Search clinical trials for: Single arm phase IIa study

Total 138736 results

Xcovery Holdings, Inc.

Completed

A Single Dose BE Study of X-396 in Healthy Volunteers Under Fasted Conditions

Bioequivalency

United States
Guangzhou Zhiyi Biotechnology Co., Ltd.

Completed

A Sequential Single and Multiple Ascending Dose (SAD/MAD) Study of SK10 Powders in Healthy Adult Subjects

Chemotherapy-induced Diarrhea

United States
Madrigal Pharmaceuticals, Inc.

Active, not recruiting

A Phase 3 Study to Evaluate the Efficacy and Safety of MGL-3196 (Resmetirom) in Patients With NASH and Fibrosis (MAESTRO-NASH)

NASH - Nonalcoholic Steatohepatitis

United States, Spain, Australia, United Kingdom, Canada, Israel, Belgium, Italy, France, Puerto Rico, Switzerland, Germany, Austria, Poland, Mexico, Hungary
University of Chicago

Active, not recruiting

Plasma 5hmC Signatures as a Marker of Colorectal / Appendiceal Peritoneal Metastasis

Colorectal Cancer Metastatic | Colorectal Cancer Stage IV | Appendix Cancer | Colorectal Cancer, Genetics of

United States
Sanofi

Active, not recruiting

Phase 1/2 Study of Amcenestrant (SAR439859) Single Agent and in Combination With Other Anti-cancer Therapies in Postmenopausal Women With Estrogen Receptor Positive Advanced Breast Cancer (AMEERA-1)

Breast Cancer

Czechia, Belgium, Spain, United States, France, Canada, Italy, Poland, Portugal, United Kingdom
New Approaches to Neuroblastoma Therapy Consortium
Pfizer; University of Southern California; Cookies for Kids' Cancer; The Evan Foundation and other collaborators

Active, not recruiting

NANT 2015-02: A Phase 1 Study of Lorlatinib (PF-06463922)

Neuroblastoma

Canada, United States, France, United Kingdom
Hoffmann-La Roche

Completed

A Study in Healthy Volunteers and in Participants With Chronic Hepatitis B to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of RO7020531

Hepatitis B, Chronic

Thailand, Taiwan, United Kingdom, Hong Kong, Netherlands, New Zealand, Bulgaria, Italy
University of Michigan Rogel Cancer Center

Withdrawn

Phase IV Multi-arm Study of CDK4/6 Pharmacokinetics in Healthy Volunteers With Known CYP3A4*22 Genotype

CYP3A4*22
Ethicon Endo-Surgery

Completed

A Prospective, Single-Arm Multi-Center Study of the ENSEAL X1 Curved Jaw Tissue Sealer in Select Procedures

Upper GI; Lower GI; Gynecological

United Kingdom, United States, Italy
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI); Canadian Cancer Trials Group

Active, not recruiting

PROSPECT: Chemotherapy Alone or Chemotherapy Plus Radiation Therapy in Treating Patients With Locally Advanced Rectal Cancer Undergoing Surgery

Colorectal Cancer

United States, Canada, Israel, Switzerland
Actelion

Completed

A Clinical Study to Investigate the Long-term Safety of the Drug Macitentan in Patients With Pulmonary Hypertension Who Were Previously Treated With Macitentan in Clinical Studies. (UMBRELLA)

Pulmonary Arterial Hypertension | Chronic Thromboembolic Pulmonary Hypertension

Belgium, France, Poland, Russian Federation, Belarus, Turkey, Ukraine
Aelis Farma
European Commission

Completed

AEF0217 First-in-Human Phase I Study in 3 Parts (Single and Multiple Ascending Doses, and Food Effect) in Healthy Subjects. (AEF0217-101)

Safety, Tolerability, Pharmacokinetics of AEF0217

Spain
Baylor College of Medicine
Center for Cell and Gene Therapy, Baylor College of Medicine

Active, not recruiting

A Phase I/II Study Of Immunization With Lymphotactin And Interleukin 2 Gene Modified Neuroblastoma Tumor Cells (CHESAT)

Neuroblastoma

United States
Lundquist Institute for Biomedical Innovation at...

Completed

Inspiratory Muscle Therapy in Subjects With Fontan Circulations

Single-ventricle
Oneness Biotech Co., Ltd.

Active, not recruiting

A Study to Evaluate the Safety and Bridging PK Profile of FB825 for Single Subcutaneous Administration in Healthy Adults

Atopic Dermatitis

United States
Jeong Eon Lee
Asan Medical Center; Seoul National University Hospital; Gangnam Severance Hospital and other collaborators

Active, not recruiting

Selective Avoidance of Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy In HER-2 Positive/Triple Negative Breast Cancer Patients With Excellent Radiologic Response to the Breast and Axilla, Prospective, Multi-center, Single-arm (ASLAN) Study (ASLAN)

Breast Cancer

Korea, Republic of
Eli Lilly and Company
ARMO BioSciences

Active, not recruiting

A Phase 1 Study of Pegilodecakin (LY3500518) in Participants With Advanced Solid Tumors (IVY)

Melanoma | Renal Cell Carcinoma | Breast Cancer | Ovarian Cancer | Prostate Cancer | Non-small Cell Lung Carcinoma | Solid Tumors | Colorectal Carcinoma | Pancreatic Carcinoma

United States
Pfizer

Completed

A Phase II Study of Single Agent MEK162 in Patients With Advanced Melanoma

BRAF or NRAS Mutant Metastatic Melanoma

United States, Netherlands, Italy, Germany, Switzerland
Eli Lilly and Company
Loxo Oncology, Inc.

Completed

A Study of Effect of Multiple Doses of LOXO-305 on the Pharmacokinetics of Single Oral Doses of CYP1A2, CYP2C9, CYP2C19 Substrates in Healthy Participants

Healthy

United States
Novartis Pharmaceuticals

Terminated

A Study of BLZ945 Single Agent or BLZ945 in Combination With PDR001 in Advanced Solid Tumors

Advanced Solid Tumors

Spain, Japan, Taiwan, Italy, Switzerland, Israel, United States, Singapore
Centre Hospitalier Universitaire Dijon

Terminated

A Multicenter Phase 2 Single-arm Proof-of-concept Trial to Assess the Efficacy and Safety of Ustekinumab in Association With Prednisone for the Treatment of Non-infectious Severe Uveitis (NISU) (USTEKINISU)

Patients With Newly Diagnosed Active NISU

France
Umeå University

Completed

TARA for Medical Students, a Single-arm Mixed Methods Pilot Study (TARA)

Depression | Anxiety | Stress-related Problem

Sweden
Sanofi

Completed

A First-in-human Single and Repeated Dose Escalation Study of SAR442501 in Healthy Adults Subjects

Osteochondrodysplasia

United States
Haisco Pharmaceutical Group Co., Ltd.

Completed

Ascending Single-Dose and Multiple-Dose Study to Evaluate HSK31679 in Healthy Subjects and Subjects With Elevated LDL-C

Healthy | Elevated LDL-C

China
ETOP IBCSG Partners Foundation
National Cancer Institute (NCI); NCIC Clinical Trials Group; Cancer and Leukemia... and other collaborators

Active, not recruiting

Suppression of Ovarian Function With Either Tamoxifen or Exemestane Compared With Tamoxifen Alone in Treating Premenopausal Women With Hormone-Responsive Breast Cancer (SOFT)

Recurrent Breast Carcinoma | Stage IIIA Breast Cancer | Stage IA Breast Cancer | Stage IB Breast Cancer | Stage IIA Breast Cancer | Stage IIB Breast Cancer | Estrogen Receptor Positive Breast Cancer | Progesterone Receptor Positive Tumor

United States, Canada, Switzerland
The First Affiliated Hospital of Soochow University

Withdrawn

An Open Label, Single-arm Clinical Study Evaluating the Safety and Efficacy of ICI201 Infusion in Relapsed/Refractory Multiple Myeloma

Relapsed/Refractory Multiple Myeloma

China
TenNor Therapeutics (Suzhou) Limited

Completed

A Phase 1, Single-center, Double-blind, Placebo-controlled Study of TNP-2092 Capsules, and the Food Effect Study After Single-dose Oral Administration of TNP-2092 Capsules

Hyperammonemia

China
BioMarin Pharmaceutical

Active, not recruiting

Single-Arm Study To Evaluate The Efficacy and Safety of Valoctocogene Roxaparvovec in Hemophilia A Patients (BMN 270-301) (BMN 270-301)

Hemophilia A

United States, Taiwan, United Kingdom, Australia, Israel, Belgium, Brazil, France, Germany, Italy, Korea, Republic of, South Africa, Spain
Pfizer

Completed

Dose Escalation Study of PF-07209326 in Healthy Participants and Participants With Sickle Cell Disease

Healthy | Sickle Cell Anemia

United States
NYU Langone Health
Leap Therapeutics, Inc.

Terminated

A Parallel Arm Phase 1b/2a Study of DKN-01 as Monotherapy or in Combination With Docetaxel for the Treatment of Advanced Prostate Cancer With Elevated DKK1

Prostate Cancer

United States
Atrogi AB
Key2Compliance; CRS Clinical Research Services

Completed

First-in-human Single and Multiple Dose Trial of ATR-258

Type 2 Diabetes Mellitus

Germany
Sanofi Pasteur, a Sanofi Company

Completed

A Phase I, Randomized, Modified Single-blind, Active-controlled (Infants Only), Four-stage, Step-down, Comparative, Multi-center Study

Meningococcal Immunization
Boston Scientific Corporation

Terminated

Trial for A Novel Facilitated Antegrade Steering Technique in Revascularization of Coronary Chronic Total Occlusions

CAD

China
Shanghai HEP Pharmaceutical Co., Ltd.

Completed

A Phase II Study of Hepalatide in Subjects With Chronic Hepatitis B

Hepatitis B, Chronic

China
Novartis Pharmaceuticals

Terminated

Phase I-Ib/II Study of MBG453 as Single Agent and in Combination With PDR001 in Patients With Advanced Malignancies

Advanced Malignancies

Taiwan, Netherlands, Italy, Korea, Republic of, Japan, United States, Switzerland, Canada, Singapore
Chinese PLA General Hospital
Dalian Zhen-Ao Bio-Tech Co., Ltd.

Active, not recruiting

A Randomized, Single-blind, Controlled Clinical Study of Cardiomyopeptidin on Improving Ischemia-reperfusion Injury in Patients With Acute ST-segment Elevation Myocardial Infarction After Primary PCI

Cardiovascular Diseases

China
Bayer

Terminated

Study of Copanlisib in Combination With Standard Immunochemotherapy in Relapsed Indolent Non-Hodgkin's Lymphoma (iNHL) (CHRONOS-4)

Lymphoma, Non-Hodgkin

United States, Hungary, China, Belgium, Korea, Republic of, France, Australia, Russian Federation, Taiwan, Denmark, Japan, United Kingdom, Spain, South Africa, Turkey, Romania, Singapore, Israel, Ireland, Canada, Poland, Greece, Cze... and more
Centre Francois Baclesse
Association de Neuro-Oncologues d'Expression Francaise

Active, not recruiting

Stereotactic Radiotherapy in Oligometastatic Brain Disease: a Randomised Phase III Study Comparing Hypofractionated Stereotactic Radiation Therapy (3*10 Gy) to the Historical Single-dose Radiosurgery (1*20 to 25 Gy) With Medico-economic Evaluation. (OligoBM-01)

Brain Metastasis | Oligoprogression

France
Abcuro, Inc.

Active, not recruiting

A Phase 1 Study of ABC008 in Ascending (Single Ascending Dose/Multiple Ascending Dose) Study in Patients With (IBM)

Inclusion Body Myositis

Australia
Dr. Reddy's Laboratories Limited
PPD

Completed

A Phase III Transition Study of DRL Rituximab to Reference Medicinal Products (RI-01-007)

Rheumatoid Arthritis

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

A Phase I Study of SOR-C13 in Patients With Advanced Solid Tumors

Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Refractory Pancreatic Carcinoma | Stage II Pancreatic Cancer AJCC v8 | Stage III Pancreatic Cancer AJCC v8 | Stage IV Pancreatic Cancer AJCC v8 | Stage IV Prostate Cancer AJCC v8 | Stage IIIA Prostate Cancer AJCC v8 | Stage IIIB... and other conditions

United States
Raziel Therapeutics Ltd.

Completed

A Single Blind, Randomized, Placebo-controlled, Phase 2a, 2-cohort Study for the Evaluation of Safety and Efficacy of RZL-012 for Submental Fat Reduction in Healthy Volunteers.

Submental Fat

United States
PHARMENTERPRISES LLC

Completed

Double-blind, Randomized, Placebo-controlled Study of the Safety, Tolerability and Pharmacokinetics of Ascending Doses of XC243 After Single and Multiple Oral Administration in Healthy Volunteers.

Healthy Volunteers

Russian Federation
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Jiangsu HengRui Medicine Co., Ltd.

Active, not recruiting

Phase II Neoadjuvant Pyrotinib Combined With Neoadjuvant Chemotherapy in HER2-low-expressing and HR Positive Early or Locally Advanced Breast Cancer: a Single-arm, Non-randomized, Single-center, Open Label Trial

Breast Cancer | Neoadjuvant Therapy | Hormone Receptor-positive Breast Cancer | HER2-low-expressing Breast Cancer

China
Nang Kuang Pharmaceutical Co., Ltd.

Suspended

A Phase I Dose-escalation Study of a Single Administration of Extended-Release Injectable Suspension (ND-340)

Pain, Postoperative

Taiwan
UNICANCER
Sanofi; European Organisation for Research and Treatment of Cancer - EORTC; I... and other collaborators

Active, not recruiting

A Phase III Study for Patients With Metastatic Hormone-naïve Prostate Cancer (PEACE1)

Metastatic Prostate Cancer

France, Ireland, Spain, Switzerland, Belgium, Italy, Romania
Bio-Thera Solutions

Active, not recruiting

A Randomized, Double-blind, Single-dose, Two-arm Parallel Study to Compare the Pharmacokinetics and Safety of BAT1806 Prefilled Subcutaneous Injection With RoActemra® in Healthy Chinese Male Subjects

Healthy Men

China
Taisho Pharmaceutical Co., Ltd.

Completed

A Phase I Study of TS-142 in Healthy Participants (Single Doses)

Healthy Volunteer

Japan
Innovent Biologics (Suzhou) Co. Ltd.

Completed

A Phase Ia/Ib Study of IBI315 in Patients With HER2-expressing Advanced Solid Tumor

Advanced Solid Tumor

China
Luye Pharma Group Ltd.
Parexel

Completed

A Pharmacokinetic Similarity Study in Healthy Male Subjects to Evaluate Pharmacokinetics, Pharmacodynamics, Safety and Immunogenicity of LY06006 Versus US-Prolia and EU-Prolia by Single-dose Subcutaneous Injection

Healthy

Germany

Search clinical trials for: Single arm phase IIa study

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