Search clinical trials for: mutant p53

Total 752 results

Array BioPharma

Terminated

Safety and Efficacy of LEE011 and LGX818 in Patients With BRAF Mutant Melanoma.

Locally Advanced Metastatic BRAF Mutant Melanoma

Australia, Canada, Netherlands, United States
Genentech, Inc.

Completed

A Study of MEHD7945A and Cobimetinib in Patients With Locally Advanced or Metastatic Cancers With Mutant KRAS

Neoplasms

United States, Spain
Bial - Portela C S.A.

Completed

Effect of Two Multiple-dose Regimens of BIA 3-202 on the Pharmacokinetics and Motor Response of Levodopa, and on the Erythrocyte Comt Activity in Parkinson's Disease Patients

Parkinson's Disease (PD)
Association HGE CHU Bordeaux Sud
University Hospital, Bordeaux

Completed

Predictive Factors of the Treatment Failure in Hepatitis C Virus (HCV) Infected Patients Treated With Telaprevir (GENUPI)

Chronic Hepatitis C

France
Assistance Publique - Hôpitaux de Paris

Unknown

Phase I-II Study With Tumor Molecular Pharmacodynamic (MPD) Evaluation and Pharmacokinetics of PD-0332991 in Patients Suffering Metastatic Melanoma (OPTIMUM)

Melanoma BRAF V600E/K Mutated | CDNKN2A Loss Defined

France
Sun Yat-sen University

Unknown

A Retrospective Study About Treatment Strategy After First/Second Line EGFR-TKI Failure

Non-Small Cell Lung Cancer

China
Göteborg University
Vastra Gotaland Region; Vinnova

Completed

The Effect of Probiotic Streptococci and pH-rising Components on the Oral Microbial Flora

Hyposalivation

Sweden
Memorial Sloan Kettering Cancer Center

Terminated

Erlotinib Re-Challenge for Recurrent EGFR-mutant Lung Cancer in Patients Who Previously Received Adjuvant Erlotinib or Gefitinib

Lung Cancer

United States
University of Minnesota

Completed

Treatment of Cocaine Dependence With Lisdexamfetamine

Cocaine Dependence

United States
Lady Davis Institute
Jewish General Hospital

Unknown

A Open-label Prospective Cohort Trial of Curcumin Plus Tyrosine Kinase Inhibitors (TKI) for EGFR -Mutant Advanced NSCLC (CURCUMIN)

Lung Cancer

Canada
IRCCS Azienda Ospedaliero-Universitaria di Bologna

Terminated

Effects of Bosentan on Respiratory Mechanics

Pulmonary Hypertension

Italy
Tang-Du Hospital

Unknown

Pemetrexed Combined With Synchronous Gefitinib as Adjuvent Therapy in Patient With EGFR Mutant Lung Adenocarcinoma

Lung Neoplasms

China
Intermountain Health Care, Inc.
Gilead Sciences

Terminated

The Use of Ranolazine for Atrial Fibrillation and Diastolic Heart Failure (RAD HF)

Heart Failure | Atrial Fibrillation

United States
Sun Yat-sen University

Unknown

Erlotinib 100mg qd Versus Gefitinib 250mg qd for EGFR Mutant Nsclc (NSCLC EGFR TKI)

Advanced Stage Non Small Cell Lung Cancer

China
Merck Sharp & Dohme LLC

Terminated

A Phase II Study of MK0457 in Patients With T315I Mutant CML and Ph+All (0457-008)

Leukemia
Pfizer

Withdrawn

A Study For Patients With EGFRm (Epidermal Growth Factor Receptor Mutant) Lung Cancer

Advanced EGFRm (Del 19 or L858R +/- T790M) NSCLC
Infinity Pharmaceuticals, Inc.

Completed

Phase 1b/2 Study of Retaspimycin HCl (IPI-504) in Combination With Everolimus in KRAS Mutant Non-small Cell Lung Cancer

Non-small Cell Lung Cancer

United States
University of Utah
Jubilant Innovation Ltd.

Terminated

Study of JI-101 in Patients With Advanced Low Grade Endocrine Tumors, Ovarian Cancers or K-RAS Mutant Colon Cancers

Cancer | Ovarian Cancer | Colon Cancer | Neuroendocrine

United States
Raphael Freitas de Souza
Fundação de Amparo à Pesquisa do Estado de São Paulo

Completed

Efficacy of a Propolis-based Denture Cleanser

Oral Hygiene | Dental Plaque | Oral Candidiasis | Denture Stomatitis

Brazil
GlaxoSmithKline

Completed

An Open-label Study of GSK1120212 Compared With Docetaxel in Stage IV KRAS-mutant Non-small Cell Lung Cancer

Lung Cancer, Non-Small Cell

United States, Spain, Korea, Republic of, Netherlands, Greece, France, Italy, Hungary
MedicalLogic
Kosin University Gospel Hospital

Unknown

A Phase II Study to Assess Efficacy of Combined Treatment With Erlotinib (Tarceva) and Silybin-phytosome (Siliphos) in Patients With EGFR Mutant Lung Adenocarcinoma

Carcinoma, Non-Small-Cell Lung

Korea, Republic of
National Cancer Institute (NCI)

Terminated

Temsirolimus/AZD 6244 for Treatment-naive With BRAF Mutant Unresectable Stage IV

Recurrent Melanoma | Stage IV Melanoma | Mucosal Melanoma

United States
GlaxoSmithKline

Completed

A Study of GSK2118436 in BRAF Mutant Metastatic Melanoma to the Brain (Break MB)

Melanoma and Brain Metastases

Australia, Germany, United States, Canada, Italy, France
University of Roma La Sapienza

Unknown

Pharmacodynamic Effects of Ranolazine Versus Amlodipine on Platelet Reactivity (ROMAN)

Coronary Artery Disease

Italy
National Institute of Allergy and Infectious Diseases...

Completed

Phase I Study of ETEC Vaccine

Gastroenteritis Escherichia Coli

United States
GlobeImmune
Memorial Sloan Kettering Cancer Center

Completed

A Pilot Phase 2 Trial of the Immunogenicity, and Safety of GI-4000; an Inactivated Recombinant S. Cerevisiae Expressing Mutant Ras Protein, as Consolidation Therapy Following Curative Treatment for Stage I-III Non-Small Cell Lung Cancer (NSCLC) With Tumor Sequence Confirmation of K-ras Mutation

NSCLC

United States
King Abdulaziz University

Completed

Impact of Maternal Xylitol Consumption on Mutans Sterptococci

Dental Caries and Streptococcus Mutans Count

Saudi Arabia
Memorial Sloan Kettering Cancer Center
Boehringer Ingelheim; National Comprehensive Cancer Network

Withdrawn

Afatinib In Combination With Cisplatin Or Carboplatin + Pemetrexed In Patients With EGFR-Mutant Lung Cancers Undergoing Definitive Chemoradiation

Non-small Cell Lung Cancer
University of Washington

Completed

Xylitol Disk Use in Adults With Dry Mouth

Xerostomia | Mutans Streptococci

United States
AstraZeneca

Completed

Retrospective Study in a NSCLC M+ p (Ca_Pulmon)

EGFR Mutated Non-small Cell Lung Cancer Patients

Spain
China Medical University Hospital

Completed

Hepatitis B Virus Mutants and the Therapeutic Effect of Peginterferon Alfa-2a in HBeAg-Positive Chronic Hepatitis B

Hepatitis B, Chronic

Taiwan
Washington University School of Medicine

Withdrawn

Lapatinib With Trastuzumab in Treating Patients With HER2-Negative/HER2 Mutant Metastatic Breast Cancer

Breast Neoplasms
Samsung Medical Center

Completed

Simvastatin + Cetuximab/Irinotecan in K-ras Mutant Colorectal Cancer (CRC)

Metastatic Colorectal Cancer

Korea, Republic of
Celgene Corporation

Terminated

A Study to Assess the Efficacy and Safety of Lenalidomide in Combination With Cetuximab in Pre-treated Patients With KRAS Mutant Colorectal Cancer

Colorectal Cancer

Australia, Belgium, Germany, Italy, Spain, Sweden
Assistance Publique - Hôpitaux de Paris

Completed

INSUlin Regimens and VASCular Functions (INSUVASC)

Type 2 Diabetes

France
Peking University Cancer Hospital & Institute

Unknown

A Phase II Study of Imatinib Versus Interferon as Adjuvant Therapy in KIT-mutated Melanoma

Melanoma

China
AstraZeneca

Terminated

A Phase I Study of AZD1480 in Patients With Advanced Solid Malignancies and Advanced Hepatocellular Carcinoma in the Escalation Phase,Non-Small Cell Lung Cancer(NSCLC) and Non-smokers With Lung Metastasis and Gastric Cancer and Solid Tumour in the Expansion Phase.

Gastric Cancer | Advanced Solid Malignancies | Solid Tumour | Child-Pugh A to B7 Advanced Hepatocellular Carcinoma | EGFR and/or ROS Mutant NSCLC | Lung Metastasis Carcinoma

Korea, Republic of
National Taiwan University Hospital

Unknown

e- Ab Sensor-based Real-time Detection of Mutant EGFR in Clinical Specimens From Patients of Non-small Cell Lung Cancer

Non-small Cell Lung Cancer (NSCLC)

Taiwan
Swiss Federal Institute of Technology

Completed

Impact of Bean Polyphenols and Phytic Acid on Iron Absorption

Blood Iron Isotope Enrichment

Switzerland
Azienda Ospedaliero, Universitaria Pisana

Completed

First-line FOLFOXIRI Plus Bevacizumab in BRAF Mutant Metastatic Colorectal Cancer

Metastatic Colorectal Cancer

Italy
NHS Fife
University of Turku

Unknown

Maternal Consumption of Xylitol to Reduce Early Childhood Decay (MaXED Study) (MaXED)

Dental Caries | Oral Microbial Colonization

United Kingdom
University of Copenhagen

Completed

β-Glucans and the Metabolic Syndrome - a Human Intervention Study Under BEST

Healthy

Denmark
University Hospital, Aker
University of Oslo; AstraZeneca; Norwegian University of Science and Technology; Diakonhjemmet Hospital and other collaborators

Completed

Treatment of Schizophrenia With an Omega-3 Fatty Acid (EPA) and Antioxidants

Psychotic Disorders | Schizophrenia | Schizoaffective Disorder | Schizophreniform Disorders

Norway
Medical University of Vienna

Completed

Efficiency of Continuous Glucose Monitoring in Critically Ill Patients

Critical Illness

Austria
Teva Pharmaceuticals USA

Completed

Leflunomide 20 mg Tablets, Non-Fasting

Healthy

United States
Cortice Biosciences, Inc.

Completed

Study of TPI 287 in Patients With Advanced Malignancies

Neoplasms | Hodgkin Disease | Non-Hodgkin Lymphoma

United States
LG Life Sciences

Completed

Safety and Efficacy Study of LB80380 in the Patients With Lamivudine-Refractory Chronic Hepatitis B

Chronic Hepatitis B

China, Korea, Republic of
OSF Healthcare System

Completed

Tolerance of Increased Infusion Rates of Intravenous Fat Emulsions in Very Low Birth Weight Infants

Low Birth Weight
St George's, University of London
Novartis Vaccines; European Union; Richmond Pharmacology Limited

Terminated

Safety Study Of Nasal HIV Vaccine Adjuvanted With LTK63

HIV Infections

United Kingdom
National Institute of Diabetes and Digestive and...

Completed

Lamivudine for Chronic Hepatitis B

Chronic Hepatitis B | Glomerulonephritis | Polyarteritis Nodosa | Chronic Hepatitis D

United States

Search clinical trials for: mutant p53

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