Search clinical trials for: Single and multiple ascending dose study

Total 479953 results

Eisai Co., Ltd.

Completed

A Single and Multiple Dose Study of Lemborexant in Healthy Chinese Participants

Healthy Volunteer

China
Amgen

Completed

Study to Evaluate the Pharmacokinetics of Single and Multiple Doses of Apremilast in Healthy Adult Male Korean Subjects

Pharmacokinetics

Korea, Republic of
Allena Pharmaceuticals

Completed

Study 102: Multiple Ascending Dose Study of ALLN-346 (Engineered Urate Oxidase) (MAD)

Hyperuricemia | Gout

United States
UCB Biopharma S.P.R.L.

Completed

A Study to Test the Safety and Tolerability of Single and Multiple Doses of Padsevonil in Adult and Elderly Study Participants

Elderly Study Participants | Adult Study Participants

United States
Larimar Therapeutics, Inc.
Veristat, Inc.; Metrum Research Group, LLC

Completed

Multiple Ascending Dose Study of CTI-1601 Versus Placebo in Subjects With Friedreich's Ataxia

Friedreich Ataxia

United States
Knopp Biosciences
Biogen

Completed

Dexpramipexole Japanese PK Study

Amyotrophic Lateral Sclerosis

United Kingdom
Neurocrine Biosciences
Takeda

Terminated

A TAK-831-1001, Single and Multiple Rising Dose Study in Healthy Participants

Schizophrenia, Cerebellar Ataxia

United Kingdom
Morphic Therapeutic, Inc

Completed

Study of MORF 057 to Evaluate Single and Multi Ascending Doses in Healthy Volunteers

Healthy Volunteers

United States
Galapagos NV

Completed

A Study to Evaluate the Effects of Single and Multiple Oral Doses of GLPG3970

Healthy | Psoriasis

Belgium, Moldova, Republic of, Ukraine
Shire

Completed

A Double-Blind, Multiple Ascending Dose Study to Assess Safety, Tolerability and Pharmacokinetics of DX-2930 in Hereditary Angioedema Participants

Hereditary Angioedema (HAE)

United States, Jordan, Italy
XOMA (US) LLC

Completed

An Open-Label Study of XOMA 358 in Patients With Hypoglycemia After Gastric Bypass Surgery (XOMA 358)

Hypoglycemia

United States
Kind Pharmaceuticals LLC

Completed

A Dose-escalation Study of AND017 in Healthy Subjects

Healthy Volunteers

Australia
Kiniksa Pharmaceuticals, Ltd.

Completed

Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Ascending Doses of KPL-404 in Healthy Subjects

Healthy Volunteers

Australia, United States
Auzone Biological Technology Pty Ltd
TIGERMED AUSTRALIA PTY LIMITED; CMAX Clinical Research Pty Ltd

Completed

A Study of TTYP01 in Healthy Adult Subjects

Healthy Adult Subjects

Australia
Hanmi Pharmaceutical Company Limited

Terminated

Multiple Ascending Dose Study of HM12460A in Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

United States
SecuraBio

Completed

IPI-145 Single Ascending, Multiple Ascending, Food Effect and Drug-Drug-Interaction Study

Healthy Volunteers

Netherlands
Pfizer

Completed

Clinical Study to Evaluate Pharmacokinetics and Safety of PF-06700841 After Single and Multiple Oral Doses as Modified Release Formulations

Healthy Participants

United States
Neurocrine Biosciences
Takeda

Completed

TAK-653 Escalating Single and Multiple Dose Study in Healthy Participants

Depressive Disorder

United Kingdom
Zambon SpA

Completed

A Study to Evaluate Pharmacokinetics, Safety and Tolerability of Single and Multiple Intravenous Doses of N-acetylcysteine (NAC) in Chinese Healthy Volunteers

Respiratory Tract Disorders

China
KoBioLabs
Novotech (Australia) Pty Limited

Completed

Study of Multiple Ascending Dose of KBL693 in Healthy Participants

Moderate to Severe Asthma

Australia
Biogen

Completed

Multiple Dose Study Of BIIB118 (PF-05251749) In Healthy Volunteers

Healthy Adult Subjects | Healthy Elderly Subjects

United States
Biogen

Completed

Safety, Tolerability and Pharmacokinetics of BIIB118 (PF-05251749)

Healthy

United States
Taisho Pharmaceutical R&D Inc.

Completed

A Single Ascending and Repeated Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TS-142 in Healthy Participants

Healthy Volunteers

United States
Ionis Pharmaceuticals, Inc.

Completed

A Phase 1/2a Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of IONIS-ENaCRx in Healthy Volunteers and Patients With Cystic Fibrosis

Cystic Fibrosis | Healthy Subjects

United Kingdom, Germany
Theravance Biopharma

Completed

Multiple Ascending Dose Study of TD-1439 in Healthy Adult and Elderly Subjects

Healthy Adults, Elderly Subjects

United States
Theravance Biopharma

Completed

Multiple Ascending Dose Study of TD-0714 in Healthy and Elderly Subjects

Healthy Adults, Elderly Subjects

United States
Youngene Therapeutics Inc., Ltd.

Completed

A Randomized, Double-blind, Placebo-controlled, Sequential Single and Multiple Ascending Doses of YG1699

Diabete Mellitus

United States
Pharmosa Biopharm Inc.
PPD

Completed

Single Ascending Dose Study for Evaluation of Safety, Tolerability and Pharmacokinetics of L606

Pulmonary Arterial Hypertension

United States
Innovent Biologics (Suzhou) Co. Ltd.

Completed

Single Ascending Dose Study of PCSK-9 Inhibitor (IBI306) in Healthy Subjects.

Hypercholesterolemia

China
Corcept Therapeutics

Completed

Single and Multiple Dose Study of Miricorilant (CORT118335) Tablet Formulations in Healthy Participants

Healthy

United Kingdom
Regeneron Pharmaceuticals

Completed

Single Ascending-dose Study of the Efficacy, Safety, Tolerability, and Pharmacokinetics of REGN1908-1909 in Allergic, Adult Participants

Allergy

United Kingdom, New Zealand, Netherlands, Sweden
AstraZeneca
Parexel

Terminated

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD6615 in Healthy Subjects

Dyslipidemia

United States
Novartis Pharmaceuticals

Completed

Single and Multiple Dose Escalation Study to Assess the Safety and Tolerability of CJM112 in Psoriasis

Chronic Plaque-type Psoriasis

United States
Novartis Pharmaceuticals

Completed

First-in-human Single Ascending Dose Study of LNA043 in Patients Scheduled for Total Knee Replacement

Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery

United States
Daiichi Sankyo, Inc.

Completed

A Phase 1 Multiple Ascending Dose Study of Milademetan in Subjects With Advanced Solid Tumors or Lymphomas

Lymphoma | Advanced Solid Tumor

United States
Novartis Pharmaceuticals

Completed

Clinical Study to Assess the Pharmacokinetics, Safety and Tolerability of Single and Multiple Oral Doses of AFQ056 in Children With Fragile X Syndrome (FXS)

Fragile X Syndrome

United States, Spain
Hanmi Pharmaceutical Company Limited

Completed

Single Ascending Dose Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM15912 in Healthy Korean Subjects

Pharmacology

Korea, Republic of
Arthrosi Therapeutics

Completed

The Study is Designed to Evaluate Single Ascending Doses of AR882 in Healthy Adult Males

Healthy Volunteers

Australia
Lee's Pharmaceutical Limited

Unknown

An Ascending, Multiple-Dose, Safety and Tolerability Study of Tecarfarin in Healthy Chinese Volunteers

Healthy Chinese Volunteers

China
Larimar Therapeutics, Inc.
Veristat, Inc.; Metrum Research Group, LLC

Completed

Single Ascending Dose Study of CTI-1601 Versus Placebo in Subjects With Friedreich's Ataxia

Friedreich Ataxia

United States
Heptares Therapeutics Limited

Completed

A Study in Healthy Subjects to Assess the Safety, Tolerability, PK and PD of HTL0030310

Healthy

United Kingdom
F-star Therapeutics, Inc.
PRA Health Sciences

Completed

A Fixed-Sequence, Drug-Drug Interaction Study Between Multiple Oral Doses of Inarigivir Soproxil and a Single Oral Dose of Midazolam in Healthy Subjects

Drug Interaction Potentiation

Netherlands
Luye Pharma Group Ltd.
Beijing Bozhiyin T&S Co., Ltd.

Completed

A Multiple Ascending Dose Study With LY03003 in Patients With Early-stage Parkinson's Disease

Parkinson Disease

China
Boston VA Research Institute, Inc.
Millennium Pharmaceuticals, Inc.

Completed

Safety and Efficacy Study of Single Weekly Bortezomib in Newly Diagnosed Multiple Myeloma

Multiple Myeloma

United States
Abrexa Pharmaceuticals, Inc.
Iqvia Pty Ltd

Completed

Study to Assess the Safety, Tolerability and Pharmacokinetics of Single Ascending Oral Doses of J147

Alzheimer's Disease

United States
KeyBioscience AG
Eli Lilly and Company; Profil Institut für Stoffwechselforschung GmbH; Nordic...

Terminated

A Clinical Study to Evaluate the Safety, Tolerability, PK, PD, and Efficacy of KBP-089 in Patients With T2DM

Type II Diabetes Mellitus

Germany
MedImmune LLC

Terminated

A 6-Part Study In Healthy Volunteers To Evaluate Safety, Tolerability and Uptake Of MEDI7219 in the Body When Given as Single and Multiple Doses

Healthy Volunteers

United Kingdom
MedImmune LLC

Completed

Single and Multiple Ascending Doses of MEDI6570 in Subjects With Type 2 Diabetes Mellitus

Cardiovascular Disease | Atherosclerosis

United States
MODAG GmbH
Quotient Sciences; Aptuit (Verona) Srl, an Evotec Company

Completed

A First-in-Human Study of Single and Multiple Doses of anle138b in Healthy Subjects

Healthy Volunteers

United Kingdom
Galapagos NV

Completed

A Study to Evaluate the Effects of Single and Multiple Oral Doses of GLPG3667

Healthy

Belgium

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