Search clinical trials for: 14-050

Total 7554 results

Merck Sharp & Dohme LLC

Active, not recruiting

A Study of MK-0616 (Oral PCSK9 Inhibitor) in Adults With Heterozygous Familial Hypercholesterolemia (MK-0616-017) CORALreef HeFH

Hypercholesterolemia | Familial Hypercholesterolemia

United States, Australia, Brazil, Canada, Chile, Colombia, Czechia, Finland, Hong Kong, Hungary, Israel, Netherlands, New Zealand, Norway, Singapore, Spain, Taiwan
National Cancer Institute (NCI)

Active, not recruiting

TORC1/2 Inhibitor MLN0128 and Bevacizumab in Treating Patients With Recurrent Glioblastoma or Advanced Solid Tumors

Recurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Ovarian Clear Cell Cystadenocarcinoma | Ovarian Endometrioid Adenocarcinoma | Ovarian Serous Cystadenocarcinoma | Endometrial Clear Cell Adenocarcinoma | Endometrial Serous Adenocarcinoma | Recurrent... and other conditions

United States
Merck Sharp & Dohme LLC

Completed

Study of Pembrolizumab (MK-3475) Versus Platinum-Based Chemotherapy for Participants With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Advanced or Metastatic Non-Small Cell Lung Cancer (MK-3475-042/KEYNOTE-042)

Non-small Cell Lung Cancer
Northwestern University
National Cancer Institute (NCI); MedImmune LLC; Avon Breast Cancer Foundation

Completed

MEDI4736 and Tremelimumab in Treating Patients With Metastatic HER2 Negative Breast Cancer

Stage IV Breast Cancer | Recurrent Breast Carcinoma | Estrogen Receptor Negative | Estrogen Receptor Positive | HER2/Neu Negative

United States
Bavarian Nordic
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

A Randomized, Double-blind, Placebo-controlled Study on Immunogenicity and Safety of MVA-BN (IMVAMUNE™) Smallpox Vaccine in Healthy Subjects

Smallpox

Germany
University College, London
London School of Hygiene and Tropical Medicine; Wellcome Trust; National Institute...

Completed

Ethnicity and Onset of Cardiovascular Disease: A CALIBER Study

Myocardial Infarction | Heart Failure | Stroke | Ischemic Stroke | Peripheral Arterial Disease | Transient Ischemic Attack | Coronary Heart Disease | Cardiac Arrest | Stable Angina Pectoris | Unstable Angina | Sudden Cardiac Death | Abdominal Aortic Aneurysm | Intracerebral Haemorrhage | Subarachnoid Haemorrhage
Takeda

Completed

A Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetics of TAK-079 in Healthy Participants

Autoimmune Disease

United Kingdom
University of Guadalajara
Cell Pharma

Completed

Efficacy of Pirfenidone Plus MODD in Diabetic Foot Ulcers

Diabetic Foot Ulcer

Mexico
Children's Cancer and Leukaemia Group

Unknown

High-Dose Methotrexate in Treating Young Patients With Residual Ependymoma

Brain and Central Nervous System Tumors

United Kingdom, Ireland
Ministry of Science and Technology, India

Completed

Efficacy and Safety of Immunomodulator as an Adjunct Therapy in New Pulmonary Tuberculosis(Category I) Patients.

Tuberculosis

India
Institut Paoli-Calmettes

Unknown

Stem Cell Transplant in Treating Patients With Hematological Cancer or Other Disorders

Lymphoma | Leukemia | Multiple Myeloma and Plasma Cell Neoplasm | Precancerous Condition | Graft Versus Host Disease

France
Hvidovre University Hospital
University Hospital, Gentofte, Copenhagen

Unknown

Comparison of Adalimumab and Infliximab Treatment of Rheumatoid Arthritis

Rheumatoid Arthritis

Denmark
Assiut University

Completed

Detection of Bloodstream Pathogens in Hematological Malignancies

Bloodstream Infection

Egypt
Forest Laboratories
Cypress Bioscience, Inc.

Completed

Discontinuation Study of the Durability of Effect of Milnacipran for the Treatment of Fibromyalgia

Fibromyalgia

United States
Sun Pharmaceutical Industries Limited

Active, not recruiting

Efficacy and Safety of Tildrakizumab Compared to Placebo in Anti-TNF naïve Subjects With Active Psoriatic Arthritis II (INSPIRE 2)

Active Psoriatic Arthritis

United States, Australia, Czechia, Germany, India, Japan, Korea, Republic of, Poland, Spain
UCB Pharma SA
Parexel

Completed

Study to Assess the Short- and Long-term Efficacy of Certolizumab Pegol Plus Methotrexate Compared to Adalimumab Plus Methotrexate in Subjects With Moderate to Severe Rheumatoid Arthritis (RA) Inadequately Responding to Methotrexate

Rheumatoid Arthritis

Romania, United States, Australia, Austria, Bulgaria, Canada, Czechia, France, Germany, Greece, Hungary, Ireland, Italy, Mexico, Monaco, Poland, Portugal, Spain, Switzerland, United Kingdom
Pfizer

Completed

A Study to Assess Immune Response Following Zoster Vaccination to Subjects With Rheumatoid Arthritis Receiving Tofacitinib or Placebo With Background Methotrexate

Rheumatoid Arthritis

United States
Glenmark Pharmaceuticals Ltd. India

Completed

To Study Generic Diclofenac Sodium Topical Gel 1% in the Treatment of Osteoarthritis of the Knee (Degenerative Joint Disease Presented as Joint Pain, Stiffness, Swelling and Restricted Motion).

Osteoarthritis

United States
Boehringer Ingelheim

Completed

Non-interventional Observational Study With Viramune® in HIV to Evaluate Gender Specific Data

HIV Infections

Germany
Boehringer Ingelheim

Completed

Safety and Effect of Mirapex(Pramipexole) Tablet Among Korean RLS

Restless Legs Syndrome

Korea, Republic of
Postgraduate Institute of Medical Education and...

Recruiting

Amphotericin Versus Posaconazole for Pulmonary Mucormycosis

Mucormycosis; Pulmonary (Etiology)

India
Aeovian Pharmaceuticals, Inc.

Recruiting

Assessment of the Safety, Tolerability and Pharmacokinetics of AV078 in Healthy Volunteers

Healthy Participants

Australia
argenx

Active, not recruiting

An Open-label Study to Investigate the Clinical Efficacy of Different Dosing Regimens of Efgartigimod IV in Patients With Generalized Myasthenia Gravis (ADAPT NXT)

Generalized Myasthenia Gravis

Georgia, United States, Austria, Belgium, Canada, France, Germany, Italy, Netherlands, Poland, Spain
Suzhou Connect Biopharmaceuticals, Ltd.

Active, not recruiting

A Study to Evaluate the Safety and Efficacy of CBP-201 in Chinese Adult Subjects With Moderate to Severe AD

Atopic Dermatitis

China
Solvay Pharmaceuticals

Completed

Intravenous Tedisamil in the Rapid Conversion of Atrial Fibrillation or Flutter to Normal Sinus Rhythm in Female Subjects

Atrial Fibrillation | Atrial Flutter

Russian Federation, Romania, United States, Argentina, Czech Republic, Former Serbia and Montenegro, Germany, Israel, Poland, Slovakia, South Africa, Ukraine, United Kingdom
Solvay Pharmaceuticals

Terminated

The Efficacy of ESTRATEST® Tablets in Relieving Menopausal Symptoms in Estrogenized, Hysterectomized Postmenopausal Women

Menopause

United States
Spectrum Pharmaceuticals, Inc

Completed

A Study to Evaluate the Effect of Multiple Doses of Itraconazole, Phenytoin, and Paroxetine on the Single-Dose Pharmacokinetics of Poziotinib in Healthy Adult Participants

Healthy

United States
DICE Therapeutics, Inc., a wholly owned subsidiary...
Eli Lilly and Company

Recruiting

A Study to Assess LY4100511 (DC-853) in Healthy Adult Participants

Healthy

United States
National Cancer Institute (NCI)

Completed

A Trial of the Safety and Immunogenicity of the COVID-19 Vaccine (mRNA-1273) in Participants With Hematologic Malignancies and Various Regimens of Immunosuppression, and in Participants With Solid Tumors on PD1/PDL1 Inhibitor Therapy

Lymphoma | Leukemia | Multiple Myeloma | Hematologic Malignancy | Solid Tumor Malignancy

United States
Cerevel Therapeutics, LLC

Completed

A Trial to Evaluate the Effects of Itraconazole and Carbamazepine on the Pharmacokinetics of Emraclidine and of Emraclidine on the Pharmacokinetics of Metformin in Healthy Adult Participants

Healthy Volunteers

United States
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.

Active, not recruiting

A Study to Investigate the Drug-drug Interactions (DDIs) of SKLB1028 With Itraconazole, Gemfibrozil or Rifampicin in Healthy Subjects

Healthy Subjects

China
First Affiliated Hospital of Zhejiang University
Wenzhou Central Hospital

Unknown

Three Induction Treatments on Cryptococcal Meningitis (TITOC)

HIV/AIDS | Cryptococcal Meningitis

China
University of Minnesota
National Institute of General Medical Sciences (NIGMS)

Completed

Pharmacogenetics of Warfarin Induction and Inhibition

Healthy

United States
Eisai Inc.

Completed

Study to Assess Pharmacokinetic Drug-Drug Interaction Between Avatrombopag When Co-Administered With Fluconazole, Itraconazole, or Rifampin in Healthy Subjects

Healthy Participants

United States
Vertex Pharmaceuticals Incorporated

Completed

A Study to Evaluate the Efficacy and Safety of VX-661 in Combination With Ivacaftor in Subjects Aged 12 Years and Older With Cystic Fibrosis, Heterozygous for the F508del-CFTR Mutation

Cystic Fibrosis

United States, Canada, France, Spain, Israel, Australia, Austria
Umm Al-Qura University

Completed

Alter-G Training on Gait and Balance in Diabetic Neuropathy Patients

Diabetic Peripheral Neuropathy

Saudi Arabia
Bristol-Myers Squibb

Completed

A Study to Assess the Effect of Multiple Doses of Itraconazole, Gemfibrozil, or Carbamazepine on BMS-986278 in Healthy Participants

Healthy Participants

Canada
Otsuka Pharmaceutical Development & Commercialization...

Completed

Aripiprazole and Effexor XR Drug Interaction Study

Healthy

United States
ETOP IBCSG Partners Foundation
Alliance for Clinical Trials in Oncology; Canadian Cancer Trials Group; Breast...

Active, not recruiting

Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer (POSITIVE)

Early Breast Cancer

Korea, Republic of, United States, France, Canada, Spain, Lebanon, Belgium, Switzerland, Israel, Ireland, Japan, Italy, Denmark, Austria, Australia, Greece, Hungary, Netherlands, Norway, Portugal, Serbia, Slovenia
Takeda

Active, not recruiting

Ponatinib in Participants With Resistant Chronic Phase Chronic Myeloid Leukemia (CP-CML) to Characterize the Efficacy and Safety of a Range of Doses (OPTIC)

Myeloid Leukemia, Chronic, Chronic Phase

United States, Spain, Taiwan, Australia, Canada, Russian Federation, Sweden, Switzerland, Germany, United Kingdom, Poland, Korea, Republic of, Argentina, Hong Kong, Singapore, Italy, Chile, Czechia, Denmark, France, Portugal
University of Nebraska
National Cancer Institute (NCI)

Completed

Combination Chemotherapy & Lenalidomide in Newly Diagnosed Stage II-IV Peripheral T-cell Non-Hodgkin's Lymphoma

Anaplastic Large Cell Lymphoma, ALK-Positive | Hepatosplenic T-Cell Lymphoma | Peripheral T-Cell Lymphoma, Not Otherwise Specified | Anaplastic Large Cell Lymphoma, ALK-Negative | Stage II Angioimmunoblastic T-cell Lymphoma | Stage II Enteropathy-Associated T-Cell Lymphoma | Stage III Angioimmunoblastic... and other conditions

United States
University of Wisconsin, Madison

Completed

Blue Light Therapy of C. Acnes

Acne

United States
CONRAD
University of Washington; Centers for Disease Control and Prevention; Kenya Medical...

Unknown

Tenofovir/Levonorgestrel Intravaginal Ring and Tenofovir Intravaginal Ring

HIV | Contraception | Prevention | Anti-Retroviral Agent

Kenya
Takeda

Terminated

A Phase 2a Pharmacodynamic Study of TAK-448 in Participants With Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism

United Kingdom
Triomed AB

Terminated

A Clinical Study of the Safety and Efficacy of a Wearable Device (CLS UF) That Delivers Continuous Administration of Glucose to Recirculated Peritoneal Dialysis Fluid for the Purpose of Ultrafiltration in Patients With Congestive Heart Failure

Heart Failure | Cardio-Renal Syndrome

Germany
Takeda

Completed

TAK-385 Phase I Absorption, Distribution, Metabolism, Excretion and Absolute Bioavailability Study

Healthy Volunteers

United Kingdom
Centre Antoine Lacassagne

Completed

Gemcitabine, Capecitabine, and Erlotinib in Treating Patients With Advanced Pancreatic Cancer

Pancreatic Cancer

France
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI); Canadian Cancer Trials Group; European Organisation...

Recruiting

Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma

Brain and Central Nervous System Tumors

United States, Canada, France, Netherlands, Austria, Belgium
UNICANCER
Myriad Genetics, Inc.

Completed

Prospective Study Assessing EndoPredict® Genomic Test Impact on Shared Decision of Adjuvant Chemotherapy in Patients With ER-positive, Her2-negative Early Breast Cancer (ADENDOM)

Breast Cancer
University of Oxford
London School of Hygiene and Tropical Medicine; University College, London; KEMRI-Wellcome... and other collaborators

Unknown

First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition (FLACSAM)

Antibiotic Resistance | Malnutrition Severe | Antibiotic Toxicity

Kenya, Uganda

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