Search clinical trials for: Pharmacokinetics and pharmacodynamics

Total 475475 results

Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

A Study of Multiple Doses of ALXN2050 in Healthy Adults

Healthy

New Zealand
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

A Study of Single-dose ALXN2050 in Healthy Adults

Healthy

New Zealand
Protagonist Therapeutics, Inc.

Completed

Pharmacokinetics and Pharmacodynamics of Different PTG-300 Regimens in Healthy Volunteers

Healthy Volunteers

Australia
Kalyra Pharmaceuticals, Inc.
United States Department of Defense; PRA Health Sciences

Terminated

A Single and Multiple Ascending Dose Study in Healthy Subjects to Assess the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of KP-1199

Analgesia

United States
Biocad

Completed

Dose Escalation Study of the Pharmacodynamics, Pharmacokinetics, Safety, and Immunogenicity of BCD-132 in Patients With Relapsing-Remitting Multiple Sclerosis

Multiple Sclerosis

Russian Federation
Zealand Pharma

Completed

A Multiple Ascending Dose Trial Assessing Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ZP7570

Healthy

Germany
Novo Nordisk A/S

Completed

A Trial Investigating the Safety, Tolerability, Pharmacokinetics (the Exposure of the Trial Drug in the Body) and Pharmacodynamics (the Effect of the Investigated Drug on the Body) of Insulin 287 in Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

Germany
Telix International Pty Ltd

Completed

Evaluation of Safety, Biodistibution and Sensitivity/Specificity of PET/CT Imaging With 89Zr-TLX250 in Subjects With RCC (ZIRDAC-JP)

Carcinoma, Renal Cell | Clear Cell Renal Cell Carcinoma

Japan
Novo Nordisk A/S

Completed

Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of Multiple Doses of COR-001

Anemia

United States
Biocon Limited
Profil Institut für Stoffwechselforschung GmbH

Completed

Comparision of Pharmacokinetics(PK) and Pharmacodynamics(PD) of Biocon Insulin R and Humulin® R

Healthy Volunteer

Germany
Cytokinetics

Completed

Study to Evaluate the Safety and Efficacy of IV Infusion Treatment With Omecamtiv Mecarbil in Subjects With Left Ventricular Systolic Dysfunction Hospitalized for Acute Heart Failure (ATOMIC-AHF)

Heart Failure

United States, Canada, Germany, Italy, Netherlands, Belgium, France, Czechia, Australia, Russian Federation, Hungary, Poland, Bulgaria, Slovakia, United Kingdom, Finland, Greece, Lithuania, Norway
Luye Pharma Group Ltd.
Shan Dong Boan Biotechnology Co., Ltd

Active, not recruiting

A Study to Evaluate LY06006 and Prolia in Healthy Adults

Healthy Adults

China
GlaxoSmithKline

Completed

Dose Response of 28 Days of Dosing of GSK962040 in Type I and II Diabetic Male and Female Subjects With Gastroparesis

Gastroparesis

United States, Australia, Belgium, United Kingdom, Canada, Sweden
Shire

Completed

A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Subcutaneous CINRYZE Administration

Hereditary Angioedema

United States
ModernaTX, Inc.

Completed

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of mRNA-1944 in Healthy Adults

Prevention of Chikungunya Virus Infection

United States
AstraZeneca
Parexel

Completed

To Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD8233 After Multiple Dose Administration in Subjects With Dyslipidemia

Dyslipidemia

United States
Gannex Pharma Co., Ltd.

Completed

Study to Evaluate Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of ASC42 in Healthy Subjects

Healthy

United States
CONRAD
National Institute of Allergy and Infectious Diseases (NIAID); Eunice Kennedy... and other collaborators

Completed

Coital Pharmacokinetics/Pharmacodynamics (PK/PD) of Tenofovir Gel

Pharmacokinetics of 1% Tenofovir Gel Following Coitus | Pharmacodynamics of 1% Tenofovir Gel Following Coitus

United States
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

Study of Danicopan in Participants With Normal Kidney Function and Participants With Kidney Dysfunction

Healthy | Renal Dysfunction

United States
Zydus Lifesciences Limited

Completed

Clinical Study to Evaluate the Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of ZYIL1 Following Oral Administration in Healthy Volunteers

Healthy

India
GlaxoSmithKline

Completed

Safety and Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD) and Efficacy of Repeat Doses of GSK2982772 in Subjects With Moderate to Severe Rheumatoid Arthritis (RA)

Arthritis, Rheumatoid

Spain, Germany, Russian Federation, United Kingdom, Italy, Poland
Region Skane
University of Colorado, Denver; Karolinska Institutet; Lund University; The Swedish... and other collaborators

Completed

Fentanyl and Clonidine for Analgesia During Hypothermia in Term Asphyxiated Infants (SANNI 1)

Asphyxia Neonatorum

Sweden
Boehringer Ingelheim

Completed

To Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BI 1467335 Following Multiple Dose Administration Over 28 Days

Healthy

Germany
Shire

Completed

Effect of Teduglutide on Gastric Emptying in Healthy Subjects

Healthy Volunteers

United States
Blade Therapeutics

Completed

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BLD-0409 in Healthy Subjects

NASH - Nonalcoholic Steatohepatitis | Chronic Liver Disease

Australia
Shire

Completed

Study To Test Whether PF-00547659 Is Safe And Improves Disease Symptoms In Patients With Crohn's Disease (OPERA)

Crohn's Disease

Korea, Republic of, United States, Spain, Japan, Serbia, Germany, Belgium, Netherlands, Poland, Austria, Bulgaria, Canada, France, Norway, Slovakia, South Africa
Acerta Pharma BV

Completed

A Study to Evaluate Safety, Pharmacokinetics, Pharmacodynamics, Food Effects, and Drug-drug Interactions of ACP-196 in Healthy Participants

Healthy Participants

United States
Biogen

Terminated

A Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB054 in Japanese Participants With Parkinson's Disease

Parkinson's Disease

Japan
GlaxoSmithKline

Completed

Proof of Mechanism Study of GSK2330811 in Diffuse Cutaneous Systemic Sclerosis

Scleroderma, Systemic

United States, United Kingdom, Netherlands, Canada
GlaxoSmithKline

Completed

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics of GSK2330811 in Healthy Japanese Participants

Healthy Volunteers

United Kingdom
GlaxoSmithKline

Completed

A Dose Escalation Study to Investigate the Safety, Pharmacokinetics (PK), Pharmacodynamics (PD) and Clinical Activity of GSK525762 in Subjects With Relapsed, Refractory Hematologic Malignancies

Neoplasms

Spain, United States, Korea, Republic of, United Kingdom, Australia
Guerbet

Completed

Pharmacokinetics, Pharmacodynamics Profile and Tolerance of P03277 in Healthy Subjects and Patients With Brain Lesions

Healthy Volunteers | Brain Lesion

Belgium
Medecins Sans Frontieres, Netherlands
London School of Hygiene and Tropical Medicine; University College, London; University... and other collaborators

Active, not recruiting

PRACTECAL-PKPD Sub Study (PRACTECAL-PKPD)

Multi-drug Resistant Tuberculosis | Pulmonary Tuberculosis | Extensively Drug-Resistant Tuberculosis

Belarus, South Africa
Hoffmann-La Roche

Terminated

A Study of RO7239958 to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Volunteers and Participants With Chronic Hepatitis B Virus Infection

Hepatitis B Virus Infection

United Kingdom, Hong Kong, Korea, Republic of, Taiwan, Poland, Bulgaria, New Zealand
Ultragenyx Pharmaceutical Inc

Completed

Safety, Pharmacokinetics and Pharmacodynamics of BPS804 in Osteogenesis Imperfecta

Osteogenesis Imperfecta

Belgium, United States, Canada, Germany
AstraZeneca

Completed

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 139 in Healthy Subjects and Subjects With Moderate to Severe Psoriasis

Psoriasis

Australia, New Zealand
Sunshine Lake Pharma Co., Ltd.

Unknown

the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of HEC83518 Tablets

Insomnia

China
Sunshine Lake Pharma Co., Ltd.

Unknown

The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of HEC83518 Tablets in Chinses Healthy Subjects

Insomnia

China
Sunshine Lake Pharma Co., Ltd.

Completed

The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of HEC96719 Tablets in Healthy Subjects

Non-alcoholic Fatty Liver Disease | Non-alcoholic Steatohepatitis

Australia
Pacira Pharmaceuticals, Inc

Terminated

Evaluation of Safety, Pharmacokinetics and Pharmacodynamics of EXPAREL® Administered Via a Single Intrathecal Injection to Healthy Volunteers

Healthy

United States
Baxalta now part of Shire

Terminated

First-in-Human and Proof-of-Mechanism Study of ARC19499 Administered to Hemophilia Patients

Hemophilia

United Kingdom
Kiniksa Pharmaceuticals, Ltd.

Completed

Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Ascending Doses of KPL-404 in Healthy Subjects

Healthy Volunteers

Australia, United States
Orient Europharma Co., Ltd.

Completed

Pharmacokinetic and Pharmacodynamic Study of Glufast Tablets 10mg(Mitiglinide)

Type 2 Diabetes Mellitus | Liver Dysfunction

Taiwan
Poznan University of Medical Sciences
Medical University of Gdansk; The Greater Poland Cancer Centre

Completed

Pharmacotherapy Personalization of Cancer Patients

Head and Neck Neoplasms | Oncologic Patients

Poland
Universitaire Ziekenhuizen KU Leuven

Active, not recruiting

Association of Cefepime Trough Levels With Clinical Efficacy and Neurotoxicity in Patients With Febrile Neutropenia

Pharmacokinetics | Pharmacodynamics | Cefepime

Belgium
Astellas Pharma Global Development, Inc.

Completed

A Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASP4345 in Patients With Schizophrenia

Schizophrenia

United States
Brigham and Women's Hospital

Completed

Tranexamic Acid Pharmacokinetics During Postpartum Hemorrhage

Postpartum Hemorrhage

United States
GlaxoSmithKline

Completed

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Clinical Effect of GSK2646264 in Cutaneous Lupus Erythematosus Subjects

Lupus Erythematosus, Cutaneous

Germany
Assistance Publique - Hôpitaux de Paris

Completed

Comparison of Two Dosage Adjustment Strategies of Vancomycin in Children (OPTIBAYE)

Methicillin-resistant Staphylococcal Infections

France
TLL Pharmaceutical, LLC

Completed

A Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Study of TLL018, With Food Effect, in Healthy Participants

Healthy

United States

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