Clinical Trials Sponsored by Killam Trusts

Total 7351 results

Medway Primary Care Trust

Completed

Surgical Consent During the COVID-19 Pandemic

Consent

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

RCT: HDWL vs Virtual Chromoendoscopy in the Detection of Intraepithelial Neoplasia in Longstanding Colitis (VIRTUOSO)

Ulcerative Colitis | Crohn's Colitis

United Kingdom
Somerset NHS Foundation Trust

Unknown

Prolonged Overnight Oximetry in Obstructive Sleep Apnoea (PROXIMO)

Obstructive Sleep Apnea
GE Healthcare
Wellcome Trust

Completed

Development of a MR Scanner Capable of Being Sited in a Neonatal Intensive Care Unit (Firefly Sheffield)

Neonatal Neuroimaging

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

Study to Explore the Relationship Between the Level of Exhaled Breath Condensate Hydrogen Peroxide (EBC H2O2) as Measured Using a New Device Against Existing Measures of Lung Disease (EXHALE 1A)

Asthma | COPD Exacerbation

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

A Prospective Study Comparing the Accuracy of Olympus Lucera Spectrum Technology vs Olympus Lucera Elite Technology in the in Vivo Diagnosis of Barrett's Oesophagus and Colorectal Polyps: The ELITE Study (ELITE)

Polyps | Barrett Esophagus

United Kingdom
Bedford Hospital NHS Trust

Unknown

Finger-prick Autologous Blood (FAB) for Use in Dry Mouth

Xerostomia | Xerostomia Due to Radiotherapy | Xerostomia Due to Hyposecretion of Salivary Gland
Medway NHS Foundation Trust

Completed

A Long Term Follow up of Anterior Meshes for Recurrent Prolapse

Pelvic Organ Prolapse | Genital Diseases, Female

United Kingdom
St Stephens Aids Trust

Unknown

Targeted Clinical Strategies and Low Level Viraemia (LLV) in Boosted Protease Inhibitor Therapy

HIV

United Kingdom
St Stephens Aids Trust

Completed

A Pilot Study to Assess the Feasibility of Switching, Individuals Receiving Atripla With Continuing Central Nervous System (CNS) Toxicity, to a Fixed Dose Combination of Tenofovir/Emtricitabine/Rilpivirine

HIV

United Kingdom
St Stephens Aids Trust

Completed

The Pharmacology/Aging Clinic (SSAT041)

HIV Infection

United Kingdom
St Stephens Aids Trust

Completed

A Phase IV, Open-label Single-arm Study Investigating the Pharmacokinetics and Pharmacodynamics of the Antiretroviral Combination of Rilpivirine and Ritonavirboosted Darunavir in Therapy-naive HIV-1 Infected Patients.

HIV

United Kingdom
Summit Therapeutics
Wellcome Trust

Completed

A Study of SMT19969 Compared With Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhoea (CDAD)

Clostridium Difficile Infection

United States, Canada
Vestre Viken Hospital Trust

Unknown

Maternal Metabolism and Pregnancy Outcomes in Obese Pregnant Women

Obesity | Pregnancy

Norway
Kingston Hospital NHS Trust

Unknown

The Effects of Serratus Plane Block Performed Under Direct Vision on Post-operative Pain in Breast Surgery

Breast Surgery | Post-operative Pain | Serratus Block
St Stephens Aids Trust

Completed

Atripla to Raltegravir Switch Study for CNS Toxicity (SSAT036)

HIV Infection

United Kingdom
St Stephens Aids Trust

Completed

Men Who Have Sex With Men (MSM) Neurocog 1&2 Study (MSM Neurocog)

HIV Related Neurocognitive Impairment

United Kingdom
St Stephens Aids Trust

Unknown

Hydroxychloroquine for Discordant CD4 Responders on Highly Active Antiretroviral Therapy (HAART) (SSAT039)

HIV Infection

United Kingdom
St Stephens Aids Trust

Completed

Pharmacokinetics of Tenofovir and Tenofovir-diphosphate, Emtricitabine and Emtricitabine-triphosphate, and Rilpivirine Once Daily Over 14 Days Following Drug Intake Cessation in Healthy Volunteers

HIV

United Kingdom
St Stephens Aids Trust

Completed

PK Switch Efavirenz to Maraviroc in Patients Initially Suppressed on an Efavirenz-containing Regimen (SSAT033)

HIV Infection

United Kingdom
St Stephens Aids Trust

Terminated

Impact of Maraviroc on the Immune Function in HIV-1 Infected Subjects Receiving Immunisation With Novel Antigens

HIV Infections

United Kingdom
St Stephens Aids Trust

Completed

Raltegravir and Ezetimibe PK Study

HIV

United Kingdom
St Stephens Aids Trust

Completed

Abacavir Pharmacokinetic Study in the Absence/Presence of Darunavir/Ritonavir or Raltegravir in HIV-infected Subjects

HIV

United Kingdom
Medway NHS Foundation Trust

Completed

Tension Free Vaginal Tape (TVT) Versus the Miniarc Sling

Urodynamic Stress Incontinence

United Kingdom
Medway NHS Foundation Trust

Unknown

Cystoscopy Plus Urethral Dilatation Versus Cystoscopy Alone in Women With Overactive Bladder Syndrome and Impaired Voiding

Overactive Bladder Syndrome | Voiding Dysfunction

United Kingdom
African Malaria Network Trust

Unknown

Safety and Immunogenicity of 30 and 100 µg of GMZ2 in Gabonese Children Aged 1-5 Years

Malaria

Gabon
African Malaria Network Trust

Unknown

Safety and Immunogenicity of Apical Membrane Antigen 1 (PfAMA-1-FVO[25-545])

Malaria

Mali
King's College London
King's College Hospital NHS Trust; Guy's and St Thomas' NHS Foundation Trust; Imperial College Healthcare NHS Trust and other collaborators

Completed

Mental Wellbeing and Quality of Life in Prostate Cancer (MIND-P)

Prostate Cancer

United Kingdom
Rett Syndrome Research Trust

Not yet recruiting

Validation of Innovative Biosensors for Rett Autonomic Symptom Tracking (VIBRANT)

Rett Syndrome

United States
Portsmouth Hospitals NHS Trust

Recruiting

BIO-CHECKPOINT 0 Biomarkers to Identify Oncology Patients on ICPI at Greater Risk of irAE

Neoplasms

United Kingdom
Vestre Viken Hospital Trust

Not yet recruiting

Improved Diagnostics, Treatment and Follow-up of Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPEXNOR)

Respiratory Tract Infections | Pneumonia | Chronic Obstructive Pulmonary Disease Exacerbation
Medway NHS Foundation Trust

Recruiting

Umbilical Cord Abnormalities in the Prediction of Adverse Pregnancy Outcomes (ULOOP)

Hypoxic-Ischemic Encephalopathy | Admission to Neonatal Unit | Stillbirth | Small for Gestational Age at Delivery

United Kingdom
Portsmouth Hospitals NHS Trust

Recruiting

A Trial Evaluating Novel Technologies for the Diagnosis of Asthma The LUNG-TECH Trial (LUNG-Tech)

Asthma

United Kingdom
Portsmouth Hospitals NHS Trust

Recruiting

Novel Technologies for Respiratory Virus Identification (ResVir)

Respiratory Tract Infections | Infections, Respiratory

United Kingdom
Portsmouth Hospitals NHS Trust

Recruiting

Portsmouth CORE-D Routine Care Data Repository (CORE-D)

Adult Hospital Patients at Risk of Adverse Outcomes

United Kingdom
Royal Cornwall Hospitals Trust

Recruiting

Singing for Chronic Pain, a New Intervention for the Management of Chronic Pain

Chronic Pain

United Kingdom
Rural Development Trust Hospital

Recruiting

Vicente Ferrer HIV Cohort Study (VFHCS)

HIV | Tuberculosis | Cryptococcosis | Opportunistic Infections | Noncommunicable Diseases

India
Vestre Viken Hospital Trust

Active, not recruiting

First-line Treatment With Osimertinib in EGFR-mutated Non-small Cell Lung Cancer (FIOL)

Lung Cancer

Denmark, Sweden, Lithuania, Norway
Royal Cornwall Hospitals Trust

Terminated

The MyoVista Angiography Angioplasty Percutaneous Coronary Intervention Trial (MAAP)

Coronary Artery Disease | Diastolic Dysfunction

United Kingdom
Royal Cornwall Hospitals Trust

Completed

Remote Rapid Onsite Evaluation (ROSE) for Head and Neck Fine Needle Aspirations (FNA) (Remote ROSE)

Head and Neck Neoplasms

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

A Study to Identify Errors in Inhaler Technique in Adults (SCORES)

Respiratory Disease

United Kingdom
Royal Cornwall Hospitals Trust

Suspended

Duration of Ameluz Application in Acral Actinic Keratoses Response

Actinic Keratoses | Photodamaged Skin

United Kingdom
Royal Cornwall Hospitals Trust

Suspended

How is COGNItive Function Affected by Cardiac Resynchronisation Therapy? (COGNI-CRT)

Heart Failure | Cognitive Impairment | Cognitive Change | Heart Failure, Systolic | Left Ventricular Dysfunction | Systolic Heart Failure | Cognitive Impairment, Mild | Left Ventricular Systolic Dysfunction | Systolic Dysfunction

United Kingdom
Medway Primary Care Trust

Completed

Observing the Perioperative Effects of Prehabilitation in Colorectal Cancer Patients

Colon Cancer

United Kingdom
Somerset NHS Foundation Trust

Unknown

Somerset and South Essex Coronavirus Antigen Testing (SOCRATES)

SARS-CoV 2 | COVID

United Kingdom
North Bristol NHS Trust

Completed

Novel Vascular Manifestations of Chronic Obstructive Pulmonary Disease (NOVASC COPD)

COPD

United Kingdom
St Stephens Aids Trust

Completed

Cardiovascular Risk in HIV Patients Switching From a Boosted Protease Inhibitor (PI) to Dolutegravir (DTG)

HIV

Germany, Spain, France, United Kingdom, Belgium, Italy
St Stephens Aids Trust

Completed

Study in Healthy Volunteers of the Safety and Metabolism of Different Doses of the Anti-HIV Drug TMC278LA.

HIV Infection

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

Tidal Irrigation Versus Intra-articular Steroid Injection in the Treatment of Knee Osteoarthritis

Knee Osteoarthritis
St Stephens Aids Trust

Completed

Open Label Trial of PEG-IFN, RBV & TVR vs. PEG-IFN & RBV Alone in Tx of HCV-1 in HIV-1 Co-infected Patients (CHAT) (CHAT)

HIV

United Kingdom

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