Search clinical trials for: Normal Volunteer

Total 15949 results

Biocon Biologics UK Ltd
Biotrial

Completed

Comparison of Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Bmab 1000 and Prolia® in Normal Healthy Volunteers: DENARIUS: DENosumab Pharmacokinetic equivAlence tRIal in Healthy volUnteerS (DENARIUS)

Healthy Volunteers

United States
National Institute of Neurological Disorders and...

Completed

Study of Volition: Behavioral Analysis and Clinical Neurophysiological Analysis

Normal Physiology

United States
Cerevel Therapeutics, LLC

Completed

To Evaluate Pharmacokinetics (PK) and Safety of Tavapadon in Participants With Severe Renal Impairment Compared to Participants With Normal Renal Function

Renal Impairment

United States
Band Therapeutics

Completed

A SAD/MAD Study of Safety, Tolerability and Pharmacologic Activity of BT200 in Normal Volunteers

Intracranial Arteriosclerosis | Cerebrovascular Stroke | Large-Artery Atherosclerosis (Embolus/Thrombosis)

Austria
Astellas Pharma Global Development, Inc.

Completed

A Study to Investigate the Effect of Renal Impairment on the Safety and Tolerability of Fezolinetant Compared to Participants With Normal Renal Function

Renal Impairment | Healthy Volunteers

United States
Astellas Pharma Global Development, Inc.

Completed

A Study to Investigate the Effect of Mild and Moderate Hepatic Impairment on the Safety and Tolerability of Fezolinetant Compared to Participants With Normal Hepatic Function

Healthy Volunteers | Hepatic Impairment

United States
mads u werner
University of Kentucky

Completed

Effect of High-dose Target-controlled Naloxone Infusion on Pain and Hyperalgesia During a Burn Injury (TCI-NX-BI)

Healthy Subjects

Denmark
ImmuneMed, Inc.

Completed

Safety, Tolerability, Pharmacokinetics of hzVSf-v13 in Healthy Adults (Intravenous and Subcutaneous Administration)

Healthy Volunteers

Australia
Haemonetics Corporation
Machaon Diagnostics; ClinStatDevice

Completed

Normal Reference Range Study With the TEG6s Heparin Neutralization Cartridge in Healthy Volunteers

Healthy

United States
Sanofi

Completed

A Study in Adults to Investigate the Impact of Mild, Moderate, and Severe Hepatic Impairment on Pharmacokinetics of Venglustat Compared to Participants With Normal Hepatic Function

Hepatic Function Abnormal

United States, Germany
Takeda

Completed

A Study of Soticlestat in Adults With Liver Failure Compared to Those With Normal Liver Function

Healthy Volunteers | Hepatic Impairment

United States, Hungary
Oregon Health and Science University

Completed

Fatty Acid Oxidation Defects and Insulin Sensitivity

Normal Volunteers | Trifunctional Protein Deficiency | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Carnitine Palmitoyltransferase II Deficiency, Myopathic

United States
National Institute of Mental Health (NIMH)

Completed

Effects of Arousal and Stress in Anxiety

Healthy Volunteers

United States
Rempex (a wholly owned subsidiary of Melinta Therapeutics...
Innovative Medicines Initiative; Universitätsklinikum Köln

Completed

Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Minocin (Minocycline) for Injection in Healthy Adults

Normal Healthy Volunteers

Netherlands
Centre Hospitalier Universitaire de Saint Etienne

Completed

Normal Values of Parameters of Thrombin Generation in Function of Different Tissue Factor Concentrations (NUAGE)

Healthy Volunteers

France
Novo Nordisk A/S

Completed

A Research Study of How NNC0174-0833 Behaves in Chinese Volunteers Who Are Normal Weight, Overweight or With Obesity

Overweight and Obesity

China
Millennium Pharmaceuticals, Inc.

Completed

A Study to Evaluate Pharmacokinetics (PK) and Safety of Oral Mobocertinib in Participants With Moderate or Severe Hepatic Impairment (HI) and Normal Hepatic Function

Healthy Volunteers | Hepatic Impairment

United States
Pfizer

Completed

Study to Evaluate the Effect of Multiple-Dose Ritlecitinib on the Pharmacokinetics (PK) of Tolbutamide

Healthy Volunteers

United States
Rempex Pharmaceuticals (a wholly owned subsidiary...
Innovative Medicines Initiative; Universitätsklinikum Köln

Withdrawn

Safety and PK Trial Evaluating the Plasma, Epithelial Lining Fluid, and Alveolar Macrophage Concentrations of Minocin IV

Normal Healthy Volunteers

Austria
Agios Pharmaceuticals, Inc.

Completed

A Pharmacokinetic Study of Mitapivat in Participants With Moderate Hepatic Impairment Compared to Matched Healthy Control Participants With Normal Hepatic Function

Moderate Hepatic Impairment

United States
University of Wisconsin, Madison
National Institute on Aging (NIA); University of Washington

Enrolling by invitation

Wisconsin Brain Donor Program (WBDP)

Mild Cognitive Impairment | Alzheimer's Disease

United States
Bayer

Completed

A Study to Learn How the Study Treatment BAY3283142 Taken as Single Dose by Mouth Moves Into, Through, and Out of the Body, How Safe it is, and How it Affects the Body in Participants With Reduced Kidney Function Compared to Participants With Normal Kidney Function of Similar Age, Gender, and Weight

Renal Impairment | Chronic Kidney Disease | Healthy Volunteers

Germany
Beijing Tiantan Hospital

Completed

Esketamine Combined With Pregabalin on Acute Postoperative Pain in Patients Undergoing Resection of Spinal Neoplasms.

Acute Postoperative Pain | Spinal Cord Neoplasms | Pregabalin | Perioperative Complication | Esketamine | Neurosurgical Procedures

China
Lawson Health Research Institute

Completed

Ketamine, Lidocaine and Combination for Postoperative Analgesia in Open Liver Resection

Hepatectomy

Canada
Rush University Medical Center

Completed

Noninvasive Ventilation Masks Carbon Dioxide Clearance in Normal Volunteers

CO2 Clearance | Mask Comfort | Rebreathing Exhaled Gas

United States
Endocyte

Completed

Safety and Biodistribution of Technetium Tc 99m EC20 in Normal Volunteers and Ovarian Cancer Patients

Ovarian Cancer | Healthy Volunteers

United States
Sanofi Pasteur, a Sanofi Company
GlaxoSmithKline

Completed

Study of Recombinant Protein Vaccine Formulations Against COVID-19 in Healthy Adults 18 Years of Age and Older

COVID-19 (Healthy Volunteers)

United States
NImmune Biopharma

Completed

Safety Tolerability and Pharmacokinetics of Oral NIM-1324 in Healthy Adult Male and Female Volunteers

Normal Healthy Volunteers

Australia
NImmune Biopharma

Completed

Safety, Tolerability, and Pharmacokinetics of Oral BT-11 in Healthy Adult Male and Female Volunteers

Normal Healthy Volunteers

United States
Cerevel Therapeutics, LLC

Completed

To Evaluate the Pharmacokinetics (PK) and Safety of Tavapadon in Participants With Mild and Moderate Hepatic Impairment Compared to Participants With Normal Hepatic Function

Hepatic Impairment

United States
Mayo Clinic

Completed

Electromyographic Assessment of the TetraGraph in Normal Volunteers

Neuromuscular Blockade

United States
Bayer

Completed

A Study to Learn How Safe the Study Treatment Elinzanetant is and How it Moves Into, Through and Out of the Body When Given as Single Increasing Doses That Are Higher Than Normally Used Compared to Placebo and Moxifloxacin in Healthy Participants

Hot Flashes | Healthy Volunteers | Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men

Germany
Bayer

Withdrawn

A Study to Learn How the Study Treatment BAY2395840 Moves Into, Through and Out of the Body, How Safe it is, and How it Affects the Body in Participants With Moderate Reduced Kidney Function and in Healthy Male and Female Participants With Normal Kidney Function

Renal Impairment | Healthy Volunteers | Diabetic Neuropathic Pain

United States
SK Bioscience Co., Ltd.
Coalition for Epidemic Preparedness Innovations

Completed

Safety and Immunogenicity Study of SARS-CoV-2 Nanoparticle Vaccine (GBP510) Adjuvanted With Aluminum Hydroxide (COVID-19)

COVID-19 (Healthy Volunteers)

Korea, Republic of
SK Bioscience Co., Ltd.

Completed

Safety and Immunogenicity of a SARS-CoV-2 Vaccine (NBP2001) in Healthy Adults (COVID-19)

COVID-19 (Healthy Volunteers)

Korea, Republic of
Takeda

Completed

Study to Investigate the Safety and Immunogenicity of a Tetravalent Chimeric Dengue Vaccine in Healthy Volunteers Between the Ages of 1.5 - 45 Years

Healthy

Colombia, Singapore, Thailand, Puerto Rico
Manchester University NHS Foundation Trust

Completed

Normative Cardiovascular Magnetic Resonance Values for Measurement of Cardiovascular Structure and Function at MCMR (NORMAL MCMR)

Healthy Volunteers

United Kingdom
Paulic Meunerie SA
Institut Polytechnique UniLaSalle

Completed

Glycaemic Index of Fibre-rich Flours in Healthy Volunteers

Healthy

France
Mayo Clinic

Completed

Renal Hemodynamic Effects of the HMG-CoA Reductase Inhibitors in Normal Volunteers and in Patients With Chronic Renal Failure

Hypertension | Hyperlipidemia | Chronic Renal Failure
ImmunityBio, Inc.

Completed

COVID-19 Vaccination Using a 2nd Generation (E1/E2B/E3-Deleted) Adenoviral-COVID-19 in Normal Healthy Volunteers

COVID-19

United States
Korea University Guro Hospital
Korean Center for Disease Control and Prevention

Active, not recruiting

Safety, Reactogenicity, and Immunogenicity Study of Heterologous Booster Vaccination of a SARS-CoV-2 Recombinant Protein Nanoparticle Vaccine (GBP510)

COVID-19 (Healthy Volunteers)

Korea, Republic of
Astellas Pharma Global Development, Inc.

Completed

A Study to Evaluate ASP0367 in Participants With Mild/Moderate Hepatic Impairment Compared to Participants With Normal Hepatic Function

Healthy Volunteers | Hepatic Impairment

United States
Ochsner Health System
Bracco Corporate

Completed

3D PET Myocardial Blood Flow and Rb82 Infusion Profiles

Myocardial Infarction | Coronary Artery Disease | Cardiac Risk Factors | Normal Healthy Volunteers Without Chronic Medical Conditions

United States
OncoImmune, Inc.
National Institute of Neurological Disorders and Stroke (NINDS)

Completed

Safety Study of Efprezimod Alfa (CD24Fc, MK-7110) When Administered Intravenously in Healthy Adult Subjects (MK-7110-001)

Healthy Volunteers

United States
National Institute of Allergy and Infectious Diseases...

Completed

Normal Blood, Bone Marrow and Buccal Mucosa Protocol

Healthy | Allergy | Atopic | Normal | Non-atopic

United States
Washington University School of Medicine
Mallinckrodt

Completed

Standardized Home Spirometry Method in Normal Population

Healthy Volunteers | Mobile Applications | Feasibility Study

United States
Cugene Inc.

Active, not recruiting

A Phase Ia Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Subcutaneously Administered CUG252 in Normal Healthy Volunteers

Systemic Lupus Erythematosus

United States
Sanofi

Completed

Study to Assess the Plasma Concentration of Tolebrutinib Given as a Tablet to Adult Participants With Mild Hepatic Impairment Compared to Participants With Normal Hepatic Function

Hepatic Function Abnormal

United States, Belgium
National Institute of Allergy and Infectious Diseases...

Completed

Study of Mast Cell Precursors

Healthy Volunteer | Mastocytosis

United States
Cingulate Therapeutics

Completed

Fed-Fast Crossover Study to Assess the Effect of Food With CTx-1301 in Healthy Subjects (Fed-Fast)

Healthy Volunteers in Fed and Fasted State

United States

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