Search clinical trials for: lentivirus vector

Total 7398 results

National Institute of Allergy and Infectious Diseases...

Completed

A Randomized Phase I Safety and Immunogenicity Trial of Live Recombinant Canarypox ALVAC-HIV vCP205 Delivered by Alternate Mucosal Routes in HIV-1 Uninfected Adult Volunteers

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...
HIV Vaccine Trials Network

Terminated

Safety and Effectiveness of HIV-1 DNA Plasmid Vaccine and HIV-1 Recombinant Adenoviral Vector Vaccine in HIV-Uninfected, Circumcised Men and Male-to-Female (MTF) Transgender Persons Who Have Sex With Men

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...

Completed

HVTN Protocol 204 - A Phase II Clinical Trial to Evaluate the Safety and Immunogenicity of a Multiclade HIV-1 DNA Plasmid Vaccine, VRC-HIVDNA016-00-VP, Followed by a Multiclade Recombinant Adenoviral Vector HIV-1 Vaccine Boost, VRCHIVADV014-00-VP, in HIV-1 Uninfected Adult Participants

HIV Infections

United States, Brazil, Haiti, Jamaica, South Africa
National Institute of Allergy and Infectious Diseases...
HIV Vaccine Trials Network

Completed

Safety of and Immune Response to a DNA HIV Vaccine Followed by an Adenoviral Vaccine Boost Given Three Different Ways to HIV Uninfected Adults

HIV Infections

United States, Peru
National Institute of Allergy and Infectious Diseases...

Completed

Safety of and Immune Response to Two Different HIV Vaccines, Each Followed by a Adenoviral Vaccine Boost, in HIV Uninfected Adults

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...

Completed

Safety of and Immune Response to Two HIV Vaccine Formulations (rMVA-HIV and rFPV-HIV) Alone or in Combination in HIV Uninfected Adults

HIV Infections

United States, Brazil
National Institute of Allergy and Infectious Diseases...
HIV Vaccine Trials Network

Completed

Safety and Immune Response to Preventive HIV Immunization With Adenovirus Serotype 5 or 35 Vector

HIV Infections

United States
Great Ormond Street Hospital for Children NHS Foundation...
Orchard Therapeutics

Completed

Lentiviral (LV) Gene Therapy for Adenosine Deaminase (ADA) Deficiency

Adenosine Deaminase Deficiency | Severe Combined Immunodeficiencies (SCID)

United Kingdom
IRCCS San Raffaele
Fondazione Telethon

Active, not recruiting

Gene Therapy With Modified Autologous Hematopoietic Stem Cells for the Treatment of Patients With Mucopolysaccharidosis Type I, Hurler Variant (TigetT10_MPSIH)

Mucopolysaccharidosis IH

Italy
CSL Behring

Terminated

CSL200 Gene Therapy in Adults With Severe Sickle Cell Disease

Anemia, Sickle Cell

United States
Genethon
Institute of Child Health; Great Ormond Street Hospital for Children NHS Foundation...

Completed

Gene Therapy for Wiskott-Aldrich Syndrome (WAS)

Wiskott-Aldrich Syndrome

United Kingdom
Genethon

Active, not recruiting

Long Term Safety Follow up of Haematopoietic Stem Cell Gene Therapy for the Wiskott Aldrich Syndrome (WASFUP)

Wiskott-Aldrich Syndrome

United Kingdom, France
National Institute of Allergy and Infectious Diseases...

Completed

Phase I Study of HIV Adenoviral Vector Vaccine in Healthy Subjects Using Needle or Biojector Injection

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...

Unknown

Lentiviral Gene Transfer for Treatment of Children Older Than 2 Years of Age With X-Linked Severe Combined Immunodeficiency (LVXSCID-OC)

X-Linked Combined Immunodeficiency Diseases

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Gene Therapy-Treated Stem Cells in Treating Patients Undergoing Stem Cell Transplant for Intermediate-Grade or High-Grade AIDS-Related Lymphoma

Lymphoma

United States
Shenzhen Geno-Immune Medical Institute

Unknown

Gene Transfer for SCID-X1 Using a Self-inactivating Lentiviral Vector （TYF-IL-2Rg）

SCID, X Linked

China
Shenzhen Geno-Immune Medical Institute

Unknown

Lentiviral Gene Therapy for CGD

Chronic Granulomatous Disease

China
Shenzhen Geno-Immune Medical Institute

Unknown

FANCA Gene Transfer for Fanconi Anemia Using a High-safety, High-efficiency, Self-inactivating Lentiviral Vector

Fanconi Anemia

China
Shenzhen Geno-Immune Medical Institute

Unknown

Lentiviral Gene Therapy for MLD

Metachromatic Leukodystrophy (MLD)

China
Shenzhen Geno-Immune Medical Institute

Unknown

Lentiviral Gene Therapy for X-ALD

X-linked Adrenoleukodystrophy

China
IRCCS San Raffaele
Orchard Therapeutics; Fondazione Telethon

Unknown

Gene Therapy for Transfusion Dependent Beta-thalassemia (TIGET-BTHAL)

Beta-Thalassemia

Italy
Shenzhen Geno-Immune Medical Institute

Unknown

Lentiviral FVIII Gene Therapy

Hemophilia A

China
Theravectys S.A.

Completed

Safety, Tolerability and Immunogenicity Induced by the THV01 Treatment in Patients Infected With HIV-1 Clade B and Treated With Highly Active Antiretroviral Therapy (HAART).

HIV Infection

France, Belgium
Drugs for Neglected Diseases
London School of Hygiene and Tropical Medicine; Institute of Tropical Medicine... and other collaborators

Completed

Efficacy Trial of Ambisome Given Alone and Ambisome Given in Combination With Miltefosine for the Treatment of VL HIV Positive Ethiopian Patients.

Visceral Leishmaniasis

Ethiopia
University of California, San Francisco
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Reducing the Burden of Malaria in HIV-Infected Pregnant Women and Their HIV-Exposed Children (PROMOTE-BC2)

Malaria | Human Immunodeficiency Virus

Uganda
Institute of Tropical Medicine, Belgium
Drugs for Neglected Diseases; Medecins Sans Frontieres, Netherlands; Addis Ababa... and other collaborators

Completed

Prophylaxis of Visceral Leishmaniasis Relapses in HIV Co-infected Patients With Pentamidine: a Cohort Study

HIV-infection/Aids | Visceral Leishmaniosis

Ethiopia
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute...

Withdrawn

HIV-Resistant Gene Modified Stem Cells and Chemotherapy in Treating Patients With Lymphoma With HIV Infection

Stage III Adult Hodgkin Lymphoma | Stage IV Adult Hodgkin Lymphoma | Human Immunodeficiency Virus 1 Positive | Stage I Adult Hodgkin Lymphoma | Stage II Adult Hodgkin Lymphoma | Stage I Adult Non-Hodgkin Lymphoma | Stage II Adult Non-Hodgkin Lymphoma | Stage III Adult Non-Hodgkin Lymphoma | Stage IV...

United States
Genethon
Hôpital Necker-Enfants Malades

Completed

Gene Therapy for WAS

Wiskott-Aldrich Syndrome

France
International AIDS Vaccine Initiative
National Institute of Allergy and Infectious Diseases (NIAID); Children's Hospital...

Unknown

A Phase 1, Randomized, Blinded, Dose-escalation Study of rAAV1-PG9DP Recombinant AAV Vector Coding for PG9 Antibody in Healthy Male Adults.

HIV Infections

United Kingdom
Shenzhen Geno-Immune Medical Institute

Unknown

Gene Therapy of Beta Thalassemia Using a Self-inactivating Lentiviral Vector

Beta-Thalassemia

China
U.S. Army Medical Research and Development Command

Completed

Safety of and Immune Response to a Modified Vaccinia Ankara (MVA) HIV Vaccine in HIV Uninfected Adults

HIV Infections

United States
National Human Genome Research Institute (NHGRI)
National Institutes of Health Clinical Center (CC); National Cancer Institute... and other collaborators

Completed

Treatment of SCID Due to ADA Deficiency With Autologous Transplantation of Cord Blood or Hematopoietic CD 34+ Cells After Addition of a Normal Human ADA cDNA by the EFS-ADA Lentiviral Vector

ADA-SCID | Adenosine Deaminase Deficiency

United States
Nanfang Hospital of Southern Medical University
Guangdong Yike Gene Science and Technology CO.,Ltd

Unknown

Gene Therapy for Beta-Thalassemia Major Using Autologous Hematopoietic Stem Cell Genetically Modified

Beta Thalassemia Major

China
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Safety and Immune Response of an Adenovirus-Based HIV Vaccine in HIV-Uninfected Adults

HIV Infections

United States
ViiV Healthcare

Terminated

GW873140 In Combination With Combivir In HIV Infected Subjects

HIV Infection | Infection, Human Immunodeficiency Virus I

United States, France, Canada, Germany, Italy, Belgium, United Kingdom, Portugal, Spain
London School of Hygiene and Tropical Medicine
Noguchi Memorial Institute for Medical Research

Completed

The Effect of Malaria on Disease Progression of HIV/AIDS

HIV Infections | Malaria

Ghana
London School of Hygiene and Tropical Medicine
DBL -Institute for Health Research and Development; Uganda AIDS Commission

Completed

Influence of Chloroquine on HIV Viral Load Among Pregnant Women in Uganda

HIV Infections | Malaria in Pregnancy

Uganda
University Hospital Center of Martinique

Completed

Seroprevalence of Chikungunya at the End of the First Chikungunya Outbreak in the French Antilles Within a Sample of Patients Treated for a HIV Infection (ChikVIH)

HIV Infections | Chikungunya Virus Infection

France
Centers for Disease Control and Prevention, China
Beijing Ditan Hospital; National Institutes for Food and Drug Control, China

Unknown

Clinical Trial of Recombinant Adenovirus Type 5 AIDS Vaccine

Acquired Immunodeficiency Syndrome

China
University of Washington
Kenya Medical Research Institute

Completed

Effect of Bednets and a Water Purification Device on HIV Disease Progression Among ART naïve Patients in Kenya (ITN)

HIV Infections | Diarrhea | Malaria | Human Immunodeficiency Virus | Plasmodium Falciparum

Kenya
Assistance Publique Hopitaux De Marseille

Completed

Microparticles, Vector of Genetic Information During HIV Infection

HIV,

France
University of Washington
Kenya Medical Research Institute

Completed

Discontinuation of Trimethoprim-sulfamethoxazole Prophylaxis in Adults on Antiretroviral Therapy in Kenya

HIV Infections | Acquired Immunodeficiency Syndrome | Immune System Diseases | Pneumonia | Disease Progression | Diarrhea | Parasitic Diseases | Malaria | Infectious Disorder of Immune System

Kenya
Fran Aweeka

Completed

Pharmacokinetic Interactions Between Antiretroviral Agents and Antimalarial Drug Combinations

HIV Infections | Malaria

United States
National Institute of Allergy and Infectious Diseases...
New York Presbyterian Hospital

Completed

Immune Therapies and Anti-HIV Therapy Withdrawal in Controlling Viral Load

HIV Infections

United States
Great Ormond Street Hospital for Children NHS Foundation...

Withdrawn

Lentiviral Gene Therapy for X-Linked Chronic Granulomatous Disease (X-CGD)

Granulomatous Disease, Chronic, X-linked, Variant

United Kingdom
Catholic University of Health and Allied Sciences
University of Cambridge; National Institute for Medical Research, Tanzania

Unknown

A Study of Co-infections of HIV-1 and Schistosoma Mansoni and Its Impact on Praziquantel Treatment Outcomes

Hematologic Diseases | Anemia | Opportunistic Infections | Human Immunodeficiency Virus I Infection | Intestinal Helminthiasis | Intestinal Schistosomiasis

Tanzania
Harvard School of Public Health (HSPH)
National Institute of Allergy and Infectious Diseases (NIAID); Fogarty International... and other collaborators

Completed

Safety of Cotrimoxazole in HIV- and HAART-exposed Infants

HIV Infections | Acquired Immunodeficiency Syndrome | Anemia | Neutropenia | Infant, Newborn

Botswana
National Institute of Allergy and Infectious Diseases...

Completed

Evaluation of the Safety of and Immune Response to an HIV Vaccine in Healthy Adults

HIV Infections

Australia
DBL -Institute for Health Research and Development
Danish Council for Development Research; The AIDS Foundation, Denmark; The Wedell-Wedellsborg...

Completed

Interaction Between HIV and Lymphatic Filariasis

HIV Infection | Lymphatic Filariasis
Center for International Health and Development
Centers for Disease Control and Prevention

Completed

Intermittent Preventive Treatment of Malaria in HIV-Seropositive Pregnant Women in Zambia

HIV Infections | Prematurity | Stillbirth | Neonatal Deaths | Placental Malaria Infection

Zambia

Search clinical trials for: lentivirus vector

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