Search clinical trials for: Multimodality treatment of locally advanced rectal cancer

Total 445979 results

University Medical Center Goettingen
German Research Foundation

Active, not recruiting

Translational Validation Study to Examine KFO179-1 Biomarker Scores for the Prediction and Prognosis of Advanced Primary Resectable Rectal Cancer Stages UICC-II-IV, With a 5-Fluorouracil-based Standard Radiochemotherapy Followed by Total Mesorectal Excision. (TransValid-A)

Locally Advanced Rectal Cancer

Germany
The First Hospital of Jilin University

Active, not recruiting

Total Neoadjuvant Treatment Plus PD-1 in Mid-Low Locally Advanced Rectal Cancer (STARS-RC03)

Locally Advanced Rectal Cancer | PD-1 | Total Neoadjuvant Treatment | Tislelizumab

China
National Cancer Institute (NCI)

Completed

Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Sarcoma That Cannot Be Removed by Surgery

Stage III Soft Tissue Sarcoma AJCC v7 | Stage IV Soft Tissue Sarcoma AJCC v7 | Pleomorphic Liposarcoma | Metastatic Undifferentiated Pleomorphic Sarcoma | Metastatic Unresectable Sarcoma | Unresectable Soft Tissue Sarcoma | Metastatic Soft Tissue Sarcoma | Locally Advanced Soft Tissue Sarcoma | Metastatic... and other conditions

United States
National Cancer Institute (NCI)

Terminated

Testing the Addition of a Radiation Sensitizing Drug, IPdR, to the Usual Chemotherapy Treatment (Capecitabine) During Radiation Therapy for Rectal Cancer

Stage III Rectal Cancer AJCC v8 | Rectal Adenocarcinoma | Stage II Rectal Cancer AJCC v8 | Locally Advanced Rectal Carcinoma

United States
Maimónides Biomedical Research Institute of Córdoba

Active, not recruiting

Clinical Trial to Evaluate Safety and Efficacy of Hyperthermic Intra-peritoneal Chemotherapy (HIPEC) With Mitomycin C Used During Surgery for Treatment of Locally Advanced Colorectal Carcinoma (HIPECT4)

Colorectal Cancer

Spain
Aalborg University Hospital

Active, not recruiting

Chemo-radiotherapy as Main Treatment Strategy for Rectal Cancer. Can we Provide a More Precise and Effective Treatment (AMPERE)

Rectal Cancer | Rectal Adenocarcinoma | Locally Advanced Malignant Neoplasm

Denmark
Swiss Group for Clinical Cancer Research

Terminated

Neoadjuvant Treatment With Regorafenib and Capecitabine Combined With Radiotherapy in Locally Advanced Rectal Cancer (RECAP)

Rectal Cancer

Switzerland
Hospital San Carlos, Madrid

Completed

"Oncologic Results and Risk Factors for Recurrence in Patients With Locally Advanced Rectal Cancer and Pathologic Complete Response After Neoadjuvant Treatment. Results From an Observational Retrospective Multicenter Long-term Follow-up Study".

Rectal Cancer Stage II | Rectal Cancer Stage III | Rectal Cancer, Adenocarcinoma | Distant Metastasis | Local Recurrence of Malignant Tumor of Rectum

Spain
Targovax ASA

Terminated

Exploratory Study of TG02-treatment as Monotherapy or in Combination With Pembrolizumab to Assess Safety and Immune Activation in Patients With Locally Advanced Primary and Recurrent Oncogenic RAS Exon 2 Mutant Colorectal Cancer

Rectal Cancer

New Zealand, Australia
Shanghai Minimally Invasive Surgery Center

Withdrawn

Anlotinib Hydrochloride Combined With Capeox in the Neoadjuvant Treatment of Locally Advanced Rectal Cancer

Rectal Cancer | Anlotinib | Neoadjuvant Treatment
Amany sayed Abass

Unknown

Role of Neoadjuvent Radiotherapy in Locally Advanced Cancer Rectum

Rectal Adenocarcinoma

Egypt
Hospital Clinic of Barcelona
Hospital Son Espases; Hospital del Mar; Hospital Universitario La Fe; Instituto... and other collaborators

Unknown

Interval Between Neoadjuvant Therapy and Surgery in the Treatment of Locally Advanced Rectal Cancer (CRONOS) (CRONOS)

Rectal Cancer | Neoadjuvant Therapy

Spain
Radiation Therapy Oncology Group
National Cancer Institute (NCI)

Completed

Radiation Therapy Plus Chemotherapy Followed by Surgery in Treating Patients With Locally Advanced Cancer of the Rectum

Colorectal Cancer

United States, Canada
Sidney Kimmel Comprehensive Cancer Center at Johns...

Completed

Study of High-Dose-Rate Endorectal Brachytherapy (HDRBT) in the Treatment of Locally Advanced Low Rectal Cancer (HDRBT)

Rectal Cancer

United States
Peking University Cancer Hospital & Institute

Unknown

Total Neoadjuvant Treatment Plus SHR1210 for High-risk Rectal Cancer and Biomarker Screening Base on Neoantigen

Rectal Cancer

China
Sixth Affiliated Hospital, Sun Yat-sen University
Sir Run Run Shaw Hospital; The Third Affiliated Hospital of Kunming Medical...

Unknown

Radiomics-based Artificial Intelligence System to Predict Neoadjuvant Treatment Response in Rectal Cancer (MRAI-pCR)

Rectal Cancer

China
Gruppo Oncologico del Nord-Ovest

Unknown

Cetuximab + Avelumab or Avelumab Alone for Unresectable, Locally Advanced or Metastatic Squamous Cell Anal Carcinoma (SCCAC) Progressed After at Least One Line of Systemic Treatment (CARACAS) (CARACAS)

Squamous Cell Anal Carcinoma

Italy
Grupo de Investigación Clínica en Oncología Radioterapia

Unknown

Dose-escalation Trial of Preoperative Radiotherapy and Concurrent Chemotherapy in Locally Advanced Rectal Cancer

Locally Advanced Rectal Cancer

Spain
National Cancer Institute (NCI)

Completed

Bevacizumab, Radiation Therapy, and Combination Chemotherapy in Treating Patients Who Are Undergoing Surgery for Locally Advanced Nonmetastatic Rectal Cancer

Rectal Adenocarcinoma | Stage III Rectal Cancer AJCC v7 | Stage II Rectal Cancer AJCC v7

United States
Zealand University Hospital
Rigshospitalet, Denmark; Herlev Hospital

Unknown

Endoscopic Assisted Electrochemotherapy in Addition to Neoadjuvant Treatment of Locally Advanced Rectal Cancer (nECT)

Neoadjuvant Therapy | Locally Advanced Rectal Cancer | Electrochemotherapy | Down Staging

Denmark
Radiation Therapy Oncology Group
National Cancer Institute (NCI); NRG Oncology

Completed

Combination Chemotherapy and Intensity-Modulated Radiation Therapy in Treating Patients Undergoing Surgery for Locally Advanced Rectal Cancer

Colorectal Cancer

United States, Canada
Centre Oscar Lambret

Completed

Combination of Metformin to Neoadjuvant Radiochemotherapy in the Treatment of Locally Advanced Rectal Cancer (METCAP).

Rectal Cancer

France
Institut Català d'Oncologia
Hoffmann-La Roche

Completed

Xeloda and Bevacizumab to Treat Rectal Cancer (xeberecto)

Rectal Cancer

Spain
Zhu Ji

Unknown

Tumor Response Prediction in Neoadjuvant Chemoradiation of Locally Advanced Rectal Cancer Using Metabonomics Analysis

Locally Advanced Rectal Cancer

China
Washington University School of Medicine

Terminated

Gene Expression and FDG PET/MRI in Evaluating Treatment Response in Patients With Locally Advanced Rectal Cancer Undergoing Chemotherapy and Radiation Therapy Before Surgery

Rectal Neoplasms

United States
European Organisation for Research and Treatment...

Completed

Chemotherapy and Radiation Therapy Before Surgery Followed by Capecitabine With or Without Oxaliplatin in Treating Patients With Locally Advanced Rectal Cancer (PETACC-6)

Colorectal Cancer
WiSP Wissenschaftlicher Service Pharma GmbH
Gesellschaft fur Medizinische Innovation - Hamatologie und Onkologie mbH

Unknown

Panitumumab in Combination With Radiotherapy in Patients With Locally Advanced RAS Wildtype Rectal Cancer (Clinical Stages II and III) (NEO-RIT)

Rectal Cancer

Germany
Royal Marsden NHS Foundation Trust
Cancer Research UK; European Organisation for Research and Treatment of Cancer... and other collaborators

Unknown

International Multicentre Study in Advanced Anal Cancer Comparing Cisplatin Plus 5 FU vs Carboplatin Plus Weekly Paclitaxel (InterAACT)

Squamous Cell Carcinoma of the Anus

United States, Australia, United Kingdom
Sheba Medical Center
Karyopharm Therapeutics Inc

Unknown

Selinexor Combined With Standard Chemoradiation as Neoadjuvant Treatment in Locally Advanced Rectal Cancer

Rectal Neoplasms

Israel
European Organisation for Research and Treatment...

Completed

Doxorubicin With or Without Ifosfamide and Pegfilgrastim in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma

Sarcoma

France, Switzerland, United Kingdom, Belgium, Germany, Canada, Spain, Netherlands, Slovakia, Austria, Denmark
AVEO Pharmaceuticals, Inc.

Completed

A Trial of Tivozanib (AV-951) in Combination With Capecitabine (Xeloda®) in Subjects With Advanced Solid Tumors

Advanced Solid Tumors | Locally Advanced or Metastatic Breast or Colorectal Cancer

United States
Austrian Breast & Colorectal Cancer Study Group
Hoffmann-La Roche; Sanofi-Synthelabo

Completed

Preoperative Combined Radiochemotherapy for Patients With Rectal Carcinoma

Rectal Cancer

Austria
Medical Research Council

Completed

Study of Tumor Tissue Testing in Selecting Treatment for Patients With Metastatic or Locally Advanced Colorectal Cancer

Colorectal Cancer

United Kingdom
European Organisation for Research and Treatment...

Terminated

Radiation Therapy, Mitomycin, and Either Fluorouracil or Cisplatin in Treating Patients With Locally Advanced Anal Cancer

Anal Cancer

France, Belgium, Germany, Egypt, Serbia, Netherlands, Italy
Daiichi Sankyo, Inc.

Completed

DJ-927 as Second-Line Therapy in Treating Patients With Progressive Locally Advanced or Metastatic Colorectal Adenocarcinoma

Colorectal Cancer

United States
Institute of Oncology Ljubljana

Unknown

Induction Chemotherapy,Radiochemotherapy, Consolidation Chemotherapy in Preoperative Treatment of Rectal Cancer

Rectal Cancer

Slovenia
International Atomic Energy Agency
Catholic University of the Sacred Heart; University of Cape Town; Tata Memorial... and other collaborators

Unknown

Resource-Sparing Curative Treatment for Rectal Cancer

Rectal Carcinoma

Algeria, Brazil, Canada, Colombia, Croatia, Cuba, India, Indonesia, Italy, Slovakia, South Africa
Institute of Oncology Ljubljana

Completed

Capecitabine as Radiosensitising Agent in Neoadjuvant Treatment of Locally Advanced Resectable Rectal Cancer

Resectable Rectal Cancer Clinical Stage II and III

Slovenia
Sanofi

Completed

Preoperative Radiotherapy/ Oxaliplatin/ Capecitabine Treatment For Unresectable Locally-advanced Rectal Cancer (PROCTFUL)

Rectal Neoplasms
National Cancer Institute (NCI)

Completed

A Multimodality Treatment Approach to Patients With Inflammatory Cancer of the Breast and Locally Advanced Non-Inflammatory Stage III Breast Cancer and Stage IV Breast Cancer

Breast Neoplasms | Neoplasm Metastasis

United States
Fujian Cancer Hospital

Not yet recruiting

Phase II Study of Different Doses of Radiotherapy Combined With Sintilimab in the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma

Esophageal Squamous Cell Carcinoma
AbbVie

Not yet recruiting

Study to Assess Adverse Events and How Intravenously (IV) Infused ABBV-400 Moves Through the Body of Adult Participants With Unresectable Locally Advanced/Metastatic Colorectal Cancer

Colorectal Cancer
Wuhan University

Not yet recruiting

A Real-World Study of Neoadjuvant/Conversion Therapy for Locally Advanced or Metastatic Gastric Cancer

Gastric Cancer

China
Akamis Bio

Not yet recruiting

NG-350A Plus Chemoradiotherapy for Locally Advanced Rectal Cancer (FORTRESS)

Locally Advanced Rectal Cancer (LARC)
University Health Network, Toronto

Not yet recruiting

A Study of High Dose Radiation Therapy for Locally Advanced Pancreatic Cancer That Responded to Initial Chemotherapy Treatment (ABLATE)

Locally Advanced Pancreatic Adenocarcinoma
Shanghai East Hospital

Recruiting

Chemokine and Co-stimulatory Molecule-modified Mesenchymal Stem Cells for the Treatment of Advanced Colorectal Cancer

Advanced Colorectal Cancer

China
Roswell Park Cancer Institute

Not yet recruiting

Tamoxifen and Pegylated Liposomal Doxorubicin for the Treatment of Patients With Metastatic or Inoperable, Locally Advanced Triple Negative Breast Cancer

Anatomic Stage III Breast Cancer AJCC v8 | Anatomic Stage IV Breast Cancer AJCC v8 | Metastatic Triple-Negative Breast Carcinoma | Locally Advanced Unresectable Triple-Negative Breast Carcinoma

United States
West China Hospital

Not yet recruiting

Sintilimab Combined With LDRT for Neoadjuvant Treatment of Locally Advanced dMMR/MSI-H Gastric Cancer

Gastric Cancer
Fudan University

Not yet recruiting

Fruquintinib Plus Camrelizumab and HAIC in the Treatment of Non-MSI-H Advanced Colorectal Cancer

Colorectal Cancer

China
Biotheus Inc.

Not yet recruiting

PM8002 or Placebo Plus Nab-Paclitaxel as First-line Treatment in Inoperable Locally Advanced/Metastatic Triple-negative Breast Cancer

Triple Negative Breast Cancer(TNBC)

China

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