Search clinical trials for: Proof of mechanism

Total 431272 results

Consano Clinical Research, LLC

Completed

Effectiveness of Exenatide Plus Dapagliflozin on 24 Hour Glucose Variability Measured by CGM. A Proof of Concept.

Diabetes Mellitus, Type 2

United States
Phoenicis Therapeutics

Terminated

A Double-blind, Randomized, Intra-subject Placebo-controlled, Multicenter, Multiple Dose Study, Evaluating Safety, Proof of Mechanism, Preliminary Efficacy and Systemic Exposure in Subjects With Confirmed DDEB or RDEB Diagnosis With One or More Pathogenic Mutations in Exon 73 in the COL7A1 Gene

Epidermolysis Bullosa Dystrophica, Recessive | Epidermolysis Bullosa Dystrophica, Dominant

United States, Spain, France
Galderma R&D

Completed

Patient-Reported Outcome Of Facial Erythema (PROOF) (PROOF)

Erythema | Rosacea

United Kingdom, Germany, Sweden
John Levine
National Cancer Institute (NCI)

Completed

A Proof of Concept Pilot Trial of Alpha-1-Antitrypsin for Pre-Emption Of Steroid-Refractory Acute GVHD

GVHD | Graft-versus-host-disease

United States
GlaxoSmithKline

Completed

Proof of Mechanism Study of GSK2330811 in Diffuse Cutaneous Systemic Sclerosis

Scleroderma, Systemic

United States, United Kingdom, Netherlands, Canada
Baxalta now part of Shire

Terminated

First-in-Human and Proof-of-Mechanism Study of ARC19499 Administered to Hemophilia Patients

Hemophilia

United Kingdom
JW Pharmaceutical

Completed

Efficacy and Safety of Pitavastatin in a Real-world Setting (PROOF)

Hypercholesterolemia
Thomas Jefferson University
Astellas Pharma Inc

Terminated

Mirabegron in Achalasia: A Clinical and Manometric Proof of Concept Pilot Study

Achalasia

United States
EmeraMed
NBMI Science AB

Completed

Pilot Proof of Concept Study of NBMI Treatment of Mercury Intoxication (NBMI)

Mercury Poisoning

Ecuador
Novartis Pharmaceuticals

Completed

Proof of Concept Study to Determine the Safety and Antiviral Effect of BZF961 With or Without Ritonavir Boosting in Hepatitis C Virus Infected Patients (CBZF961X2201)

Hepatitis C

United States
Bayer

Completed

Repeat Doses of BAY1902607 in Healthy Males and Proof of Concept in Chronic Cough Patients

Cough

Netherlands, United Kingdom
Unity Health Toronto
University of Toronto; Li Ka Shing Knowledge Institute

Unknown

Proof-of-Concept: A Pilot, Randomized, Double-Blind Study of Oseltamivir Versus Placebo for Immune Thrombocytopenia

Immune Thrombocytopenia

Canada
Instituto de Investigación Hospital Universitario...

Unknown

Antiretroviral Treatment Guided by Proviral Genotype: Pilot Trial of Proof of Concept.

HIV-1-infection

Spain
NYU Langone Health

Terminated

A Proof of Concept Study of the Prevention of Mild Cognitive Impairment and Eventual Alzheimer's Disease Using F18 Flutemetamol

Alzheimer Disease

United States
Cairo University

Unknown

Intravenous Tranexamic Acid Versus IV Carbetocin in Abdominal Myomectomy

Myomectomy
Université de Sherbrooke
Alzheimer's Association

Completed

Proof of Mechanism of a New Ketogenic Supplement Using Dual Tracer PET (Positron Emission Tomography) (BENEFIC)

Mild Cognitive Impairment

Canada
GlaxoSmithKline

Completed

A Proof of Mechanism Study With GSK2126458 in Patients With Idiopathic Pulmonary Fibrosis (IPF)

Idiopathic Pulmonary Fibrosis

United Kingdom
Gregory Jicha, 323-5550
University of Kentucky; Kentucky Alzheimer's Center

Completed

Valproic Acid in Subjects With Intact Cognition - Proof of Concept Study (VPA)

Alzheimer's Disease

United States
Centre Hospitalier Universitaire de Nice

Unknown

Acid-Sensing Ion Channel and Migraine Disease Proof of Concept Study on the Efficacy of Amiloride in the Prophylaxis of Migraine Aura (APAM)

Migraine With Aura

France
HaEmek Medical Center, Israel
AbbVie

Completed

Proof of Concept Study To Evaluate the Efficacy and Justification Of OBV/PTV/r and DSV In Adults With Chronic Hepatitis C Virus Genotype 2K/1B

HCV Coinfection

Israel
The Christie NHS Foundation Trust
University of Manchester

Withdrawn

A Proof of Concept, Window Trial of the IMmunological Effects of AveLumab and Aspirin in Triple-Negative Breast Cancer (IMpALA)

Breast Cancer
University of California, San Francisco
Novartis

Completed

Phase I Dose Finding and Proof-of-concept Study of Panobinostat With Standard Dose Cytarabine and Daunorubicin for Untreated Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome

Acute Myeloid Leukemia | Advanced Myelodysplastic Syndrome

United States
Boehringer Ingelheim

Completed

Alzheimer Disease Proof of Concept Study With BI 409306 Versus Placebo

Alzheimer Disease

United States, Spain, Canada, United Kingdom, Germany, Italy, Netherlands, Portugal, Austria, Belgium, France, Poland
Dartmouth-Hitchcock Medical Center
Merck Sharp & Dohme LLC

Completed

A Clinical Trial to Validate Molecular Targets of Vorinostat in Patients With Aerodigestive Tract Cancer

Head and Neck Cancer | Esophageal Cancer | Lung Cancer | Aerodigestive Tract Cancer

United States
Massachusetts General Hospital
Stanley Medical Research Institute

Completed

A Proof of Concept Study of Intravenous Sodium Nitroprusside in Adults With Symptomatic Schizophrenia

Schizophrenia

United States
Boston University Charles River Campus

Completed

Improving Therapeutic Learning in Depression: Proof of Concept

Major Depressive Disorder

United States
Sidney Kimmel Comprehensive Cancer Center at Johns...
National Cancer Institute (NCI)

Completed

Phase 2 Study of Rituximab-ABVD in Classical Hodgkin Lymphoma

Lymphoma

United States
Alcon, a Novartis Company

Completed

LHA510 Proof-of-Concept Study as a Maintenance Therapy for Patients With Wet Age-Related Macular Degeneration

Exudative Age-Related Macular Degeneration

United States
McGill University Health Centre/Research Institute...
CIHR Canadian HIV Trials Network

Completed

Niacin on Immune Activation : a Proof-of-concept Study

HIV

Canada
Orion Corporation, Orion Pharma

Completed

Efficacy and Safety Proof of Concept Study in Patients With Parkinson's Disease and End-of-dose Wearing-off (COMPOC) (COMPOC)

Parkinson's Disease

Finland, Germany, Hungary, Latvia
GlaxoSmithKline

Withdrawn

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Proof of Mechanism of GSK2618960 in Primary Sjögren's Syndrome (pSS)

Autoimmune Diseases

United Kingdom
Khondrion BV
Radboud University Medical Center

Completed

The KHENERGY Study (KHENERGY)

Mitochondrial Diseases | Mitochondrial Myopathies | MELAS | Mitochondrial Encephalomyopathies | MIDD

Netherlands
Hoffmann-La Roche

Completed

A Study of Hypoxia-inducible Factor 1a (HIF1A) Messenger Ribonucleic Acid (mRNA) Antagonist (RO7070179), to Demonstrate Proof-of-mechanism in Adult Participants With Hepatocellular Carcinoma (HCC)

Carcinoma, Hepatocellular

United States
Barbara J. Coffey

Completed

Proof-of-Concept Safety Study of CPP-109 (Vigabatrin) for Treatment Refractory Tourette's Disorder

Tourette's Disorder

United States
Alexza Pharmaceuticals, Inc.

Completed

Staccato Loxapine in Agitation (Proof of Concept)

Schizophrenia

United States
Alcon Research

Terminated

Proof-of-Concept Study of a Single Application of an Investigational Otic Suspension in Treatment of Acute Otitis Media With Tympanostomy Tubes

Acute Otitis Media
Bristol-Myers Squibb

Terminated

Single Ascending Dose and Multiple Ascending Dose Study in Healthy Participants and Proof of Mechanism Study in Patients With Ulcerative Colitis

Healthy Volunteers | Ulcerative Colitis

Australia, Georgia, Moldova, Republic of
Strategic Science & Technologies, LLC

Completed

Phase 2a Topical Sildenafil Proof-of-Concept Study in Men With Mild to Moderate ED

Erectile Dysfunction

United States
ContraVir Pharmaceuticals, Inc.

Completed

Phase 2, Multiple Ascending Dose Proof of Concept Study

Infectious Disease

Thailand
GlaxoSmithKline

Completed

723/726 Proof of Concept Study in Allergen Challenge Chamber in Hannover

Rhinitis, Allergic, Seasonal

Germany
Mead Johnson Nutrition
Midwest Children's Health Research Institute

Completed

Exploratory/Proof of Principle Microbiota Study

Fecal Microbiota

United States
GlaxoSmithKline

Completed

Proof of Mechanism in ELT (PoM)

Premature Ejaculation

Italy
GlaxoSmithKline

Completed

A Phase II, Repeat Dose, Proof of Mechanism Study of Losmapimod to Reduce Proteinuria in Patients With Focal Segmental Glomerulosclerosis (FSGS)

Glomerulosclerosis, Focal Segmental

United States, Canada
Drugs for Neglected Diseases

Unknown

Proof-of-Concept Superiority Trial of Fosravuconazole Versus Itraconazole for Eumycetoma in Sudan

Mycetoma

Sudan
Neomed Institute

Completed

A Proof-of-Concept Study Assessing NEO6860 in Osteoarthritis Pain

Pain | Osteoarthritis of the Knee

Canada
Massachusetts General Hospital

Completed

A Proof of Concept Study of Electrical Discharge Produced Nitric Oxide for Inhalation

Hypertension, Pulmonary

United States
AstraZeneca

Completed

Roflumilast Plus Alogliptin Proof-of-Mechanism Study in Type2 Diabetes

Type 2 Diabetes

United States
Biogen

Terminated

BIIB023 Proof-of-Concept Study in Participants With Lupus Nephritis (ATLAS)

Lupus Nephritis

United States, Peru, Belgium, Italy, Philippines, Malaysia, Hong Kong, Argentina, Germany, Hungary, Australia, Colombia, Russian Federation, Portugal, Mexico, Korea, Republic of, France, Thailand, Brazil, Poland, Spain
GlaxoSmithKline

Completed

A Proof of Concept Study to Assess Effect of Fluticasone Furoate (FF)/Levocabastine Fixed Dose Combination (FDC) Compared With Levocabastine and FF Alone in Subjects With Allergic Rhinitis (AR)

Rhinitis, Allergic, Perennial and Seasonal

Austria
Hee Jun Kim
HK inno.N Corporation

Unknown

Proof-of-Concept Trial of Palonosetron and Olanzapine Without Dexamethasone for the Prevention of CIN

Chemotherapy-induced Nausea and Vomiting

3

Subscribe