Search clinical trials for: Orphan drug

Total 261393 results

Riphah International University

Recruiting

Combined Effects of Blow Bottle Device and Postural Drainage in Moderate to Severe Elderly COPD Patients

Chronic Obstructive Pulmonary Disease

Pakistan
University of California, Davis

Recruiting

The Influence of Chardonnay Marc Intake on Gut and Cardiometabolic Health

Cardiovascular Diseases | Adiposity | Cardiometabolic Syndrome

United States
European Institute of Oncology

Recruiting

Characterization of Biophysical and Mechanical Parameters on Skin of Breast Cancer Patients

Breast Cancer | Estrogen Receptor Positive Tumor

Italy
Tang-Du Hospital

Not yet recruiting

Neoadjuvant/Adjuvant Tislelizumab Combined With Anlotinib and Platinum Doublet Chemotherapy With Resectable NSCLC

Non-Small Cell Lung Cancer | Anti Angiogenesis

China
Children's Hospital of Fudan University

Not yet recruiting

Effects of an Emollient Containing Postbiotic Saccharomyces and Lactobacillus on Pediatric Atopic Dermatitis

Eczema | Atopic Dermatitis | Emollient
Fudan University

Not yet recruiting

HAIC Combined With TQB2450 and Anlotinib in Second-line Treatment of Advanced Hepatocellular Carcinoma

Hepatocellular Carcinoma

China
Bristol-Myers Squibb

Not yet recruiting

A Study Evaluating Deucravacitinib Concentrations in the Breast Milk and Plasma of Healthy Lactating Female Participants

Healthy Volunteers
Tang-Du Hospital
Jiangsu Hengrui Pharmaceutical Co., Ltd.

Recruiting

Neoadjuvant Adebrelimab + DOS in Locally Advanced Resectable Gastric Cancer

Gastric Cancer

China
Riphah International University

Not yet recruiting

Telerehabilitation Exercise: Effects on Maternal Psychological Health and Delivery Outcomes

Gestational Diabetes | Gestational Diabetes Mellitus in Pregnancy | Maternal Psychological Distress

Pakistan
Pak Emirates Military Hospital

Not yet recruiting

Comparison of Efficacy of Methotrexate and Azathioprine in Patients With Chronic Actinic Dermatitis: A Randomized Controlled Trial

Chronic Actinic Dermatitis
M.D. Anderson Cancer Center

Not yet recruiting

T Cell Membrane-Anchored Tumor-Targeted IL12 -Modified TIL Cell Therapy (attIL12-TIL) for Advanced/Metastatic Soft Tissue and Bone Sarcoma Patients.

Metastatic Soft-tissue Sarcoma

United States
Sichuan Baili Pharmaceutical Co., Ltd.
Baili-Bio (Chengdu) Pharmaceutical Co., Ltd.

Not yet recruiting

A Study of BL-B01D1+PD-1 Monoclonal Antibody in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer, Nasopharyngeal Carcinoma and Other Solid Tumors

Nasopharyngeal Carcinoma | Solid Tumor | Non-small Cell Lung Cancer

China
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Not yet recruiting

Anlotinib Hydrochloride Capsules Combined With TQB2450 in the Treatment of Endometrial Cancer

Endometrial Cancer

China
Nordlandssykehuset HF
University Hospital of North Norway; University of Tromso; Helgelandssykehuset...

Recruiting

Safer Personalised Cancer Treatment Digital Follow-up (SPecT)

Patient Reported Outcome Measure

Norway
Children's Hospital of Philadelphia
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Multidimensional Phenotype Classification in Grade 3 Bronchopulmonary Dysplasia

Bronchopulmonary Dysplasia

United States
Massachusetts General Hospital

Recruiting

Permissive Hypotension After Cardiac Surgery (PHACS)

Surgery

United States
Nanjing First Hospital, Nanjing Medical University

Not yet recruiting

Risk Assessment of Proximal Contact Loss Between Implant-supported Prostheses and Adjacent Teeth.

Peri-Implantitis and Peri-implant Mucositis

China
Eli Lilly and Company

Not yet recruiting

A Bioequivalence Study of Citrate Free Mirikizumab (LY3074828) in Healthy Participants

Healthy

United States
Wuhan Union Hospital, China

Not yet recruiting

Clinical Effectiveness of CEM in Diagnosis of Additional Findings at Preoperative Breast Magnetic Resonance Imaging (COMBO-I)

Breast Cancer

China
Federal Research Institute of Pediatric Hematology...

Recruiting

Preventing of GVHD With Post-transplantation Cyclophosphamide, Abatacept, Vedolizumab and Baricitinib at Children and Young Adults With Hemoblastosis

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Acute Lymphoblastic Leukemia | Malignant Lymphoma | Biphenotypic Acute Leukemia

Russian Federation
Pfizer

Not yet recruiting

A Study to Learn About the Safety of BESPONSA Injection in Pediatric Patients With Acute Lymphocytic Leukemia.

Acute Lymphocytic Leukemia
University of Southern California

Not yet recruiting

Salt Water Gargling on Swallowing Following ACDF

Dysphagia | Cervical Radiculopathy | Cervical Myelopathy | Cervical Spondylosis | Degeneration Spine | Cervical Stenosis

United States
University of Washington

Not yet recruiting

Local Anesthetic for Plateau Fractures

Tibial Plateau Fractures
Henan Cancer Hospital

Not yet recruiting

Efficacy of Pyrotinib Plus Capecitabine in HER2-positive MBC With Active Brain Metastases That Have Failed ADCs

Metastatic Breast Cancer in the Brain
UNICANCER

Not yet recruiting

Dose Individualization of Chemotherapy in Patients With Gastrointestinal Cancers Lacking a Specific Liver Enzyme (FUDOSE)

Colorectal Cancer | Digestive Cancer
Concordia University Wisconsin

Not yet recruiting

M4C Nutraceutical Intervention Human Health Effects Pilot (M4C Pilot)

Obesity | Weight Management | Exercise Tolerance | Cardiovascular Health | Digestive Health | General Health and Wellness | Energy and Vitality | Cognitive Function and Mental Health | Bone and Joint Health | Skin, Hair, and Nail Health | Immune Support | Sports Performance and Recovery | Sleep and Relaxation | Anti...
Fujian Shengdi Pharmaceutical Co., Ltd.

Not yet recruiting

A Trial of HRS5580 in Prevention of Postoperative Nausea and Vomiting of Adults

Preventing of Postoperative Nausea and Vomiting in Adults

China
University of Pittsburgh

Not yet recruiting

Dietary Interventions in Cancer Patients Treated With Immune Checkpoint Inhibitors

Cancer

United States
Tang-Du Hospital
Jiangsu Hengrui Pharmaceutical Co., Ltd.

Recruiting

Adebrelimab + Apatinib in SCLC Maintenance Therapy

SCLC

China
Petrovsky National Research Centre of Surgery

Recruiting

Validation of Hematological Indices

Pneumonia | Sepsis | Wound Infection | Multiple Organ Dysfunction

Russian Federation
ARCAGY/ GINECO GROUP
Horizon 2020 - European Commission

Not yet recruiting

Utility of Adjusting Chemotherapy Dose & Dosing Schedule With the SALVage Weekly Dose-dense Regimen in Patients With Poor Prognostic OVARian Cancers Based on the Tumor Unfavorable Primary Chemosensitivity and Incomplete Debulking Surgery (SALVOVAR)

Ovarian Cancer

France
Bristol-Myers Squibb

Not yet recruiting

A Study to Evaluate the Safety, Tolerability, Drug Levels, and Drug Effects of Single Doses of BMS-986435 (MYK-224) in Healthy Chinese Participants

Healthy Volunteers

China
Universitas Diponegoro

Recruiting

Combination Oral Acetazolamide and Intravenous Furosemide on Acute Decompensated Heart Failure Outcomes (COAF-HF)

Acute Decompensated Heart Failure

Indonesia
Atif Shafqat

Recruiting

Opioid-based Versus Opioid-free Anaesthesia for Laparoscopic Cholecystectomy

Laparoscopic Cholecystectomy | Surgical Procedure, Unspecified

Pakistan
Assistance Publique - Hôpitaux de Paris
University of Oslo

Not yet recruiting

Adherence to Antidepressants During Pregnancy (MAMP-DEP)

Antidepressants During Pregnancy
Hacettepe University

Not yet recruiting

Investigation of the Relationship Between Core Endurance and Awareness of Injury Prevention in Adolescent Basketball Players

Sports Physical Therapy

Turkey
H. Lee Moffitt Cancer Center and Research Institute
National Cancer Institute (NCI)

Recruiting

Mindfulness-Based Ecological Momentary Intervention For Smoking Cessation Among Cancer Survivors

Lung Cancer

United States
RenJi Hospital

Not yet recruiting

Efficacy and Safety of Rivaroxaban in the Early Postoperative Period for Patients With Bioprosthetic Valves

Anticoagulation
Chulalongkorn University

Not yet recruiting

Artificial Saliva Containing Cumin and Ginger Extract in Hemodialysis Patients With Xerostomia

Xerostomia
Fudan University

Recruiting

A Phase II Trial of Adebrelimab in Combination With NALIRIFOX in LAPC

Pancreatic Cancer

China
Charite University, Berlin, Germany
Kyverna Therapeutics

Not yet recruiting

Comparison of B-cell Depletion by Rituximab and Anti-CD 19 CAR-T Therapy in Patients With Rheumatoid Arthritis (COMPARE)

Rheumatoid Arthritis
Beijing Chest Hospital
Anhui Chest Hospital; Changsha Central Hospital; Wuhan Institute for Tuberculosis... and other collaborators

Recruiting

The Safety and Efficacy of BDL(Bedaquiline Plus Delamanid Plus Linezolid) Regimen in Subjects With Pulmonary Infection of Multi-drug Resistant Tuberculosis (MDR-TB) or Rifampicin-Resistant Tuberculosis (RR-TB)

Pulmonary Tuberculosis

China
Vigonvita Life Sciences

Not yet recruiting

A Study to Assess Serotonin Transporter Occupancy of Healthy Adults Using 11C-DASB PET

Major Depressive Disorder
First Affiliated Hospital of Chongqing Medical...

Not yet recruiting

the Psychological Interventions for Alleviating Anxiety and Depressive Emotion Among Oocyte Retrieval Patients

Infertility | Anesthesia, General | in Vitro Fertilization | Mental Health
University of Sheffield
National Health Service, United Kingdom

Not yet recruiting

Feasibility and Acceptability of Implementing DIALOG+ in a Psychiatric Rehabilitation Unit

Psychological Recovery

United Kingdom
M.D. Anderson Cancer Center

Not yet recruiting

A Phase I Study Investigating the Combination of Cladribine, Low Dose Cytarabine and Sorafenib Alternating With Decitabine in Pediatric Relapsed and Refractory Acute Leukemias

Refractory Acute Leukemia | Relapsed Acute Leukemia

United States
Istituto Auxologico Italiano

Recruiting

EMDR vs. CBT in the Treatment of Inpatients With Obesity and Binge Eating Disorder: the EMDRDCA Study. (EMDRDCA)

Binge-Eating Disorder

Italy
Dana-Farber Cancer Institute
Merck Sharp & Dohme LLC

Not yet recruiting

Pembrolizumab + Chemotherapy in Newly Diagnosed PCNSL

Lymphoma | Primary Central Nervous System Lymphoma

United States
Peking University People's Hospital

Not yet recruiting

Fecal Microbiota Transplantation in the Treatment of Major LARS (FMT-LARS)

Low Anterior Resection Syndrome | Fecal Microbiota Transplantation
National Institute of Allergy and Infectious Diseases...

Not yet recruiting

Belumosudil to Block Chronic Lung Allograft Dysfunction (CLAD) in High Risk Lung Transplant Recipients (CLAD)

Lung Transplant

United States, Canada

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