Search clinical trials for: DDI with sensitive CYP3A4 substrate

Total 159512 results

Abbott Medical Devices

Terminated

Substrate Targeted Ablation Using the FlexAbility™ Ablation Catheter System for the Reduction of Ventricular Tachycardia (STAR-VT)

Monomorphic Ventricular Tachycardia

United States, United Kingdom, France, Australia, Italy
University Hospital, Clermont-Ferrand

Unknown

Comparison of the Use of Energy Substrates and Hormonal Regulation of Blood Sugar During Exercise of Increasing Intensity Between Children With Type 1 Diabetes and Non-diabetic Control Children. (DIABSPORT)

Type 1 Diabetes

France
Clifford Hospital, Guangzhou, China

Unknown

Vitamin C and Tyrosine Kinase Inhibitor in Lung Cancer Patients With Epidermal Growth Factor Receptor Mutations

Carcinoma, Non-Small-Cell Lung

China
Assistance Publique - Hôpitaux de Paris

Completed

Prevalence of PE in ED Patients With Isolated Syncope (PEEPS)

Syncope

France
Assiut University

Unknown

Changes in High Sensitive C Reactive Protien With Different Treatment Modalities in Acute Pancreatitis

Pancreatitis, Acute

Egypt
Istituto Scientifico Romagnolo per lo Studio e...

Terminated

Temozolomide in Patients Affected by Relapsed Sensitive or Refractory Small Cell Lung Cancer With MGMT Methylation (TeRes)

Small Cell Lung Cancer Recurrent

Italy
Amicus Therapeutics

Completed

A 12-Week Safety and Pharmacodynamic Study of AT1001 (Migalastat Hydrochloride) in Participants With Fabry Disease

Fabry Disease

Australia, Brazil
Amicus Therapeutics

Completed

Study of the Effects of Oral AT1001 (Migalastat Hydrochloride) in Patients With Fabry Disease

Fabry Disease

United States, Italy, Spain, Turkey, Brazil, Canada, United Kingdom, France, Poland, Australia, Egypt, Argentina, Denmark
Amicus Therapeutics

Completed

A Study of AT1001 (Migalastat Hydrochloride) in Participants With Fabry Disease

Fabry Disease

United States
Mundipharma Research Limited

Completed

Assessment of the Efficacy and Safety of FlutiForm® pMDI 125/5 µg (2 Puffs Bid) Versus Symbicort® Turbohaler® 200/6 µg (2 Puffs Bid) in Adolescent and Adult Subjects With Moderate to Severe Persistent, Reversible Asthma

Asthma

Poland, Bulgaria, Romania, India, Hungary
University Hospital "Sestre Milosrdnice"

Unknown

Hormone Therapy With or Without Definitive Radiotherapy in Metastatic Prostate Cancer

Prostate Cancer

Croatia
University of Birmingham
Lucozade Ribena Suntory

Completed

Dietary Macronutrient Manipulation and Substrate Oxidation During Exercise

Dietary Manipulation

United Kingdom
Amicus Therapeutics

Completed

A 12-Week Safety and Pharmacodynamic Study of AT1001 (Migalastat Hydrochloride) in Female Participants With Fabry Disease

Fabry Disease

United States, Australia, France, United Kingdom, Brazil, Canada
Amicus Therapeutics

Terminated

Open-label Long-term Safety Study of AT1001 (Migalastat Hydrochloride) in Participants With Fabry Disease Who Have Completed a Previous AT1001 Study

Fabry Disease

United Kingdom, United States, Australia, Brazil, France
Istituto Oncologico Veneto IRCCS
Association for Translational Research in Oncology (AS.T.R.O.)

Completed

Preoperative Study With Trastuzumab, Pertuzumab and Letrozole in Breast Cancer Patients Sensitive to Hormonal Therapy (PER-ELISA)

Endocrine Sensitive HER2+/HR+ Breast Cancer

Italy
Dana-Farber Cancer Institute
Massachusetts General Hospital; Merck Sharp & Dohme LLC; Brigham and Women's...

Terminated

Vorinostat, Carboplatin and Gemcitabine in Women With Recurrent, Platinum-Sensitive Ovarian Cancer

Ovarian Cancer | Fallopian Tube Cancer | Peritoneal Cancer

United States
Amicus Therapeutics

Completed

A 24-Week Safety and Pharmacodynamic Study of AT1001 (Migalastat Hydrochloride) in Participants With Fabry Disease

Fabry Disease

France, United Kingdom
Johnson & Johnson Consumer Inc. (J&JCI)

Completed

A Study to Evaluate the Tolerance of an Acne Treatment in Sensitive Skin Subjects With Mild to Moderate Acne Vulgaris

Acne Vulgaris

United States
University of Washington
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Terminated

Optimizing Pediatric HIV-1 Treatment in Infants With Prophylactic Exposure to Nevirapine, Nairobi, Kenya

HIV Infections

Kenya
SOTIO a.s.

Completed

Phase II Study DCVAC/OvCa Plus Carboplatin Gemcitabine Relapsed Platinum (Pt)-Sensitive Epithelial Ovarian Carcinoma

Ovarian Neoplasms | Ovarian Epithelial Cancer | Ovarian Cancer (OvCa)

Czechia, Poland, Germany
Ohio State University Comprehensive Cancer Center
Pfizer

Completed

Exemestane in Combination With Fulvestrant in Postmenopausal Women With Hormone Sensitive Advanced Breast Cancer

Breast Cancer

United States
Global Alliance for TB Drug Development

Completed

Evaluation of 8 Weeks of Treatment With the Combination of Moxifloxacin, PA-824 and Pyrazinamide in Patients With Drug Sensitive and Multi Drug-Resistant Pulmonary Tuberculosis (TB) (NC-002)

Pulmonary Tuberculosis

Tanzania, South Africa
Memorial Ankara Hospital

Unknown

Association of Genetic Polymorphisms With Atrial Fibrosis and Thrombogenic Substrate in Patients With Non-valvular Atrial Fibrillation (ANATOLI-AF)

Heart Diseases | Stroke | Thrombosis | Atrial Fibrillation | Genetic Predisposition
AstraZeneca

No longer available

Olaparib Expanded Access Program for BRCA Mutated Platinum Sensitive Relapsed High Grade Epithelial Ovarian Cancer Patients in Japan

PSR Ovarian Cancer With a BRCA Mutation

Japan
University of Virginia

Unknown

Mechanisms of Alcohol Sensitivity in AERD

Aspirin-Sensitive Asthma With Nasal Polyps | Samter's Syndrome

United States
Ottawa Heart Institute Research Corporation
Heart and Stroke Foundation of Ontario

Completed

Rt Ventricular Substrate Metabolism as a Predictor of Rt Heart Failure in Patients With Pulmonary Arterial Hypertension (RVMET)

Pulmonary Arterial Hypertension

Canada
PharmaMar, Spain

Completed

An Observational Study of YONDELIS®+PLD for the Treatment of Patients With Platinum-sensitive Relapse of Ovarian Cancer (NIS-OvaYond)

Recurrent Ovarian Cancer

Germany
Dartmouth-Hitchcock Medical Center
American Epilepsy Society

Completed

Imaging Neuroinflammation in Epilepsy With Ferumoxytol MRI (IRONMAN)

Epilepsy

United States
Jeil Pharmaceutical Co., Ltd.

Completed

Drug-drug Interaction Following Oral Administration of Telmisartan/Amlodipine and Atorvastatin in Healthy Adult Volunteers

Hypertension With Hyperlipidemia

Korea, Republic of
Suriya Yessentayeva
Johnson & Johnson

Unknown

An Observational Study of Combination of Pegylated Liposomal Doxorubicin and Trabectedin in Routine Practice in Patients With Recurrent Partial-platinum Sensitive Ovarian Cancer (Renaissance)

Ovarian Cancer

Kazakhstan
National Institute of Allergy and Infectious Diseases...

Completed

Evaluation of Oral Activated Charcoal on Antimalarial Drug's Ability to Kill Parasites in Malian Children With Malaria

Malaria | Severe Malaria

Mali
Children's Oncology Group

Completed

VEGF Receptor Tyrosine Kinase Inhibitor Axitinib in Children With Recurrent or Refractory Solid Tumors

Refractory or Recurrent Solid Tumors, Excluding CNS Tumors

United States, Canada
University of Aarhus
Aarhus University Hospital

Withdrawn

Substrate Metabolism and Insulin Sensitivity in Patients With Hyperprolactinemia Before and After Treatment

Insulin Resistance | Hyperprolactinemia

Denmark
University of Aarhus
Aarhus University Hospital

Terminated

Insulin Sensitivity and Substrate Metabolism in Patients With Cushing's Syndrome

Insulin Resistance | Cushing's Syndrome

Denmark
Bayer

Completed

Interaction With HIV Antiretroviral Agents

HIV-DDI

United States
Hospital St. Joseph, Marseille, France

Completed

Substrate Ablation Guided by High Density Mapping in Atrial Fibrillation (SUBSTRATE-HD)

Atrial Fibrillation

France
University of Aberdeen

Unknown

Bakery Products for Non-Coeliac Gluten Sensitive Consumers

Non Coeliac Gluten Sensitivity

United Kingdom
AstraZeneca
Parexel

Approved for marketing

Expanded Access Program for Olaparib Tablets as Maintenance Therapy in Patients With Ovarian, Fallopian Tube or Primary Peritoneal Cancer.

Ovarian Cancer

United States
University Hospital, Brest

Completed

Quantitative Sensory Testing in Subjects With Sensitive Skin or Not (SENSISKIN)

Sensitive Skin

France
Genentech, Inc.

Completed

A Study to Evaluate the Safety and Pharmacology of DNIB0600A in Participants With Platinum-Sensitive Ovarian Cancer or Non-Squamous Non-small Cell Lung Cancer

Non-Squamous Non-Small Cell Lung Cancer

United States
ViiV Healthcare
GlaxoSmithKline

Completed

A Open-label, Drug-Drug Interaction With Maraviroc (DDI)

Infection, Human Immunodeficiency Virus

United States
ViiV Healthcare
GlaxoSmithKline

Completed

DDI Study of BMS-663068 With Etravirine (ETR) and/or Darunavir (DVR) + Ritonavir (RTV)

Infection, Human Immunodeficiency Virus
Gustave Roussy, Cancer Campus, Grand Paris

Unknown

Trial Evaluating Maintenance Olaparib in Patients With Platinum-sensitive Advanced Non-small Cell Lung Cancer (PIPSeN)

Non Small Cell Lung Cancer

France
Spanish Cooperative Group for the Treatment of...

Completed

Study of FOLFIRI + Panitumumab Using Ultra-selection Technology of Patients With Stage IV Colorectal Cancer Refractory to Irinotecan Without Any Mutation on KRAS, PIK3Ca, BRAF and NRAS Genes Detected With Highly Sensitive Techniques (ULTRA)

Stage IV Colorectal Cancer

Spain
Astellas Pharma Europe B.V.
Medivation, Inc.

Completed

A Study to Evaluate How Daily Dosing With Enzalutamide Affects the Metabolism of Caffeine and Dextromethorphan in Men With Prostate Cancer

Prostate Cancer | Pharmacokinetics of Dextromethorphan | Pharmacokinetics of Caffeine

Moldova, Republic of
Astellas Pharma Europe B.V.
Medivation, Inc.

Completed

Drug-drug Interaction Study With MDV3100 and a Cocktail of Substrates

Castration Resistant Prostate Cancer (CRPC) | Pharmacokinetics of MDV3100

South Africa
Nova Scotia Health Authority
Nova Scotia Health Research Foundation

Completed

Atrial Substrate Modification With Aggressive Blood Pressure Lowering to Prevent AF (SMAC AF)

Atrial Fibrillation

Canada
GlaxoSmithKline
Octagon Research Solutions, Incoporated

Completed

Study to Assess the Pharmacokinetics of GSK1278863A Coadministered With a High Fat Meal or an Inhibitor of CYP2C8 (Gemfibrozil) (DDI)

Anaemia

India
Boehringer Ingelheim

Completed

Drug-drug Interaction (DDI) With a P-gp Inhibitor, Organic Anion Transporting Polypeptide OATP-inhibitor, Food Effect

Healthy

Germany
Eli Lilly and Company

Completed

A Drug Drug Interaction (DDI) Study of Baricitinib (LY3009104) and Digoxin in Healthy Participants

Healthy Volunteers

United Kingdom

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