Search clinical trials for: Second line

Total 22464 results

Tianjin Medical University Cancer Institute and...

Recruiting

Adebrelimab and Fruquintinib Combined With Paclitaxel/Albumin Paclitaxel for Advanced Gastric Cancer After PD-1 Antibody Failed

Gastric Cancer

China
Tianjin Medical University Cancer Institute and...

Recruiting

Adebrelimab and Fruquintinib Combined With Paclitaxel/Albumin Paclitaxel for Advanced Gastric Cancer

Gastric Cancer

China
The Second Affiliated Hospital of Shandong First...

Not yet recruiting

The Efficacy and Safety of TAS-102(Suyuan) Combined With Bevacizumab as First-line Therapy in Patients With Advanced Colorectal Cancer

Colorectal Cancer

China
Assiut University

Not yet recruiting

Immune Markers in Pediatric ITP on Second Line Therapy

ITP - Immune Thrombocytopenia
Shanghai Ming Ju Biotechnology Co., Ltd.

Not yet recruiting

Relmacabtagene Autoleucel as Second-Line Therapy in Adult Patients With Aggressive B-cell NHL

Lymphoma, Large B-Cell, Diffuse | High-grade B-cell Lymphoma | Follicular Lymphoma Grade 3B | Mediastinal B-Cell Diffuse Large Cell Lymphoma

China
M.D. Anderson Cancer Center
Bayer

Not yet recruiting

Phase 2 Study to Evaluate the Efficacy of Regorafenib in Specific GIST Mutation Subsets (KIT Exon 17, 18, or 14 Mutation and SDHB Deficient GIST) in the Post-imatinib Second-line Setting.

Gastrointestinal Stromal Tumors

United States
Beijing Chest Hospital
National Medical Center for Infectious Diseases

Recruiting

Innovating Shorter, All- Oral, Precised, Individualized Treatment Regimen for Rifampicin Resistant Tuberculosis：Contezolid, Delamanid and Bedaquiline Cohort (INSPIRE-CODA)

Pulmonary Tuberculosis | Rifampicin-resistant Tuberculosis

China
The First Affiliated Hospital of Zhengzhou University

Not yet recruiting

IBI110 Combined With Sintilimab in Second-line Advanced or Metastatic Esophageal Squamous Cell Carcinoma(ESCC)

Esophageal Squamous Cell Carcinoma (ESCC) | PD-1 Inhibitors

China
University Hospital, Toulouse
Orkyn'; ELIVIE France; EVER Pharma France SAS; NHC SAS, France; ETPARK Association...

Recruiting

Personality and Quality of Life Amelioration After Continuous Subcutaneous Apomorphine Infusion in Parkinson's Disease (PERSO-PERF)

Parkinson Disease

France
Huda Salman
The Leukemia and Lymphoma Society; iCell Gene Therapeutics

Recruiting

Chimeric Antigen Receptor T Cell Therapy Redirected to CD4 (CD4CAR)as a Second Line Treatment for Chronic Myelomonocytic Leukemia, CMML.

Chronic Myelomonocytic Leukemia

United States
Peking Union Medical College Hospital

Recruiting

RC48 Combined With Tislelizumab for Second-line Treatment of HER2 Expression in Recurrent Cervical Cancer

Cervical Cancer Recurrent

China
Peking University First Hospital
Merck Sharp & Dohme LLC

Not yet recruiting

Efficacy and Safety of Nab-paclitaxel-Lenvatinib-Pembrolizumab as Second-line Treatment in Advanced NSCLC Patients

Advanced Non-squamous Non-small-cell Lung Cancer | Metastatic Non-squamous Non Small Cell Lung Cancer | Recurrent Non-Squamous Non-Small Cell Lung Cancer

China
Bristol-Myers Squibb

Recruiting

A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Progressive Pulmonary Fibrosis

Progressive Pulmonary Fibrosis

China, United States, Japan, Korea, Republic of, Taiwan, Hungary, Canada, Argentina, Australia, Austria, Belgium, Brazil, Chile, Colombia, Czechia, Denmark, Finland, France, Germany, Greece, India, Ireland, Italy, Mexico, Netherlands, Peru, Polan... and more
Sun Yat-sen University

Recruiting

Predictive Value of Serum and Tissue Molecular Markers and Imaging Features in the Invasiveness and Prognosis of Pituitary Neuroendocrine Tumors

Pituitary Adenoma | Neuroendocrine Tumors

China
Bristol-Myers Squibb

Recruiting

A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Idiopathic Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis

China, Taiwan, United States, Australia, Japan, Korea, Republic of, United Kingdom, Canada, Israel, Argentina, Austria, Belgium, Brazil, Chile, Colombia, Czechia, Denmark, Finland, France, Germany, Greece, Hungary, India, Ireland, Italy, ... and more
Akeso

Not yet recruiting

A Study of AK104/Tislelizumab With Chemotherapy as First-line Treatment in PD-L1 TPS < 1% Non-small Cell Lung Cancer

Locally Advanced or Metastatic NSCLC

China
Fudan University

Recruiting

Disitamab Vedotin, Fruquintinib and Tislelizumab in Second-line Treatment for HER2-positive MGC

HER2-positive Gastric Cancer | Immunotherapy

China
Tel Aviv Medical Center

Not yet recruiting

Lenvatinib, Pembrolizumab, and Tumor Treating Fields (TTFields) for Second-line Treatment of Glioblastoma

GBM
Dr. Inge Winter
Universität Münster

Recruiting

The Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. (INTENSIFY BD)

Bipolar Depression

Austria, Germany, Italy, Spain, United Kingdom
Dr. Inge Winter
Universität Münster

Recruiting

The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. (INTENSIFY MDD)

Major Depressive Disorder | Treatment Resistant Depression

Austria, Germany, Italy, Spain, United Kingdom
Dr. Inge Winter
Universität Münster

Recruiting

The Effect of a Six Week Intensified Pharmacological Treatment for Schizophrenia Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. (INTENSIFY SZ)

Schizophrenia and Related Disorders | Early Treatment-Resistance

Austria, Germany, Italy, Spain, United Kingdom
Merck Sharp & Dohme LLC

Recruiting

A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010)

Leukemia, Lymphocytic, Chronic, B-Cell | Lymphoma, Small Lymphocytic | CLL | SLL | Small-Cell Lymphoma | Leukemia, Chronic Lymphocytic

Italy, Argentina, Chile, Brazil, Israel, South Africa, United States, Australia, Puerto Rico, Spain, Canada, Germany, France, United Kingdom, Colombia
Bristol-Myers Squibb

Recruiting

A Study to Evaluate the Efficacy and Safety of Deucravacitinib in Adults With Active Sjögren's Syndrome (POETYK SjS-1)

Sjögren's Syndrome

United States, Australia, Germany, Korea, Republic of, Austria, China, Japan, Puerto Rico, Poland, Canada, Hungary, Spain, Argentina, Chile, Denmark, France, Italy, Mexico, Peru, Netherlands, Belgium, Brazil, Colombia, United Kingdom, P... and more
The University of Texas Health Science Center,...

Not yet recruiting

Fetal Growth Restriction: Management Using Two Guidelines - Fetal Growth Antenatal Management Evaluation (FAME)

Fetal Growth Retardation

United States
shifeng Lou

Recruiting

A Randomized Controlled Study of High-dose Cyclophosphamide Induction Therapy in Adult Patients With HLH

Hemophagocytic Syndrome

China
National Health Research Institutes, Taiwan
China Medical University Hospital; Chang Gung Memorial Hospital; Kaohsiung Medical... and other collaborators

Not yet recruiting

Ramucirumab (Cyramza), Nal-IRI (ONIVYDE) and Trifluridine/Tipiracil (Lonsurf) in Second Line Metastatic Gastric Cancer .

Chemotherapy | Metastatic Gastric Adenocarcinoma | Second Line
Second Affiliated Hospital, School of Medicine,...

Recruiting

Efficacy and Safety of Cadonilimab Plus Anlotinib in Advanced STS That Failed the Previous First-line Standard Treatment

Soft Tissue Sarcoma

China
Sun Yat-sen University

Recruiting

Comparing Modified XELOX Plus Sintilimab With Standard XELOX Plus Sintilimab in First-line Treatment for HER2-negative Gastric/Gastroesophageal Junction Adenocarcinoma

Gastric Cancer

China
Fudan University

Not yet recruiting

Envafolimab Plus Docetaxel In Combination With or Without Trilaciclib Versus Docetaxel in Advanced NSCLC

Advanced Non-Small Cell Lung Cancer
Second Affiliated Hospital of Zunyi Medical University
Guizhou Provincial People's Hospital; The First People's Hospital of Zunyi; Guizhou... and other collaborators

Recruiting

Cadonilimab (AK104) With or Without CT as 2rd Line Treatment for ES-SCLC

Immunotherapy | Second-line Treatment

China
Sheng-Li Xue, MD
Northern Jiangsu Province People's Hospital; The Second People's Hospital of... and other collaborators

Recruiting

Venetoclax Combined With Azactidine in the Treatment of ALAL

Acute Leukemia of Ambiguous Lineage

China
Biotheus Inc.

Recruiting

A Study of PM8002 in Combination With Chemotherapy in Patients With SCLC

SCLC

China
Biotheus Inc.

Recruiting

A Study of PM8002 Injection in Combination With Chemotherapy in Patients With NEN

Neuroendocrine Neoplasm

China
Yanqing Li
The Affiliated Hospital of Qingdao University; The Second Affiliated Hospital... and other collaborators

Recruiting

Comparison of Two Dual Therapies in the First-line Treatment of Helicobacter Pylori Infection （SHARE2301）

Helicobacter Pylori Infection

China
Xinqiao Hospital of Chongqing

Recruiting

A Real-world Study of the Efficacy and Safety of ICIs as First-line Therapy for Advanced Malignancies

Artificial Intelligence | Malignant Tumor | Immunotherapy

China
Shanghai Zhongshan Hospital
Fudan University; Amoy Diagnostics Co., LTD

Not yet recruiting

Application of ctDNA in Evaluation of Neoadjuvant Chemotherapy Efficacy and Exploration of Chemoresistance Mechanisms in Pancreatic Cancer

Patients With Non-metastatic Pancreatic Cancer | Evaluation of Tumor Resectability Shall be Made in Consensus at Multidisciplinary Meetings, According to NCCN Guideline Version 1.2022 Pancreatic Adenocarcinoma

China
Sun Yat-sen University
First Affiliated Hospital, Sun Yat-Sen University; Third Affiliated Hospital... and other collaborators

Recruiting

Dapagliflozin Effect on FunctiOnal Mitral Regurgitation and Myocardial Fibrosis (DEFORM) (DEFORM)

Functional Mitral Regurgitation

China
Hunan Cancer Hospital
Hutchison Medipharma Limited

Not yet recruiting

Fruquintinib Plus FOLFIRI in RAS-mutated Metastatic Colorectal Cancer

Colorectal Cancer

China
Monash University
Novartis Pharmaceuticals

Recruiting

VICTORION-ASCERTAIN: Implementation Study (v-ASCERTAIN) (v-ASCERTAIN)

Cerebrovascular Disease | Coronary Heart Disease (CHD) | Peripheral Arterial Disease (PAD) | Atherosclerotic Cardiovascular Disease (ASCVD)

Australia
Shuhong Yi

Recruiting

Hepatic Arterial Infusion Chemotherapy in Combination With Atezolizumab and Bevacizumab for Second-line Treatment of Patients With Recurrent Liver Cancer After Liver Transplantation

Recurrent Liver Cancer After Liver Transplantation

China
The Hospital for Sick Children
Ottawa Hospital Research Institute; Women's College Hospital

Not yet recruiting

ONLOOP Trial: Evaluating a New Surveillance and Support System for Survivors of Childhood Cancer in Ontario

Heart Diseases | Cancer | Breast Cancer | Colorectal Cancer | Survivorship | Secondary Cancer
Turning Point Therapeutics, Inc.

Recruiting

A Phase 1 Study to Evaluate the Potential Drug Interactions Between Repotrectinib and Metformin, Digoxin, and Rosuvastatin in Patients With Advanced Solid Tumors

Advanced Solid Tumor | Metastatic Solid Tumor

United States
Pulnovo Medical (Wuxi) Co., Ltd.
The First Affiliated Hospital with Nanjing Medical University; The First Affiliated... and other collaborators

Recruiting

A Trial to Evaluate the Safety and Efficacy of Pulmonary Artery Denervation for the Treatment of Pulmonary Hypertension Associated With Left Heart Failure (PADN-HF-PH)

Cardiovascular Diseases | Vascular Diseases | Heart Failure | Hypertension | Pulmonary Hypertension | Heart Failure With Reduced Ejection Fraction | Heart Failure With Preserved Ejection Fraction | Heart Failure With Mid Range Ejection Fraction

China
UNC Lineberger Comprehensive Cancer Center

Recruiting

Measuring Changes in Body Composition and Physical Function in Patients With Childhood Cancers

Cancer | Malignant Neoplasm

United States
Cluj Municipal Clinical Hospital
Iuliu Hatieganu University of Medicine and Pharmacy

Recruiting

Pharmacokinetics and Pharmacodynamics of Linezolid Continuous and Intermittent Administration

Critical Illness | Pharmacokinetics | Efficacy | Side-effect of Antibiotic | Intensive Care Unit ICU

Romania
Stanford University
Kite Pharma

Recruiting

Evaluate Safety of Axicabtagene Ciloleucel Reinfusion (Axi-Cel-2) in Patients With Relapsed and/or Refractory Second Line High-Risk Non-Hodgkin Lymphoma After Standard of Care Axi-Cel

Non-Hodgkin Lymphoma | Large B-cell Lymphoma

United States
Chongqing University Cancer Hospital

Recruiting

Selinexor Combined With R-GemOx as Second-line Treatment in Patients With Diffuse Large B-cell Lymphoma

Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

China
IGLESIAS Juan Fernando
Clinical Trials Unit University of Bern

Not yet recruiting

STEMI Treated With a Polymer-free Sirolimus-coated Stent and P2Y12 Inhibitor-based SAPT Versus Conventional DAPT (STARS DAPT)

ST Elevation Myocardial Infarction

Switzerland
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Recruiting

A Clinical Trial of TQB2618 Injection Combined With Penpulimab Injection and Chemotherapy Versus Penpulimab Injection Combined With Chemotherapy in First-line Treatment of Relapsed/Metastatic Head and Neck Squamous Cell Carcinoma

Recurrent Squamous Cell Carcinoma of the Head and Neck | Metastatic Squamous Cell Carcinoma

China
Suzhou Puhe Pharmaceutical Technology Co., LTD

Not yet recruiting

YK-029A as First-Line Treatment Versus Platinum-Based Chemotherapy for Non-Small Cell Lung Cancer (NSCLC) With EGFR Exon 20 Insertion Mutations

Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)

China

Search clinical trials for: Second line

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