Search clinical trials for: OX40 ligand (OX40)

Total 595 results

Maastricht University Medical Center

Unknown

Haploidentical Bone Marrow Stem Cell Transplantation in Patients With Multiple Myeloma

Multiple Myeloma

Netherlands
Invion, Inc.

Completed

Efficacy and Safety of Βeta-adrenoceptor Inverse Agonist and Biased Ligand, Nadolol, In Smoking Cessation of Patients With Chronic Cough With or Without Airflow Obstruction

Smoking Cessation

United States
Nantes University Hospital
Chugai Pharmaceutical; French Innovative Leukemia Organisation

Completed

Efficacy of Gemtuzumab Ozogamycin for Patients Presenting an Acute Myeloid Leukemia (AML) With Intermediate Risk (LAM2006IR)

Acute Myeloid Leukemia

France
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Completed

Denileukin Diftitox in Treating Patients With Fludarabine-Refractory B-Cell Chronic Lymphocytic Leukemia

Leukemia

United States
Assiut University

Unknown

Neopterin Effects on Ischemic Stroke

Stroke

Egypt
Institut de Cancérologie de Lorraine

Completed

Prognostic Impact of Programmed Death Ligand-1 Expression in Advanced Endometrial Cancer

Endometrial Cancer
National University Hospital, Singapore

Unknown

Evaluation of PET/MRI Using a Somatostatin Analog Tracer as a Novel Approach to Detecting Pathology in High Risk TB-exposed Contacts

Tuberculosis, Pulmonary

Singapore
Southwest Hospital, China

Unknown

a Clinical Research of Sequential CAR-T Bridging HSCT in the Treatment of Relapse/Refractory B-cell Malignancies

Lymphoma, Large B-Cell, Diffuse | Leukemia, Lymphocytic, Chronic, B-Cell | Lymphoma，Malignant

China
VA Office of Research and Development

Completed

Effects of PPAR Ligands on Ectopic Fat Accumulation and Inflammation

Prediabetic State | Metabolic Syndrome X

United States
Astellas Pharma Global Development, Inc.
Yale University

Completed

A Positron Emission Tomography Occupancy Study Using Ligand [11C]AS2471907 and Following Oral Dosing of ASP3662

Healthy Volunteers | Pharmacokinetics of ASP3662 | Displacement of Radiotracer

United States
Children's Hospital Los Angeles

Completed

Unrelated Hematopoietic Stem Cell Transplantation(HSCT) for Genetic Diseases of Blood Cells

Granuloma | Anemia | Thrombocytopenia | Neutropenia | Sickle Cell Disease | Thalassemia | Niemann-Pick Disease | Wiskott-Aldrich Syndrome | Osteopetrosis | Fucosidosis | Chediak Higashi Syndrome | Hurler Disease

United States
Ligand Pharmaceuticals
Medpace, Inc.

Completed

A Comparison Study of the Bioavailability of a Capsule Formulation of LGD-6972 to an Oral Solution Formulation

Type 2 Diabetes Mellitus (T2DM)

United States
Weill Medical College of Cornell University

Withdrawn

Efficacy Study on the Transfer of Adenovirus With the CD40 Ligand Gene (AdcuCD40L) to Patients With Esophageal Carcinoma (cd40)

Esophageal Neoplasms
Weill Medical College of Cornell University
National Cancer Institute (NCI)

Withdrawn

Safety Study on the Transfer of the CD40 Ligand Gene (AdcuCD40L) to Patients With Esophageal Carcinoma

Esophageal Neoplasms

United States
Baylor College of Medicine
The Methodist Hospital Research Institute; Center for Cell and Gene Therapy...

Terminated

Treatment of B-CLL With Autologous IL2 and CD40 Ligand-Expressing Tumor Cells + Lenalidomide (TAIL)

B-cell Chronic Lymphocytic Leukemia

United States
Mayo Clinic

Completed

Role of CXCR2 Ligands/CXCR2 Biological Axis in Pancreatic Cancer

Pancreatic Cancer | Chronic Pancreatitis

United States
GlaxoSmithKline

Terminated

SPECT Investigation Of The NMDA Receptor System In Healthy Volunteers And Patients With Schizophrenia

Schizophrenia

Spain
Janssen Research & Development, LLC

Completed

A Study to Investigate the Regional Brain Kinetics of the Positron Emission Tomography Ligand 11C-MK-3168 and the Blocking of the Retention of the Ligand in the Human Brain by JNJ-42165279

Healthy

Belgium
Memorial Sloan Kettering Cancer Center
United States Department of Defense

Completed

Positron Emission Tomography (PET) Using Hormone Receptor Ligands in Breast Cancer

Breast Cancer

United States
Akdeniz University
Pamukkale University

Completed

Topical Ketoprofen Versus Placebo in Patients With Ankle Sprain

Ankle Sprain

Turkey
Ligand Pharmaceuticals

Completed

Safety and Tolerability Study of Oral LGD-6972 for Type 2 Diabetes Mellitus (L6972-02)

Type 2 Diabetes Mellitus

United States
Duke University

Terminated

Local Modulation of Immune Receptors to Enhance the Response to Dendritic Cell Vaccination in Metastatic Melanoma

Metastatic Melanoma

United States
University Hospital Erlangen

Completed

Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma

Melanoma (Skin)

Germany
National Cancer Institute (NCI)

Completed

Biological Therapy in Treating Patients With Metastatic Melanoma or Metastatic Kidney Cancer

Kidney Cancer | Melanoma (Skin)

United States
CERESPIR

Completed

Safety, Pharmacokinetics and Pharmacodynamics Study of Treatment With CHF 5074 in Healthy Young Male Subjects (CT01)

Alzheimer's Disease

United States
Alaunos Therapeutics

Completed

Adenoviral Vector Monotherapy or Combination With Chemotherapy in Subjects With Recurrent/Metastatic Breast Cancer.

Breast Cancer Nos Metastatic Recurrent

United States
Alaunos Therapeutics

Completed

Safety Study of Adenovirus Vector Engineered to Express hIL-12 in Combination With Activator Ligand to Treat Melanoma

Melanoma

United States
Ligand Pharmaceuticals
Medpace, Inc.; Beckloff Associates, Inc.

Completed

Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LGD-6972 in Healthy Subjects and Subjects With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

United States
Innovaderm Research Inc.

Completed

Effect of RANKL Inhibition on UV-induced Immunosuppression

Hypersensitivity, Delayed | Immunosuppression | Ultraviolet Rays | Immune Tolerance/Drug Effects

Canada
University of Southern California
National Cancer Institute (NCI)

Terminated

Vaccine Therapy Followed by Biological Therapy in Treating Patients With Stage III or Stage IV Melanoma

Melanoma (Skin)

United States
Lion Corporation
Osaka University; Nihon University; Tohoku University

Completed

Effects of Antioxidant Dentifrice on Gingivitis

Gingivitis

Japan
Chiesi Farmaceutici S.p.A.

Completed

Evaluation of Safety & Tolerability of Multiple Dose Regimens of CHF 5074 and Exploration of Effects on Potential Markers of Clinical Efficacy in Patients With Mild Cognitive Impairment - Open Label Extension (CT04 OLEP)

Alzheimer's Disease

United States, Italy
Baylor College of Medicine
The Methodist Hospital Research Institute; Center for Cell and Gene Therapy...

Completed

Treatment of B-Chronic Lymphocytic Leukemia (B-CLL) With Autologous CD40 Ligand and IL-2-Expressing Tumor Cells (PRIMAL)

Chronic Lymphocytic Leukemia (CLL)

United States
Pharmatech Oncology

Unknown

Denileukin Diftitox in Treating Patients With Non-Hodgkin's Lymphoma

Lymphoma | Leukemia

United States
Millennix

Unknown

Chemotherapy and Photodynamic Therapy in Treating Patients With Cutaneous T-Cell Lymphoma

Lymphoma

United States
Centre Hospitalier Universitaire Dijon

Withdrawn

Determination of the Nature of the Endogenous Ligand of TREM-1 and Its Use as a New Diagnostic Biomarker in Sepsis

Sepsis
Centocor Research & Development, Inc.

Completed

A Study of the Safety and Efficacy of Single-agent Carlumab (an Anti-Chemokine Ligand 2 [CCL2]) in Participants With Metastatic Castrate-Resistant Prostate Cancer

Prostate Cancer

United States, United Kingdom, Belgium, Russian Federation
Eastern Cooperative Oncology Group
National Cancer Institute (NCI); Southwest Oncology Group; Cancer and Leukemia...

Completed

flt3L in Treating Patients With Acute Myeloid Leukemia

Leukemia

United States
Jonsson Comprehensive Cancer Center
National Cancer Institute (NCI)

Completed

Denileukin Diftitox in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma

Lymphoma

United States
Ligand Pharmaceuticals

Completed

Dexamethasone Followed by Denileukin Diftitox in Treating Patients With Persistent or Recurrent T-Cell Lymphoma

Lymphoma | Drug/Agent Toxicity by Tissue/Organ

United States
Ligand Pharmaceuticals

Completed

Bexarotene in Treating Patients With Metastatic Breast Cancer

Breast Cancer

United States
Hadassah Medical Organization

Unknown

Modified Melanoma Vaccine for High Risk or Low Residual Disease Patients

Metastatic Disease | High Risk HLA-A2+ Melanoma
Fox Chase Cancer Center
Ligand Pharmaceuticals

Terminated

Phase II Trial to Evaluate the Efficacy of Topical Bexarotene Gel in Patients With Parapsoriasis

Parapsoriasis

United States
University Hospital, Clermont-Ferrand

Completed

Soluble Forms and Ligands of RAGE in ALI/ARDS (SoLiRAGE). (SoLiRAGE)

Acute Respiratory Distress Syndrome | Acute Lung Injury | Mechanical Ventilation

France
M.D. Anderson Cancer Center

Completed

Decitabine and Gemtuzumab Ozogamicin in Acute Myelogenous Leukemia and High-risk Myelodysplastic Syndrome

Myelodysplastic Syndrome | Acute Myelogenous Leukemia

United States
Duke University
National Cancer Institute (NCI)

Completed

Flt3L in Treating Patients With Metastatic Colorectal Cancer

Colorectal Cancer | Metastatic Cancer

United States
Pfizer

Completed

Efficacy And Safety Of Parecoxib 40mg vs. Ketoprofen 100mg In The Management Of Acute Renal Colic (NAP)

Pain

Brazil, Costa Rica, Chile, Ecuador, Honduras, Peru
Ligand Pharmaceuticals

Completed

Compare CE-Budesonide Nasal Solution & Rhinocort Aqua in an EEC Study of AR

Seasonal Allergic Rhinitis

Canada
Ligand Pharmaceuticals

Completed

Compare Captisol-Enabled (CE) Budesonide + Azelastine Nasal Solution and Rhinocort Aqua + Astelin in an Environmental Exposure Chamber (EEC) Study of Allergic Rhinitis

Seasonal Allergic Rhinitis

Canada
M.D. Anderson Cancer Center
Ligand Pharmaceuticals

Completed

Phase II Randomized Bilateral Comparison of Topical Targretin Gel 1% in Alopecia Areata

Alopecia Areata

United States

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