Search clinical trials for: severe

Total 8583 results

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Recruiting

A Clinical Study of TQH2722 Injection in the Treatment of Moderate to Severe Atopic Dermatitis

Atopic Dermatitis

China
Mazandaran University of Medical Sciences

Recruiting

Baricitinib Versus Azathioprine in Patients With Moderate-to-Severe Atopic Dermatitis

Atopic Dermatitis

Iran, Islamic Republic of
Laboratoires Thea

Recruiting

Comparison of the Performance and Safety of T2769 Versus Vismed® Multi in the Treatment of Moderate to Severe Dry Eye Syndrome

Dry Eye

France
Henan Cancer Hospital

Recruiting

Real World Study of Oxycodone Sustained-release Tablets for Patients With Moderate to Severe Cancer Pain

Cancer Pain | Oxycodone | Real-world Study

China
Changping Laboratory

Recruiting

pBFS-guided High-dose TMS Over DMPFC for Treatment-resistant Major Depressive Disorder

Depression | Major Depressive Disorder | Severe Depression

China
Aptarion Biotech AG

Recruiting

Safety and Efficacy of AON-D21 in Severe Community-Acquired Pneumonia.

Community-acquired Pneumonia

Belgium, United Kingdom, Germany, France, Spain
Sun Yat-sen University

Recruiting

Cetuximab and Envafolimab Plus mFOLFOXIRI as First-line Treatment for RAS/BRAF Wild-type, MSS, Unresectable Left-side Metastatic Colorectal Cancer (CEIL)

Metastatic Colorectal Cancer

China
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Acceptance and Effectiveness of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) Vaccination in Systemic Sclerosis Patients Treated by Autologous Hematopoietic Stem Cell Transplantation (COV2-VACCinSSc)

Systemic Sclerosis | SARS-CoV 2 Vaccination
AbbVie

Recruiting

An Observational Study to Validate the Cumulative Life Course Impairment (CLCI) Instrument (DermCLCI-p) in Adult Participants With Moderate to Severe Chronic Plaque Psoriasis (PsO) (IMMagine)

Psoriasis

Canada, Belgium, Germany
LEO Pharma

Recruiting

A 32-week Trial to Evaluate the Efficacy and Safety of Tralokinumab in Subjects With Moderate-to-severe Atopic Hand Eczema Who Are Candidates for Systemic Therapy (ADHAND)

Atopic Dermatitis | Atopic Hand Eczema

United States, Canada, United Kingdom, Korea, Republic of
Changping Laboratory

Not yet recruiting

pBFS Guided 20min Inter-session Interval rTMS Treatment for MDD

Major Depressive Disorder | Severe Depression | Moderate Depression
Hospital Departamental de Villavicencio
Cooperative University of Colombia

Not yet recruiting

Trauma Registry in Villavicencio, Colombia (TRaVi)

Trauma | Severe Trauma | Polytrauma | Registries | Trauma Blunt | Penetrating Wounds

Colombia
Hope Biosciences
The University of Texas Health Science Center, Houston

Recruiting

Autologous Adipose Derived Mesenchymal Stem Cells for Chronic Traumatic Brain Injury

Traumatic Brain Injury

United States
Apreo Health, Inc.

Recruiting

Study to Assess Safety, Feasibility, and Preliminary Efficacy of the Apreo Implant for Severe Emphysema (BREATHE-2)

Emphysema or COPD

United Kingdom, Austria, Netherlands
Vertex Pharmaceuticals Incorporated

Not yet recruiting

Evaluation of Efficacy and Safety of a Single Dose of Exa-cel in Participants With Severe Sickle Cell Disease, βS/βC Genotype

Sickle Cell Disease
60P Australia Pty Ltd

Not yet recruiting

A Clinical Evaluation of the Safety and Efficacy of Randomized Placebo Versus the 8-aminoquinoline Tafenoquine for Early Symptom Resolution in Patients With Mild to Moderate COVID 19 Disease and Low Risk of Disease Progression

Infectious Disease | SARS-CoV-2 | Severe Acute Respiratory Syndrome Coronavirus 2 | COVID 19 Disease | Mild to Moderate COVID 19 Disease
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Manufacturing of Allogeneic Adipose Tissue-derived Mesenchymal Stromal Cells for Treatment of Severe Systemic Sclerosis (Pre_MSC-AT-SSc)

Systemic Sclerosis | Mesenchymal Stromal Cell
BioAegis Therapeutics Inc.

Not yet recruiting

Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)

Infections | Acute Respiratory Distress Syndrome
Lisbon Institute of Global Mental Health - LIGMH
Columbia University

Recruiting

Critical Time Intervention-Peer Support (CTI-PS)

Psychotic Disorders | Schizophrenia | Bipolar Disorder | Schizo Affective Disorder

Portugal
AusDiagnostics Pty Ltd.

Not yet recruiting

Clinical Evaluation of SARS-COV-2 (COVID-19), Influenza and RSV 8-Well MT-PCR Panel for In Vitro Diagnostics

Respiratory Viral Infection
Azienda Ospedaliera Universitaria Policlinico Paolo...

Recruiting

The BASA Study: Breath Analysis for Severe Asthma Patients

Severe Asthma

Italy
Medstar Health Research Institute

Not yet recruiting

Biomarkers in Concussion

Concussion, Mild | Concussion, Severe | Concussion, Intermediate
Poznan University of Medical Sciences

Recruiting

Erector Spinae Plane Block for Pediatric Idiopathic Scoliosis Surgery (ESPB)

Scoliosis Idiopathic

Poland
University Hospital, Ghent

Recruiting

Real Life Study of Biologicals in Patients With Severe CRSwNP (NASUMAB)

Chronic Rhinosinusitis With Nasal Polyps

Belgium
Central Hospital, Nancy, France

Not yet recruiting

Sequencing of 14 Genes From Leptin Melanocortin Pathway in Severe Obesity in Childhood. (OBEGEN)

Obesity, Child
Saglik Bilimleri Universitesi

Recruiting

Adductor Ratio in Severe Varus Gonarthrosis

Osteoarthritis, Knee | Genu Varum | Joint Prosthesis; Complications

Turkey
Aqualung Therapeutics Corp.

Not yet recruiting

Study of Safety and Efficacy of ALT-100mAb in Participants With Moderate/Severe ARDS

Acute Respiratory Distress Syndrome (ARDS)
Hospital Departamental de Villavicencio
Cooperative University of Colombia

Recruiting

Severe Dengue in Critical Care at Villavicencio, Colombia.

Severe Dengue

Colombia
Chinese PLA General Hospital

Recruiting

Efficiency and Safety of Paxlovid for COVID-19 Patients With Severe Chronic Kidney Disease (ESPTCSCKD)

COVID-19 | Renal Insufficiency, Chronic

China
Italian Academy of Rhinology
Accademia Italiana di Citologia Nasale

Recruiting

Rhinosinusitis Italian Network: the Italian Registry for Severe, Uncontrolled Chronic Rhinosinusitis (RINET)

Chronic Rhinosinusitis

Italy
Octapharma

Recruiting

Nuwiq for Perioperative Management Of Patients With Haemophilia A on Emicizumab Regular Prophylaxis Study (NuPOWER)

Severe Hemophilia A

Spain, Croatia, Italy, North Macedonia, Serbia
AnaptysBio, Inc.

Recruiting

This Study Will Evaluate the Safety, Tolerability, and Efficacy of ANB032 in Subjects With Moderate to Severe Atopic Dermatitis (AD).

Atopic Dermatitis Eczema

Georgia, United States, Australia, Canada, Czechia, New Zealand, Poland
University of California, San Francisco
Centre de Recherche en Sante de Nouna, Burkina Faso

Recruiting

Mother Screening for Relapse Using Mid-upper Arm Circumference Among Children Recovered From Severe Acute Malnutrition

Severe Acute Malnutrition

Burkina Faso
AbbVie

Recruiting

Study to Assess Speed of Onset and Durability of Effectiveness of Upadacitinib in Adult Participants With Moderate to Severe Crohn's Disease (CD) in Real World Clinical Practice. (UPlift)

Crohn's Disease

Australia, France, Germany, Canada, Greece, Hungary, Japan
University Hospital, Clermont-Ferrand

Recruiting

Evaluation of the Impact of an Expert Opinion During the Management of Patients With Severe Bleeding on Oral Anticoagulants. (BANET)

Hemorrhage

France
University of Calgary
Alimentiv Inc.

Recruiting

PATHFINDER: Evaluating the Optimal First-Line Treatment Strategy for Moderate-to-Severely Active Ileal-dominant Crohn's Disease

Crohn Disease

Canada
Centre de Recherche Médicale de Lambaréné
Institute of Tropical Medicine, University of Tuebingen

Not yet recruiting

A Crossover Bioavailability Clinical Trial of Parenteral Pyronaridine and Artesunate

Severe Malarial Treatment

Gabon
Janssen Research & Development, LLC

Recruiting

A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease (MACARONI-23)

Crohn's Disease

Poland, United States, Japan, Spain, Norway
Novartis Pharmaceuticals

Recruiting

Long Term Observational Study to Collect in a Real-world populatIon Data on the Treatment Pattern of secukinumAb in Adult Patients With Moderate to Severe Hidradenitis Suppurativa. (ANIMA)

Hidradenitis Suppurativa

Germany
LEO Pharma

Recruiting

A Trial to Evaluate the Efficacy and Safety of Different Doses of LEO 138559 in Adults With Moderate-to-severe Atopic Dermatitis

Atopic Dermatitis

United States, Canada, France, Germany, Japan, Poland, United Kingdom, Czechia, Spain, Romania, Hungary
University Hospital, Grenoble
University Hospital, Clermont-Ferrand

Recruiting

EffecT of eARly analGesia With Erector Spinae Plane Block to Reduce Ventilation After Severe Chest Trauma (TARGET)

Severe Chest Trauma

France
Xue-chun Lu

Recruiting

Combination Regimen With Sodium Valproate for Severe Hemophilia: a Single-arm, Phase 1, Pilot Trial.

Hemophilia

China
Rush University Medical Center
Hospital Civil de Guadalajara

Recruiting

Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients

Obesity, Morbid | Extubation Failure

United States, Mexico
AstraZeneca

Recruiting

A Phase I Study to Investigate the Effect of Hepatic Impairment on the PK, Safety, and Tolerability of AZD2693

Hepatic Impairment

United States
Yi Han
Qianfoshan Hospital

Recruiting

Study on the Correlation Between NAT2(N-acetyltransferase2) Gene Polymorphism and CrCl(Creatine Clreance) and the Efficacy and Safety of Levosimendan in Patients With Severe Heart Failure

Heart Failure | Efficacy | Safety | Levosimendan

China
Xijing Hospital of Digestive Diseases

Not yet recruiting

Autologous Platelet-rich Plasma (PRP) and Thrombin Coagulum for the Topical Treatment of Rectal Mucosal Ulcers

Ulcerative Colitis Chronic Moderate | Ulcerative Colitis Chronic Severe | Rectal Ulcer

China
Eli Lilly and Company

Recruiting

A Study of LY3454738 in the Treatment of Adult Participants With Moderate-to-Severe Atopic Dermatitis

Atopic Dermatitis

Taiwan, China, Canada, United States, Hungary, Mexico, Poland, Japan, Korea, Republic of
Janssen Research & Development, LLC

Recruiting

A Study of Nipocalimab in Pregnancies at Risk for Severe Hemolytic Disease of the Fetus and Newborn (HDFN) (AZALEA)

Hemolytic Disease of the Fetus and Newborn

Israel, Japan, Australia, United States, United Kingdom, Brazil
Valve Medical

Recruiting

FIH Study of the GEMINUS TAVI System in Patients With Severe Symptomatic Aortic Stenosis

Aortic Valve Stenosis

Israel
Hellenic Institute for the Study of Sepsis

Recruiting

Assessing the Procalcitonin-guidance and Molecular-guided Diagnosis for Therapy of Severe Infections (the MODIFY Trial) (MODIFY)

Sepsis

Greece

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