Clinical Trials Sponsored by Aestus Therapeutics

Total 6412 results

The First Affiliated Hospital of Soochow University
Fundamenta Therapeutics, Ltd.

Recruiting

ThisCART19A for B-NHL Relapsed After Auto-CAR T

B Cell Lymphoma | CAR | Relapsed Non-Hodgkin Lymphoma

China
Fundamenta Therapeutics, Ltd.
The First Affiliated Hospital of Zhengzhou University

Not yet recruiting

Safety and Efficacy of ThisCART19A Bridging Hematopoietic Stem Cell Transplantation in Patients With Refractory or Relapsed B-cell Acute Lymphoblastic Leukemia

Allogeneic, CAR-T, Protein Sequestration, Non-gene Edited
Seventh Medical Center of PLA General Hospital
GeneCradle Therapeutics, Inc

Recruiting

Clinical Exploration of Adeno-associated Virus (AAV) Expressing Human Acid Alpha- Glucosidase (GAA) Gene Therapy for Patients With Infantile-onset Pompe Disease

Infantile-onset Pompe Disease

China
Edwin Posadas, MD
Enviro Therapeutics, Inc.

Recruiting

Study of Apalutamide With Carotuximab in Metastatic, Castration-Resistant Prostate Cancer

Castration-resistant Prostate Cancer

United States
Donald Jeffrey Newport
Sage Therapeutics

Recruiting

An Open Label Pilot Study of IV Brexanolone for the Treatment of Post-Traumatic Stress Disorder

Post-Traumatic Stress Disorder

United States
Mindful Diagnostics and Therapeutics, LLC
Infectious Disease Society of America

Not yet recruiting

Tdap and Biomarkers of Alzheimer's Disease

Alzheimer Disease, Late Onset

United States
Anup Kasi
Cend Therapeutics Inc.

Recruiting

CEND-1 in Combination With Neoadjuvant FOLFIRINOX With or Without Panitumumab (CENDIFOX)

Colon Cancer | Pancreas Cancer | Digestive Cancer

United States
Kenneth Krantz, MD, PhD
FHI Clinical, Inc.

Not yet recruiting

SLV213 Treatment in Ambulatory COVID-19 Patients

Covid19
Jonsson Comprehensive Cancer Center
Mirati Therapeutics Inc.; Phase One Foundation

Recruiting

Mocetinostat With Vinorelbine in Children, Adolescents & Young Adults With Refractory and/or Recurrent Rhabdomyosarcoma

Rhabdomyosarcoma

United States
Sanjay Mohan
AbbVie; Karyopharm Therapeutics Inc

Active, not recruiting

Venetoclax and Selinexor in Treating Patients With Relapsed or Refractory High Risk Hematologic Malignancies

Acute Myeloid Leukemia | Non-Hodgkin's Lymphoma | Diffuse Large B-cell Lymphoma

United States
Juno Therapeutics, Inc., a Bristol-Myers Squibb...
Celgene Corporation

Withdrawn

A Study to Compare the Efficacy and Safety of Lisocabtagene Maraleucel vs Investigator's Choice Options in Adult Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma, Whose Disease Has Failed Treatment With Both BTKi and BCL2i Therapies

Leukemia, Lymphocytic, Chronic, B-Cell

United States, Austria, Belgium, France, Germany, Italy, Netherlands, Norway, Spain, Sweden, United Kingdom
Glenn J. Hanna
Actuate Therapeutics Inc.

Active, not recruiting

9-ING-41 Plus Carboplatin in Salivary Gland Carcinoma

Adenoid Cystic Carcinoma | Metastatic Cancer | Salivary Gland Cancer | Recurrent Salivary Gland Cancer

United States
Children's Oncology Group
National Cancer Institute (NCI); SpringWorks Therapeutics, Inc.

Active, not recruiting

A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by Surgery

Desmoid Fibromatosis | Recurrent Desmoid Fibromatosis | Unresectable Desmoid Fibromatosis

United States, Canada, Puerto Rico, Australia, New Zealand
University of Colorado, Denver
Pfizer; Criterium, Inc.; Cascadian Therapeutics Inc.

Completed

Tucatinib, Palbociclib and Letrozole in Metastatic Hormone Receptor Positive and HER2-positive Breast Cancer

Breast Cancer

United States
Jerry R. Mendell
Duchenne Alliance; Milo Therapeutics

Completed

Clinical Intramuscular Gene Transfer of rAAV1.CMV.huFollistatin344 Trial to Patients With Duchenne Muscular Dystrophy

Duchenne Muscular Dystrophy

United States
Merit E. Cudkowicz, MD
Seelos Therapeutics, Inc.

Completed

HEALEY ALS Platform Trial - Regimen E SLS-005 - Trehalose

Amyotrophic Lateral Sclerosis

United States
Memorial Sloan Kettering Cancer Center
Stanford University; Juno Therapeutics, Inc.

Active, not recruiting

Cyclophosphamide Followed by Intravenous and Intraperitoneal Infusion of Autologous T Cells Genetically Engineered to Secrete IL-12 and to Target the MUC16ecto Antigen in Patients With Recurrent MUC16ecto+ Solid Tumors

Solid Tumors

United States
Weijia Fang, MD
Innovative Cellular Therapeutics Co., Ltd.

Completed

CART Therapy in GUCY2C-positive Digestive Tract Tumors (CART)

Malignant Neoplasms of Digestive Organs

China
Mylan Inc.
Vyne Therapeutics Inc.; DPT Laboratories, Ltd.

Completed

A Dose Ranging Vehicle Controlled Study to Determine the Safety and Efficacy of Permethrin Foam, 5% and Permethrin Foam, 4% for the Treatment of Scabies

Scabies

United States, Dominican Republic, Honduras, Puerto Rico
Aevi Genomic Medicine, LLC, a Cerecor company

Completed

Safety and Efficacy Study of NFC-1 in Subjects Aged 12-17 Years With 22q11.2DS & Associated Neuropsychiatric Conditions

22q11.2 Deletion Syndrome

United States
Craig McDonald, MD
Cardero Therapeutics, Inc.

Completed

(-)- Epicatechin Becker Muscular Dystrophy

Becker Muscular Dystrophy

United States
University College, London
Merck Sharp & Dohme LLC; Celleron Therapeutics Ltd.

Withdrawn

A Study of CXD101 in Combination With Pembrolizumab for Relapsed or Refractory Diffuse Large B-Cell Lymphoma (PLACARD)

Diffuse Large B Cell Lymphoma
Pain Therapeutics
National Institute on Aging (NIA)

Completed

A Safety Study of PTI-125 in Healthy Volunteers

Alzheimer Disease | Alzheimer Disease, Early Onset

United States
Bioverativ Therapeutics Inc.
Swedish Orphan Biovitrum; Syntonix Pharmaceuticals, Inc.

Completed

Phase I/IIa Study of FIXFc in Hemophilia B Patients

Hemophilia B

United States
First Affiliated Hospital of Zhejiang University
CARsgen Therapeutics Co., Ltd.

Active, not recruiting

Clinical Study of CAR-BCMA T in Patients With Refractory or Relapsed Multiple Myeloma

Refractory or Relapsed Multiple Myeloma

China
Bausch Health Americas, Inc.
Galderma R&D; Oceana Therapeutics, Inc.

Completed

A Randomized, Blinded, Multicenter Study to Evaluate NASHA/Dx for the Treatment of Fecal Incontinence

Fecal Incontinence

United States, Germany, Sweden, United Kingdom
Vanderbilt-Ingram Cancer Center
Astex Pharmaceuticals, Inc.; Forma Therapeutics, Inc.

Withdrawn

ASTX727 and FT-2102 in Treating IDH1-Mutated Recurrent/Refractory Myelodysplastic Syndrome or Acute Myeloid Leukemia

Acute Myeloid Leukemia | Myelodysplastic Syndrome | Recurrent Acute Myeloid Leukemia | Recurrent Myelodysplastic Syndrome | Refractory Acute Myeloid Leukemia | Refractory Myelodysplastic Syndrome
Roswell Park Cancer Institute
National Cancer Institute (NCI); Nektar Therapeutics

Completed

Pegylated Irinotecan NKTR 102 in Treating Patients With Relapsed Small Cell Lung Cancer

Recurrent Small Cell Lung Carcinoma

United States
Abramson Cancer Center of the University of Pennsylvania
Halozyme Therapeutics

Withdrawn

MRI Effects of Pegvorhyaluronidase Alfa (PEGPH20) in Pancreatic Ductal Adenocarcinoma

Pancreatic Ductal Adenocarcinoma

United States
Viela Bio
MedImmune LLC

Completed

A Phase 1 Study of MEDI7734 in Type I Interferon-Mediated Autoimmune Diseases

Dermatomyositis, Polymyositis, Sjogren's, SLE, SSc

United States
Acorda Therapeutics
United States Department of Defense; DP Clinical, Inc.

Terminated

AC105 in Patients With Acute Traumatic Spinal Cord Injury (AC105)

Acute Spinal Cord Injury
VA Office of Research and Development
Helsinn Therapeutics (U.S.), Inc

Terminated

The Role of Ghrelin in Cancer Cachexia

Cancer Cachexia

United States
Johns Hopkins University
Juvenile Diabetes Research Foundation; iCo Therapeutics Inc.

Terminated

A Randomized, Multi-center, Phase II Study of the Safety, Tolerability and Bioactivity of Repeated Intravitreal Injections of iCo-007 as Monotherapy or in Combination With Ranibizumab or Laser Photocoagulation in the Treatment of Diabetic Macular Edema (the iDEAL Study) (iDEAL)

Diabetic Macular Edema

United States
Galera Therapeutics, Inc.
INC Research Australia Pty Ltd; Nucleous Network

Completed

A Study of the Safety, Tolerability and Pharmacokinetics of Orally-administered GC4702 in Healthy Volunteers

Healthy Volunteer

Australia
Schön Klinik Berchtesgadener Land
Grifols Therapeutics LLC; Alpha-1 Foundation

Completed

Effects of Exercise Training in Chronic Obstructive Pulmonary Disease Versus Alpha-1-Antitrypsin-deficiency-patients

Chronic Obstructive Pulmonary Disease | Alpha-1-antitrypsin-deficiency

Germany
Radboud University Medical Center
Dutch Heart Foundation; Synvista Therapeutics, Inc

Completed

Effects of Exercise Training and AGE-crosslink Breaker on Cardiovascular Structure and Function

Cardiovascular Disease | Physical Activity | Aging | Endothelial Dysfunction

Netherlands
University of Washington
National Institute on Aging (NIA); ASCEND Therapeutics

Completed

Effect of Dihydrotestosterone (DHT) on Prostate Tissue [Short Title: DHT-3] (DHT-3)

Healthy

United States
Rheumatology Therapeutics Medical Center
Kochan Institute for Healing Arts Research

Unknown

Safety and Efficacy Study of Bee Venom to Treat Knee Osteoarthritis

Persons With Mild to Moderate Knee Osteoarthritis

United States
Hepatitis Resource Network
Integrated Therapeutics Group; Subsidiary of Schering-Plough

Completed

PEG-Interferon a-2b + Ribavirin for Treatment of Chronic HRN 005 Hepatitis C Infection in HIV-Infected Persons Not Previously Treated With Interferon

HIV Infections | Chronic Hepatitis C Infection in HIV-Infected Persons

United States
Regend Therapeutics
Peking Union Medical College Hospital; Ruijin Hospital; The First Affiliated... and other collaborators

Completed

Treatment of Idiopathic Pulmonary Fibrosis(IPF) by REGEND001

Idiopathic Pulmonary Fibrosis

China
Intira Sriprasert
TherapeuticsMD

Completed

Effect of Oral Estradiol and Progesterone Therapy on Vaginal Cytokines in Postmenopausal Women

Menopause

United States
Sight Medical Doctors PLLC
Ocular Therapeutix, Inc.

Completed

Intracanalicular Dexamethasone Insert for Post-Corneal Cross-Linking Inflammation and Pain- The LINK Study

Postoperative Pain | Keratoconus, Unstable | Collagen Crosslinking

United States
Lambda Therapeutic Research Ltd.
Intas Pharmaceutical Limited (Biopharma Division)

Recruiting

Denosumab Biosimilar Injection in Post Menopausal Women With Osteoporosis

Osteoporosis, Postmenopausal

India
Colorado State University
Hearts and Horses Therapeutic Riding Center

Completed

Piloting an Enhanced Protocol of Occupational Therapy in an Equine Environment for Youth With Autism

Autism Spectrum Disorder

United States
Vanderbilt-Ingram Cancer Center
National Cancer Institute (NCI); Karyopharm Therapeutics Inc

Not yet recruiting

Eltanexor and Venetoclax in Relapsed or Refractory Myelodysplastic Syndrome and Acute Myeloid Leukemia

Acute Myeloid Leukemia | Recurrent Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia | Refractory Myelodysplastic Syndrome | Relapsed Myelodysplastic Syndrome

United States
YANRU WANG
Rui Therapeutics Co., Ltd

Recruiting

A Clinical Study of CD19 CAR NK Cells for the Treatment of Relapsed/Refractory B-cell Related Autoimmune Diseases

Autoimmune Diseases

China
China Medical University, China
Beijing Bio-Targeting Therapeutics Technology Co., Ltd

Not yet recruiting

A Clinical Study of BioTTT001 in Combination With Toripalimab and Regorafenib in Patients With Colorectal Cancer

Colorectal Cancer Metastatic
Regend Therapeutics
Peking Union Medical College Hospital; RenJi Hospital; Ruijin Hospital

Recruiting

A Clinical Study to Evaluate the Efficacy and Safety of REGEND001 Cell Therapy on Idiopathic Pulmonary Fibrosis (IPF)

Idiopathic Pulmonary Fibrosis

China
Cognition Therapeutics
National Institute on Aging (NIA); Alzheimer's Clinical Trials Consortium

Recruiting

A Study to Evaluate the Safety and Efficacy of CT1812 in Early Alzheimer's Disease

Early Alzheimer's Disease

United States
Second Affiliated Hospital, School of Medicine,...
TCRx Therapeutics Co.Ltd

Not yet recruiting

TCRx_T Cells for Advanced or Recurrent Gastric/Gastroesophageal Junction Cancer After Failure of First Chemotherapy

Gastric Cancer | Gastroesophageal-junction Cancer

Clinical Trials Sponsored by Aestus Therapeutics

Sponsors and Collaborators

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CROs in Ethiopia

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