Search clinical trials for: Genetically attenuated parasites

Total 957 results

National Institute of Allergy and Infectious Diseases...

Completed

Preventing the Spread of Malaria in Mali

Malaria

Mali
GlaxoSmithKline
Merck Sharp & Dohme LLC

Withdrawn

Clinical Trial of Safety, Tolerability and Antitumor Activity of Genetically Engineered T Cells in Combination With Anti-Cancer Agents in Relapsed and Refractory Synovial Sarcoma Expressing New York Esophageal Antigen-1 (NY-ESO-1) and/or LAGE-1a

Neoplasms
Centre for Infectious Disease Research in Zambia
Imperial College London; Christian Medical College, Vellore, India

Completed

Development of a Live Attenuated Rotavirus Vaccine as a Human Infection Challenge Model

Diarrhoeal Disease

Zambia
University Hospital, Strasbourg, France

Completed

MRIPositive Diagnosis of Vestibular Neuritis Using Fluid Attenuated Inversion Recuperation (FLAIR) Sequence on a 1.5 Tesla

Vestibular Neuritis

France
Universiteit Antwerpen
European Research Council

Completed

Ivermectin Treatment of Persons With Onchocerciasis-associated Epilepsy (OAETREATe)

Epilepsy

Congo, The Democratic Republic of the
Sangamo Therapeutics

Completed

Study of Autologous T-cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases in HIV-Infected Subjects

HIV Infection | HIV

United States
London School of Hygiene and Tropical Medicine
Murdoch Childrens Research Institute; Kirby Institute; Atoifi Adventist Hospital...

Completed

Azithromycin - Ivermectin Mass Drug Administration for Skin Disease (AIM-Skin)

Yaws | Scabies | Impetigo

Solomon Islands
U.S. Army Medical Research and Development Command
Bill and Melinda Gates Foundation; Seattle Children's Research Institute (SCRI)

Completed

Immunization Via Mosquito Bite With Radiation-attenuated Sporozoites (IMRAS)

Malaria

United States
Drugs for Neglected Diseases

Completed

Thermotherapy + a Short Course of Miltefosine for the Treatment of Uncomplicated Cutaneous Leishmaniasis in the New World¨

Cutaneous Leishmaniasis

Colombia, Peru
University of Pennsylvania

Completed

Redirected MazF-CD4 Autologous T Cells for HIV Gene Therapy (MazF)

HIV

United States
Valneva Austria GmbH

Completed

Study to Assess the Safety and Immunogenicity of a Chikungunya Virus Vaccine Candidate (VLA1553) in Healthy Volunteers

Chikungunya

United States
Public Health England

Completed

Assessment of Viral Shedding in Children Previously in Receipt of Multiple Doses of Live Attenuated Influenza Vaccine (LAIV) Compared to Influenza Vaccine-naïve Controls (Flushed)

Influenza | Vaccination | Influenza Vaccination

United Kingdom
Aurobindo Pharma Ltd
Axis Clinicals Limited

Completed

Steady State Global Bioequivalence Study of Amphotericin B Liposome for Injection 50 mg/ Vial in Fed Condition

Visceral Leishmaniasis

Bangladesh, India
International Centre for Diarrhoeal Disease Research...
Thrasher Research Fund

Completed

Miltefosine for Children With PKDL

Post Kala Azar Dermal Leishmaniasis

Bangladesh
Janssen Research & Development, LLC

Completed

Safety & Immunogenicity of JNJ-64041809, a Live Attenuated Double-deleted Listeria Immunotherapy, in Participants With Metastatic Castration-resistant Prostate Cancer

Prostatic Neoplasms, Castration-Resistant

United States
Florida A&M University

Completed

Intervention of Attenuated Psychosis Syndrome With M-Health Technology

Adolescent - Emotional Problem

China
Federico II University

Enrolling by invitation

Risk Factors for the Development of Celiac Disease in Genetically Predisposed Children (NEOCEL)

Prevention of Clinical Symptoms in Celiac Disease

Italy
Sanofi Pasteur, a Sanofi Company

Completed

Study of a Tetravalent Dengue Vaccine in Healthy Adults in Australia

Dengue Fever | Dengue Hemorrhagic Fever

Australia
Edward Via Virginia College of Osteopathic Medicine

Completed

Veron Scabies Education and Eradication Program (VSEEP)

Scabies

Dominican Republic
National Institute of Allergy and Infectious Diseases...

Completed

Host Response to Infection and Treatment in Lymphatic Filarial Disease in India

Lymphatic Filarial Disease

India
M.D. Anderson Cancer Center
Bellicum Pharmaceuticals

Terminated

Donor Lymphocyte Infusion (DLI) of T-cells Genetically Modified With iCasp9 Suicide Gene

Leukemia | Myeloma | Myeloproliferative Diseases

United States
Assiut University

Unknown

Parasitological Evaluation of Fascioliasis in Clinically Suspected Patients .

Fascioliasis

Egypt
IRCCS San Raffaele
Orchard Therapeutics; Fondazione Telethon

Unknown

Gene Therapy for Transfusion Dependent Beta-thalassemia (TIGET-BTHAL)

Beta-Thalassemia

Italy
Vanderbilt University Medical Center

Completed

Genetically Determined Response to Atenolol in Patients With Persistent Atrial Fibrillation

Atrial Fibrillation

United States
London School of Hygiene and Tropical Medicine

Completed

Impact of Community Scabies Treatment on Head Lice Prevalence in the Solomon Islands

Head Lice | Scabies

Solomon Islands
Hospices Civils de Lyon

Completed

Immunoblotting and Goldmann-Witmer Coefficient for Ocular Toxoplasmosis (COPILOT)

Ocular Toxoplasmosis

France
Imperial College London
Public Health England

Completed

Safety of Nasal Influenza Immunisation in Children With Asthma (SNIFFLE-4)

Asthma
Indian Institute of Science
Wellcome Trust; PATH; University of Liverpool; National Institute of Mental Health...

Completed

A Prospective, Open Label Study of Human T Cell Responses to Live Attenuated Japanese Encephalitis Vaccine SA14-14-2

Japanese Encephalitis | Japanese Encephalitis Vaccine

India
University Hospitals Cleveland Medical Center

Completed

Efficacy of Ivermectin and Albendazole Against Onchocerciasis in the Volta Region, Ghana

Onchocerciasis

Ghana
PATH
Institute of Experimental Medicine, Russia; Research Institute of Influenza... and other collaborators

Completed

Safety Trial of Live Attenuated Influenza (H7N3) Vaccine

Influenza | Avian Influenza

Russian Federation
Chinese PLA General Hospital

Unknown

Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD22

Recurrent Adult Diffuse Large Cell Lymphoma | Recurrent Grade 1 Follicular Lymphoma | Recurrent Grade 2 Follicular Lymphoma | Recurrent Grade 3 Follicular Lymphoma | Recurrent Mantle Cell Lymphoma | Hematopoietic/Lymphoid Cancer | Adult Acute Lymphoblastic Leukemia in Remission | Prolymphocytic Leukemia and other conditions

China
Götz Thomalla, MD
Else Kröner-Fresenius-Stiftung (Foundation); Stroke Imaging Repositoy (STIR); MR Stroke Group

Completed

Identification of Stroke Patients ≤ 3 and ≤ 4.5 Hours of Symptom Onset by Fluid Attenuated Inversion Recovery (FLAIR) Imaging and Diffusion Weighted Imaging (DWI) (PRE-FLAIR)

Acute Ischemic Stroke

Germany
University of Pennsylvania
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

A Phase I Study of T-Cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases SB-728mR in HIV-Infected Patients

Human Immunodeficiency Virus (HIV)

United States
Drugs for Neglected Diseases
London School of Hygiene and Tropical Medicine; Institute of Tropical Medicine... and other collaborators

Completed

Efficacy Trial of Ambisome Given Alone and Ambisome Given in Combination With Miltefosine for the Treatment of VL HIV Positive Ethiopian Patients.

Visceral Leishmaniasis

Ethiopia
Aduro Biotech, Inc.
Incyte Corporation

Terminated

Safety and Efficacy of CRS-207 With Epacadostat in Platinum Resistant Ovarian, Fallopian or Peritoneal Cancer (SEASCAPE)

Platinum-resistant Ovarian Cancer | Platinum-resistant Fallopian Cancer | Platinum-resistant Peritoneal Cancer

United States, Canada
Encube Ethicals Pvt. Ltd.
Novum Pharmaceutical Research Services

Completed

Multiple-Site Study to Evaluate the Therapeutic Equivalence of Permethrin Cream, 5% in the Treatment of Scabies

Scabies

United States, El Salvador, Puerto Rico
National Institute of Allergy and Infectious Diseases...

Completed

A Study in Healthy Adults to Assess Priming With Antigenically Mismatched Live Attenuated A/H7N3 Influenza Virus Vaccine Followed by Inactivated A/H7N9 Influenza Virus Vaccine

Influenza

United States
NIZO Food Research
FrieslandCampina

Completed

The Protective Immune Response to Attenuated Enterotoxigenic Escherichia Coli Infection (MIRRE)

Diarrhea

Netherlands
Gilead Sciences

Completed

Sofosbuvir/Velpatasvir Fixed Dose Combination for 12 Weeks in Adults With Chronic Hepatitis C Virus (HCV) Infection

Hepatitis C Virus Infection

India
St. Louis University
MedImmune LLC

Completed

Live Attenuated Influenza Vaccine (LAIV) Versus Trivalent Inactivated Influenza Vaccine in Healthy Adults 18-49 Years

Influenza
Knight Therapeutics (USA) Inc

Completed

Spermiogram Assessment in Bolivian Patients Taking Impavido® (Miltefosine) for Mucocutaneous Leishmaniasis

Mucocutaneous Leishmaniasis

Bolivia
Lihir Medical Centre
London School of Hygiene and Tropical Medicine

Completed

Safety of Co-administration of IDA and Azithromycin for NTDs ( ComboNTDs )

Yaws | Scabies | Lymphatic Filariases | Trachoma | Strongyloidiasis

Papua New Guinea
Institut de Recherche pour le Developpement

Completed

Treatment of Pediculosis (Head Lice) in Senegal (IVERAZITH)

Pediculoses

Senegal
Gilead Sciences

Completed

Safety and Efficacy of Sofosbuvir/Velpatasvir/Voxilaprevir Fixed-Dose Combination With or Without Ribavirin in Participants With Chronic Genotype 1 HCV Infection Previously Treated With a Direct Acting Antiviral Regimen

Hepatitis C Virus Infection

United States
GlaxoSmithKline

Completed

A Trial of a Walter Reed Army Institute of Research (WRAIR) Live Attenuated Virus Tetravalent Dengue Vaccine in Healthy US Adults

Dengue

United States
PATH
Institute of Experimental Medicine, Russia; Research Institute of Influenza...

Completed

Immunogenicity of H5N1 Vaccine Following H5N2

Influenza Vaccine

Russian Federation
Fundação de Medicina Tropical Dr. Heitor Vieira...

Completed

Efficacy and Safety of Pentamidine (7mg/kg) for Patients With Cutaneous Leishmaniasis Caused by L. Guyanensis

Cutaneous Leishmaniases
Institute of Tropical Medicine, Belgium
Drugs for Neglected Diseases; Medecins Sans Frontieres, Netherlands; Addis Ababa... and other collaborators

Completed

Prophylaxis of Visceral Leishmaniasis Relapses in HIV Co-infected Patients With Pentamidine: a Cohort Study

HIV-infection/Aids | Visceral Leishmaniosis

Ethiopia
PATH

Completed

Live Attenuated ETEC Vaccine ACE527 With and Without dmLT Adjuvant in Adults

Diarrhea

United States
PATH
Mahidol University; Ministry of Health of Sri Lanka; Quintiles Singapore

Completed

Live Attenuated Japanese Encephalitis (JE) Vaccine Coadministered With Measles Vaccine in Infants 9 Months of Age (JEV03)

Japanese Encephalitis

Sri Lanka

Search clinical trials for: Genetically attenuated parasites

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