Search clinical trials for: U3-1402

Total 950 results

Santen Pharmaceutical Co., Ltd.

Completed

Efficacy and Safety of Betamethasone Microsphere in Patients With Macular Edema Following Branch Retinal Vein Occlusion (HIKARI)

Macular Edema Following Branch Retinal Vein Occlusion

Japan, Korea, Republic of
St George's, University of London
Novartis Vaccines; European Union; Richmond Pharmacology Limited

Terminated

Safety Study Of Nasal HIV Vaccine Adjuvanted With LTK63

HIV Infections

United Kingdom
TG Therapeutics, Inc.

Terminated

Study to Assess the Efficacy and Safety of Ublituximab + Umbralisib With or Without Bendamustine and Umbralisib Alone in Patients With Previously Treated Non-Hodgkins Lymphoma (UNITY-NHL)

Follicular Lymphoma | Diffuse Large B-Cell Lymphoma | Mantle Cell Lymphoma | Marginal Zone Lymphoma | Small Lymphocytic Lymphoma

United States, Poland, Australia, Italy, United Kingdom, Israel, Korea, Republic of, Slovakia, Spain
Mayo Clinic
National Comprehensive Cancer Network

Completed

Trifluridine/Tipiracil and Irinotecan for the Treatment of Advanced Refractory Biliary Tract Cancer

Stage III Gallbladder Cancer AJCC v8 | Stage IIIA Gallbladder Cancer AJCC v8 | Stage IIIB Gallbladder Cancer AJCC v8 | Refractory Gallbladder Carcinoma | Stage IV Gallbladder Cancer AJCC v8 | Stage IV Distal Bile Duct Cancer AJCC v8 | Stage IV Intrahepatic Bile Duct Cancer AJCC v8 | Stage IVB Gallbladder... and other conditions

United States
M.D. Anderson Cancer Center
Taiho

Suspended

TAS-102 in ctDNA-defined Minimal Residual Disease in Colorectal Cancer After Completion of Adjuvant Chemotherapy

Colorectal Cancer

United States
Medical University of Warsaw

Completed

Changes in Volumetric Hemodynamic Parameters Induced by Fluid Removal on Hemodialysis (CI/HD)

End Stage Renal Failure on Dialysis | Cardiac Output, Low | Body Fluid Retention | Impedance

Poland
Amgen

Completed

Phase 1/1b Study of Rilotumumab in Japanese Subjects With Advanced Solid Tumors or Advanced or Metastatic Gastric or GEJ

Part 1- Advanced Solid Tumors | Part 2- Advanced or Metastatic Gastric Cancer | Part 2- Advanced or Metastatic GEJ

Japan
OHSU Knight Cancer Institute
Oregon Health and Science University; Taiho Pharmaceutical Co., Ltd.

Recruiting

TAS-102 With Concurrent Radiation for the Treatment of Untreated Resectable Stage II-III Rectal Cancer

Stage III Rectal Cancer AJCC v8 | Stage IIIA Rectal Cancer AJCC v8 | Stage IIIB Rectal Cancer AJCC v8 | Stage IIIC Rectal Cancer AJCC v8 | Rectal Adenocarcinoma | Stage IIA Rectal Cancer AJCC v8 | Stage IIB Rectal Cancer AJCC v8

United States
Mayo Clinic
National Cancer Institute (NCI)

Completed

TAS-102 and Radiation Therapy in Treating Patients With Rectal Cancer That Is Locally Recurrent, Metastatic, or Cannot Be Removed by Surgery

Recurrent Rectal Carcinoma | Rectal Adenocarcinoma | Stage IV Rectal Cancer AJCC v7 | Stage IVA Rectal Cancer AJCC v7 | Stage IVB Rectal Cancer AJCC v7

United States
Santen Pharmaceutical Co., Ltd.

Completed

Efficacy and Safety of Betamethasone Microsphere in Patients With Diabetic Macular Edema (TSUBASA)

Diabetic Macular Edema

Japan
Hong Kong WD Pharmaceutical Co., Limited

Unknown

A Single Dose Bioequivalence Study of WD-1602 Versus Pradaxa® in Healthy Subjects Under Fed Condition

Anticoagulant
Amorepacific Corporation

Completed

Cumulative Irritation Test of PAC-14028 in Healthy Volunteers

Healthy

Korea, Republic of
St. Louis University
Hoffmann-La Roche

Completed

Orlistat (Xenical) in the Treatment of Overweight Patients With Nonalcoholic Steatohepatitis (NASH)

Hepatitis | Fatty Liver

United States
TG Therapeutics, Inc.

Terminated

Ublituximab + TGR-1202 Compared to Obinutuzumab + Chlorambucil in Participants With Untreated and Previously Treated Chronic Lymphocytic Leukemia (UNITY-CLL)

Chronic Lymphocytic Leukemia

United States, Israel, Italy, Poland, Russian Federation, Spain, United Kingdom
Takara Bio Inc.

Completed

A Study of Combination With TBI-1401(HF10) and Ipilimumab in Japanese Patients With Unresectable or Metastatic Melanoma

Melanoma Stage IV | Melanoma Stage III

Japan
TG Therapeutics, Inc.

Completed

Novel PI3K Delta Inhibitor TGR-1202, in Combination With Brentuximab Vedotin for Hodgkin's Lymphoma Patients

Hodgkin's Lymphoma

United States
Alcobra Ltd.

Completed

A 6 Week Study of MG01CI 1400 mg Compared With Placebo in Adults With ADHD ( Attention Deficit/Hyperactivity )

ADHD | Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

United States, Israel
Tonix Pharmaceuticals, Inc.

Terminated

A Phase 3 Study to Evaluate the Efficacy and Safety of TNX-102 SL in Participants With PTSD (RECOVERY)

PTSD

United States
Southeast University, China

Recruiting

Comparison of Epithelial Lining Fluid and Blood Pharmacokinetics and Pharmacodynamics of Intravenous and Intravenous Plus Nebulized Polymyxin B in Multidrug Resistant Bacteria Ventilator-associated Pneumonia Patients

Ventilator-associated Pneumonia | Multidrug Resistant Bacterial Infection | Polymyxin B | Pharmacogenomic Drug Interaction

China
Tianjin Medical University Cancer Institute and...

Recruiting

Trifluridine/Tipiracil Combined With Oxaliplatin and Bevacizumab Versus XELOX Plus Bevacizumab in mCRC (TOBACO)

Advanced Colorectal Cancer | First-line Treatment

China
Baylor Research Institute
Taiho Oncology, Inc.

Recruiting

TAS-102 in Extrapulmonary Neuroendocrine Carcinoma (TAS-102 NEC)

High-grade Extra Pulmonary Neuroendocrine Cancer

United States
Reata, a wholly owned subsidiary of Biogen

Terminated

Study With Gemcitabine and RTA 402 for Patients With Unresectable Pancreatic Cancer

Pancreatic Neoplasms | Pancreatic Cancer

United States
Fudan University

Recruiting

Regorafenib Combined With TAS-102 Versus Regorafenib Monotherapy in Third or Later Line Therapy of mCRC

Metastatic Colorectal Cancer

China
First Affiliated Hospital Xi'an Jiaotong University

Completed

In-hospital Initiation of PCSK9 Inhibitor in Patients With Acute Myocardial Infarction

Coronary Disease
Nektar Therapeutics

Completed

A Study in Cancer Patients to Evaluate the Effect of a Single Dose of NKTR-102 (Etirinotecan Pegol) on the QTc Interval and to Assess Pharmacokinetics and Safety

Advanced Cancer | Metastatic Solid Tumors

United States
Jiangsu Yahong Meditech Co., Ltd aka Asieris

Recruiting

A Phase 3 Study to Evaluate the Safety and Efficacy of APL-1202 as a Single-agent Oral Treatment Versus Intravesical Instillation of Epirubicin Hydrochloride in naïve Intermediate-risk NMIBC Patients (ASCERTAIN)

Non-muscle Invasive Bladder Cancer

China
Case Comprehensive Cancer Center

Withdrawn

A Trial of CDX-1401 in Combination With Poly-ICLC and Pembrolizumab, in Previously Treated Advanced Solid Tumor Patients

Small Cell Lung Cancer | Non Small Cell Lung Cancer | Mesothelioma | Urothelial Cancer | Malignant Melanoma | Advanced Triple Negative Breast Cancer
gicare Pharma Inc.
Algorithme Pharma Inc

Completed

Study on Analgesia of GIC-1001 & GIC-1002 on Visceral Pain, Rectal Sensory Threshold Using the Barostat Method

Pain | Cancer | Colonic Disease

Canada
PharmaEngine

Completed

Nanoliposomal Irinotecan (Nal-IRI, ONIVYDE®) in Combination With TAS-102 (LONSURF®) in Refractory Solid Tumors

Refractory Solid Tumors

Taiwan
University Hospital Inselspital, Berne
Amgen; University of Bern

Completed

EVOlocumab for Early Reduction of LDL-cholesterol Levels in Patients With Acute Coronary Syndromes (EVOPACS) (EVOPACS)

Acute Coronary Syndrome

Switzerland
Nektar Therapeutics

Completed

Study to Evaluate the Safety and Efficacy of NKTR-102 in Patients With Metastatic or Locally Advanced Breast Cancer

Breast Cancer | Tumor

United States, Belgium, United Kingdom
Aeras

Completed

A Leukapheresis Study for Immune Responses in Healthy US Adults Who Receive BCG Vaccination Followed by Boosting With AERAS-402 (C-021-402)

Tuberculosis
Sichuan Kelun Pharmaceutical Research Institute...

Recruiting

Comparison of A140 and Erbitux Combined With mfolfox6 to Evaluate Efficacy and Safety of First-line Treatment for Ras Wild-type mCRC

Metastatic Colorectal Cancer

China
Massachusetts General Hospital
Taiho Oncology, Inc.

Recruiting

Study of TAS-102 Plus Radiation Therapy for the Treatment of the Liver in Patients With Hepatic Metastases From Colorectal Cancer

Colorectal Cancer

United States
Advaxis, Inc.
Merck Sharp & Dohme LLC

Completed

ADXS31-142 Alone and in Combination With Pembrolizumab (MK-3475) in Participants With Previously Treated Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Cancer | Prostate Cancer

United States
Hellenic Study Group of Psychoneuroimmunology in...
Servier

Completed

A Study of Trifluridine/ Tipiracil in Chemorefractory mCRC in Greece (RETRO-TAS)

Metastatic Colorectal Cancer

Greece
Alexion Pharmaceuticals

Completed

Safety, Tolerability and Pharmacokinetics of SBC-102 (Sebelipase Alfa) in Adult Participants With Lysosomal Acid Lipase Deficiency

Lysosomal Acid Lipase Deficiency | Cholesterol Ester Storage Disease(CESD) | LAL-Deficiency

France, United States, United Kingdom, Czechia
TG Therapeutics, Inc.

Completed

TGR-1202, a PI3K Delta Inhibitor, in Combination With Obinutuzumab and Chlorambucil in Patients With Chronic Lymphocytic Leukemia (CLL)

Chronic Lymphocytic Leukemia

United States
Esperion Therapeutics, Inc.

Completed

A Multiple Ascending Dose Study of ETC-1002 in Healthy Subjects

Safety Evaluation of Escalating Doses

United States
Academic and Community Cancer Research United
National Cancer Institute (NCI)

Active, not recruiting

Binimetinib and Palbociclib or TAS-102 in Treating Patients With KRAS and NRAS Mutant Metastatic or Unresectable Colorectal Cancer

Metastatic Colorectal Carcinoma | Stage IV Colorectal Cancer AJCC v8 | Stage IVA Colorectal Cancer AJCC v8 | Stage IVB Colorectal Cancer AJCC v8 | Stage IVC Colorectal Cancer AJCC v8 | Unresectable Carcinoma

United States
Second Affiliated Hospital, School of Medicine,...

Not yet recruiting

A Real-world Study of Trifluridine/Tipiracil Containing Regimen for the Treatment of Patients With mCRC (REFLECT Study)

Metastatic Colorectal Cancer
University of Wisconsin, Madison
Taiho Pharmaceutical Co., Ltd.

Terminated

Safety of TAS-102 in Combination With Temozolomide for Metastatic Pancreatic NETs

Neoplasms | Cancer | Neuroendocrine Tumors | Tumors

United States
Cancer Institute and Hospital, Chinese Academy...

Recruiting

Irinotecan, TAS-102 Plus Bevacizumab as a Second-Line Therapy in mCRC Patients

Metastatic Colorectal Cancer

China
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Completed

Bioequivalence Study of Trifluridine and Tipiracil Tablets in Colorectal Cancer Patients

Colorectal Cancer

China
Takeshi Morimoto

Terminated

Effect of Intensive Blood Pressure Control on Progression of Coronary Atherosclerosis: Randomized Evaluation by Intravascular Ultrasound (PREVUS)

Coronary Artery Disease | Hypertension

Japan
Cancer Institute and Hospital, Chinese Academy...

Active, not recruiting

Irinotecan, TAS-102 Plus Bevacizumab as a Third-Line or Beyond Therapy in mCRC Patients

Metastatic Colorectal Cancer

China
Bausch Health Americas, Inc.

Terminated

Efficacy, Safety, and Withdrawal and Retreatment With Brodalumab in Moderate to Severe Plaque Psoriasis Subjects (AMAGINE-1)

Psoriasis

United States, Germany, Poland, Switzerland, France, Canada
Symphogen A/S

Withdrawn

Sym004 Versus TAS-102 in Patients With mCRC

Carcinoma | Metastatic Colorectal Cancer | Colorectal Cancer Metastatic
Newsoara Biopharma Co., Ltd.

Recruiting

Safety and Efficacy of THR-1442 Compared to Dapagliflozin as Add-on Therapy to Metformin in T2DM

T2DM

China
Esperion Therapeutics, Inc.
Medpace, Inc.

Completed

Evaluation of ETC-1002 in Participants With Hypercholesterolemia and Hypertension

Hypertension | Hypercholesterolemia

United States

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