Search clinical trials for: CDK 4/6

Total 18040 results

EmitBio Inc.

Completed

Evaluation of the RD-X19 Treatment Device in Individuals With Mild to Moderate COVID-19

COVID19

United States
Evelo Biosciences, Inc.

Completed

A Study of EDP1815 in Healthy Participants and Participants With Mild to Moderate Psoriasis and Atopic Dermatitis

Psoriasis | Atopic Dermatitis

United Kingdom
UCB Pharma

Completed

Effect on RLS Symptom Severity After Switching to Neupro® in Patients Who Previously Experienced Augmentation (AURORA)

Restless Legs Syndrome

Germany
Thesan Pharmaceuticals, Inc.

Withdrawn

TSN2898-201 Safety and Efficacy of TSN2898 in the Treatment of Acne Vulgaris

Acne Vulgaris

United States, Dominican Republic, Honduras
Heidelberg University
German Center for Lung Research

Completed

Preventive Inhalation of Hypertonic Saline in Infants With Cystic Fibrosis (PRESIS)

Cystic Fibrosis Lung Disease

Germany
Chulalongkorn University

Not yet recruiting

Efficacy and Safety of Astaxanthin in Volunteer With Refraction Errors

Refractive Errors
University of Pennsylvania

Active, not recruiting

Evaluation of Neuroinflammation in Parkinson's Disease Using 18F-NOS PET/CT

Parkinson Disease | Healthy Volunteer

United States
Fudan University

Recruiting

Initial CDK 4/6 Inhibitor Plus Endocrine Therapy Versus Initial Chemotherapy in HR Positive, HER2 Negative Unresectable or Metastatic Breast Cancer

Breast Cancer

China
Novartis Pharmaceuticals

Withdrawn

A Randomized,Double Blind, Placebo Controlled Study to Assess Efficacy,Safety and Tolerability of BGG492 in Migraine Prevention

Patients With Migraine Equal of /More Than 3 and Equal of/ Less Than 12 Migraine Attacks/4 Weeks for Each of the Last 6 Months Preceding the Screening
ViGenCell Inc.

Not yet recruiting

A Prospective, Open Label, Dose-escalation, SAD/MAD, Multicenter, 24weeks, Phase I/IIa Clinical Trial to Evaluate the Safety, Tolerability and Pharmacodynamics of Investigational Product (VM-001) in Patients With Graft-versus-host Disease(GvHD)

Graft Versus Host Disease
Kari Wisinski
Novartis; University of Wisconsin, Madison; Big Ten Cancer Research Consortium

Recruiting

Ribociclib and Bicalutamide in AR+ TNBC

Triple Negative Breast Cancer

United States
Cairo University

Unknown

Effect of Changing the Activation Frequency of the Arch Wires on the Rate of Leveling and Alignment in Moderate Crowding Cases

Leveling and Alignment of Teeth
University of Copenhagen
Clinical Immunological Department, Rigshospitalet; The Danish Blood Donor Study

Recruiting

Characterization of Natural IL-6 Inhibition in Healthy Individuals (FIDI)

Autoantibodies | Interleukin-6

Denmark
University of Milano Bicocca

Recruiting

Retrospective Study of 2nd-line Therapies After CDK4/6i + Hormonal Therapy in HR+/HER2- Advanced Breast Cancer (HERMIONE-13)

Advanced Breast Cancer | Hormone Receptor Positive Breast Carcinoma | HER2-negative Breast Cancer

Italy
Cliniques universitaires Saint-Luc- Université...

Completed

Comparison Between 6 Minute Walk Test, 6 Minute Step Test and 4 Metre Gait Speed

Healthy | Children

Belgium
Hôpital NOVO

Completed

Evaluation of Positioning Protocols on a Wheelchair in Hemiplegic Patients (POSIT-HEMI)

Hemiplegia and/or Hemiparesis Following Stroke

France
Coloplast A/S

Completed

An Exploratory Study Investigating Human Skin Reaction to Output

Ileostomy

Denmark
Thai Red Cross AIDS Research Centre

Recruiting

Study to Evaluate the Feasibility of Integrating the Point-of-care Testing for Sexually Transmitted Infections and HIV Into Community-based Clinics for MSM and TGW in Thailand

Men Who Have Sex With Men and Transgender Women

Thailand
Theracos

Completed

Efficacy and Safety of EGT0001442 in Patients With Type 2 Diabetes Mellitus

Diabetes Mellitus

United States
Solvay Pharmaceuticals

Completed

Study Investigating a Delayed-Release Pancrelipase in Patients With Pancreatic Exocrine Insufficiency (PEI) Due to Cystic Fibrosis (CF)

Cystic Fibrosis | Pancreatic Exocrine Insufficiency

United States
National University of Malaysia

Completed

4 Versus 6 cm Active Phase of Labour

Labor Complication | Cervix; Open

Malaysia
Coloplast A/S

Completed

An Exploratory Study Investigating Adhesive Reaction to Output

Ileostomy

Denmark
Yuhan Corporation

Completed

Pharmacokinetic Drug Interaction Between Revaprazan and Itopride HCl in Healthy Male Subjects

Healthy

Korea, Republic of
Armauer Hansen Research Institute, Ethiopia
United States Agency for International Development (USAID); Tulane University; Addis Continental Institute of Public Health and other collaborators

Unknown

Evaluation of Targeted Mass Drug Administration for Malaria in Ethiopia

Malaria

Ethiopia
Grünenthal GmbH

Terminated

Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Pain Due to Osteoarthritis Taking WHO Step III Analgesics But Showing a Lack of Tolerability.

Osteoarthritis | Chronic Pain

Germany, United Kingdom, Spain, Australia, Denmark, Poland
Pharmacyclics LLC.
Celgene Corporation

Completed

Ibrutinib and Lenalidomide With Dose Adjusted EPOCH-R in Subjects With Relapsed/Refractory Diffuse Large B-cell Lymphoma

Diffuse Large B Cell Lymphoma Refractory | Diffuse Large B Cell Lymphoma Relapsed

United States
University of Pennsylvania

Recruiting

Molecular Imaging of the Underlying Mechanism of Cardiotoxicity in Patients With Light Chain Amyloidosis Using PET/CT

Cardiac Amyloidosis

United States
Chong Kun Dang Pharmaceutical

Unknown

A Study to Investigate Drug-Drug Interaction Between D326, D337 and CKD-828 in Healthy Subjects

Hypertension | Dyslipidemias

Korea, Republic of
Sunovion

Completed

A Study to Evaluate a Drug (Dasotraline) on the Safety, Effectiveness and How Well the Body Tolerates it, in Adults With Moderate to Severe Binge Eating Disorder

Binge Eating Disorder

United States
Stanford University

Active, not recruiting

Abemaciclib in Metastatic or Locally Advanced Anaplastic/Undifferentiated Thyroid Cancer

Thyroid Cancer | Anaplastic Thyroid Cancer | Undifferentiated Thyroid Cancer

United States
Tianjin Medical University Cancer Institute and...

Not yet recruiting

Advanced Breast Cancer Study of CDK4/6 Inhibitor Combined With Endocrine Therapy Endocrine Therapy in HR+/HER2- Advanced Breast Cancer

Advanced HR+ HER2 Negative Breast Carcinoma
G1 Therapeutics, Inc.

Terminated

Trilaciclib (G1T28), a CDK 4/6 Inhibitor, in Combination With Gemcitabine and Carboplatin in Metastatic Triple Negative Breast Cancer (mTNBC)

Breast Cancer | Breast Neoplasm | Triple-Negative Breast Cancer | Triple-Negative Breast Neoplasms

United States, Bulgaria, Croatia, Slovenia, Serbia, Belgium, North Macedonia, Slovakia
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Enasidenib as Maintenance Therapy in Treating Patients With Acute Myeloid Leukemia With IDH2 Mutation After Donor Stem Cell Transplant

Acute Myeloid Leukemia

United States
Kowa Research Institute, Inc.

Completed

Pharmacokinetic Drug-Drug Interaction Study Between K-877 and CSG452 in Healthy Adult Volunteers

Healthy

United States
Sanofi
Kowa Company, Ltd.

Completed

TOFO Insulin Combination Trial

Type 2 Diabetes Mellitus

Japan
Keimyung University Dongsan Medical Center

Completed

The Impact of Nurse Education on the Quality of Inpatient Bowel Preparation for Colonoscopy

Ottawa Scale <6

Korea, Republic of
CRISPR Therapeutics AG

Recruiting

A Safety and Efficacy Study Evaluating CTX131 in Adult Subjects With Relapsed or Refractory Solid Tumors

Clear Cell Renal Cell Carcinoma | Pancreatic Adenocarcinoma | Cervical Carcinoma | Malignant Pleural Mesothelioma | Esophageal Carcinoma

United States
PharmaTher Inc.

Suspended

Randomized, Double-Blind, Active Placebo-Controlled Study of Ketamine to Treat Levodopa-Induced Dyskinesia

Central Nervous System Diseases | Nervous System Diseases | Neurologic Manifestations | Movement Disorders | Dyskinesias

United States
Thai Red Cross AIDS Research Centre
United States Agency for International Development (USAID)

Active, not recruiting

HIV Self-Testing AND Uptake and Retention of PrEP Among Older Adolescent MSM and TGW

Men or Transgender Women Who Have Sex With Men

Thailand
Bausch & Lomb Incorporated

Completed

A Study to Evaluate the Safety and Effectiveness of a Silicone Hydrogel Custom Contact Lens When Compared to Alden Optical HP Sphere Lens

Contact Lens Wear

United States
Changping Laboratory
Beijing HuiLongGuan Hospital

Recruiting

The Dosage Effect of pBFS Guided rTMS Treatment for MDD

Major Depressive Disorder | Severe Depression | Moderate Depression

China
Shinshu University
Kowa Company, Ltd.

Recruiting

Effect of Tofogliflozin on UACR Compared to Metformin Hydrochloride in Diabetic Kidney Disease (TRUTH-DKD) (TRUTH-DKD)

T2DM (Type 2 Diabetes Mellitus) | Metformin | SGLT2-Inhibitors

Japan
Kowa Research Institute, Inc.

Completed

Study to Demonstrate the Bioequivalence of Single Oral Administration of K-001 Relative to Single Oral Coadministration of Separate Tablets of K-877-ER and CSG452

Healthy

United States
Imam Abdulrahman Bin Faisal University

Completed

Low Tidal Volume and EVLWI During OLV

Lung Diseases

Saudi Arabia
Solvay Pharmaceuticals

Completed

Study to Compare the Effect of Hormone Replacement Therapy (HRT) on Breast and Cardiovascular Metabolic Markers in Postmenopausal Women

Menopause

Italy
Henry Ford Health System

Completed

A Randomized Trial of Clinical Decision Making in Asymptomatic Carotid Stenosis

Carotid Stenosis

United States
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany

Terminated

Phase Ib/II Study of M3814 With Etoposide and Cisplatin in Small Cell Lung Cancer (SCLC) Extensive Disease (ED)

Small Cell Lung Cancer

Belgium, Denmark, Italy, United States, Bulgaria, Canada, Czechia, Germany, Hungary, Poland, Romania, Spain, United Kingdom
Region Örebro County
Helsinki University Central Hospital; Hospital Clinic of Barcelona; University... and other collaborators

Recruiting

Implementing Geriatric Assessment for Dose Optimization of Cyclin-dependent Kinase (CDK) 4/6-inhibitors in Older Breast Cancer Patients (IMPORTANT)

Quality of Life | Advanced Breast Cancer | Metastatic Breast Cancer | Toxicity | Older Patients

Sweden, Finland, Greece, Italy, Norway, Spain
Fuzhou General Hospital

Not yet recruiting

ctDNA as a Biomarker for Treatment in Advanced NSCLC

Non-small Cell Lung Cancer

China
Philip Morris Products S.A.

Active, not recruiting

Pharmacokinetics and Comparative Bioavailability of Nicotine From Two Variants of NP2, NP2-4mg and NP2-6mg, Compared to Nicotine Lozenge 4mg (Loz-4mg) and Nicotine Gum 4mg (Gum-4mg)

Tobacco Use

Canada

Search clinical trials for: CDK 4/6

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