Search clinical trials for: pharmacology.

Total 1968 results

University Medicine Greifswald

Completed

Impact of Two Genetic Variants of OATP1B3 or MRP2 or Rifampin on Systemic Disposition and Biological Efficacy of CCK-8

Gastrointestinal Hormones

Germany
Johns Hopkins University
National Institute on Drug Abuse (NIDA)

Completed

Assessment of Tramadol as a Treatment for Opioid Addiction

Opioid-Related Disorders

United States
Rigshospitalet, Denmark
Klinisk Biokemisk Afdeling; Klinisk farmakologisk Afdeling; Sektion for Biomedicin...

Completed

SIMOX - Induction of Oxidative Stress (SIMOX)

Oxidative Stress

Denmark
Medical University of Vienna

Terminated

Does eNOS Gene Polymorphism Play a Role in the Maintenance of Basal Vascular Tone in the Choroid or Optic Nerve Head?

Ocular Physiology | Regional Blood Flow

Austria
Medical University of Vienna

Completed

Effect of Xalacom® (Latanoprost/Timolol) and Combigan® (Brimonidine/Timolol) Fixed Combination on Intraocular Pressure and Ocular Blood Flow in Patients With Primary Open Angle Glaucoma or Ocular Hypertension

Ocular Physiology | Retina

Austria
Arduino Mangoni

Completed

Mechanisms of Anti-VEGF Induced Hypertension

Renal Cancer

Australia
Theraclone Sciences, Inc.

Completed

Safety Study of Human Anti-Cytomegalovirus Monoclonal Antibody

Cytomegalovirus Infections

United States
Medical University of Vienna

Completed

Optic Nerve Head Autoregulation During Changes in Arterial Blood Pressure

Decreased Vascular Flow

Austria
Stealth BioTherapeutics Inc.

Completed

Study to Assess the Pharmacodynamic Effects of Unfractionated Heparin (UFH) in Healthy Volunteers With and Without Bendavia

Healthy Volunteers

United States
Astellas Pharma Inc

Completed

Pharmacokinetic Interaction Study to Assess the Effect of ASP015K on Tacrolimus in Healthy Volunteers

Healthy Subjects | Drug Interactions | Pharmacokinetics of ASP015K

United States
University Medicine Greifswald

Completed

Pharmacokinetic and Pharmacodynamic Interactions Between the Cholesterol-lowering Ezetimibe and the Non-nucleoside Reverse Transcriptase Inhibitor Efavirenz During Chronic Treatment in Healthy Volunteers With Reference to Intestinal Expression of CYP3A4, UGT1A1, ABCB1 and ABCC2

Pharmacokinetics | Pharmacodynamics | Drug Interactions | Intestinal Transporter Expression

Germany
Millet Roux

Unknown

Therapeutic Effect of an Herbal Medicine on Anxiety

Anxiety Disorders

Brazil
Arbutus Biopharma Corporation

Terminated

Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Liposomal siRNA in Subjects With High Cholesterol

Hypercholesterolemia

United States
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating the Safety and Pharmacokinetics (PK) of Ascending Single IV Doses of ERB-257 in Healthy Japanese Males

Healthy Subjects

Japan
Ranbaxy Laboratories Limited

Completed

Bioequivalence Study of Quinapril Hydrochloride 20 mg and Hydrochlorothiazide 25 mg Tablets Under Fasting Conditions

Healthy

India
Sheba Medical Center

Unknown

Pharmacogenetic Study of Warfarin Dose-Response: a Prospective Trial (PGxWarfarin)

Cardiovascular Diseases

Israel
University Medicine Greifswald

Completed

Pharmacokinetic Drug Interaction Between Ezetimibe and Sirolimus After Single Dose Administration in Healthy Subjects

Hypercholesterolemia | Pharmacokinetics | Immunosuppression | Drug Interactions

Germany
Medical University of Vienna

Completed

A Randomized, Double-Masked, Placebo-Controlled Two Cross Over Study Comparing the Effects of Moxaverine and Placebo on Ocular Blood Flow

Ischemia

Austria
Medical University of Vienna

Completed

Effects of Indomethacin on Retinal and Choroidal Blood Flow in Healthy Volunteers

Ocular Physiology | Regional Blood Flow

Austria
Qianfoshan Hospital

Completed

Population Pharmacokinetic Study Based on Quantitative Pharmacology in Patients With Lenalidomide

Lymphoma | Myelodysplastic Syndromes | Multiple Myeloma

China
Agios Pharmaceuticals, Inc.

Completed

A Study of AG-120 (Ivosidenib) in Subjects With Mild or Moderate Hepatic Impairment or Normal Hepatic Function

Hepatic Impairment

United States
Abbott

Completed

A Study of ABT-384 Levels and Pharmacodynamic Activity Measured in Cerebrospinal Fluid

Healthy

United States
Merck Sharp & Dohme LLC

Completed

A Study to Evaluate Molnupiravir (MK-4482) in Participants With Moderate Hepatic Impairment (MK-4482-016)

Hepatic Impairment

United States
Centre of Clinical Pharmacology, Hanoi Medical...

Completed

An in Vivo Bioequivalence Study of 2 Loxoprofen Sodium Products in Vietnamese Healthy Male Volunteers

Bioequivalence

Vietnam
SPD Development Company Limited
Richmond Pharmacology Limited

Completed

Urine Sample Collection From Non Pregnant Peri and Post-menopausal Women

Pregnancy
Center for Clinical Pharmacology Research Bdbeq...

Completed

Fed Bioequivalence Study of CBZ Formulations

Bio-equivalence Study | Fed Conditions

Uruguay
Hamamatsu University
Yokoyama Foundation for Clinical Pharmacology

Unknown

Tailored Treatment of H. Pylori Infection Based Polymorphisms of CYP2C19 and 23S rRNA of H. Pylori

Gastritis | Helicobacter Infections | Gastric Ulcer | Duodenal Ulcer

Japan
Mitsubishi Tanabe Pharma Corporation

Completed

A Clinical Pharmacology Study of MT-3921 in Healthy Adult Males

Healthy Adult Males

Japan
Jennifer Plebani
National Institute on Drug Abuse (NIDA)

Withdrawn

Human Behavioral Pharmacology Laboratory Study of Varenicline's Impact on Cocaine Reinforcement

Cocaine Dependence

United States
University Hospital, Clermont-Ferrand
Unither Pharmaceuticals

Completed

Pilot Study of Pharmacology of Paracetamol Administered Per-oral Mucosa (PMB)

Healthy
Johns Hopkins University
National Institute on Drug Abuse (NIDA)

Not yet recruiting

Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance

Cognitive Impairment | Cannabis Use | Impaired Driving

United States
University Hospital, Caen
Hospices Civils de Lyon; Centre Hospitalier Universitaire de Saint Etienne; Saint... and other collaborators

Not yet recruiting

Subcutaneous Cardiac Monitoring of Patients With BTK Inhibitors (IRAF-ISCM)

Atrial Fibrillation

France
Chiesi Farmaceutici S.p.A.
SGS S.A.

Recruiting

Clinical Study to Evaluate the Safety, Tolerability and the Concentration of the BDP (Beclomethasone Dipropionate), Active Metabolite of BDP, FF( Formoterol Fumarate) and GB (Glycopyrronium Bromide), After Inhalation of CHF 5993 at Two Different Doses and QVAR®

Asthma

Belgium
Johns Hopkins University
National Institute on Drug Abuse (NIDA)

Not yet recruiting

The Impact of Product Formulation on the Pharmacokinetics and Pharmacodynamics of Cannabis Edibles

Cannabis Use

United States
Johns Hopkins University
National Institute on Drug Abuse (NIDA)

Recruiting

The Impact of Oral Cannabis Administration and Co-Administration of Alcohol on Impairment

Alcohol Intoxication | Cannabis Intoxication

United States
ReST Therapeutics

Withdrawn

First-In-Human (FIH), Single Ascending Dose (SAD) Study of FluoroEthylNorMemantine (FENM)

Brain Diseases | PTSD | Alzheimer Disease | Major Depressive Disorder | Treatment Resistant Depression | Neuro-Degenerative Disease

Belgium
Calico Life Sciences LLC
AbbVie

Completed

A Phase 1 Study Assessing the Effect of Food on the Pharmacokinetics of ABBV- CLS-7262

Healthy

United States
University Hospital, Basel, Switzerland

Completed

LSD Base and LSD Tartrate Bioequivalence and Bioavailability in Healthy Subjects (LSD-Bio)

Healthy

Switzerland
Cytoki Pharma
SGS Life Sciences, a division of SGS Belgium NV

Completed

A Phase 1 Study to Investigate Safety, Tolerability, and Pharmacokinetics of CK-0045 in Healthy Participants and Otherwise Healthy Participants With Obesity

Healthy

Belgium
University Hospital, Caen

Completed

Clozapine-associated Infection

Infections

France
Johns Hopkins University
Cultivate Biologics

Completed

The Pharmacokinetics and Pharmacodynamics of a Single Acute Dose of a Hemp-derived Oral Product With a 1:1 Ratio of CBD:CBD-A

Cannabis

United States
Mitsubishi Tanabe Pharma America Inc.

Completed

Study to Assess Pharmacokinetics, Safety, and Tolerability of MT-7117 in Subjects With Normal and Impaired Hepatic Function

Mild and Moderate Hepatic Impairment

United States
University Hospital, Caen

Completed

Association Between Antidepressant Use and Falls in Older Adults: Analysis of the World Health Organization Global Database

Fall | Antidepressants Causing Adverse Effects in Therapeutic Use

France
AbbVie
KU Leuven; Syndesi Therapeutics

Completed

A Single Ascending Oral Dose Study of SDI-118 in Healthy Male Subjects Including an Assessment of Receptor Occupancy and Food Effect

Cognitive Disorders

Belgium
University Hospital, Caen

Active, not recruiting

Association Between Prescription of Antidepressants and Delirium in the Elderly : Analysis From the World Health Organization Global Database

Delirium | Aged | Antidepressive Agents

France
Medicines for Malaria Venture
Sanaria Inc.; Institute of Tropical Medicine, Belgium; Iqvia Pty Ltd; SGS Life... and other collaborators

Completed

Study in Blood Stage Malaria Infection After DVI of Cryopreserved P. Falciparum (NF54 Strain) Sporozoites

Protozoan Infections | Parasitemia | Malaria,Falciparum | Parasitic Disease

Belgium
Shire

Completed

Pharmacokinetics (PK) of 20 mg Teduglutide in Participants With Moderately Impaired Hepatic Function Compared to Healthy Participants

Hepatic Impairment

United States
Bristol-Myers Squibb

Completed

An Investigational Study of Continuous 8-Hour Intravenous Administrations of BMS-986231 in Participants With Heart Failure and Reduced Heart Function Given a Standard Dose of Loop Diuretic

Congestive Heart Failure | Heart Decompensation | Cardiac Failure | Myocardial Failure

United Kingdom
Medicines for Malaria Venture
AbbVie

Completed

Malaria: Relative Bioavailability and Food Effect of DSM265

Healthy Volunteers

United States
Medicines for Malaria Venture
University of Cape Town

Completed

Phase I Study of Ascending Doses of MMV390048 in Healthy Adult Volunteers

Malaria

South Africa

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