Search clinical trials for: K304E mutation

Total 3276 results

Giselle Sholler
Y-mAbs

Recruiting

Naxitamab Added to Induction for Newly Diagnosed High-Risk Neuroblastoma

High-risk Neuroblastoma

United States, Canada
Prevail Therapeutics
Eli Lilly and Company

Recruiting

A Clinical Trial of PR001 (LY3884961) in Patients With Peripheral Manifestations of Gaucher Disease (PROCEED)

Gaucher Disease | Gaucher Disease, Type 1

United States, Spain, Germany
HUYABIO International, LLC.

Recruiting

A Dose Escalation Study of HBI-2438 in Patients With Solid Tumors Harboring KRAS G12C Mutation

Cancer | Colorectal Cancer | Lung Cancer | Solid Tumor | Non Small Cell Lung Cancer | Colon Cancer | Cancer of Pancreas

United States, Puerto Rico
Okayama University
Merck Sharp & Dohme LLC

Recruiting

Novel Neoadjuvant and Adjuvant Strategy for Germline BRCA 1/2 Mutated Triple Negative Breast Cancer

Breast Cancer | Breast Neoplasms | Triple Negative Breast Cancer | Triple Negative Breast Neoplasms | BRCA1 Mutation | BRCA2 Mutation | BRCA Mutation | BRCA-Associated Breast Carcinoma

Japan
Hasselt University

Recruiting

Functional Strength Training and Neuromuscular Electrical Stimulation in Severe Acute Exacerbations of COPD

Acute Exacerbation of COPD | Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Belgium
Navire Pharma Inc., a BridgeBio company
Amgen

Recruiting

SHP2 Inhibitor BBP-398 in Combination With Sotorasib in Patients With Advanced Solid Tumors and a KRAS-G12C Mutation (Argonaut)

Non Small Cell Lung Cancer | Metastatic Solid Tumor | Solid Tumor, Adult | Metastatic NSCLC

Spain, Australia, France, Denmark, Greece, Italy, Netherlands
National Institute of Diabetes and Digestive and...

Recruiting

Study of Growth Hormone Inhibition Using Pegvisomant in Severe Insulin Resistance

Insulin Receptor Mutation | Partial Lipodystrophy

United States
Konkuk University Medical Center
Yuhan Corporation

Recruiting

Neoadjuvant Lazertinib Therapy in EGFR-Mutation Positive Lung Adenocarcinoma Detected by BALF Liquid Biopsy

Non Small Cell Lung Cancer

Korea, Republic of
Peking Union Medical College

Recruiting

Efficacy and Safety of Furmonertinib in Patients With EGFR Mutations in Advanced NSCLC With Brain Metastases: A Single-center, Open-label, Phase II Trial（iFORCE）

NSCLC | Brain Metastases | Furmonertinib | EGFR-mutation

China
Xinhua Zhang, MD
Xijing Hospital; Chongqing University Cancer Hospital; Xiangya Hospital of Central... and other collaborators

Not yet recruiting

Avapritinib in the Treatment of Unresectable or Recurrent Metastatic GIST Non-exon18 Mutations of PDGFRA

Gastrointestinal Stromal Tumors | Unresectable Solid Tumor | Recurrent Metastatic Malignant Neoplasm
Myung-Ju Ahn

Recruiting

Lazertinib for NSCLC Harboring Activating EGFR Mutations in TKI naïve Patients

NSCLC

Korea, Republic of
Yonsei University

Recruiting

Circulating Tumor DNA and BRCA Reversion Mutation in Advanced or Recurrent Ovarian Cancer Patients With Germline Mutation.

Ovarian Cancer

Korea, Republic of
Azienda Socio Sanitaria Territoriale degli Spedali...

Recruiting

Quality of Sexual Function in BRCA Mutated Women (BRCA_SFQ28)

Sexual Dysfunction | Sexual Dysfunctions, Psychological | Sexual Dysfunction, Physiological | BRCA Mutation

Italy
SynDevRx, Inc.

Recruiting

Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Women With a PI3K Alteration and HR+/Her2- Breast Cancer (Amelia-1)

Metastatic Breast Cancer | HR+/HER2-negative Breast Cancer

United States
Eloxx Pharmaceuticals, Inc.

Recruiting

A Study of ELX-02 in Patients With Alport Syndrome

Alport Syndrome

United Kingdom, Australia
Instituto Nacional de Cancerologia de Mexico

Recruiting

Metformin Plus Tyrosine Kinase Inhibitors for Treatment of Patients With Non-small Cell Lung Cancer With EGFR Mutations (METLUNG)

Non Small Cell Lung Cancer

Mexico
Region Skåne

Recruiting

BioMEL- Diagnostic and Prognostic Factors in Melanoma. (BioMEL)

Melanoma | Mutation | Image | Dysplastic Nevi | Melanoma in Situ | Mole (Dermatology)

Sweden
Boston Medical Center
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Recruiting

Gabapentin to Reduce Alcohol and Improve Viral Load Suppression (GRAIL)

HIV | Heavy Drinking

Uganda
Sohag University
Assiut University; Kyoto University

Recruiting

Mutations and Phenotypes of Unclassifiable Inherited Bone Marrow Failure Syndromes

Inherited BMF Syndrome

Egypt
Jiangsu Hansoh Pharmaceutical Co., Ltd.

Recruiting

Hase 1/2 Study of HS-10375 in Patients With Advanced or Metastatic Non-Small-Cell Lung Cancer(NSCLC)

Advanced or Metastatic NSCLC

China
Jiangsu Hansoh Pharmaceutical Co., Ltd.

Recruiting

Phase 1/2 Study of HS-10376 in Patients With Non-Small Cell Lung Cancer

Advanced Non-Small-Cell Lung Cancer

China
Peking Union Medical College Hospital

Recruiting

Drug Sensitivity Detection of Micro Tumor (PTC) to Guide Postoperative Adjuvant Treatment Strategy of Colorectal Cancer

Rectal Cancer | Colon Cancer | Chemotherapy Effect | PTC | Exon Mutation

China
University Hospital, Clermont-Ferrand
Diagnostica Stago

Recruiting

Evaluation of the Inter-center Variability of the Measurement of Thrombin Generation by the ST Genesia System (EVIGE)

Patients Without a Medical History of Thrombosis or Hemorrhage | Hemophilic Patient | Patient With FV Leiden Mutation | Patient With Cirrhosis | Patient on Anticoagulant

France
Memorial Sloan Kettering Cancer Center

Recruiting

An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk

BRCA1 Mutation | BRCA2 Mutation | APC Gene Mutation | MLH1 Gene Mutation | RAD51C Gene Mutation | RAD51D Gene Mutation | BRIP1 Gene Mutation | PALB2 Gene Mutation | PTEN Gene Mutation | ATM Gene Mutation | CHEK2 Gene Mutation | BARD1 Gene Mutation | MSH2 Gene Mutation | MSH6 Gene Mutation | PMS2 Gene Mutation | POLD1 Gene... and other conditions

United States
Jiangsu Tasly Diyi Pharmaceutical Co., Ltd.

Recruiting

A Study to Evaluate the Efficacy and Safety of TSL-1502 Capsules in Breast Cancer Patients With Germline BRCA Mutations

Breast Cancer Metastatic

China
Novartis Pharmaceuticals

Recruiting

A Phase I/II Study of DYP688 in Patients With Metastatic Uveal Melanoma and Other GNAQ/11 Mutant Melanomas

Metastatic Uveal Melanoma

United States, Australia, France, Netherlands, Switzerland, Germany, Spain
Beijing Chest Hospital
Jiangsu HengRui Medicine Co., Ltd.

Not yet recruiting

A Real-World Study of Pyrotinib Maleate in the Treatment of Advanced/Metastatic Non-Small Cell Lung Cancer With Rare Mutations in HER2

HER2 Mutant Non-small Cell Lung Cancer
European Institute of Oncology

Recruiting

LobularCard Trial: Searching for Novel Germline Mutations in Lobular Breast Cancer Patients (LobularCard)

BRCA1 Mutation | BRCA2 Mutation | Lobular Breast Carcinoma | Lobular in Situ Breast Carcinoma

Italy
D3 Bio (Wuxi) Co., Ltd

Recruiting

A Study of D3S 001 Monotherapy or Combination Therapy in Subjects With Advanced Solid Tumors With a KRAS p.G12C Mutation

KRAS P.G12C

Australia, Korea, Republic of, China, United States, Hong Kong
Fundació Institut de Recerca de l'Hospital de la...

Recruiting

Study of Quality of Life Post Salpingo-oophorectomy in BRCA1/2 & PALB2 Mutation Carriers (BRCA-HRT) (BRCA-HRT)

Hereditary Breast and Ovarian Cancer

Spain
Massachusetts General Hospital
GlaxoSmithKline

Recruiting

Niraparib In Recurrent IDH 1/2 Gliomas

Recurrent Glioma | Low-grade Glioma | Glioma, Malignant | IDH2 Gene Mutation | IDH1 Mutation

United States
Banaras Hindu University

Recruiting

of Androgen Receptor Expression in Breast Cancer With or Without BRCA Mutation

Breast Cancer

India
Sensorion

Recruiting

Natural History in Children up to 10 Years With Moderate to Profound Hearing Loss Due to Mutations in GJB2 / OTOF Genes (Otoconex)

Sensorineural Hearing Loss, Bilateral | Congenital Deafness | AUNB1 | DFNB1A | DFNB9 | OTOF Gene Mutation | GJB2 Gene Mutation

France
Sichuan Cancer Hospital and Research Institute

Not yet recruiting

Tislelizumab +Bevacizumab+pc for Untreated EGFR+ and High PD-L1 Non-squamous NSCLC

Non-squamous Non-small Cell Lung Cancer | EGFR Gene Mutation

China
SwanBio Therapeutics, Inc.

Recruiting

A Study to Evaluate Administration of SBT101 Gene Therapy in Adult Patients With Adrenomyeloneuropathy (AMN) (PROPEL)

AMN | AMN Gene Mutation | X-ALD

Netherlands, United States
J Ints Bio

Recruiting

A Phase 1/2 Study to Evaluate the Safety, Tolerability and PK of JIN-A02 in Patients With EGFR Mutant Advanced NSCLC

EGFR Mutant Advanced Non-small Cell Lung Cancer

Korea, Republic of, United States, Thailand
Borstkanker Onderzoek Groep
Novartis Pharma B.V.; BOOG Study Center

Recruiting

SEQUence of Endocrine Therapy in Advanced Luminal Breast Cancer (SEQUEL-Breast) (SEQUEL-Breast)

Neoplasm, Breast | Congenital, Familial and Genetic Disorders

Netherlands
Erasmus Medical Center

Recruiting

Bilateral Prophylactic Mastectomy; Should we Preserve the Pectoral Fascia? (PROFAS)

Seroma | BRCA1/2 Mutation | Bilateral Prophylactic Mastectomy | Pectoral Fascia

Netherlands
Novartis Pharmaceuticals

Recruiting

Asciminib Monotherapy, With Dose Escalation, for 2nd and 1st Line Chronic Myelogenous Leukemia (ASC2ESCALATE)

Chronic Myelogenous Leukemia - Chronic Phase

United States
Nuvalent Inc.

Recruiting

A Study of NVL-655 in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)

Metastatic Solid Tumor | Locally Advanced Solid Tumor

Canada, United States, Australia, Taiwan, Spain, United Kingdom, Korea, Republic of, Italy, France, Singapore, Netherlands
TYK Medicines, Inc

Recruiting

Phase III Study of TY-9591 in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer (FLETEO)

NSCLC | EGFR Activating Mutation

China
Assiut University

Not yet recruiting

FLT3-ITD Gene Mutation and CD135 Expression in Acute Myeloid Leukemia.

Acute Myeloid Leukemia
Revolution Medicines, Inc.

Recruiting

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

Advanced Solid Tumors | Non-small Cell Lung Cancer (NSCLC) | Pancreatic Ductal Adenocarcinoma (PDAC) | Colorectal Cancer (CRC)

United States
Institut Claudius Regaud
Artios Pharma Ltd

Recruiting

Study Evaluating DNA Double-strand Breaks (DSBs) REpair Factors (POLQ, Shieldin Complex and 53BP1) Expression as Biomarker of PARP Inhibitor Resistance in Patients With Deleterious Germline Mutation in BRCA 1/2 and HER2-negative, Metastatic or Locally Advanced Breast Cancer. (REPARP)

Breast Cancer

France
Verastem, Inc.
Mirati Therapeutics Inc.

Recruiting

Study of Avutometinib (VS-6766) + Adagrasib in KRAS G12C NSCLC Patients (RAMP204)

Non Small Cell Lung Cancer | Metastatic Cancer | Advanced Cancer | Malignant Neoplasm of Lung | Malignant Neoplastic Disease | KRAS Activating Mutation

United States
Navire Pharma Inc., a BridgeBio company
Bristol-Myers Squibb

Recruiting

SHP2 Inhibitor BBP-398 in Combination With Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer With a KRAS Mutation

Solid Tumor | Non Small Cell Lung Cancer

United States
Assiut University

Not yet recruiting

The Prevelence of IVS 1-6 (T-C) [HBB:c.92 +6 T-C] Gene Mutation in Suspected Cases of β Thalassemia in Assiut University Hospitals

Beta-Thalassemia
Jiangsu Hansoh Pharmaceutical Co., Ltd.

Recruiting

Phase 1/2 Study of HS-10370 in Patients With Advanced Solid Tumors

Advanced Solid Tumor

China
Institut National de la Santé Et de la Recherche...

Recruiting

Molecular Diagnosis of Systemic Autoinflammatory Diseases (SAIDiag)

Genetic Disease | Inflammatory Disease | Somatic Mutation | Molecular Sequence Variation | Molecular Pathway Deregulation

France
ArriVent BioPharma, Inc.

Recruiting

Study of Furmonertinib in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Activating, Including Uncommon, Epidermal Growth Factor Receptor (EGFR) or Human Epidermal Growth Factor Receptor 2 (HER2) Mutations

Advanced Non-Small Cell Lung Cancer | Metastatic Non-Small Cell Lung Cancer | Non-Small Cell Lung Cancer (NSCLC) | HER2 Exon 20 Mutations | EGFR Exon 20 Mutations | EGFR Uncommon Mutations, Including G719X and S768I

United States, Australia, Spain, United Kingdom, France, China, Korea, Republic of, Canada, Japan, Netherlands, Italy

Search clinical trials for: K304E mutation

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