Search clinical trials for: Single Ascending Dose

Total 26106 results

Fujian Akeylink Biotechnology Co., Ltd.
The First Hospital of Jilin University

Recruiting

Safety, Tolerability and Pharmacokinetic Characteristics Evaluation on GST-HG121 Tablets

Pharmacokinetics | Food Affect | Single Ascending Dose | Maximum Applicable Dose

China
NeuroTrauma Sciences, LLC
Parexel

Recruiting

Single Ascending Dose Safety and Tolerability of NTS-104 Healthy Adults

Acute Ischemic Stroke

United States
Afasci Inc

Recruiting

Phase I Single Ascending Dose and Multiple Ascending Doses of Oral AFA-281 in Healthy Volunteers

Pain, Neuropathic | Pain, Inflammatory

United States
Suzhou Ribo Life Science Co. Ltd.

Recruiting

A Single and Multiple Ascending Doses Study to Evaluate the Safety and Pharmacokinetics of RBD5044

Health Volunteer

Australia
Godavari Biorefineries Limited

Not yet recruiting

Phase One Clinical Trial to Assess the Safety, Tolerability and Pharmacokinetics of MSP008-22 in Healthy Adult Volunteers

COVID-19

India
Godavari Biorefineries Limited

Not yet recruiting

Assessment of Safety, Tolerability and PK Profile of MSP008-22 in Patients With Advanced Solid Tumours

Advanced Solid Tumor

India
AstraZeneca
Parexel

Recruiting

AZD7798 Safety, Tolerability, and Pharmacokinetics After a Single Ascending and Repeat Dose Administrations to Healthy Subjects, and Patients With Crohn's Disease

Healthy Subjects | Crohns Disease

United Kingdom
Eli Lilly and Company

Recruiting

A Single-Ascending and Repeated Dose Study of LY3849891 in Participants With Nonalcoholic Fatty Liver Disease

Non-Alcoholic Fatty Liver Disease

United States, Japan
Shandong Suncadia Medicine Co., Ltd.

Not yet recruiting

A Phase I Single- and Multiple- Ascending Dose and Food Effect Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HRS-7535 in Healthy Subjects

Healthy Subjects
Beijing Suncadia Pharmaceuticals Co., Ltd

Not yet recruiting

Single Ascending Dose and Multiple Dose Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SHR-1816 in Healthy Subjects

Diabetes
Nanjing Immunophage Biotech Co., Ltd
Novotech (Australia) Pty Limited

Not yet recruiting

A Study of Orally Administered IPG7236 in Healthy Adult Participants

Atopic Dermatitis

Australia
Annexon, Inc.

Recruiting

Single Ascending Dose Study of ANX105

Healthy

Netherlands
UCB Biopharma SRL

Recruiting

A Single-ascending Dose (Part A) and Repeat-dose (Part B) Study to Investigate the Safety, Pharmacokinetics and Efficacy (Part B Only) of UCB1381 in Healthy Study Participants (Part A) and in Study Participants With Moderate to Severe Atopic Dermatitis (Part B)

Atopic Dermatitis

United States
Sanofi

Recruiting

Single Ascending Dose Study of SAR439459 in Adults With Osteogenesis Imperfecta (OI)

Osteogenesis Imperfecta

United States, Australia, Canada, France
Keymed Biosciences Co.Ltd

Recruiting

Single Ascending Dose Study of CM338 in Healthy Volunteers

Healthy

China
Jiangsu Nhwa Pharmaceutical Co., Ltd.

Recruiting

Single Ascending Dose Study of NH102 in Healthy Subjects

Depression

China
Jiangsu Nhwa Pharmaceutical Co., Ltd.

Recruiting

A Single Ascending Dose Study Of CY150112 After Single Oral Administration in Healthy Chinese Subjects

Schizophrenia

China
Fochon Pharmaceuticals, Ltd.

Recruiting

A Safety and Tolerability Study of FCN-207 in Healthy Volunteers

Hyperuricemia

China
Regeneron Pharmaceuticals

Active, not recruiting

A Trial to Learn if Single Ascending Intravenous (IV) Doses of REGN7508 Are Safe and Well Tolerated, and How it Works in the Body of Healthy Adult Participants

Healthy Volunteer

United Kingdom
Amgen

Completed

Single and Multiple Ascending Dose Study to Evaluate AMG 786 in Healthy Participants and Participants With Obesity

Obesity

United States
Pfizer

Completed

A Preliminary Study to Evaluate PF-07264660 in Healthy Participants

Healthy

United States
Abcuro, Inc.

Active, not recruiting

A Phase 1 Study of ABC008 in Ascending (Single Ascending Dose/Multiple Ascending Dose) Study in Patients With (IBM)

Inclusion Body Myositis

Australia
Nuvamid SA
Medpace, Inc.; Anapharm; LGD

Completed

Study of the Safety, Tolerability, and Pharmacokinetics of NUV001 Administered Orally to Healthy Adult Participants

Healthy Volunteers

United States
Arcus Biosciences, Inc.

Completed

Study to Investigate the Safety, Tolerability, and Pharmacokinetic Profile With Oral AB521 in Healthy Volunteers (ARC-14)

Healthy Participants

Netherlands
Cidara Therapeutics Inc.

Completed

A Single Ascending Dose Study of CD101 IV in Healthy Subjects

Healthy

United States
AstraZeneca

Completed

Assess the Safety, Tolerability and Pharmacokinetics of AZD5055 Following Single and Multiple Ascending Doses in Healthy Participants

Idiopathic Pulmonary Fibrosis

United States
Amgen

Completed

Single Ascending Dose Study of AMG 570 in Healthy Subjects

Systemic Lupus Erythematosus

United States
Amgen

Completed

Single and Multiple Ascending Dose Study of AMG 133 in Participants With Obesity

Obesity

United States
Medikine, Inc.
Medikine Australia Pty Ltd.

Completed

A Single Ascending Dose Study to Evaluate MDK-703 in Healthy Adult Volunteers

Healthy Volunteers

Australia
Ono Pharmaceutical Co. Ltd

Completed

Single and Multiple Ascending Dose Study to Assess the Safety, Tolerability and PK of ONO-2910 in Japanese and Caucasian Subjects

Healthy Volunteers

Japan
Oxford Cannabinoid Technologies Holdings PLC
Simbec-Orion Group

Completed

Single Ascending Oral Dose Study to Investigate the Effects of OCT461201 in Healthy Volunteers

Healthy

United Kingdom
ReST Therapeutics

Withdrawn

First-In-Human (FIH), Single Ascending Dose (SAD) Study of FluoroEthylNorMemantine (FENM)

Brain Diseases | PTSD | Alzheimer Disease | Major Depressive Disorder | Treatment Resistant Depression | Neuro-Degenerative Disease

Belgium
Ono Pharmaceutical Co. Ltd

Completed

Single Ascending Dose Study to Assess the Safety, Tolerability, PK and PD of ONO-4685 in Japanese and Caucasian Healthy Adult Male Subjects

Healthy Volunteers

Japan
AbbVie

Active, not recruiting

A Study to Evaluate Adverse Events and How Single Ascending Doses of ABBV-141 Move Through the Body of Healthy Adult Western and Asian Participants

Healthy Volunteers

United States
Altimmune, Inc.

Completed

Single-ascending-dose Study of the Safety and Immunogenicity of NasoVAX

Influenza

United States
Mabwell (Shanghai) Bioscience Co., Ltd.

Active, not recruiting

Single Ascending Dose Study of 9MW3011 in Chinese Healthy Subject

Healthy

China
Dompé Farmaceutici S.p.A

Terminated

Ascending Dose Tolerability Trial and PK Assessment in Healthy Volunteers After Single & Multiple Oral Intake of DF2755A

no Condition

France
Stoke Therapeutics, Inc

Completed

An Open-Label Study to Investigate the Safety of Single and Multiple Ascending Doses in Children and Adolescents With Dravet Syndrome

Dravet Syndrome

United States
Allgenesis Biotherapeutics Inc.
Lexitas Pharma Services, Inc.

Active, not recruiting

AG-73305 Single Ascending Dose Cohort Study in DME

Diabetic Macular Edema

United States
Walden Biosciences

Completed

Single Ascending Dose Study of WAL0921 in Healthy Subjects

Healthy

United States
Ornovi, Inc.

Withdrawn

A First in Human Single and Multiple Ascending Dose and Open Label Food Effect Study of OR-101 in Healthy Subjects

Alopecia Areata

Australia
Pfizer

Completed

A Study to Learn About the Study Medicine (PF-07293893) at Different Dose Levels in Healthy Adults

Healthy Participants

Belgium
Bugworks Research Inc.
Avance Clinical Pty Ltd.

Terminated

The Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of BWC0977 in Healthy Adult Volunteers

Bacterial Infections | Infectious Diseases

Australia
Beckley Psytech Limited

Completed

Single Ascending Dose Study With BPL-003 in Healthy Subjects

Pharmacokinetics in Healthy Adults

United Kingdom
Galapagos NV

Completed

First-in-Human Single Ascending Dose of GLPG0492

Healthy

Belgium
KBP Biosciences

Completed

Phase 1 Single Ascending Dose Study to Evaluate Safety, Tolerability and Pharmacokinetics of KBP-5074

Healthy
Mayo Clinic

Completed

Perampanel Single Ascending Dose Transcranial Magnetic Stimulation Biomarker Study in Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis

United States
GlaxoSmithKline

Completed

Safety, Tolerability and Pharmacokinetics (PK) Investigation of GSK3494245 in Healthy Participants

Leishmaniasis

United Kingdom
Pfizer

Completed

A Study of Single Ascending Doses of PF-07258669 in Healthy Adult Participants

Healthy Participants

United States
Endevica Bio

Completed

A Study to Assess the Safety, Tolerability and Pharmacokinetics of TCMCB07 in Single and Multiple Ascending Doses in Health Subjects

Cachexia

United States

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