Search clinical trials for: Cocktail of CYP450 substrates

Total 107 results

Johnson & Johnson Pharmaceutical Research & Development...

Completed

Phase 1 Pharmacokinetic Study of Tapentadol Prolonged-Release 250 Milligram (mg) Formulation in Healthy Participants

Healthy

Netherlands
Lindsey Bordone

Withdrawn

Clinical Trial to Evaluate the Efficacy of Fecal Microbiota Transplantation in Patients With Alopecia Areata

Alopecia Areata | Alopecia Totalis | Alopecia Universalis
Yale University
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Compromised Microcirculation in Women With Polycystic Ovary Syndrome

Polycystic Ovary Syndrome

United States
Xijing Hospital

Unknown

Intracoronary Cocktail Injection Combined With Thrombus Aspiration in STEMI Patients Treated With Primary Angioplasty

ST-elevation Myocardial Infarction

China
Mahidol University

Unknown

Influence of Cytochrome P2B6 on Efavirenz Dose in HIV-infected Thai Patients

HIV | Cytochrome P-450 CYP2B6 | Efavirenz

Thailand
Sanofi
Antaros Medical

Completed

A Clinical Study to Investigate if SAR425899 Binds to the Liver and Pancreas in Overweight to Obese Type 2 Diabetes Mellitus Patients

Type 2 Diabetes Mellitus

Sweden
Lawson Health Research Institute

Completed

Evaluation of the Use of Spinal Epimorph in Total Knee Arthroplasty

Osteoarthritis | Post-operative Pain

Canada
Thammasat University

Completed

The Efficacy of Periarticular Single Drug Compared With Multimodal Drug Injection in Controlling Pain After TKA (TKA)

Postoperative Pain

Thailand
University Hospital, Basel, Switzerland

Completed

Pharmacokinetic Study to Characterize Phenotyping Metrics of the "Basel" Cocktail After CYP Induction or Inhibition

Metabolic Detoxication, Phase I

Switzerland
H. Lundbeck A/S

Completed

Effects of Repeated Doses of Foliglurax on Drug Metabolizing Enzymes in Healthy Subjects

Healthy

France
Augusta University

Completed

Long Term Nitric Oxide Bioavailability on Vascular Health in Chronic Obstructive Pulmonary Disease (COPD-LT)

Chronic Obstructive Pulmonary Disease (COPD)

United States
Aragon Pharmaceuticals, Inc.

Recruiting

A Study to Evaluate the Effect of Multiple Doses of JNJ-56021927 on the Pharmacokinetics of Multiple Cytochrome P450 and Transporter Substrates in Participants With Castration-Resistant Prostate Cancer

Prostatic Neoplasms, Castration-Resistant

Moldova, Republic of, Spain
University of Utah

Completed

Exercise in Health and Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

United States
Bristol-Myers Squibb

Recruiting

A Study to Evaluate Effectiveness and Safety of Deucravacitinib in Participants With Non-Pustular Palmoplantar and Genital Psoriasis

Palmoplantar Psoriasis | Genital Psoriasis

United States, Germany, Spain, Italy, Poland, Argentina, Canada
Synermore Biologics (Suzhou) Co., Ltd.
Simoon Record Pharma Information Consulting Co., Ltd.

Completed

A Phase III Clinical Study to Evaluate SYN023's Efficacy and Safety

RNA Virus Infections | Virus Diseases | Mononegavirales Infections | Rabies | Rhabdoviridae Infections | Communicable Disease

China
Ain Shams University

Recruiting

Combined Cerebrolysin and Amantadine Sulfate Administration for Patients With Traumatic Brain Injury in the ICU

Traumatic Brain Injury

Egypt
Richard Barry Moss

Completed

(Study: Vertex IIS) Does Ivacaftor Alter Wild Type CFTR-Open Probability In The Sweat Gland Secretory Coil?

Cystic Fibrosis

United States
Eli Lilly and Company

Completed

A Study of Mirikizumab in Participants With Plaque Psoriasis

Psoriasis

United States
Peking Union Medical College Hospital
National Institute for Biomedical Imaging and Bioengineering (NIBIB)

Unknown

68Ga-NOTA-exendin-4 PET/CT for the Localization of Insulinoma and Diagnosis of Nesidioblastosis

Insulinoma | Nesidioblastosis

China
IRCCS San Raffaele

Completed

Gemcitabine or Combination Chemotherapy Followed by Chemoradiation for Stage IB, II, or III Pancreatic Cancer (PACT-7)

Pancreatic Cancer

Italy
Bristol-Myers Squibb

Completed

Drug Interaction Study With a Potential Alzheimer's Disease Compound

Alzheimer Disease

United States
IRCCS Azienda Ospedaliera Universitaria San Martino...

Unknown

Combination Chemotherapy in Treating Women With Stage II or Stage III Breast Cancer

Breast Cancer

Italy
Augusta University
National Heart, Lung, and Blood Institute (NHLBI)

Active, not recruiting

Nitric Oxide Bioavailability and Early Life Stress (NO-Stress) (NO-Stress)

Cardiovascular Disease

United States
University of Guadalajara

Completed

Effect of Chlorogenic Acid on Patients With Impaired Glucose Tolerance

Impaired Glucose Tolerance

Mexico
Hospital General Universitario Elche

Completed

Reduction of Postoperative Pain After Milligan-Morgan Haemorrhoidectomy With Application of Vitamin E Ointment

Pain
Academisch Medisch Centrum - Universiteit van Amsterdam...
Erasmus Medical Center

Terminated

Sorafenib PK in Patients With Advanced HCC and Child-Pugh B (SORBE)

BCLC Stage C HCC | CP-B Liver Cirrhosis

Netherlands
Abbott

Completed

Study of ABT-267 in Both Healthy Volunteers and Hepatitis C Virus (HCV) Genotype 1 Infected Subjects

HCV Infection

United States
Morristown Medical Center

Recruiting

"The Efficacy of Exparel Versus a Multidrug Cocktail in Soft Tissue Tumors"

Musculoskeletal Diseases | Soft Tissue Mass

United States
Daiichi Sankyo, Inc.

Completed

Pharmacokinetics (PK) Drug Interaction Study of Milademetan and Itraconazole or Posaconazole in Healthy Participants

Pharmacokinetics

United States
Shire

Completed

Ciprofloxacin XR Drug Interaction Study With MMX® Mesalazine/Mesalamine

Healthy

United States
Radboud University Medical Center

Completed

In Vivo Effects of C1-esterase Inhibitor on the Innate Immune Response During Human Endotoxemia (VECTOR)

Inflammation | Endotoxemia | Multi Organ Dysfunction Syndrome

Netherlands
Charite University, Berlin, Germany

Unknown

Glucagon Modulation of Ghrelin Secretion

Obesity | Diabetes Mellitus, Type 1 | Healthy Subjects

Germany
Johns Hopkins University
Washington State University; National Center for Complementary and Integrative...

Completed

Interactions Between Cannabinoids and Cytochrome P450-Metabolized Drugs

Drug-Interactions

United States
Cambridge University Hospitals NHS Foundation Trust

Unknown

Neoadjuvant Epirubicin, Cyclophosphamide, and Paclitaxel With or Without Gemcitabine in Treating Women Who Are Undergoing Surgery for Early Breast Cancer

Breast Cancer

United Kingdom
National Taiwan University Hospital

Withdrawn

Efficacy of Type-5 Phosphodiesterase Inhibitors in Primary and Secondary Pulmonary Hypertension

Primary and Secondary Pulmonary Hypertension

Taiwan
Tesaro, Inc.

Completed

An Open Label, Single Dose, Three Part Study to Assess the Effects of Rolapitant (2 mg/mL IV Solution) on the Pharmacokinetics of Digoxin; Sulfasalazine; and the Cooperstown Cocktail (Midazolam, Omeprazole, Warfarin, Caffeine, and Dextromethorphan in Healthy Subjects

Chemotherapy-induced Nausea and Vomiting

United States
Eli Lilly and Company

Completed

A Study of Abemaciclib in Participants With Cancer That is Advanced or Has Spread to Another Part(s) of the Body

Neoplasm Metastasis

United States
Nutrition 21, Inc.

Completed

Efficacy and Safety Study of Chromium Picolinate + Biotin on Glucose and Cholesterol Control in T2DM

Diabetes Mellitus, Type 2
Yantai Yuhuangding Hospital

Completed

Application of Iced Normal Saline Combined With Cocktail Perfusion in Total Knee Arthroplasty

Pain, Postoperative | Blood Loss, Postoperative

China
University of Louisville
Arthroplasty Foundation, Inc.

Withdrawn

Peri-articular Injection Utilizing a Pain Cocktail With and Without Exparel

Pain Management | Total Knee Arthroplasty
National Cancer Institute (NCI)

Completed

A Phase I/II Trial of BMS-247550 for Treatment of Patients With Recurrent High-Grade Gliomas

Adult Anaplastic Astrocytoma | Adult Giant Cell Glioblastoma | Adult Gliosarcoma | Recurrent Adult Brain Tumor

United States
Daewoong Pharmaceutical Co. LTD.

Completed

A Randomized, Double Blind, Multi-center, Active Drug Controlled, Phase III Clinical Trial to Compare the Safety and Efficacy of DWP450 Versus Botox® in Treatment of Post Stroke Upper Limb Spasticity

Stroke | Spasticity

Korea, Republic of
Jules Desmeules

Completed

Cocktail Approach for Cytochrome P450 and P-glycoprotein Activity Assessment Using Dried Blood Spot

Healthy Volunteers

Switzerland
Amgen

Terminated

Safety and Efficacy of Therapies for Metastatic Castration-resistant Prostate Cancer (mCRPC)

Metastatic Castration-resistant Prostate Cancer

United States, Sweden, Spain, United Kingdom, Australia, Denmark
Michael Hoelscher
Radboud University Medical Center; German Federal Ministry of Education and... and other collaborators

Completed

BTZ-043 - Multiple Ascending Dose (MAD) to Evaluate Safety, Tolerability and Early Bactericidal Activity (EBA)

Pulmonary Tuberculoses | Other Specified Pulmonary Tuberculosis

South Africa
University of Guadalajara

Completed

Effect of Aerobic Training and Ginkgo Biloba on Lipids Levels in HIV-positive Patients Undergoing Antiretroviral Treatment

Human Immunodeficiency Virus

Mexico
University of Southern California

Completed

Herbal Therapy for Treatment of Recurrent Prostate Cancer

Prostate Cancer

United States
AstraZeneca

Completed

Drug Interaction Study Between AZD3480 and Cytochrome P450 (Cocktail)

Alzheimer's Disease | Metabolism

Sweden
Spanish Breast Cancer Research Group
Merck Sharp & Dohme LLC

Completed

Incidence of Chemotherapy-Induced Nausea and Vomiting Associated With Docetaxel-Cyclophosphamide in Early Breast Cancer.

Breast Cancer

Spain
Eli Lilly and Company

Completed

A Study of Ixekizumab in Participants With Plaque Psoriasis

Psoriasis

United States

3

Subscribe