Search clinical trials for: Antimalarial drugs

Total 257317 results

Sanofi
Medicines for Malaria Venture

Terminated

To Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of a Single Dose Regimen of Ferroquine and Artefenomel in Adults and Children With Uncomplicated Plasmodium Falciparum Malaria (FALCI)

Plasmodium Falciparum Infection

Benin, Burkina Faso, Gabon, Kenya, Mozambique, Uganda, Vietnam
Dr Fabrice BRUNEEL

Completed

Very Severe Malaria Treated by Intravenous Artesunate (Palustar)

Severe Malaria

France
Sanofi
Medicines for Malaria Venture

Completed

Study to Investigate the Clinical and Parasiticidal Activity and Pharmacokinetics of Different Doses of Artefenomel and Ferroquine in Patients With Uncomplicated Plasmodium Falciparum Malaria

Plasmodium Falciparum Infection

Benin, Burkina Faso, Gabon, Kenya, Uganda
Norwegian University of Science and Technology
Oslo University Hospital; St. Olavs Hospital

Completed

Combined Carfilzomib and Hydroxychloroquine in Patients With Relapsed/Refractory Multiple Myeloma (MYELOMA-HCQ)

Multiple Myeloma

Norway
Haiphong University of Medicine and Pharmacy

Completed

Comparison of Efficacy of Two Combination Regimens for the Neisseria Gonorrhoeae and Chlamydia Coinfection

Chlamydia Trachomatis Infection | Neisseria Gonorrhoeae Infection

Vietnam
Chinese SLE Treatment And Research Group
Peking Union Medical College Hospital

Terminated

Cyclophosphamide and Hydroxychloroquine for Thrombocytopenia in SLE (CHORUS)

Thrombocytopenia

China
London School of Hygiene and Tropical Medicine
Radboud University Medical Center; Imperial College London; Institute of Tropical... and other collaborators

Completed

Mass Drug Administration of Ivermectin and Dihydroartemisinin-piperaquine as an Additional Intervention for Malaria Elimination (MASSIV)

Malaria

Gambia
Hospital Alemão Oswaldo Cruz
Hospital Israelita Albert Einstein; Hospital Moinhos de Vento; Hospital do Coracao and other collaborators

Completed

Randomized Placebo-controlled Trial of Hydroxychloroquine in Outpatient Cases With Coronavirus Disease 2019 (COVID-19) (COALITION-V)

COVID-19

Brazil
HonorHealth Research Institute

Terminated

Atovaquone and Azithromycin Combination for Confirmed COVID-19 Infection

Covid19

United States
The Third Xiangya Hospital of Central South University
Livzon Pharmaceutical Group Inc.; Yung Shin Pharm. Ind. Co., Ltd.

Completed

The Efficacy and Safety of Ilaprazole/Doxycycline-based Bismuth-containing Quadruple Therapy on Hp Infected Duodenal Ulcers

Duodenal Ulcer Due to Helicobacter Pylori

China
University of Oxford
Mahidol Oxford Tropical Medicine Research Unit

Completed

P.Vivax Treatment Trial (Lao Pv)

Plasmodium Vivax

Lao People's Democratic Republic
University of the Philippines

Completed

Public Health Emergency: SOLIDARITY TRIAL Philippines

Covid19

Philippines
Ann & Robert H Lurie Children's Hospital of Chicago
The Hospital for Sick Children

Active, not recruiting

Prophylactic Antibiotics or Placebo After Hypospadias Repair (PROPHY)

Hypospadias

Canada, United States
University of New Mexico

Terminated

Efficacy of Hydroxychloroquine Prophylaxis for Health Care Workers at High Risk for COVID-19

COVID-19

United States
Medstar Health Research Institute
Society of Family Planning

Completed

A Randomized Controlled Trial of Three Antibiotic Regimens for First Trimester Abortions

First Trimester Abortion

United States
Shehnoor Azhar

Completed

Hydroxychloroquine, Oseltamivir and Azithromycin for the Treatment of COVID-19 Infection: An RCT (PROTECT)

COVID 19

Pakistan
Novartis Pharmaceuticals
Medicines for Malaria Venture

Completed

Efficacy and Safety of KAF156 in Combination With LUM-SDF in Adults and Children With Uncomplicated Plasmodium Falciparum Malaria

Acute Uncomplicated Plasmodium Falciparum Malaria

Thailand, Gabon, Mali, Uganda, Burkina Faso, India, Kenya, Mozambique, Vietnam
Ministry of Public Health, Democratic Republic...
World Health Organization; Institut National de Recherche Biomédicale. Kinshasa... and other collaborators

Completed

Safety and Efficacy of Recommended Antimalarial in the Democratic Republic of the Congo (TET2020)

Malaria

Congo, The Democratic Republic of the
Medical College of Wisconsin

Completed

Topical Antisepsis in Head and Neck Cancer Surgery

Head and Neck Cancer

United States
National Institute of Respiratory Diseases, Mexico

Completed

Hydroxychloroquine Chemoprophylaxis in Healthcare Personnel in Contact With COVID-19 Patients (PHYDRA Trial) (PHYDRA)

Severe Acute Respiratory Syndrome | COVID-19

Mexico
National Institute of Respiratory Diseases, Mexico

Completed

Hydroxychloroquine Treatment for Severe COVID-19 Pulmonary Infection (HYDRA Trial) (HYDRA)

Severe Acute Respiratory Syndrome | COVID-19

Mexico
National Institute of Allergy and Infectious Diseases...

Completed

Safety and Immunogenicity of Pfs25M-EPA/AS01 and Pfs230D1M-EPA/AS01 Vaccines, Transmission Blocking Vaccines Against Plasmodium Falciparum, at Full and Fractional Dosing in Adults in Mali

Malaria

Mali
Medicines for Malaria Venture
Shin Poong Pharmaceuticals

Completed

Human Mass Balance Study of Pyronaridine

Malaria

Switzerland
Medicines for Malaria Venture
Shin Poong Pharmaceuticals

Terminated

Safety and Efficacy of Pyronaridine Artesunate Vs Chloroquine in Children and Adult Patients With Acute Vivax Malaria

Malaria

Korea, Republic of
Peng Wang, MD PhD

Completed

Biological Effects of Agent on PAR-4 Levels With Resected Solid Tumors

Solid Tumor

United States
Columbia University

Terminated

Saved From COVID-19 - Chloroquine (CQ) Prophylaxis for Health Care Workers at Risk for COVID

Coronavirus Infection | COVID

United States
LCMC Health

Terminated

Treatment in Patients With Suspected or Confirmed COVID-19 With Early Moderate or Severe Disease (RCT)

COVID-19

United States
Susanne Arnold

Terminated

Novel Agents for Treatment of High-risk COVID-19 Positive Patients

COVID | Sars-CoV2

United States
Abramson Cancer Center of the University of Pennsylvania

Completed

Dabrafenib, Trametinib and Hydroxychloroquine in Patients With Advanced BRAF Mutant Melanoma (BAMM)

Advanced BRAF Mutant Melanoma

United States
London School of Hygiene and Tropical Medicine

Completed

Gametocytocidal and Transmission-blocking Efficacy of PQ in Combination With AL and TQ in Combination With SPAQ in Mali (NECTAR3)

Malaria,Falciparum

Mali
Barcelona Institute for Global Health
Fundación de investigación HM; Hospital Clinic of Barcelona; Institut Català... and other collaborators

Completed

Hydroxychloroquine Efficacy and Safety in Preventing SARS-CoV-2 Infection and COVID-19 Disease Severity During Pregnancy and Postpartum (COVID-Preg)

Covid-19 | Pregnancy Related | COVID

Spain
Fondation Ophtalmologique Adolphe de Rothschild

Completed

Studying the Performance of OCT C-scan in the Screening for Retinopathy Related to Synthetic Antimalarials (PERFOCTAPS)

Maculopathy | Toxicity, Drug

France
University of South Alabama

Terminated

Trial of Hydroxychloroquine In Covid-19 Kinetics (THICK)

Corona Virus Infection | Covid 19

United States
University of Sao Paulo General Hospital
Fundação de Amparo à Pesquisa do Estado de São Paulo

Completed

Relevance of Monitoring Blood and Salivar Levels of Drugs Used in Rheumatic Autoimmune Diseases

Systemic Lupus Erythematosus (SLE) | Cutaneous Lupus | Juvenile SLE

Brazil
University of Washington
Bill and Melinda Gates Foundation

Completed

Hydroxychloroquine for COVID-19 Post-exposure Prophylaxis (PEP)

COVID-19 | Corona Virus Infection | SARS-CoV-2 | SARS (Severe Acute Respiratory Syndrome)

United States
University Hospital, Montpellier

Terminated

Hydroxychloroquine Plus Azithromycin Versus Hydroxychloroquine for COVID-19 Pneumonia (COVIDOC Trial) (COVIDOC)

Coronavirus Infection | Pneumonia, Viral

France
Washington University School of Medicine
National Heart, Lung, and Blood Institute (NHLBI); Singulex

Completed

Atheroma Reduction With Chloroquine in Patients With the Metabolic Syndrome (ARCH-MS) (ARCH-MS)

Hypertension | Overweight | Dyslipidemias | Prediabetic State | Metabolic Syndrome X

United States
University of Texas Southwestern Medical Center

Completed

Atovaquone for Treatment of COVID-19

COVID-19

United States
Sanford Health

Terminated

Hydroxychloroquine as Post-Exposure Prophylaxis Against COVID-19 Infection

COVID-19 | SARS-CoV 2

United States
International Brain Research Foundation

Withdrawn

Safety and Efficacy of Hydroxychloroquine for the Treatment & Prevention of Coronavirus Disease 2019 (COVID-19) Caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Covid19 | SARS (Severe Acute Respiratory Syndrome)
Avanir Pharmaceuticals

Completed

Efficacy, Safety and Tolerability Study of AVP-923 (Dextromethorphan/Quinidine) for Treatment of Symptoms of Agitation in Participants With Alzheimer's Disease

Alzheimer's Disease | Agitation

United States
University of Maryland, Baltimore
National Institute on Aging (NIA)

Completed

Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA^3CT)

Aneurysm

United States
Taiwan Liposome Company

Completed

The Safety, Tolerability, and Pharmacokinetics of Inhaled TLC19 in Healthy Volunteers

COVID-19

Taiwan
University of Florida
ALS Association; Holy Cross Hospital, Florida

Completed

Impact of Nuedexta on Bulbar Physiology and Function in ALS

Amyotrophic Lateral Sclerosis

United States
El Instituto Nacional de Neurologia y Neurocirugia...

Completed

Dapsone Use in Patients With Aneurysmal Subarachnoid Hemorrhage.

Brain Ischemia | Subarachnoid Hemorrhage | Subarachnoid Hemorrhage, Aneurysmal | Delayed Cerebral Ischemia | Aneurysmal Subarachnoid Hemorrhage | Vasospasm, Cerebral

Mexico
Brigham and Women's Hospital
Johns Hopkins University; National Institute on Aging (NIA); Rutgers University

Completed

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Methotrexate vs Hydroxychloroquine

Rheumatoid Arthritis

United States
Avanir Pharmaceuticals

Completed

Safety and Efficacy of AVP-923 in the Treatment of Central Neuropathic Pain in Multiple Sclerosis (PRIME)

Multiple Sclerosis | Central Neuropathic Pain

United States, Spain, Czechia, Poland, Argentina
Medicines for Malaria Venture
Shin Poong Pharmaceuticals

Completed

Pyronaridine Artesunate 3:1 Granule Formulation vs. Coartem© Crushed Tablets in P. Falciparum Malaria Pediatric Patients

Malaria

Burkina Faso, Congo, The Democratic Republic of the, Kenya, Mali, Mozambique, Philippines, Côte D'Ivoire, Gabon
Hedi Gharsallah
Dacima Consulting

Completed

OD-doxy-PNV-COVID-19 Old Drug " DOXY " for Prevention of New Virus " COVID-19 "

Covid19

Tunisia
National Institute of Allergy and Infectious Diseases...
Teva Pharmaceutical Industries, Ltd.

Terminated

Evaluating the Efficacy of Hydroxychloroquine and Azithromycin to Prevent Hospitalization or Death in Persons With COVID-19

COVID-19 | SARS-CoV 2

United States

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