Search clinical trials for: Angiogenesis Inhibitors

Total 64157 results

Ophthotech Corporation

Completed

A Study to Establish the Safety and Tolerability of Zimura® (Anti-C5 Aptamer) in Combination With Anti-VEGF Therapy in Subjects With Idiopathic Polypoidal Choroidal Vasculopathy (IPCV)

Idiopathic Polypoidal Choroidal Vasculopathy

United States
Bayer

Completed

Special Drug Use Investigation of EYLEA for Diabetic Macular Edema

Macular Edema

Japan
Jaeb Center for Health Research
National Eye Institute (NEI); Pediatric Eye Disease Investigator Group

Completed

Phase 1 Trial of Bevacizumab Treatment for Severe Retinopathy of Prematurity (ROP1)

Retinopathy of Prematurity

United States
University of California, Irvine
Beckman Laser Institute University of California Irvine

Withdrawn

Combined Pulsed Dye Laser and Topical Ranibizumab for Treatment of Port Wine Stain Birthmarks

Port-Wine Stain
Novartis Pharmaceuticals

Completed

Efficacy and Safety of Brolucizumab vs Aflibercept in Patients With Visual Impairment Due to Diabetic Macular Edema (KINGFISHER)

Diabetic Macular Edema

United States, Hungary, Israel, Slovakia, Puerto Rico
TOT Biopharm Co., Ltd.

Completed

TAB008 Compared to Avastin® in Patients With EGFR Wild-type Non-squamous Non-small Cell Lung Cancer

Efficacy

China
King Khaled Eye Specialist Hospital

Completed

Bevacizumab and Peripheral Retinal Changes on Wide Field Angiography in Diabetic Macular Edema

Diabetic Macular Edema | Proliferative Diabetic Retinopathy | Non-proliferative Diabetic Retinopathy

Saudi Arabia
First Affiliated Hospital of Zhejiang University
Sinocelltech Ltd.

Completed

PK and Safety of SCT510

Healthy

China
Hospices Civils de Lyon

Completed

The ELLIPSE Study: A Phase-1 Study Evaluating the Tolerance of Bevacizumab Nasal Spray to Treat Epistaxis in Hereditary Hemorrhagic Telangiectasia (ELLIPSE)

Telangiectasia, Hereditary Hemorrhagic | Rendu Osler Disease
Natalie Callendar
Bristol-Myers Squibb

Withdrawn

Phase II Study of Immunomaintenance Using POmalidomide With Elotuzumab afteR Second Autologous Transplant (Immuno-POWER)

Multiple Myeloma
University of Rochester

Withdrawn

Evaluation of the Retina in Patients With Non-proliferative Diabetic Retinopathy After Aflibercept Injection in the Eye (PRAVA)

Retinopathy, Diabetic

United States
University of Wisconsin, Madison

Completed

Bevacizumab Against Recurrent Retinal Detachment (BEARRD)

Retinal Detachment | Proliferative Vitreoretinopathy

United States
Anders Kvanta

Completed

Comparing Injection Frequency Between Aflibercept and Ranibizumab in Patients With CRVO With a Treat& Extend Regimen

Central Retinal Vein Occlusion

Sweden
Hoffmann-La Roche

Completed

An Extension Study to Provide Continued Bevacizumab Therapy to Participants With Solid Tumors Who Were Previously Enrolled in a Roche/Genentech Sponsored Study

Neoplasms

Brazil, Estonia, France, Italy, Spain, Sweden, Germany, United Kingdom, Korea, Republic of, Romania, Czechia, Russian Federation, Canada, Mexico, South Africa, Turkey, Bulgaria, Slovakia, Austria, Netherlands, Hungary
Hoffmann-La Roche

Completed

A Study of Faricimab (RO6867461) in Participants With Center-Involving Diabetic Macular Edema (BOULEVARD)

Diabetic Macular Edema

United States
M.D. Anderson Cancer Center
Genentech, Inc.

Completed

Neoadjuvant Clinical Trial to Evaluate the Efficacy of Bevacizumab for Renal Cell Carcinoma

Kidney Cancer | Renal Cell Carcinoma

United States
Ameera Gamal Abdelhameed

Completed

Intravitreal Ranibizumab in Recurrent ROP

Retinopathy of Prematurity

Egypt
Peking University Third Hospital
Liuzhou Workers Hospital; Cancer Institute and Hospital, Chinese Academy of... and other collaborators

Unknown

SBRT With S1 Combined With Endostar in the Treatment of Lung Cancer (SBRTLCES)

Radiotherapy Side Effect

China
Celgene

Completed

Safety Study of CC-292 and Lenalidomide in Subjects With Chronic Lymphocytic Leukemia/ Small Lymphocytic Lymphoma

Leukemia Lymphocytic Chronic B-Cell

United States, Austria
Second Affiliated Hospital of Xi'an Jiaotong University

Unknown

Study of Endostar Combined With TP Regimen for Esophageal Cancer

Patients With Esophageal Cancer(Ⅱ-Ⅲ)

China
Celgene

Completed

Study to Evaluatethe Bioavailability and Food Effect Lenalidomide as an Oral Suspension

Healthy Volunteers

United States
Novartis Pharmaceuticals

Completed

Comparison of Treatment Regimens Using Ranibizumab: Intensive (Resolution of Intra- and Sub-retinal Fluid) vs Relaxed (Resolution of Intra-retinal Fluid and/or Sub-retinal Fluid >200µm at the Foveal Centre) (FLUID)

Subfoveal Choroidal Neovascularization CNV Secondary to Wet Age-related Macular Degeneration AMD

Australia
Celgene

Completed

A Study to Determine the Efficacy and Safety of Lenalidomide in Patients With Mantle Cell NHL Who Have Relapsed or Progressed After Treatment With Bortezomib or Are Refractory to Bortezomib. The "EMERGE" Trial (EMERGE)

Mantle Cell Lymphoma

United States, France, Belgium, Austria, Israel, Singapore, Spain, United Kingdom, Hungary, Colombia, Germany, Italy, Turkey, Puerto Rico
Bayer
Regeneron Pharmaceuticals

Completed

The Impact of Baseline Visual Acuity on the Treatment Outcomes in Patients Treated With AflIbercept in Real-life Clinical Setting (INSIGHT)

Wet Macular Degeneration

Sweden
Vista Klinik
Bayer

Completed

Intravitreal Aflibercept in Neovascular AMD With Limited Response to Ranibizumab

Neovascular Age-related Macular Degeneration
Retina Research Institute, LLC

Completed

Intravitreal Aflibercept Injection (IAI) for Presumed Ocular Histoplasmosis Syndrome

Choroidal Neovascularization | Presumed Ocular Histoplasmosis

United States
Luye Pharma Group Ltd.

Unknown

A Study of LY01008 and Bevacizumab Combined With Paclitaxel and Carboplatin for Treatment of Naïve Subjects With Metastatic or Recurrent Nonsquamous Non-small Cell Lung Cancer

Non Small Cell Lung Cancer | Non Small Cell Lung Cancer Metastatic | Non Small Cell Lung Cancer Recurrent

China
Regeneron Pharmaceuticals

Completed

Study to Assess Best Corrected Visual Acuity (BCVA) in Patients With Neovascular Age-Related Macular Degeneration (AMD) Who Are Administered VEGF Trap-Eye (Intravitreal Aflibercept Injection) (RE-VIEW)

Age - Related Macular Degeneration (AMD)

United States
Novartis Pharmaceuticals

Completed

Head to Head Study of Anti-VEGF Treatment. (RELIANCE)

Age-related Macular Degeneration

China
Institut Curie
Henri Mondor University Hospital

Terminated

Intrapleural Bevacizumab After Pleural Drainage in the Context of Breast Cancer (BEVAP)

Breast Cancer | Pleural Effusion, Malignant

France
Massachusetts General Hospital
Genentech, Inc.

Terminated

Avastin (Bevacizumab) Plus Adriamycin, Bleomycin, Vinblastine and Dacarbazine (ABVD) for Advanced Stage Hodgkin Lymphoma

Hodgkin Lymphoma

United States
National Cancer Institute (NCI)

Completed

Bevacizumab to Treat Kaposi's Sarcoma in HIV-Positive and HIV-Negative Patients

HIV Infections | Kaposi's Sarcoma | HIV Seronegativity

United States
Hoffmann-La Roche

Completed

Observational Study to Evalute the Efficacy and Safety of Avastin (Bevacizumab) in Addition to Platinum-Based Chemotherapy for First-Line Treatment of Participants With Non-Small Cell Lung Cancer (AVALANCHE)

Carcinoma, Non-Small-Cell Lung

Hungary
Novartis Pharmaceuticals

Withdrawn

24 Week Study to Compare Systemic VEGF-levels of Ranibizumab and Aflibercept in DME. (TIDE DME)

Visual Impairment Due to Diabetic Macular Edema
Peking University Cancer Hospital & Institute

Unknown

Rh-endostatin in Combination With Dacarbazine and Cisplatin as the First Line Therapy for Metastatic Melanoma

Melanoma

China
Dana-Farber Cancer Institute
Massachusetts General Hospital; Beth Israel Deaconess Medical Center; Genentech... and other collaborators

Completed

Safety Study Of Avastin And Pelvic Radiation In Women With Recurrent Gynecological Cancers

Cervical Cancer | Ovarian Cancer | Endometrial Cancer | Vaginal Cancer | Carcinoma of the Vulva

United States
Novartis Pharmaceuticals

Completed

Efficacy and Safety of Ranibizumab (Intravitreal Injections) Versus Laser Treatment in Patients With Visual Impairment Due to Diabetic Macular Edema (RED-ES)

Diabetic Macular Edema | Visual Impairment

Spain
CR-CSSS Champlain-Charles-Le Moyne
Sanofi; Regeneron Pharmaceuticals; Quebec Clinical Research Organization in Cancer

Terminated

Study to Identify Biomarkers of Clinical Response to Aflibercept in Patients With Metastatic Colorectal Cancer

Metastatic Colorectal Cancer

Canada
Yale University
Celgene Corporation

Completed

Continuous Versus Intermittent Dosing Regimens for Pomalidomide in Relapsed/Refractory Multiple Myeloma

Multiple Myeloma

United States
Novartis Korea Ltd.

Completed

Combination of Ranibizumab and Verteporfin Therapy in Neovascular Age-related Macular Degeneration

Neovascular Age-related Macular Degeneration

Korea, Republic of
Johns Hopkins University
Genentech, Inc.; Guthy Jackson Charitable Foundation

Completed

Efficacy of Bevacizumab (Avastin) in Treatment of Acute NMO Exacerbations

Neuromyelitis Optica | Neuromyelitis Optica Spectrum Disorder

United States
Ophthalmic Consultants of Boston
Regeneron Pharmaceuticals

Completed

Impact of Intravitreal Aflibercept Injections on Capillary Non-Perfusion (ANDROID)

Central Retinal Vein Occlusion | Proliferative Diabetic Retinopathy

United States
Universitätsklinikum Hamburg-Eppendorf

Completed

Dose-finding of Lenalidomide as Maintenance in Multiple Myeloma

Multiple Myeloma

Germany
SCRI Development Innovations, LLC
Genentech, Inc.

Completed

High-dose Bevacizumab in Advanced Renal Carcinoma Patients

Kidney Cancer | Renal Cancer

United States
Southeast Retina Center, Georgia
Genentech, Inc.

Unknown

Ranibizumab For Persistent Diabetic Macular Edema After Bevacizumab (ROTATE)

Diabetic Macular Edema

United States
Sun Yat-sen University
First Affiliated Hospital, Sun Yat-Sen University; Second Affiliated Hospital...

Unknown

Efficacy and Safety Study of Bevacizumab Plus Chemotherapy in EGFR-TKI Resistant Non-Squamous Non-Small Cell Lung Cancer

Lung, Carcinoma
Medical University of Vienna

Completed

Intranasal Submucosal Bevacizumab for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT)

Epistaxis | HHT | Morbus Osler

Austria
Jiangsu Simcere Pharmaceutical Co., Ltd.
The First People's Hospital of Lianyungang

Unknown

Continuous Endostar Infusion Combined With Radiotherapy in Esophageal Cancer Patients

Esophageal Cancer

China
Stanford University
Genentech, Inc.

Completed

Avastin/[18-F]-5-fluorouracil PET/CT Imaging Feasibility Project

Colorectal Neoplasms | Rectal Cancer | Colon Cancer | Anal Cancer

United States
Retina Research Foundation

Completed

Scotoma Reduction in AMD Patients Treated With Ranibizumab (SALVAGE)

Macular Degeneration

United States

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