Therapeutics

Active, not recruiting

Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NTLA-2001 in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy (ATTRv-PN) and Patients With Transthyretin Amyloidosis-Related Cardiomyopathy (ATTR-CM)

Transthyretin-Related (ATTR) Familial Amyloid Cardiomyopathy | Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy | Wild-Type Transthyretin Cardiac Amyloidosis

France, United Kingdom, New Zealand, Sweden
Pfizer

Completed

Burden of Disease Study In Patients With Transthyretin Familial Amyloidosis Polyneuropathy (TTR-FAP) orTransthyretin Cardiomyopathy (TTR-CM) And Caregivers

Transthyretin Familial Amyloidosis Polyneuropathy (TTR-FAP) | Transthyretin Cardiomyopathy (TTR-CM) | Familial Amyloid Cardiomyopathy | Senile Systemic Amyloidosis (SSA)
Eidos Therapeutics, a BridgeBio company

Active, not recruiting

Open-Label Study of AG10 in Patients With Cardiomyopathy

Amyloid Cardiomyopathy

United States
Pfizer

Completed

Safety And Efficacy Evaluation Of Fx-1006a In Patients With V122i Or Wild-Type Transthyretin (TTR) Amyloid Cardiomyopathy

ATTR-CM | TTR-CM

United States
Brigham and Women's Hospital

Unknown

24 Month Open Label Study of the Tolerability and Efficacy of Inotersen in TTR Amyloid Cardiomyopathy Patients

Amyloidosis

United States
Alnylam Pharmaceuticals

Completed

A Extension Study to Evaluate Revusiran (ALN-TTRSC) in Patients With Transthyretin (TTR) Cardiac Amyloidosis

TTR-mediated Amyloidosis

United States, Canada, United Kingdom
Thibaud Damy

Completed

Prevalence of Transthyretin Amyloidosis in Hypertrophic Cardiomyopathy (Amylo)

Cardiac Amyloidosis | Hypertrophic Cardiomyopathy (HCM) | Amyloidosis in Transthyretin (TTR)

France
Pfizer

Completed

Safety and Efficacy of Tafamidis in Patients With Transthyretin Cardiomyopathy (ATTR-ACT)

Transthyretin (TTR) Amyloid Cardiomyopathy

United States, Spain, Czechia, Canada, Belgium, Netherlands, Germany, Japan, France, United Kingdom, Brazil, Italy, Sweden
Alnylam Pharmaceuticals

Completed

ENDEAVOUR: Phase 3 Multicenter Study of Revusiran (ALN-TTRSC) in Patients With Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC)

Amyloid Neuropathies | Amyloid Neuropathies, Familial | Amyloidosis, Hereditary | Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC) | Amyloidosis, Hereditary, Transthyretin-Related | Familial Transthyretin Cardiac Amyloidosis

United States, France, Italy, Spain, Canada, Germany, Belgium, Sweden, United Kingdom
Alnylam Pharmaceuticals

Completed

DISCOVERY: A Study Examining the Prevalence of TTR Mutations in Subjects Suspected of Having Cardiac Amyloidosis

Familial Amyloidotic Cardiomyopathy (FAC)

United States, France, Spain, United Kingdom, Belgium, Brazil
Pfizer

Completed

A Study To Determine Any Effect Of Tafamidis On Electrocardiographic Intervals, Specifically The Rate Corrected QT Interval (QTc)

TTR Cardiomyopathy

United States, Singapore, Belgium
Pfizer

Completed

The Effects Of Fx-1006A On Transthyretin Stabilization And Clinical Outcome Measures In Patients With V122I Or Wild-Type TTR Amyloid Cardiomyopathy

Cardiomyopathy

United States
Pfizer

Completed

Safety And Pharmacokinetic Assessment Of Orally Administered Tafamidis In Healthy Volunteers

TTR Cardiomyopathy

Singapore
Lexicon Pharmaceuticals

Recruiting

A Study to Evaluate the Efficacy and Safety of Sotagliflozin in Symptomatic Obstructive and Non-obstructive Hypertrophic Cardiomyopathy (SONATA-HCM)

Non-obstructive Hypertrophic Cardiomyopathy | Obstructive Cardiomyopathy, Hypertrophic

United States
Hospices Civils de Lyon

Not yet recruiting

Act on Quality of Life in Patients With aortIc Stenosis (ALPINIST)

Severe Aortic Stenosis

France
Institut d'Investigació Biomèdica de Bellvitge
Hospital Universitari de Bellvitge; Fundació La Marató de TV3

Not yet recruiting

Left Septal or Deep Septal Pacing to Prevent Pacing-induced Cardiomyopathy (DEEP)

Complete Heart Block | Second Degree Atrioventricular Block Möbitz Type II

Spain
AstraZeneca
ICON plc

Not yet recruiting

Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis (MaesTTRo)

Transthyretin Amyloidosis | ATTR-CM | ATTRv-PN | ATTR | ATTR-Mixed | hATTR
Emory University
The Marcus Foundation

Not yet recruiting

A Phase 1 Open-Label Study of the Safety of Intravenous Allogeneic Neonatal Mesenchymal Cells (nMSCs) in Young Adult (1A) and Pediatric (1B) Patients With Dilated Cardiomyopathy (DCM)

Dilated Cardiomyopathy

United States
American Heart Association

Not yet recruiting

Hypertrophic Cardiomyopathy Federated Learning Implementation Platform (HCM FLIP)

Hypertrophic Cardiomyopathy
Corporacion Parc Tauli

Not yet recruiting

Preoperative Chemoradiotherapy and Transanal Endoscopic Microsurgery Versus Ttransanal Endoscopic Microsurgery in T1 N0, M0 Rectal Cancer (TAUTEM-T1 Study) (TAUTEM-T1)

Rectal Cancer Stage I
Guy's and St Thomas' NHS Foundation Trust
King's College Hospital NHS Trust; Imperial College Healthcare NHS Trust

Not yet recruiting

The PICM Risk Prediction Study - Application of AI to Pacing

Heart Failure | Pacemaker-Induced Cardiomyopathy | Pacemaker Complication

United Kingdom
NHS Greater Glasgow and Clyde
University of Glasgow; Roche Diagnostics GmbH

Not yet recruiting

Biomarkers in SCOTland CardiomyopatHy Registry (Bio-SCOTCH)

Cardiomyopathies | Genetic Predisposition | Cardiomyopathy, Primary
Post Graduate Institute of Medical Education and...
Indian Council of Medical Research

Not yet recruiting

Carvedilol + Simvastatin vs. Carvedilol Alone for Chronic Liver Disease and Cirrhotic Cardiomyopathy and Its Impact on Hepatic Decompensation and Survival; a Double-blind Randomized Controlled Trial (CIRROSTAT)

Decompensated Cirrhosis | Acute Kidney Injury | Cirrhosis, Liver | Left Ventricular Diastolic Dysfunction | Cirrhotic Cardiomyopathy
University of Pennsylvania
National Heart, Lung, and Blood Institute (NHLBI)

Not yet recruiting

Sodium Glucose Co-transporter (SGLT) Inhibitors in Nonobstructive Hypertrophic Cardiomyopathy (SOTA-CROSS HCM)

Hypertrophic Cardiomyopathy Without Obstruction
Tanta University

Not yet recruiting

Evaluation of the Possible Safety and Efficacy of Dapagliflozin in the Prophylaxis of Doxorubicin-Induced Cardiotoxicity

Breast Cancer | Doxorubicin Induced Cardiomyopathy

Egypt
Cytokinetics

Recruiting

A Study to Evaluate the Effect of Aficamten in Pediatric Patients (Age 12 to <18 Years) With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM). (CEDAR-HCM)

Pediatric | Symptomatic Obstructive Hypertrophic Cardiomyopathy

United States
University of Edinburgh

Recruiting

Cardiomyopathies and Heart Muscle Diseases: Cardiac Imaging in the Evaluation of Myocardial Fibrosis Transition (CHIEFTain)

Myocarditis | Hypertrophic Cardiomyopathy | Cardiac Sarcoidosis | Heart Failure With Preserved Ejection Fraction | Hypertensive Heart Disease | Arrhythmogenic Right Ventricular Cardiomyopathy 1 | Tako Tsubo Cardiomyopathy

United Kingdom
Amsterdam UMC, location VUmc

Recruiting

Assessment of Cardiac Function, Microvascular Function and Cardiac Perfusion in Different Disease Stages of Hypertrophic Cardiomyopathy (FUSION-HCM)

Hypertrophic Cardiomyopathy | Hypertrophic Cardiomyopathy, Obstructive

Netherlands
China National Center for Cardiovascular Diseases

Recruiting

Use of SGLT2i in noHCM With HFpEF

Hypertrophic Cardiomyopathy | Heart Failure With Preserved Ejection Fraction

China
RenJi Hospital

Not yet recruiting

Efficacy and Safety of Telitacicept for Prevention of Flares in SLE Patients

Systemic Lupus Erythematosus
China National Center for Cardiovascular Diseases

Recruiting

Efficacy and Safety of Thoracoscopic Morrow Surgery in the Treatment of Hypertrophic Obstructive Cardiomyopathy

Minimally Invasive Surgery | Cardiomyopathy, Hypertrophic Obstructive

China

Search clinical trials for: TTR cardiomyopathy

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