Search clinical trials for: Refractory autoimmune disease

Total 383141 results

Biogen

Recruiting

A Study to Assess the Efficacy and Safety of BIIB059 (Litifilimab) in Participants With Active Subacute Cutaneous Lupus Erythematosus (SCLE) and/or Chronic Cutaneous Lupus Erythematosus (CCLE) With or Without Systemic Manifestations and Refractory and/or Intolerant to Antimalarial Therapy (AMETHYST)

Subacute Cutaneous Lupus Erythematosus | Chronic Cutaneous Lupus Erythematosus

United States, Italy, Korea, Republic of, Taiwan, Argentina, Chile, Spain, Canada, Serbia, France, Germany, Japan, Brazil, United Kingdom, Bulgaria, Portugal, Switzerland, Philippines, Saudi Arabia, Sweden, Mexico, Poland, Hungary, Puerto... and more
Mohamed Abdelmoneim El Meligy

Recruiting

Effect of Electroacupuncture on Refractory Pain in Juvenile Rheumatoid Arthritis: Randomized Controlled Trial

Juvenile Rheumatoid Arthritis

Egypt
iCell Gene Therapeutics
iCAR Bio Therapeutics Ltd. China

Recruiting

BCMA-CD19 cCAR T Cell Treatment of Relapsed/Refractory Systemic Lupus Erythematosus (SLE)

Relapsed/Refractory, Systemic Lupus Erythematosus (SLE)

China
Zhejiang Provincial People's Hospital

Recruiting

Efficacy and Safety of Abatacept Combined With JAK Inhibitor for Refractory Rheumatoid Arthritis

Rheumatoid Arthritis | Treatment Compliance | Abatacept

China
First Affiliated Hospital, Sun Yat-Sen University

Recruiting

Efficacy and Safety of Low-dose Rituximab in the Treatment of Refractory Myasthenia Gravis

Refractory Myasthenia Gravis | Rituximab

China
Zhejiang University
Yake Biotechnology Ltd.

Recruiting

A Clinical Study of CD19/BCMA CAR-T Cells in the Treatment of Refractory POEMS Syndrome, Amyloidosis, Autoimmune Hemolytic Anemia, and Vasculitis

Vasculitis | Amyloidosis | Autoimmune Hemolytic Anemia | POEMS Syndrome

China
GlaxoSmithKline

Recruiting

Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA) (OCEAN)

Eosinophilic Granulomatosis With Polyangiitis

Canada, France, Italy, Spain, Belgium, Korea, Republic of, United States, Japan, China, Czechia, Hungary, Israel, Portugal, Poland, Netherlands, United Kingdom, Austria, Argentina, Australia, Brazil, Germany, Sweden
Zhejiang University
Yake Biotechnology Ltd.

Recruiting

Clinical Study of Targeting CD7 CAR-T Cells in the Treatment of Autoimmune Diseases

Autoimmune Diseases | Crohn Disease | Ulcerative Colitis | Dermatomyositis | Still Disease

China
Zhejiang University
Yake Biotechnology Ltd.

Recruiting

A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Scleroderma

Autoimmune Diseases | Scleroderma

China
Zhejiang University
Yake Biotechnology Ltd.

Recruiting

A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Sjogren's Syndrome

Autoimmune Diseases | Sjogren's Syndrome

China
Zhejiang University
Yake Biotechnology Ltd.

Recruiting

A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Immune Nephritis

Autoimmune Diseases | Lupus Nephritis | Immune Nephritis

China
Zhejiang University
Yake Biotechnology Ltd.

Recruiting

A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Systemic Lupus Erythematosus

Autoimmune Diseases | Systemic Lupus Erythematosus

China
Shandong University

Not yet recruiting

A Clinical Trial of the Orelabrutinib in the Management of Refractory ITP

Immune Thrombocytopenia | Bruton's Tyrosine Kinase
Nanjing First Hospital, Nanjing Medical University

Recruiting

Sacral Nerve Stimulation for Mild-to-Moderate or Refractory Rheumatoid Arthritis

Rheumatoid Arthritis

China
Tongji Hospital
Nanjing IASO Biotechnology Co., Ltd.

Recruiting

Safety and Efficacy of CT103A Cells for Relapsed/Refractory Antibody-associated Inflammatory Diseases of the Nervous System (CARTinNS)

Multiple Sclerosis | Autoimmune Diseases of the Nervous System | Autoimmune Diseases | Myasthenia Gravis | Neuromyelitis Optica Spectrum Disorder | Autoimmune Encephalitis | Idiopathic Inflammatory Myopathies | Chronic Inflammatory Demyelinating Polyradiculoneuropathy | Myelin Oligodendrocyte Glycoprotein... and other conditions

China
Huashan Hospital

Recruiting

Safety And Efficacy Of Tofacitinib In Patients With Refractory Myasthenia Gravis: A Pilot Study

Myasthenia Gravis, Generalized

China
Institute of Hematology & Blood Diseases Hospital...

Recruiting

The Safety and Efficacy of Ibrutinib in Refractory/Relapsed Autoimmune Hemolytic Anemia

Refractory/Relapsed Autoimmune Hemolytic Anemia

China
Third Affiliated Hospital, Sun Yat-Sen University
Zhongshan Ophthalmic Center, Sun Yat-sen University; Guangdong 999 Brain Hospital

Not yet recruiting

Comparison of the Efficacy and Safety of Immunoadsorption and Plasma Exchange for Acute Attack of Refractory Neuromyelitis Optica Spectrum Disorders (CAMPUS)

Neuromyelitis Optica Spectrum Disorder
Baylx Inc.

Not yet recruiting

Safety and Tolerability of a Single Intravenous Infusion of BX-U001 in Refractory Rheumatoid Arthritis

Rheumatoid Arthritis
Centre Hospitalier Universitaire Dijon

Recruiting

Ustekinumab for the Treatment of Relapse of Refractory Giant Cell Arteritis (ULTRA)

Patients Relapsing Refractory Giant Cell Arteritis

France
Assistance Publique - Hôpitaux de Paris

Recruiting

Treatment of Refractory Systemic Lupus Erythematosus by Allogeneic Mesenchymal Stem Cells Derived From the Umbilical Cord (MSC-SLE)

Stem Cell Transplant | Lupus Erythematosus

France
Peking University People's Hospital

Not yet recruiting

The Combination of Atorvastatin, Acetylcysteine and Danazol as the Treatment of Steroid-resistant/Relapse Immune Thrombocytopenia

Immune Thrombocytopenia

China
Biogen

Enrolling by invitation

A Long-Term Extension Study to Evaluate Continuous Safety and Efficacy of BIIB059 (Litifilimab) in Adults With Active Subacute Cutaneous Lupus Erythematosus (CLE) and/or Chronic CLE With or Without Systemic Manifestations and Refractory and/or Intolerant to Antimalarial Therapy (AMETHYST LTE)

Subacute Cutaneous Lupus Erythematosus | Chronic Cutaneous Lupus Erythematosus

Spain, United States, France, Switzerland, Chile, Sweden
City of Hope Medical Center
National Cancer Institute (NCI)

Active, not recruiting

Acalabrutinib for the Treatment of Relapsed or Refractory Autoimmune Hemolytic Anemia in Patients With Chronic Lymphocytic Leukemia

Chronic Lymphocytic Leukemia | Autoimmune Hemolytic Anemia | Warm Antibody Autoimmune Hemolytic Anemia | Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

United States
Peking Union Medical College Hospital

Completed

Single-dose Anti-CD20 Antibody With Bortezomib for Relapsed Refractory Autoimmune Hemolytic Anemia (RRAIHA01)

Autoimmune Hemolytic Anemia | Autoimmune Hemolytic Anemia and Autoimmune Thrombocytopenia

China
PTC Therapeutics

Completed

A Study to Evaluate Efficacy and Safety of Vatiquinone for Treating Mitochondrial Disease in Participants With Refractory Epilepsy (MIT-E)

Mitochondrial Diseases | Drug Resistant Epilepsy | Leigh Disease | Leigh Syndrome | Mitochondrial Encephalopathy (MELAS) | Pontocerebellar Hypoplasia Type 6 (PCH6) | Alpers Disease | Alpers Syndrome

United States, Spain, United Kingdom, Canada, France, Italy, Poland, Sweden, Japan
SetPoint Medical Corporation

Active, not recruiting

Vagus Nerve Stimulation for Moderate to Severe Rheumatoid Arthritis (RESET-RA)

Rheumatoid Arthritis

United States
Institute of Hematology & Blood Diseases Hospital...
YL-Pharma

Terminated

PI3K Delta Inhibitor in Relapsed / Refractory Autoimmune Hemolytic Anemia Patients After Receiving Two or More Lines of Therapy

Autoimmune Hemolytic Anemia | Failure of Two Rounds of Treatment

China
Modern Biosciences Ltd

Completed

Phase 2b Study of MBS2320 in Participants With Methotrexate-Refractory RA

Rheumatoid Arthritis

Bosnia and Herzegovina, Bulgaria, Chile, Czechia, Guatemala, Mexico, Poland, Serbia
Peking Union Medical College Hospital

Active, not recruiting

An Exploratory Clinical Study on Bortezomib for the Treatment of Refractory Rheumatoid Arthritis (bortezomib4ra)

Rheumatoid Arthritis

China
Dartmouth-Hitchcock Medical Center

Active, not recruiting

The Safety of Repurposing Daratumumab for Relapsed or Refractory Autoimmune Antibody Mediated Hemolytic Anemia (DARA-AIHA)

Hemolytic Anemia

United States
Novartis Pharmaceuticals

Completed

A Study to Assess the Ability of Eltrombopag to Induce Sustained Response Off Treatment in Subjects With ITP (TAPER)

Immune Thrombocytopenic Purpura (ITP)

Spain, Italy, Greece, Switzerland, United Kingdom, France, Turkey, Russian Federation, Brazil, Austria, Mexico, Oman, Chile, Japan, United States
Alexion Pharmaceuticals, Inc.

Completed

A Phase 3 Open-Label Study of Eculizumab in Pediatric Participants With Refractory Generalized Myasthenia Gravis (gMG)

Myasthenia Gravis | Myasthenia Gravis, Generalized | Myasthenia Gravis, Juvenile Form

United States, Japan, Netherlands
Qiang Shu

Completed

The Efficacy and Safety of Tacrolimus in Refractory Rheumatoid Arthritis Patients for 6 Months and Long-term Treatment

Arthritis, Rheumatoid

China
Mario Negri Institute for Pharmacological Research
MorphoSys AG

Active, not recruiting

MOR202 for Refractory MN (MONET)

Membranous Nephropathy

Italy
European Society for Blood and Marrow Transplantation
EULAR

Withdrawn

Autologous Stem Cell Transplantation: International Lupus Trial (ASTIL)

REFRACTORY SYSTEMIC LUPUS ERYTHEMATOSUS

France
Chiara Zecca
ABREOC

Completed

Wireless, Implantable Tibial Nerve Stimulator System for the Treatment of Refractory Lower Urinary Tract Symptoms in Patients With Multiple Sclerosis (Stimrouter)

Multiple Sclerosis, Relapsing-Remitting

Switzerland
Cambridge University Hospitals NHS Foundation Trust

Active, not recruiting

Biologics in Refractory Vasculitis (BIOVAS)

Giant Cell Arteritis | Polyarteritis Nodosa | Takayasu Arteritis | Cryoglobulinemic Vasculitis | IgA Vasculitis | Cogan Syndrome | Relapsing Polychondritis | Cutaneous Polyarteritis Nodosa | Primary Angiitis of Central Nervous System

United Kingdom
Tampere University Hospital
University of Helsinki; Tampere University

Enrolling by invitation

Dermatitis Herpetiformis Refractory to Gluten Free Diet

Dermatitis Herpetiformis

Finland
Peking Union Medical College Hospital

Enrolling by invitation

CNCT19 Cell Injection for Refractory Systemic Lupus Erythematosus

Lupus Nephritis | Immune Thrombocytopenia | Refractory Systemic Lupus Erythematosus

China
Institute of Hematology & Blood Diseases Hospital

Active, not recruiting

Study of Human Umbilical Cord-derived Mesenchymal Stem Cells for Treatment of Refractory Immune Thrombocytopenia

Thrombocytopenia | Mesenchymal Stem Cells

China
Amgen

Completed

AMG 531 Treatment of Thrombocytopenic Subjects With Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Refractory to Splenectomy

Thrombocytopenia | Idiopathic Thrombocytopenic Purpura
Stony Brook University

Withdrawn

High-dose Cyclophosphamide for Moderate to Severe Refractory Chronic Inflammatory Demyelinating Polyneuropathy

Chronic Inflammatory Demyelinating Polyneuropathy
Assiut University

Active, not recruiting

Reappraisal of the Therapies of Refractory Autoimmune Hemolytic Anemia in Systemic Lupus Erythematosus

Systemic Lupus Erythematosus | Autoimmune Hemolytic Anemia

Egypt
FibroBiologics

Completed

Feasibility Study of Tolerogenic Fibroblasts in Patients With Refractory Multiple Sclerosis (MSFibroblast)

Multiple Sclerosis | Multiple Sclerosis, Relapsing-Remitting

Mexico
Seoul National University Hospital

Completed

IL-2 in Refractory Autoimmune Encephalitis

Encephalitis
Seoul National University Hospital

Withdrawn

Effect of Vigabatrin in Refractory Autoimmune Encephalitis Patients

Autoimmune Encephalopathy

Korea, Republic of
Seoul National University Hospital

Withdrawn

Effect of Erythropoietin in Refractory Autoimmune Encephalitis Patients

Autoimmune Encephalitis

Korea, Republic of
Nagoya University
Japan Agency for Medical Research and Development; Zenyaku Kogyo Co., Ltd.

Completed

The Evaluation of Efficacy and Safety of Rituximab in Refractory CIDP Patients With IgG4 Autoantibodies (RECIPE)

Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

Japan
Peking University Third Hospital

Unknown

Arthroscopic Synovectomy Combined With DMARDs in the Treatment of Refractory Elbow Rheumatoid Arthritis

Rheumatoid Arthritis of Ankle

China

Search clinical trials for: Refractory autoimmune disease

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