Clinical Trials Sponsored by Health Effects Institute

Total 24911 results

National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

JAK1/2 Inhibitor Ruxolitinib for Relapsed/Refractory Immune Bone Marrow Failure

Severe Aplastic Anemia | Single Lineage Cytopenias, T-LGL | Hypoplastic MDS

United States
Northwestern University
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health...

Recruiting

Rest to Overcome Loss and Reduce Risk (RESTore Plus)

Quality of Life | Inflammation | Sleep Disturbance | Bereavement | Spouses

United States
Duke University
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health...

Recruiting

Mitigating Racial Disparities in Shared Decision Making in the Intensive Care Unit

Health Care Disparities

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Exploring Near Infrared Spectroscopy (NIRS) Technologies for Assessment of Muscle Physiology, Tissue Oxygenation, and Blood Flow in Patients With Sickle Cell Disease (SCD)

SCD

United States
National Heart, Lung, and Blood Institute (NHLBI)

Not yet recruiting

NHLBI-Emory Advanced Cardiac CT Reconstruction

Structural Heart Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia

Sickle Cell Anemia | Beta Thalassemia

United States
Mayo Clinic
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health...

Recruiting

Hot Flashes and Neurovascular Function in Women

Hot Flashes | Menopause | Vasomotor System; Labile

United States
Columbia University
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health...

Recruiting

Sleep Duration and Blood Pressure During Sleep

Hypertension | Sleep | Blood Pressure | Elevated Blood Pressure | Short Sleep Phenotype

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Natural History of Acquired and Inherited Bone Marrow Failure Syndromes

Severe Aplastic Anemia | Telomere Biology Disorders | Inherited Bone Marrow Failure Syndromes

United States
Profusa, Inc.
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health...

Recruiting

Monitoring Local Tissue Oxygen Changes Using the Wireless Lumee Oxygen Platform in Correlation to TcPO2

Peripheral Artery Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)

Severe Aplastic Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

CHIP/CCUS Natural History Protocol

Clonal Cytopenia of Undetermined Significance | Clonal Hematopoiesis of Indeterminate Potential

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Vascular Disease Discovery Protocol

Genetic Predisposition | Vascular Dysfunction | Genetic Mutations

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System

CAD

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Sirolimus (Rapamune ) for Relapse Prevention in People With Severe Aplastic Anemia Responsive to Immunosuppressive Therapy

Severe Aplastic Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Human Biospecimen Procurement Protocol: Biorepository to Support Translational Research to Identify Disease Mechanism(s)

Cardiovascular Disease | Undiagnosed Diseases

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Genome Transplant Dynamics

Thoracic Organ Transplantation

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Prospective Evaluation of Next Generation CT Reconstruction (NextGenIR)

Healthy Subjects

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Heart Health Study in Washington D.C. to Develop a Community-Based Behavioral Weight Loss Intervention

Obesity | Cardiovascular Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Evaluating New Radiation Techniques for Cardiovascular Imaging

Coronary Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells

MDS (Myelodysplastic Syndrome) | Severe Aplastic Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Natural History of Bronchiectasis

Bronchiectasis | Common Variable Immunodeficiency | Cystic Fibrosis | Autoimmune Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Collection and Analysis of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers

Healthy Volunteers

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Collection and Storage of Umbilical Cord Stem Cells for Treatment of Sickle Cell Disease

Sickle Cell Disease | Sickle Cell Trait

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Genes Involved in Lipid Disorders

Lipid Disorders

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

The Psoriasis, Atherosclerosis, and Cardiometabolic Disease Initiative (PACI)

Inflammation | Cardiovascular Disease | Psoriasis | Metabolic Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

High Image Matrix CT Reconstruction

Healthy Subjects | Pulmonary-Related Conditions | Cardiac-Related Conditions

United States
National Institutes of Health Clinical Center (CC)
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Effectiveness of a Stress Reduction Intervention in Caregivers of Allogeneic Hematopoietic Stem Cell Transplant (HSCT) Recipients

Stress, Psychological | Caregivers

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Cardiovascular Evaluation of Patients With High Cholesterol and Normal Volunteers

Homozygous Familial Hypercholesterolemic

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

WS-SAVE Study (Williams Syndrome Skin and Vessel Elasticity Study)

Hypertension | Cardiovascular Disease | Williams Syndrome | Multisystem Developmental Disorder | Elastin Gene Deletion

United States
National Heart, Lung, and Blood Institute (NHLBI)

Active, not recruiting

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat

Sickle Cell Disease | Hemolytic Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Effect of Fasting and Refeeding on T-cell Fate

Inflammation | Asthma

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Cardiac Function in Patients With Hereditary Hemochromatosis

Hereditary Hemochromatosis

United States
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders

Lymphedema | Lymphangiomatosis | Lymphangiectasia | Pulmonary Lymphangiectasia

United States
Emory University
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health...

Completed

Improving Mitral Repair for Functional Mitral Regurgitation (IMPROVE-FMR)

Cardiovascular Diseases | Coronary Artery Disease | Heart Disease | Valvular Heart Disease | Congestive Heart Failure | Cardiomyopathy | Mitral Valve Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Anti-Inflammatory Effects of Time-Restricted Feeding

Psoriasis | Systemic Inflammation

United States
National Heart, Lung, and Blood Institute (NHLBI)

Active, not recruiting

Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

Sickle Cell Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Hereditary Parkinson s Disease Natural History Protocol

Parkinson Disease 6, Early-Onset | Parkinson Disease (Autosomal Recessive, Early Onset) 7, Human | Parkinson Disease Autosomal Recessive, Early Onset | Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/Dj1

United States
Yale University
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health...

Completed

Exercise in Genetic Cardiovascular Conditions (LIVE-HCM/LQT)

Hypertrophic Cardiomyopathy | Long QT Syndrome

United States, United Kingdom, Canada, Australia, New Zealand
National Heart, Lung, and Blood Institute (NHLBI)

Active, not recruiting

NHLBI DIR Transcatheter Mitral Cerclage Annuloplasty Early Feasibility Study

Functional Mitral Regurgitation

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Retrospective Study of Patients With Severe Aplastic Anemia Who Relapsed After Immunosuppressive Therapy

Severe Aplastic Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Transmural Systems Transcaval Closure Device for Transcaval Access Ports During Transcatheter Aortic Valve Replacement

Aortic Stenosis

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Retrospective Study of Patients With Severe Aplastic Anemia Who Developed High Risk Clonal Evolution With Chromosome 7 Abnormalities After Immunosuppressive Therapy

Severe Aplastic Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Stem Cell Collection for Adult Volunteers

Sickle Cell

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Magnetic Resonance Imaging of the Blood Vessels of the Heart

Heart Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Withdrawn

The Effect of Inflammation in Heart Failure

Heart Failure | Inflammation | Myocardial Dysfunction

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Patients' Long-Term Survival of Obstructive Hypertrophic Cardiomyopathy (HCM)

Cardiomyopathy | Obstructive Hypertrophic Cardiomyopathy

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Evaluation of the Causes and Disease Processes of Chronic Lung Disease

Pulmonary Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Alemtuzumab (Campath) to Treat T-Large Granular Lymphocyte Leukemia

T-LGL Lymphoproliferative Disorders

United States
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Duvelisib for Ibrutinib-Resistant Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Chronic Lymphocytic Leukemia (CLL) | Small Lymphocytic Leukemia (SLL)

United States

Clinical Trials Sponsored by Health Effects Institute

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