Search clinical trials for: HIV Protease Inhibitors

Total 72814 results

Pfizer

Completed

Relative Bioavailability Study of Nirmatrelvir/Ritonavir Oral Powder Relative to the Commercial Tablets and Estimation of the Effect of Food on Bioavailability of the Nirmatrelvir/Ritonavir Oral Powder in Healthy Participants.

Biological Availability

Belgium
IrsiCaixa

Completed

Impact of Raltegravir Intensification on HIV-1-infected Subjects With Complete Viral Suppression Under Monotherapy With Protease Inhibitors

HIV-1 Infection

Spain
Pfizer

Active, not recruiting

A Study to Learn About the Use of Paxlovid in Patients With COVID-19 in the Kingdom of Bahrain.

COVID-19

Bahrain
National Cancer Institute (NCI)

Completed

Brentuximab Vedotin or Crizotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II-IV Anaplastic Large Cell Lymphoma

Anaplastic Large Cell Lymphoma, ALK-Positive | Ann Arbor Stage II Noncutaneous Childhood Anaplastic Large Cell Lymphoma | Ann Arbor Stage III Noncutaneous Childhood Anaplastic Large Cell Lymphoma | Ann Arbor Stage IV Noncutaneous Childhood Anaplastic Large Cell Lymphoma

United States
AIDS Malignancy Consortium
National Cancer Institute (NCI); University of California, Los Angeles; Montefiore... and other collaborators

Completed

Nelfinavir Mesylate in Treating Patients With Kaposi Sarcoma

Skin Kaposi Sarcoma | Recurrent Kaposi Sarcoma

United States, Uganda, South Africa
Indiana University

Withdrawn

High-Dose Post-Transplant Cyclophosphamide, Bortezomib, and Sitagliptin for the Prevention of GVHD

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Chronic Myelomonocytic Leukemia | Acute Lymphoblastic Leukemia, Adult | Bone Marrow Transplant Complications

United States
Pfizer

Completed

A Study of COVID-19 Patients Receiving Treatment With Nirmatrelvir; Ritonavir in the Kingdom of Saudi Arabia

Covid-19

Saudi Arabia
M.D. Anderson Cancer Center

Active, not recruiting

Combination Chemotherapy and Ponatinib Hydrochloride in Treating Patients With Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia | Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Philadelphia Chromosome Positive | B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 | Untreated Adult Acute Lymphoblastic Leukemia | Accelerated Phase Chronic Myelogenous Leukemia,... and other conditions

United States
The Crofoot Research Center, Inc.
Janssen Scientific Affairs, LLC

Completed

Rapid Reinitiation of a Single Tablet Antiretroviral Therapy Using Symtuza® in HIV-1 Infected Treatment-Experienced Patients Off Therapy. (ReSTART) (ReSTART)

HIV-1-infection

United States
Vanderbilt University Medical Center
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Brigham... and other collaborators

Suspended

Optimal Management of HIV Infected Adults at Risk for Kidney Complications in Nigeria

Kidney Diseases | HIV/AIDS | Albuminuria | Genetic Predisposition

Nigeria
The First Affiliated Hospital of Zhengzhou University
Luoyang Central Hospital; Nanyang Central Hospital; The Fifth People's Hospital... and other collaborators

Completed

The Real-world Clinical Study of Azvudine Tablets in the Treatment of COVID-19

COVID-19 | Azvudine

China
Pfizer

Completed

A Study to Learn About the Medicine (PF-07321332 or Nirmatrelvir/Ritonavir) in Healthy Lactating Women

Healthy Participants

Belgium
Pfizer

Suspended

EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease

COVID-19

United States, United Kingdom, Japan, South Africa, Bulgaria, Puerto Rico, Mexico, Hungary
Pfizer

Completed

PF-07321332/Ritonavir and Ritonavir on Dabigatran Study in Healthy Participants

Healthy Participants

United States
Pfizer

Withdrawn

A Study to Learn About the Patients With COVID-19 Prescribed Paxlovid in Morocco

COVID-19 Drug Treatment
Pfizer

Completed

A Study to Learn About a Repeat 5-Day Treatment With the Study Medicines (Called Nirmatrelvir/Ritonavir) in People 12 Years Old or Older With Return of COVID-19 Symptoms and SARS-CoV-2 Positivity After Finishing Treatment With Nirmatrelvir/Ritonavir

COVID-19

United States, Taiwan, Italy, Canada, Greece
Hospital do Coracao

Completed

Antiviral Agents Against COVID-19 Infection (REVOLUTIOn)

COVID-19

Brazil
Merck Sharp & Dohme LLC

Completed

Safety and Efficacy of Doravirine (MK-1439) in Participants With Human Immunodeficiency Virus 1 (HIV-1) (MK-1439-018) (DRIVE-FORWARD)

HIV-1
Instituto de Investigación Hospital Universitario...

Completed

Clinical Trial to Evaluate the Efficacy of Different Treatments in Patients With COVID-19

SARS-CoV-2 Infection

Spain
Harlan M Krumholz
Pfizer

Active, not recruiting

A Decentralized, Randomized Phase 2 Efficacy and Safety Study of Nirmatrelvir/Ritonavir in Adults With Long COVID. (PAXLC)

Long COVID

United States
Vanderbilt University Medical Center
AbbVie

Completed

Trial of Early Therapies During Non-hospitalized Outpatient Window for COVID-19 (TREATNOW)

COVID-19

United States
The HIV Netherlands Australia Thailand Research...
Khon Kaen University

Active, not recruiting

A Prospective Cohort of Children With HIV Infection

HIV Infections

Thailand
ViiV Healthcare
GlaxoSmithKline

Completed

A Study to Determine Safety and Efficacy of Dolutegravir/Abacavir/Lamivudine (DTG/ABC/3TC) in Human Immunodeficiency Virus (HIV)-1 Infected Antiretroviral Therapy (ART) Naïve Women (ARIA)

HIV Infections | Infection, Human Immunodeficiency Virus

United States, France, Spain, United Kingdom, Canada, Thailand, Italy, Portugal, Russian Federation, Mexico, Argentina, South Africa, Puerto Rico
Istituto Auxologico Italiano
European Society of Hypertension; Chinese Hypertension League

Completed

Optimal Blood Pressure and Cholesterol Targets for Preventing Recurrent Stroke in Hypertensives (ESH-CHL-SHOT)

Stroke | Hypertension | Transient Ischemic Attack

Russian Federation
Castagna Antonella
Bristol-Myers Squibb; ViiV Healthcare

Completed

A Study of a Nucleoside Sparing Regimen in HIV-1 Infected Patients With Detectable Viremia (Dolatav)

HIV-1 Infection

Italy
IRCCS San Raffaele
Bristol-Myers Squibb

Completed

Efficacy of Atazanavir/Ritonavir Monotherapy as Maintenance in Patients With Viral Suppression

HIV-1 Infection

Italy
Chinese University of Hong Kong

Completed

Safety and Clinical and Virologic Outcomes in CKD Patients Treated With Nirmatrelvir-ritonavir

COVID-19 | Chronic Kidney Disease stage4 | Chronc Kidney Disease Stage 5

Hong Kong
Franck Boccara
Institut National de la Santé Et de la Recherche Médicale, France; Amgen; National...

Completed

COPANA - A09 PCSK 9 Substudy: Impact of Protease Inhibitors on PCSK9 Levels in Naive HIV-Infected Patients (COPANA)

Dyslipidemias | HIV Seropositivity | PCSK9

France
Pfizer

Completed

A Study to Learn About the Study Medicines (Nirmatrelvir Plus Ritonavir) in People Aged 12 Years or Older With COVID-19 and a Compromised Immune System

COVID-19

Spain, United States, Australia, Canada, Bulgaria, Slovakia, Mexico, Hungary, Brazil
Westlake Pharmaceuticals (Hangzhou) Co., Ltd.

Completed

Study of WPV01 in Healthy Subjects

Healthy Participants

China
Bristol-Myers Squibb

Terminated

Open-Label Study Comparing Efficacy and Safety of ATV/RTV+3TC With ATV/RTV+TDF/FTC in HIV-Infected, Treatment Naïve Subjects, Followed by Treatment With ATV/RTV+3TC

HIV
National Institute of Neurological Disorders and...

Completed

HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS)

Amyotrophic Lateral Sclerosis

United States
Bristol-Myers Squibb

Withdrawn

Second-line Treatment of HIV-1 With Ritonavir Boosted Atazanavir or Darunavir With an Optimized NRTI Backbone (SUPPRESS)

HIV

United States
Universidade do Porto
Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS); Rede... and other collaborators

Active, not recruiting

Effectiveness and Safety of New Oral Antivirals for COVID-19 (ESOA-19)

COVID-19

Portugal
Daiichi Sankyo Co., Ltd.
AstraZeneca

Completed

Study of DS-8201a for Participants With Advanced Solid Malignant Tumors

Neoplasm Metastasis

Korea, Republic of, Taiwan, Japan
Pfizer

Terminated

A Study to Measure the Amount of Study Medicine in Blood in Adult Participants With COVID-19 and Severe Kidney Disease

COVID-19

United States
Boehringer Ingelheim

Completed

Dual Boosted - Protease Inhibitor (PI) Pharmacokinetics (PK) Trial (Tipranavir / Ritonavir) in Highly Treatment-experienced HIV-1 Infected Patients

HIV Infections

Netherlands, Germany, Canada, United States, France, United Kingdom, Switzerland, Denmark, Australia, Greece, Portugal, Belgium, Italy
National Institutes of Health Clinical Center (CC)

Completed

Impact of Steady State Cobicistat and Darunavir/Cobicistat on the Pharmacokinetics and Pharmacodynamics of Oral Anticoagulants (Rivaroxaban, Apixaban) in Health Volunteers

Healthy Volunteers

United States
Institut National de la Santé Et de la Recherche...

Completed

Trial of Treatments for COVID-19 in Hospitalized Adults (DisCoVeRy)

Corona Virus Infection

Norway, Austria, France, Greece, Portugal, Belgium, Luxembourg
Technical University of Munich

Completed

Dual Therapy With Boosted Darunavir + Dolutegravir (Dualis)

HIV-Infection

Germany
ViiV Healthcare
GlaxoSmithKline; Janssen Pharmaceuticals

Completed

Regimen Switch to Dolutegravir + Rilpivirine From Current Antiretroviral Regimen in Human Immunodeficiency Virus Type 1 Infected and Virologically Suppressed Adults (SWORD-1)

HIV Infections

Germany, Taiwan, France, United States, Canada, Belgium, Australia, Netherlands, Spain, United Kingdom, Italy, Argentina, Russian Federation
University of Liverpool
University of Southampton; Liverpool University Hospitals NHS Foundation Trust and other collaborators

Active, not recruiting

AGILE (Early Phase Platform Trial for COVID-19)

Covid19

United Kingdom, South Africa
ViiV Healthcare
GlaxoSmithKline; Janssen Pharmaceuticals

Completed

Regimen Switch to Dolutegravir + Rilpivirine From Current Antiretroviral Regimen in Human Immunodeficiency Virus Type 1 Infected and Virologically Suppressed Adults (SWORD-2)

HIV Infections

Germany, Spain, United States, Canada, Taiwan, France, Italy, Argentina, United Kingdom, Russian Federation, Australia
Azienda Ospedaliera Universitaria Integrata Verona
Agenzia Italiana del Farmaco; Azienda Sanitaria-Universitaria Integrata di...

Completed

Non-inferiority Trial on Treatments in Early COVID-19

COVID-19

Italy
Fujian Akeylink Biotechnology Co., Ltd.

Completed

Drug-Drug Interaction Study of Itraconazole With GST-HG171/Ritonavir in Healthy Participants

Healthy Participant

China
Fujian Akeylink Biotechnology Co., Ltd.

Active, not recruiting

Food Effects of GST-HG171 Tablets Combined With Ritonavir in Healthy Chinese Participants

COVID-19 Respiratory Infection

China
Fujian Akeylink Biotechnology Co., Ltd.

Completed

Study of GST-HG171/Ritonavir Compared With Placebo in Patients With Mild to Moderate COVID-19

COVID-19 Pneumonia

China
University of Nebraska
National Cancer Institute (NCI)

Completed

Chemotherapy, Stereotactic Body Radiation Therapy & Nelfinavir Mesylate in Locally Advanced Pancreatic Cancer

Pancreatic Adenocarcinoma | Stage III Pancreatic Cancer | Stage IIA Pancreatic Cancer | Stage IIB Pancreatic Cancer | Stage II Pancreatic Cancer | Stage I Pancreatic Cancer | Resectable Pancreatic Carcinoma | Stage IA Pancreatic Cancer | Stage IB Pancreatic Cancer

United States
Stanford University
Pfizer

Completed

Paxlovid for Treatment of Long Covid (STOP-PASC)

Long COVID | Post-acute Sequelae of SARS-CoV-2 Infection

United States
ViiV Healthcare
GlaxoSmithKline

Completed

Study Of An Investigational Regimen Including FDA Approved HIV Drugs In HIV-Infected Pediatric Subjects

HIV Infections | Infection, Human Immunodeficiency Virus

United States, Portugal, Russian Federation, Mexico, Argentina, South Africa, Puerto Rico

Search clinical trials for: HIV Protease Inhibitors

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