Search clinical trials for: Moderate Hepatic Impairment

Total 15887 results

Zhejiang Medicine Co., Ltd.
Huashan Hospital

Completed

Pharmacokinetics Study of Nemonoxacin Malate Capsules in Subjects With Moderate Impaired Hepatic Function

Liver Dysfunction

China
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Single-Dose Pharmacokinetics and Safety of Oral Lofexidine in Hepatically-Impaired Subjects

Liver Failure

United States
Hoffmann-La Roche

Completed

A Study of The Impact of Severe Hepatic Impairment on the Pharmacokinetics and Safety of Vemurafenib in BRAF V600 Mutation-Positive Cancer Participants

Neoplasms

United Kingdom, Israel, United States, Russian Federation, Australia, Greece, Turkey
OSI Pharmaceuticals

Completed

A Pharmacokinetic Study of Erlotinib in Cancer Patients With Advanced Solid Tumors, With Adequate and Moderately Impaired Hepatic Function

Advanced Solid Tumors

United States, United Kingdom
Institute of Liver and Biliary Sciences, India

Completed

Effect of Goal Directed Ammonia Lowering Therapy in Acute on Chronic Liver Failure Patients With Hepatic Encephalopathy.

Acute-On-Chronic Liver Failure

India
Pfizer

Completed

A Study To Describe The Effect Of Impaired Hepatic Function Of The Pharmacokinetics Of Palbociclib

Healthy, Hepatic Insufficiency

United States
Allergan

Completed

Impact of Severe Hepatic Impairment on Pharmacokinetics of Cenicriviroc and Its Metabolites

Hepatic Impairment

United States
Biotie Therapies Inc.
Acorda Therapeutics

Terminated

Study to Investigate the Influence of Hepatic Insufficiency on the Pharmacokinetics of Tozadenant

Hepatic Impairment

United States
Erasme University Hospital

Completed

Optimized Anesthesia to Reduce Postoperative Cognitive Impairment in the Elderly

Elderly ; Moderate Risk Surgery

Belgium
FUJIFILM Toyama Chemical Co., Ltd.
Celerion

Completed

PK Study of T-817 in Subjects With Hepatic Impairment

Healthy | Hepatic Impairment

United States
GlaxoSmithKline

Completed

Study Of SB-497115 in Healthy Subjects and Subjects With Mild, Moderate or Severe Renal Impairment

Purpura, Thrombocytopaenic, Idiopathic

United States
GlaxoSmithKline

Completed

Investigating The Pharmacokinetics Of An Inhaled Dose Of A New Corticosteroid In Patients With Impaired Liver Function

Asthma
Takeda

Completed

Phase I Open-label Study to Evaluate Pharmacokinetics of TAK-272 in Participants With Renal or Hepatic Impairment

Renal Impairment | Hepatic Impairment

Japan
Nektar Therapeutics

Completed

A Study in Cancer Patients With Hepatic Impairment to Evaluate the Pharmacokinetics and Safety of NKTR-102 (Etirinotecan Pegol)

Advanced or Metastatic Solid Tumors in Patients With Hepatic Impairment

United States
ViiV Healthcare
GlaxoSmithKline

Completed

Single-dose Pharmacokinetics of BMS-626529, Administered as BMS-663068, in Subjects With Hepatic Impairment Compared to Healthy Subjects

Infection, Human Immunodeficiency Virus

United States
GlaxoSmithKline

Completed

Observational Study Evaluating The Processing Or Breakdown Of GW679769 In Subjects With Hepatic Impairment

Vomiting

United States
GlaxoSmithKline

Completed

A Study To Compare The Effects Of The Infusion Of A Sepsis Drug Between Healthy Adults And Adults With Damaged Livers

Sepsis

Slovakia
CSL Behring

Completed

A Study of CSL112 in Healthy Adults and in Adults With Moderate Renal Impairment

Acute Myocardial Infarction

Germany, United Kingdom
Bayer

Completed

Effect of Hepatic Impairment on the Pharmacokinetics, Safety and Tolerability of BAY1002670 (Vilaprisan)

Leiomyoma

Germany
GlaxoSmithKline

Completed

Study to Evaluate the Pharmacokinetics and Safety of GSK2336805 in Subjects With Hepatic Impairment and Healthy Matched Control Subjects

Hepatitis C

United States
Jiangsu HengRui Medicine Co., Ltd.

Unknown

Safety and Pharmacokinetics/Pharmacodynamics of SHR3824 in Patients With Hepatic Impairment

Hepatic Impairment

China
Janssen Research & Development, LLC

Completed

A Study to Assess the Effects of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Intranasally Administered Esketamine

Hepatic Impairment | Normal Hepatic Function

United States
Bristol-Myers Squibb
Nitto Denko Corporation

Completed

Phase 1b/2, Open Label, Repeat Dose, Dose Escalation Study of ND-L02-s0201 Injection in Subjects With Moderate to Extensive Fibrosis (METAVIR F3-4)

Moderate to Extensive Hepatic Fibrosis (METAVIR F3-4)

Bulgaria, United States
Amgen

Completed

Study of the Pharmacokinetics and Safety of Carfilzomib in Patients With Advanced Malignancies and Hepatic Impairment

Hepatic Impairment | Solid Tumors | Hematologic Malignancies

United Kingdom, Netherlands, United States, France
Ardea Biosciences, Inc.

Completed

Mild, Moderate and Severe Renal Impairment Study

Gout

United States
Merck Sharp & Dohme LLC

Completed

Pharmacokinetics of Peginterferon Alfa-2b in Participants With Moderate and Severe Renal Impairment (P05655)

Renal Insufficiency
Genzyme, a Sanofi Company

Completed

A Study of the Effects of Hepatic Impairment on the Pharmacokinetics and Tolerability of Eliglustat Tartrate

Gaucher Disease

United States
AstraZeneca
Bristol-Myers Squibb

Completed

Glycemic Efficacy and Renal Safety Study of Dapagliflozin in Subjects With Type 2 Diabetes Mellitus and Moderate Renal Impairment

Diabetes Mellitus, Type 2

Australia, United States, Italy, Argentina, Canada, Mexico, India, Peru, Spain, Denmark, France, Singapore, Puerto Rico
Bristol-Myers Squibb

Withdrawn

A Study to Evaluate the Pharmacokinetics of BMS-986141 in Participants With Hepatic Impairment Compared to Healthy Participants

Hepatic Impairment

United States
Régis AUBRY

Completed

Health Care Courses of Elderly Hospitalized Patients for Inappropriate Reasons: Qualitative and Economic Analyzes (PAGE)

Cognitive Impairment

France
Lexicon Pharmaceuticals

Completed

PK Study of Sotagliflozin in Subjects With Hepatic Impairment

Healthy | Hepatic Impairment

United States
Takeda

Completed

Efficacy and Safety of Extended Release and Immediate Release Febuxostat in Participants With Gout and Moderate Renal Impairment

Gout | Moderate Renal Impairment

United States
Hoffmann-La Roche

Completed

A Study of Aleglitazar in Type 2 Diabetes Patients With Moderate Renal Impairment

Diabetes Mellitus Type 2

Australia, Hong Kong, Colombia, Russian Federation, Germany, Hungary, Italy, Mexico, Peru, Romania, Slovakia, Brazil, El Salvador
Hoffmann-La Roche

Completed

A Study on The Effect of Hepatic Impairment on The Pharmacokinetics of RO4917838

Healthy Volunteer

France, Russian Federation
Hoffmann-La Roche

Completed

A Safety And Pharmacokinetic Study of Setrobuvir Alone and In Combination With Ritonavir-Boosted Danoprevir in Subjects With Mild Hepatic Impairment Compared to Healthy Controls

Healthy Volunteer

Poland, Hungary
Hoffmann-La Roche

Completed

A Study of Danoprevir in Healthy Volunteers And Patients With Hepatic Impairment

Healthy Volunteer

Slovakia, United States, Czech Republic
Indivior Inc.

Completed

Single Dose Pharmacokinetics of Suboxone Study in Hepatic Impaired Subjects

Hepatic Impairment | Hepatic Failure | Chronic Hepatitis C Infection With Hepatic Coma

United States
AstraZeneca

Completed

Study to Assess the Blood Levels and Safety of Olaparib in Patients With Advanced Solid Tumours and Normal or Impaired Kidney Function

Solid Tumours

Belgium, France, Netherlands, United Kingdom, Denmark
Hoffmann-La Roche

Terminated

A Study of the Pharmacokinetics/Pharmacodynamics of GK Activator (2) in Type 2 Diabetes Patients With Hepatic Impairment.

Diabetes Mellitus, Type 2

Germany, Slovakia
AstraZeneca

Completed

To Assess the Pharmacokinetics, Safety and Tolerability of Selumetinib in Patients With Hepatic Impairment and Healthy Subjects

Solid Tumors

United States
Trius Therapeutics LLC

Completed

A PK and Safety Study in Subjects With Hepatic Impairment

Hepatic Impairment

United States
Life Extension Foundation Inc.

Completed

Short Term Efficacy and Safety of Perispinal Administration of Etanercept in Mild to Moderate Alzheimer's Disease

Alzheimer's Disease

United States
Eisai Inc.

Completed

Rabeprazole Extended-Release 50 mg Versus Esomeprazole 40 mg for Healing and Symptomatic Relief of Mild to Moderate Erosive Gastroesophageal Reflux Disease (GERD)

Gastroesophageal Reflux Disease (GERD)

United States
Sanofi

Completed

Effect of Otamixaban Versus Unfractionated Heparin + Eptifibatide in Patients With Unstable Angina/Non ST Elevation Myocardial Infarction Undergoing Early Invasive Strategy (TAO)

Acute Coronary Syndrome

Austria, Korea, Republic of, Brazil, Belarus, India, Latvia, Belgium, Canada, Israel, Portugal, Germany, United States, Argentina, Australia, Bulgaria, Chile, Colombia, Croatia, Czech Republic, Egypt, Estonia, France, Greece, Hong Kong, Hungar... and more
Gilead Sciences

Completed

Cobicistat-containing Highly Active Antiretroviral Regimens in HIV-1 Infected Patients With Mild to Moderate Renal Impairment

HIV Infections | Acquired Immunodeficiency Syndrome

Puerto Rico, United States, United Kingdom, Canada, Germany, Austria, Australia, Dominican Republic, Mexico
LG Life Sciences

Completed

A Phase IIIb Study to Evaluate the Safety and Efficacy of Gemigliptin in Type 2 Diabetes Mellitus Patients With Moderate or Severe Renal Impairment(GUARD Study) (GUARD)

Type 2 DM Patients With Moderate or Severe Renal Impairment

Korea, Republic of
Konkuk University Medical Center

Unknown

Impact of Positive End-expiratory Pressure on Hepatic Venous Flow

Valvular Heart Disease
Conatus Pharmaceuticals Inc.

Completed

PK and PD Study of IDN-6556 in Subjects With Hepatic Impairment and Matched Healthy Volunteers

Liver Diseases | Digestive System Diseases | Hepatic Impairment

United States
Institute of Liver and Biliary Sciences, India

Completed

Role of Hypertonic Saline Versus Mannitol in the Management of Raised Intracranial Pressure in Patients With ALF

Acute Liver Failure

India
Alkermes, Inc.

Completed

Pharmacokinetics and Safety of ALKS 5461 in Healthy Subjects and Subjects With Hepatic Impairment and Normal Hepatic Function

Hepatic Impairment

United States

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