Search clinical trials for: First in class

Total 460376 results

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Recruiting

Phase Ib/II Trail of Neoadjuvant of Tislelizumab Combined With Palbociclib in Patients With Platinum-refractory Bladder Urothelial Carcinoma

Bladder Cancer

China
Changhai Hospital
First People's Hospital of Hangzhou; Peking Union Medical College Hospital

Not yet recruiting

Efficacy of ERCP in the Diagnosis and Treatment of Idiopathic Recurrent Acute Pancreatitis (ESPRIT)

Recurrent Acute Pancreatitis

China
Beijing 302 Hospital
Beijing GD Initiative Cell Therapy Technology Co., Ltd.; Chinese Academy of...

Not yet recruiting

Allogeneic Gamma-delta T Cells Combined With Targeted Therapy and Immunotherapy in a Phase 1 Clinical Trial for First-line Treatment of Hepatocellular Carcinoma

Hepatocellular Carcinoma
Ruijin Hospital
The First Affiliated Hospital with Nanjing Medical University; Shanghai Longyao...

Recruiting

An Evaluation of LY007 Cell Injection for r/r B-NHL (r/r B-NHL)

B-NHL

China
Universidade do Porto
Fundação para a Ciência e a Tecnologia; Federação Portuguesa de Futebol

Recruiting

Postprandial Metabolic and Appetite Responses to Different Food Intake Sequences in Athletes

Healthy | Craving | Postprandial Hyperglycemia | Nutrition, Healthy | Hunger

Portugal
Harbin Medical University
Shanghai Shenqi Medical Technology Co., Ltd

Recruiting

Preventive Drug-coated Balloon Angioplasty in Vulnerable Atherosclerotic Plaque (RESTORE Trial)

Acute Coronary Syndrome (ACS)

China
Zhuhai Tonbridge Medical Tech. Co., Ltd.

Not yet recruiting

Evaluation of the Ton-bridge Carotid Stent for Carotid Artery Stenosis

Carotid Artery Stenosis

China
David Sheyn

Not yet recruiting

Acupuncture First for IC/BPS

Interstitial Cystitis | Bladder Pain Syndrome
Kylonova (Xiamen) Biopharma co., LTD.

Recruiting

Dose Escalation Study of Kylo-0603 in Healthy Subjects

Nonalcoholic Steatohepatitis

China
Mayo Clinic

Recruiting

Non-Invasive Identification of Endometrial Cancer/Endometrial Atypical Hyperplasia With an AI-Based Classifier Applied to Transvaginal Ultrasound in Patients With Post-Menopausal Bleeding

Endometrial Carcinoma

United States
Beijing Tiantan Hospital
West China Hospital; The First Affiliated Hospital of Zhengzhou University; Capital... and other collaborators

Recruiting

Evaluate the Effectiveness and Safety of Raman IVD Analyzer in the Molecular Diagnosis of Gliomas During Surgery

Glioma

China
The First Affiliated Hospital with Nanjing Medical...

Recruiting

Multi-parametric MRI in Patients of Bladder Cancer

Artificial Intelligence | Muscle-invasive Bladder Cancer

China
Anhui Provincial Hospital

Not yet recruiting

The Efficacy and Safety of Desensitation Regimen for Patients With High Titers of Anti-HLA Antibodies Prior to Allo-HSCT

High Titers of Anti-HLA Antibody (MFI ≥5000)

China
Sulai Liu

Recruiting

HAIC Combined With Durvalumab and Tremelimumab and Lenvatinib in uHCC

Hepatocellular Carcinoma

China
Huihua Xiong

Not yet recruiting

A Multicenter, Prospective Study of Diarrhea Tolerance of Pyrotinib Combined With Trastumab and Taxane in the First-line Treatment of HER2-positive Advanced Breast Cancer

Breast Cancer
Sunshine Guojian Pharmaceutical (Shanghai) Co.,...

Recruiting

A Phase II Study of SSGJ-707 Monotherapy in First-line PD-L1 Positive Advanced NSCLC Patients

NSCLC

China
Peking University First Hospital

Recruiting

Comparison of MRI AI-cTB Versus Routine cTB in Prostate Cancer Diagnosis: a Prospective Randomized Controlled Trial

Prostate Cancer

China
Hutchmed

Recruiting

A Phase II/III Trial to Evaluate the Efficacy and Safety of Surufatinib Combined With Camrelizumab, Nab-paclitaxel, and Gemcitabine in Metastatic Pancreatic Cancer

Metastatic Pancreatic Cancer

China
Daiichi Sankyo
Merck Sharp & Dohme LLC

Not yet recruiting

A Study of I-DXd in Combination With Atezolizumab With or Without Carboplatin as First-Line Induction or Maintenance in Subjects With Extensive Stage-Small Cell Lung Cancer (IDeate-Lung03)

Extensive Stage-small Cell Lung Cancer
Peking Union Medical College Hospital

Recruiting

Toripalimab With or Without Lenvatinib or Chemotherapy in First-Line Treatment of Advanced Biliary Tract Cancer

Biliary Tract Neoplasms Immunotherapy

China
Celgene

Recruiting

A Study to Evaluate the Effect of Cytochrome P450 (CYP) 3A Inhibitor (Itraconazole) and Inducer (Rifampin) on the Drug Levels of Golcadomide (BMS-986369) in Healthy Participants

Healthy Volunteers

United States
Wan-Jin Chen

Not yet recruiting

Methylprednisolone Adjunctive to Endovascular Treatment for Stroke

Acute Ischemic Stroke
Guang'anmen Hospital of China Academy of Chinese...
Guangdong Provincial Hospital of Traditional Chinese Medicine; Hubei Hospital... and other collaborators

Not yet recruiting

Acupuncture for Obesity With Prediabetes

Obesity | Pre-diabetes

China
The First Affiliated Hospital with Nanjing Medical...

Recruiting

Fertility Preservation and Pregnancy and Offspring Health Outcomes in Female Cancer

Cancer | Fertility Issues

China
First Affiliated Hospital of Zhejiang University

Recruiting

Comparing the Efficacy of VHAG and Traditional Chemotherapy Regimens in Newly Diagnosed ETP-ALL

ETP-ALL

China
Changchun BCHT Biotechnology Co.
The First Affiliated Hospital of Yunnan University of Traditional Chinese... and other collaborators

Not yet recruiting

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of the Fully Human Anti-tetanus Toxin Monoclonal Antibody A82 / B86 Injection Combination Formulation

Clostridium Tetanus
Peking University Cancer Hospital & Institute

Recruiting

Anti-PD-1/PD-L1 Combined With Anti-angiogenic Agents as First-line Treatment for Unresectable HCC

Unresectable Hepatocellular Carcinoma

China
China Medical University, China

Recruiting

Effects of Different Inhaled Oxygen Concentrations on Lung Function in Older Patients After Laparoscopic Gastrointestinal Surgery Under General Anesthesia

Oxygenation Index

China
AdjuTec Pharma AS
CTC Clinical Trial Consultants AB

Not yet recruiting

A First-in-human Trial to Evaluate Safety, Tolerability, and Pharmacokinetics of APC148 in Healthy Adults

Healthy Subjects

Sweden
Allife Medical Science and Technology Co., Ltd.
First Affiliated Hospital Xi'an Jiaotong University

Recruiting

Safety and Preliminary Efficacy of Allogeneic Endothelial Progenitor Cells (EPCs) in Patients With Critical Limb Ischemia

Critical Limb Ischemia

China
Kuirong Jiang
CSPC Ouyi Pharmaceutical Co., Ltd.

Recruiting

Irinotecan Liposome Combined With Oxaliplatin and Tegafur as Adjuvant Therapy for Pancreatic Cancer

Pancreatic Cancer | Adjuvant Therapy

China
University Hospital Heidelberg

Recruiting

Success Rates of Video- vs. Direct Laryngoscopy for Endotracheal Intubation in Anesthesiology Residents: A Randomized Controlled Trial" (The JuniorDoc-VL-Trial) (JuniorDoc-VL)

Intubation | Intubation Complication

Germany
The First Affiliated Hospital of Dalian Medical...

Recruiting

Tumor Nutritional Therapy in the First-line Treatment of Stage IV NSCLC

Long-Term Effects Secondary to Cancer Therapy

China
Bristol-Myers Squibb

Recruiting

Transgene Assay Testing Service of Tumor Samples From Patients Who Received a Bristol-Myers Squibb Manufactured Gene Modified Cell Therapy and Have a Qualifying Secondary Malignancy

Multiple Myeloma | Non-Hodgkin Lymphoma | Chronic Lymphocytic Leukaemia

Belgium
Sun Jing

Not yet recruiting

Nocardia Rubra Cell Wall Skeleton in Combination With Prior Second- or Third-line Regimens for the Treatment of Potentially Hazardous Colorectal Cancer SD Status

Colorectal Neoplasms | Colorectal Cancer
Shanghai NewMed Medical Co., Ltd.
Shanghai Phigine Medical Technology Co., Ltd.

Not yet recruiting

Phitys I™ Percutaneous Left Ventricular Assist System Study

Coronary Artery Disease

China
Qing Ni

Not yet recruiting

Buyuan-zhixiao Formula in the Treatment of Elderly Patients With Diabetes and Multiple Metabolic Disorders

Aging | Diabete Mellitus | Randomized Controlled Trial | Metabolic Disorders | Traditional Chinese Medicine

China
MinYoung Kim, MD, PhD

Not yet recruiting

A Pilot Study for Efficacy of Cognitive and Physical Training in Patients With Mild Cognitive Impairment

Patients With Mild Cognitive Impairment (MCI)
Sun Jing

Not yet recruiting

A Clinical Study on the Efficacy and Safety of Paclitaxel Polymer Micelles and Cisplatin Combined With Cadonilimab as a Neoadjuvant Therapy for Locally Advanced Esophageal Squamous Cell Carcinoma

Neoadjuvant Therapy | Locally Advanced Esophageal Squamous Cell Carcinoma
The First Affiliated Hospital, Guangzhou University...

Not yet recruiting

A Single-arm Pilot Study of Tislelizumab Combined With Anlotinib in Patients With Advanced NSCLC With Driver-negative After Progression to Immunotherapy

Advanced NSCLC
AstraZeneca
Daiichi Sankyo

Recruiting

Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations (TROPION-Lung10)

Non-Small Cell Lung Cancer

Spain, Italy, Korea, Republic of, United States, Japan, Brazil, Taiwan, Australia, Austria, Canada, Poland, Belgium, United Kingdom, Turkey, Hungary, Germany, India
Jing-yuan Fang, MD, Ph. D

Recruiting

Tislelizumab With Fruquintinib, Metronidazole, in Mismatch Repair-proficient or Microsatellite Stability, Advanced Colorectal Cancer: a Multicenter, Single Arm, Clinical Trial

Colorectal Cancer

China
RenJi Hospital
Huashan Hospital; First Affiliated Hospital of Zhejiang University; Shenzhen... and other collaborators

Not yet recruiting

Safety and Efficacy of Ventricular Irrigation for Ventriculitis

Central Nervous System Infections

China
Celgene

Recruiting

Study to Compare the Effectiveness and Safety of Golcadomide Plus R-CHOP vs Placebo Plus R-CHOP in Participants With Previously Untreated High-risk Large B-cell Lymphoma (GOLSEEK-1)

Large B-cell Lymphoma

Korea, Republic of, Canada, United States, Argentina, Australia, Austria, Brazil, Bulgaria, Chile, China, Colombia, Croatia, Czechia, Denmark, Finland, France, Germany, Greece, Hungary, India, Japan, Malaysia, Mexico, New Zealand, Norway, Polan... and more
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Unclassified GENotypes of Autoinflammatory Diseases and AA Amyloidosis (IPHYGENI MAI)

Autoinflammatory Disease | AA Amyloidosis
Qu Shen
The First Affiliated Hospital of Xiamen University

Recruiting

Feasibility Study of Multidimensional Rehabilitation in the Metaverse

Colorectal Neoplasms

China
The First Affiliated Hospital with Nanjing Medical...

Recruiting

Serplulimab Combined With Concurrent Chemoradiotherapy for Locally Advanced Treatment Esophageal Cancer in Old Age

Esophageal Carcinoma

China
Ain Shams University
British University In Egypt

Recruiting

Soft Tissue Volume, Dimensions and Tomographic Alveolar Ridge Classification System for Dental Implant Treatment.

Soft Tissue Volume

Egypt
CHU de Reims

Recruiting

Bronchiectasis Prevalence in Patients With Primary Humoral Immunodefiency in Champagne-Ardenne Region, France (PREDDICHA)

Primary Immunodeficiency | Common Variable Immunodeficiency | Igg Subclass Deficiency | Selective IgM Deficiency

France
University Hospital, Gasthuisberg
Fondazione Policlinico Universitario Agostino Gemelli IRCCS; University Medical...

Recruiting

Improving Endometrial Cancer Assessment by Combining Genomic Profiling and Surgical Assessment (EUGENIE)

Endometrial Cancer

Belgium

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