Search clinical trials for: proof of concept

Total 431018 results

H. Lee Moffitt Cancer Center and Research Institute
Turnstone Biologics, Corp.

Recruiting

Proof of Concept of TBio-4101, Lymphodepleting Chemo, IL-2 for Relapsed/Refractory Melanoma

Metastatic Melanoma | Conjunctival Melanoma | Ocular Melanoma | Unresectable Melanoma | Uveal Melanoma | Cutaneous Melanoma | Mucosal Melanoma | Iris Melanoma | Acral Melanoma | Non-Cutaneous Melanoma

United States
Tropical Gastroenterology & Nutrition Group (TROPGAN)
Bill and Melinda Gates Foundation

Not yet recruiting

Ability of the Probiotic Vivomixx to Improve Environmental Enteropathy in Pregnant Women: a Proof of Concept Trial in Bangladesh, Pakistan, Senegal and Zambia (EMP)

Environmental Enteropathy

Bangladesh, Pakistan, Senegal, Zambia
Changi General Hospital
KK Women's and Children's Hospital (KKH)

Not yet recruiting

Developing a Virtual Reality (VR)-Based Prototype for Perioperative Care - a Proof of Concept Study

Postoperative Pain | Anxiety | Pain, Acute

Singapore
Johnson & Johnson Surgical Vision, Inc.

Recruiting

PROOF-OF-CONCEPT STUDY FOR NEW INTRAOCULAR LENS, MODEL C0002

Cataracts

France
University Hospital, Geneva

Not yet recruiting

Dynamic Response to Probiotics in Context of Alzheimer Disease: a Proof-of-concept Study (HISTEPPA)

Alzheimer Disease
Kira Pharmacenticals (US), LLC.

Not yet recruiting

Study to Evaluate Safety, Tolerability and Pharmacodynamics of KP104 in Participants With Thrombotic Microangiopathy Secondary to Systemic Lupus Erythematosus

Systemic Lupus Erythematosus
COMPASS Pathways

Recruiting

Efficacy and Safety of COMP360 Psilocybin Therapy in Anorexia Nervosa: a Proof-of-concept Study

Anorexia Nervosa

Ireland, United States, United Kingdom
Kira Pharmacenticals (US), LLC.

Not yet recruiting

To Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of KP104

Paroxysmal Nocturnal Hemoglobinuria

China
Alzeca Biosciences, Inc.
pharmtrace klinische Entwicklung GmbH

Recruiting

Proof-of-concept Study of New Imaging Diagnostic in Patients With Suspected Alzheimer's Disease

Alzheimer Disease

Germany
Natural Immune Systems Inc

Recruiting

Clinical Proof-of-concept Study on Immune Surveillance and Alertness

Immune Surveillance

United States
Clinical Academic Center (2CA-Braga)

Not yet recruiting

Proof-of-concept Study to Evaluate the Safety and Efficacy of Tryptophan in Patients With BPH. (TryptoBPH)

BPH
Natural Immune Systems Inc

Recruiting

Clinical Proof-of-concept Study on Rapid Immune Modulating Effects

Immune Surveillance

United States
Fundacin Biomedica Galicia Sur
Germans Trias i Pujol Hospital; Hospital del Mar; Hospital Universitario 12 de... and other collaborators

Recruiting

Precision Medicine in LN: A Multicenter Proof-of-concept Study for Histopathological Biomarkers Analysis in Renal Biopsy

Systemic Lupus Erythematosus | Lupus Nephritis

Spain
Medical University of Graz

Not yet recruiting

Impact of Hepatitis B Immunoglobulins in Patients With Chronic Hepatitis B on Hepatocellular Carcinoma - a Proof of Concept Study (HBIG)

Hepatocellular Carcinoma | HBV
Szeged University

Recruiting

Open Label Single Arm Proof of Concept Trial to Evaluate the Efficacy and Safety of Cytori Celution System in Diabetic Leg Ulcers

Leg Ulcer | Diabetic Foot Ulcer | Mesenchymal Stem Cells | Autologous Adipose Stromal Vascular Fraction | Adipose-Derived Mesenchymal Stem Cells

Hungary
Bioprojet

Recruiting

Proof of Concept Study Evaluating BP1.3656 in Patients With Fatigue Following Ischemic Stroke

Fatigue

France, Switzerland
EOM Pharmaceuticals

Recruiting

A Proof-of-Concept Study Evaluating EOM613 in COVID-19 Infected Patients With Severe Symptoms

COVID-19 Pneumonia | COVID-19 Respiratory Infection | COVID-19 Acute Respiratory Distress Syndrome

Brazil
Verrica Pharmaceuticals Inc.
Instat Clinical Research; HeartcoR Solutions; Myonex; Vial Health Technology, Inc

Recruiting

Open-Label Proof of Concept Study of VP-315 in Basal Cell Carcinoma

Carcinoma | Skin Cancer | Basal Cell Carcinoma | Cancer of the Skin, Basal Cell | Cancer of the Skin

United States
Szeged University

Recruiting

Open Label Single Arm Proof of Concept Trial to Evaluate the Efficacy and Safety of Cytori Celution System in Chronic Non-Healing Venous Leg Ulcers

Mesenchymal Stem Cells | Venous Leg Ulcer | Autologous Adipose Stromal Vascular Fraction | Adipose-Derived Mesenchymal Stem Cells

Hungary
University Hospital, Strasbourg, France

Recruiting

Personalized Repetitive Transcranial Magnetic Stimulation (rTMS) in Cognitive Fluctuations of Dementia With Lewy Bodies (DLB): Proof of Concept (STIMLEWY)

Dementia With Lewy Bodies Diagnosis | Significant Cognitive Fluctuations in DLB

France
Bispebjerg Hospital
Mirai Medical, Ireland

Recruiting

Calcium Electroporation for Basal Cell Carcinomas - Proof of Concept Study

Basal Cell Carcinoma

Denmark
ANRS, Emerging Infectious Diseases
EUCLID Clinical Trial Platform

Recruiting

ANRS HB07 IP-Cure-B Proof of Concept (PoC) Clinical Trial. Educating the Liver Immune Environment Through TLR8 Stimulation Followed by NUC Discontinuation (IP-CURE-B)

Hepatitis B, Chronic

France, Germany, Italy, Spain
Brennan Eadie

Not yet recruiting

Evaluation of a Novel Head-Mounted Device for Glaucoma Testing: A Proof-of-Concept Study

Glaucoma

Canada
UBP Greater China (Shanghai) Co., Ltd

Not yet recruiting

A Proof of Concept Study to Evaluate the Effect of UB-421 in Combination With Chidamide on HIV Viral Reservoir

HIV-1-infection
Cancer Institute and Hospital, Chinese Academy...
Guangzhou Burning Rock Dx Co., Ltd.

Recruiting

A Proof of Concept Study of Pan-cancer Early Detection by Liquid Biopsy (PROMISE)

Cancer

China
Assistance Publique - Hôpitaux de Paris

Recruiting

Fetoscopic Endoluminal Tracheal Occlusion (FETO) With Smart-TO (Smart-FETO)

Congenital Diaphragmatic Hernia

France
University Hospital, Toulouse

Recruiting

ASPirin in Immune thRombocytopenia Patients With Cardiovascular disEase (ASPIRE)

Purpura, Thrombocytopenic

France
Mitsui Chemicals, Inc.

Not yet recruiting

A Proof of Concept Alleviating the Symptoms of Photosensitive Migraine.

Migraine
Thorasys Thoracic Medical Systems Inc.
MedTeq

Not yet recruiting

Proof-of-concept of the Measurement of Lung Function Using the Relaxed Expiratory Occlusion Monitor (REOM)

Asthma in Children

Canada
University Hospital, Lille

Recruiting

Rapid Detection of COVID-19 by Portable and Connected Biosensor : Biological Proof of Concept (COR-DIAL-S)

Covid19 | SARS-CoV Infection

France
McMaster University
GlaxoSmithKline; University of Manchester

Recruiting

Mepolizumab for the Treatment of Chronic Cough With Eosinophilic Airways Diseases (MUCOSA)

Asthma | Eosinophilic Bronchitis | Chronic Cough

Canada
University of Thessaly

Not yet recruiting

CE-IOUS for Patients With Pancreatic Cancer Undergoing Surgery: A Prospective, Proof-of-concept Trial

Pancreatic Cancer | Liver Metastases
Rabin Medical Center
The Leona M. and Harry B. Helmsley Charitable Trust; DreaMed Diabetes

Recruiting

Evaluation of a Decision Support System for People With Diabetes Who Use Multiple Daily Insulin Injections- Feasibility and Proof of Concept Studies

Type1diabetes

Israel
Clinique Générale dAnnecy

Recruiting

Biomodulating Rotator Cuff Healing - A Proof of Concept Trial (BIOHACK)

Rotator Cuff Tears

France
University Hospital, Tours

Recruiting

Effects of Auditory Brain Stimulation by "Pink Noise" on Memory Capacities in Alzheimer's Disease: Proof of Concept Study (PINK-AD)

Alzheimer's Disease (AD)

France
IRCCS National Neurological Institute "C. Mondino...
Ministry of Health, Italy

Recruiting

BIOmarkers of MIGraine: a Proof of Concept Study Based on the Stratification of Responders to CGRP Monoclonal Antibodies (BIOMIGA)

Migraine

Germany, Italy, Spain
Massachusetts General Hospital
National Institute of Allergy and Infectious Diseases (NIAID); AIDS Healthcare...

Recruiting

Community-based Venues for Delivery of Healthcare Services: Proof of Concept Pilot

STI | Contraceptive Usage | Pre-Exposure Prophylaxis

South Africa
The Christie NHS Foundation Trust
University of Manchester

Not yet recruiting

A Proof of Concept Window Trial of the IMmunological Effects of AveLumab and Aspirin in Triple-Negative Breast Cancer (IMpALA)

Breast Cancer
Mauro Manconi
Clinical Trial Unit Ente Ospedaliero Cantonale

Recruiting

A Proof of Concept, Phase 2, Double-blind, Randomized Trial With d-Methadone Product Versus Placebo (Glu-REST)

Restless Legs Syndrome

Switzerland, Italy
National Institute of Nursing Research (NINR)

Recruiting

A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue

Fatigue

United States
UniQure Biopharma B.V.

Recruiting

Safety and Proof-of-Concept (POC) Study With AMT-130 in Adults With Early Manifest Huntington's Disease

Huntington's Disease

United States
Institut Bergonié
Bristol-Myers Squibb

Recruiting

Combination of Nivolumab Plus Relatlimab in Patients With Advanced or Metastatic Soft-tissue Sarcoma: a Proof-of-concept Randomized Phase II Study (CONGRATS)

Advanced Cancer | Soft Tissue Sarcoma Adult

France
SynerFuse, Inc

Recruiting

SynerFuse Spinal Fusion and Neuromodulation Proof of Concept Study

Chronic Pain | Spinal Fusion | Radiculopathy Lumbar

United States
Imperial College London

Recruiting

Closed-loop Control of Penicillin Delivery (CLCPD)

Healthy Volunteers

United Kingdom
Philippe Meyer

Recruiting

Effect of Radiotherapy on ATTR Cardiac Amyloidosis : a Proof of Concept Study

Amyloid Cardiomyopathy

Switzerland
International Centre for Diarrhoeal Disease Research...
Washington University School of Medicine

Recruiting

'Pre-Proof of Concept (Pre-POC)' Clinical Trials to Optimize Lead Microbiota-directed Complementary Food (MDCF) Prototypes for Their Ability to Repair Microbiota Immaturity and Establish Their Organoleptic Acceptability (MDCF)

Pre Proof of Concept Clinical Trial

Bangladesh
Miltenyi Biomedicine GmbH
Cromsource

Recruiting

Proof-of-Concept Trial on Selective Removal of sFlt-1 in Pregnant Women With Preeclampsia Via Apheresis (SAVE)

Preeclampsia

Germany, United Kingdom
Rambam Health Care Campus

Recruiting

Interhemispheric Anterior Delta Desynchronization in Children Who Present to the Emergency Department With Acute Concussion: A Proof of Concept Study

Concussion, Mild Traumatic Brain Injury

Israel
Gustave Roussy, Cancer Campus, Grand Paris
National Cancer Institute, France

Recruiting

European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors (ESMART)

Pediatric Cancer

Italy, France, Denmark, Germany, Netherlands, Spain, United Kingdom
Massachusetts General Hospital
Brain & Behavior Research Foundation; J Willard and Alice S. Marriott Foundation

Recruiting

BezafibrateTreatment for Bipolar Depression: A Proof of Concept Study

Bipolar Disorder | Depressive Episode

United States

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