Search clinical trials for: VEGF signaling pathway

Total 2749 results

Wuhan Union Hospital, China

Completed

The Effects of VEGF-B Signaling Pathway in Obesity and Metabolic Disease (Obesity)

Obesity | Metabolic Disease

China
University of Southern California
National Cancer Institute (NCI); Prism Pharma Co., Ltd.

Withdrawn

Combination Chemotherapy and Bevacizumab With or Without PRI-724 in Treating Patients With Newly Diagnosed Metastatic Colorectal Cancer (PRIMIER)

Colorectal Adenocarcinoma | Stage IVA Colorectal Cancer | Stage IVB Colorectal Cancer

United States
University of Chicago

Terminated

Pilot Study of the Treatment of Vascular Endothelial Growth Factor(VEGF)Signaling Pathway Inhibitor-Induced Hypertension

Treatment Induced Hypertension

United States
First Affiliated Hospital, Sun Yat-Sen University
Guangdong Province, Department of Science and Technology

Unknown

VEGF Signaling Promotes Cell Growth and Metastasis in Extrahepatic Cholangiocarcinoma in a VEGF Receptor Mediated Pathway (ECC) (VEGF ECC)

Extrahepatic Cholangiocarcinoma

China
First Affiliated Hospital, Sun Yat-Sen University
Guangdong Province, Department of Science and Technology

Unknown

VEGF Signaling Promotes Cell Growth and Metastasis in Intrahepatic Cholangiocarcinoma in a VEGF Receptor Mediated Pathway (icc)

Intrahepatic Cholangiocarcinoma

China
First Affiliated Hospital, Sun Yat-Sen University
Guangdong Province, Department of Science and Technology

Unknown

VEGF Signaling Promotes Cell Growth and Metastasis in Hepatocellular Carcinoma in a VEGF Receptor Mediated Pathway (HCC)

Hepatocellular Carcinoma

China
Xie Kangjie

Recruiting

Predictive Effect of TGF-β Combined With INS-PI3K-AKT Signaling Pathway Related Proteins (ADNP, MAP6, Pgc-1α) for POD on Diabetes Patients

Diabetes | Postoperative Delirium

China
Tianjin Medical University Cancer Institute and...

Recruiting

Osimertinib Plus Dalpiciclib in Patients With EGFR-mutant, CDK4/6 Pathway Aberrant, Advanced Non-small Cell Lung Cancer Following Acquired Resistance to Third-generation EGFR TKI: a Phase II Trial

Non-small Cell Lung Cancer | EGFR Activating Mutation | EGFR-TKI Resistant Mutation | Cell Cycle Deregulation

China
Ziauddin University

Not yet recruiting

Metformin Repurposing in Oral Submucous Fibrosis: Unveiling In Vitro Signaling Pathways, Progressing to Clinical Trial (MROSF)

Oral Submucous Fibrosis

Pakistan
University of Alabama at Birmingham

Not yet recruiting

VITAL-IMPACT: Improving Cardiometabolic Health in Black Individuals Through Therapeutic Augmentation of Cyclic Guanosine Mono-Phosphate Signaling Pathway (VITAL-IMPACT)

Cardiovascular Diseases | Obesity | Insulin Sensitivity/Resistance | Metabolic Disease | Energy Expenditure | Metabolism

United States
Pasithea Therapeutics Corp.

Recruiting

PAS-004 in Patients With Advanced Solid Tumors

Advanced Solid Tumors | RAS Mutation | NF1 Mutation | RAF Mutation

United States
Fondazione IRCCS Ca' Granda, Ospedale Maggiore...
University of Trieste; IRCCS Fondazione Stella Maris; CNR Institute of Neuroscience...

Recruiting

Integrins and Protocadherins in Glutamatergic Circuits: Identification of Common Signaling Pathways and Molecular Targets in Anxiety and Major Depressive Disorders (GAPsy) (GAPsy)

Healthy | Depression, Anxiety

Italy
Fudan University

Not yet recruiting

An Umbrella Trial Based on Molecular Pathway for Patients With Metastatic TNBC in First-line Treatment (FUTURE-Trop2)

TNBC - Triple-Negative Breast Cancer
Novartis Pharmaceuticals

Recruiting

A Post Approval Commitment Study on Tabrecta® (Capmatinib) in South Korea

Non-Small-Cell Lung Carcinoma

Korea, Republic of
Shaw Cancer Center
Steadman Philippon Research Institute

Recruiting

Losartan to Reduce Radiation Induced Fibrosis in Breast Cancer Patients

Radiation Induced Fibrosis

United States
University of California, San Diego

Recruiting

ADRB3 Signaling Pathway in Human Adipose Tissue

Obesity, Prediabetes

United States
M.D. Anderson Cancer Center
Novartis; Puma Biotechnology, Inc.; Celcuity Inc

Recruiting

Neratinib and Capmatinib Combination (Phase Ib/II) in Metastatic Breast Cancer and Inflammatory Breast Cancer Patients With Abnormal HER-family and c-Met Pathway Activity as Measured by the CELsignia Signaling Analysis Test

Breast Cancer | Metastatic Breast Cancer

United States
Dongzhimen Hospital, Beijing

Recruiting

Characteristics of LKDS and PBSS of KOA Based on the Enhancement of Inflammatory Response by TGF-β/Smad Pathway Inhibited

Syndrome | Knee Osteoarthritis | Traditional Chinese Medicine

China
University of Messina
Natasha Irrera; Gianluca Di Bella; Antonio Micari; Roberto Licordari

Recruiting

Modulation of Fibrosis-inducing Pathways in Acute Myocardial Infarction (BETA-MI)

Myocardial Infarction | Myocardial Fibrosis | Myocardial Remodeling, Ventricular

Italy
M.D. Anderson Cancer Center
National Cancer Institute (NCI); United States Department of Defense; National...

Recruiting

PROSPECT - Profiling of Resistance Patterns & Oncogenic Signaling Pathways in Evaluation of Cancers of the Thorax and Therapeutic Target Identification

Lung Cancer | Cancer of Thorax

United States
M.D. Anderson Cancer Center

Recruiting

Interrogating Biological Signaling Pathway Dysregulations and In Vitro Screening With Personalized Therapies in Relapsed or Refractory Mantle Cell Lymphoma, MCL MATCH Trial

Recurrent Mantle Cell Lymphoma | Refractory Mantle Cell Lymphoma

United States
Second Affiliated Hospital of Guangzhou Medical...

Recruiting

Trametinib Combined With Everolimus and Lenvatinib for Recurrent/Refractory Advanced Solid Tumors

Hepatocellular Carcinoma | Solid Tumor, Adult

China
Dokuz Eylul University

Not yet recruiting

JAK-STAT Signaling Pathway in Pyoderma Gangrenosum

Psoriasis | Hidradenitis Suppurativa | Pyoderma Gangrenosum
Henan Cancer Hospital

Recruiting

Camrelizumab Combined With AVD in the First-line Treatment for Patients With Advanced Classical Hodgkin's Lymphoma

Classical Hodgkin Lymphoma

China
Columbia University
Pfizer

Recruiting

Study of Axitinib (AG-013736) With Evaluation of the VEGF-pathway in Pheochromocytoma/Paraganglioma

Pheochromocytoma | Paraganglioma

United States
Tianjin Medical University Second Hospital
Tianjin Medical University General Hospital; Tianjin First Central Hospital; The...

Not yet recruiting

Everolimus in Castrated Resistant Prostate Cancer(CRPC)Patients With PI3K-AKT-mTOR Signaling Pathway Deficiency

Prostate Cancer

China
NuCana plc

Completed

A Safety, Pharmacokinetic and Efficacy Study of NUC-3373 in Combination With Standard Agents Used in Colorectal Cancer Treatment

Colorectal Neoplasms | Colorectal Cancer | Colorectal Tumors | Colorectal Carcinoma | Neoplasms, Colorectal

United States, France, United Kingdom
Novartis Pharmaceuticals

Completed

Study of Oral cMET Inhibitor INC280 in Patients With EGFR Wild-type (wt), Advanced Non-small Cell Lung Cancer (NSCLC) (Geometry Mono-1)

Carcinoma, Non-Small-Cell Lung

Italy, Spain, Germany, Japan, Taiwan, Belgium, Netherlands, Singapore, Argentina, France, Israel, Sweden, Korea, Republic of, Lebanon, United Kingdom, United States, Austria, Mexico, Norway, Russian Federation
Anna Martling
Skane University Hospital; Uppsala University Hospital

Active, not recruiting

Adjuvant Low Dose Aspirin in Colorectal Cancer (ALASCCA)

Colorectal Cancer

Sweden, Denmark, Norway, Finland
National Cancer Institute (NCI)

Active, not recruiting

Trial of Topotecan With VX-970 (M6620), an ATR Kinase Inhibitor, in Small Cell Cancers and Extrapulmonary Small Cell Cancers

Uterine Cervical Neoplasms | Small Cell Lung Carcinoma | Ovarian Neoplasms | Carcinoma, Neuroendocrine | Extrapulmonary Small Cell Cancer | Carcinoma, Non-Small -Cell Lung

United States
Fudan University

Active, not recruiting

An Umbrella Trial Based on Molecular Pathway for Patients With Metastatic TNBC. (FUTURE-SUPER)

TNBC - Triple-Negative Breast Cancer

China
Turning Point Therapeutics, Inc.

Active, not recruiting

Study of TPX-0022 in Patients With Advanced NSCLC, Gastric Cancer or Solid Tumors Harboring Genetic Alterations in MET (SHIELD-1)

Advanced Solid Tumor | Metastatic Solid Tumors | MET Gene Alterations

United States, France, Korea, Democratic People's Republic of, Korea, Republic of, Spain
University of Cologne

Completed

Analysis of Mother-child Interaction and Regulation of Candidate Genes of Stress Signaling Pathways in Mature Infants

Mother-Child Interaction

Germany
Basilea Pharmaceutica
ArQule, Inc. (a wholly owned subsidiary of Merck Sharp and Dohme, a subsidiary...

Completed

Phase 1/2 Study of Derazantinib (ARQ 087) in Adult Subjects With Advanced Solid Tumors With FGFR Genetic Alterations

Solid Tumor

United States, Italy
Tanta University

Completed

Role of Nitazoxanide and Escitalopram in Patients With Rheumatoid Arthritis

Rheumatoid Arthritis

Egypt
National Cancer Institute (NCI)

Completed

M7824 in Subjects With HPV Associated Malignancies

Cervical Cancer | Anal Cancer | Oropharyngeal Cancer | Human Papilloma Virus | Vaginal or Penile Cancer

United States
National Cancer Institute (NCI)

Completed

A Phase 2 Study of the MET Kinase Inhibitor INC280 in Papillary Renal Cell Cancer

Kidney Cancer

United States
AbbVie
Roche-Genentech

Completed

A Phase 2 Open-Label Study of the Efficacy and Safety of ABT-199 (GDC-0199) in Chronic Lymphocytic Leukemia (CLL) Subjects With Relapse or Refractory to B-Cell Receptor Signaling Pathway Inhibitor Therapy

Chronic Lymphocytic Leukemia

United States
Neuromed IRCCS

Completed

Autophagy, Oxidative Stress and Hippo Signaling in Human Aortic Aneurysm

Aortic Aneurysm

Italy
Dallas VA Medical Center

Active, not recruiting

Itraconazole as a Targeted Therapy for Inhibiting Hedgehog Pathway Signaling in Esophageal Cancer Patients

Esophageal Cancer

United States
OmicsWay Corp.
Oncobox Ltd., Russia; Vitamed LLC, Russia; Republican Oncological Dispensary...

Active, not recruiting

Molecular Pathway Activation Markers Predicting Efficacy of Trastuzumab Therapy for HER2-positive Breast Cancer

HER2-positive Breast Cancer

United States, Russian Federation
OmicsWay Corp.
Oncobox Ltd; Vitamed LLC; N.N. Blokhin National Medical Research Center of Oncology and other collaborators

Active, not recruiting

Identification of Molecular Biomarkers for Cancer Target Therapy Efficacy

Cancer

Russian Federation, United States
National Cancer Institute (NCI)

Completed

Phase II Study of Axitinib (AG-013736) With Evaluation of the VEGF-pathway in Metastatic, Recurrent or Primary Unresectable Pheochromocytoma/Paraganglioma

Pheochromocytoma | Paraganglioma

United States
Novartis Pharmaceuticals

Completed

Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors

Metastatic Colorectal Cancer | Gastric Cancer | Advanced Solid Tumors | Metastatic Breast Cancer | Gastroesophageal Junction Cancer | Recurrent Glioblastoma Multiforme | Advanced Pancreatic Adenocarcinoma | Safety | Triple Negative Metastatic Breast Cancer | Dose Escalation | Preliminary Efficacy | Hormone Receptor...

Canada, United Kingdom, Spain, Germany, Italy, Belgium, Australia, United States
ArQule, Inc. (a wholly owned subsidiary of Merck...

Terminated

Open-label Phase 1b Study of ARQ 092 in Combination With Anastrozole

Ovarian Cancer | Endometrial Cancer | Solid Tumors

United States
Lithuanian University of Health Sciences
University of Groningen; Research Council of Lithuania

Unknown

Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma (ECMA)

Extracellular Matrix Alteration | Allergic Asthma | Airway Remodelling

Lithuania
Arbor Life Labs

Completed

A Study Evaluating the Hair Regrowth Efficacy and Safety of ALRV5XR in Male Subjects With Hair Loss (REBOOT-MEN)

Androgenetic Alopecia | Androgenic Alopecia | Hair Loss/Baldness | Hair Thinning | Telogen Effluvium | Thinning Hair

United States
Arbor Life Labs

Completed

A Study Evaluating the Hair Regrowth Efficacy and Safety of ALRV5XR in Female Subjects With Hair Loss (REBOOT-WOMEN)

Androgenetic Alopecia | Androgenic Alopecia | Hair Loss/Baldness | Hair Thinning | Telogen Effluvium | Thinning Hair

United States
Assiut University

Completed

Signaling Pathways Targeting Colorectal Cancer in Egypt

Colorectal Cancer

Egypt
Novartis Pharmaceuticals

Completed

A Phase Ib/II Dose-finding Study to Assess the Safety and Efficacy of LDE225 + INC424 in Patients With MF

Bone Marrow Diseases | Hematologic Diseases | Blood Coagulation Disorders | Hemorrhagic Disorders | Primary Myelofibrosis | Myeloproliferative Disorders | Polycythemia Vera | Thrombocytosis | Essential Thrombocythemia | Blood Platelet Disorders

United Kingdom, Belgium, Canada, France, Australia, Netherlands, Spain, Denmark, Ireland, Italy, Germany

Search clinical trials for: VEGF signaling pathway

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