Search clinical trials for: P-glycoprotein Inhibition

Total 1297 results

Novartis

Completed

Safety of AEB071 in Healthy Volunteers and to Compare the Ethnicity, Metabolic, and Safety Effects Between Caucasian and Japanese Healthy Subjects

Healthy

Canada
Innovative Medical

Completed

Aqueous Concentrations and PGE2 Inhibition of Ketorolac 0.4% vs. Bromfenac 0.09% in Cataract Patients: Trough Drug Effects

Cataract

United States
Franklin D. Gaylis, MD Inc.

Completed

Treatment of Refractory Urinary Retention Secondary to Benign Prostatic Hyperplasia (BPH) With Dual Five Alpha Reductase Inhibition Combined With an Alpha Blocker (AUR)

Benign Prostatic Hyperplasia | Urinary Retention
Regional Hospital Holstebro

Completed

Short Term Effects of HMG-CoA Reductase Inhibition (Atorvastatin)on Renal Hemodynamics, Tubular Function and Vasoactive Hormones on Healthy Subjects

Healthy

Denmark
Regional Hospital Holstebro

Completed

Acute Effect of HMG-CoA Reductase Inhibition (Atorvastatin)on Renal Hemodynamics, Tubular Function and Vasoactive Hormones on Healthy Subjects

Healthy

Denmark
Radboud University Medical Center

Completed

Effect of Selective iNOS Inhibition During Human Endotoxemia

Endotoxemia

Netherlands
Critical Therapeutics

Terminated

Zileuton CR vs Placebo in Poorly Controlled Asthma Patients on Moderate Dose ICS

Asthma

United States
National Institute of Neurological Disorders and...

Completed

The Physiology of Tricks

Dystonia | Torticollis

United States
National Institute of Neurological Disorders and...

Completed

Study of Brain Control of Movement

Healthy | Movement Disorder

United States
National Cancer Institute (NCI)

Completed

A Study of Combination Chemotherapy and Surgical Resection in the Treatment of Adrenocortical Carcinoma: Continuous Infusion Doxorubicin, Vincristine and Etoposide With Daily Mitotane Before and After Surgical Resection

Adrenal Cortical Carcinoma

United States
National Cancer Institute (NCI)

Completed

A Phase I Study of Continuous Intravenous Infusion of PSC 833 and Vinblastine in Patients With Metastatic Renal Cancer

Kidney Neoplasms | Neoplasm Metastasis

United States
National Institute of Neurological Disorders and...

Completed

Brain Inhibition of Muscle Movement in Normal Volunteers

Dystonic Disorders

United States
National Institute of Neurological Disorders and...

Completed

Surround Inhibition in Patients With Dystonia

Healthy | Dystonic Disorders

United States
National Institute of Neurological Disorders and...

Completed

Brain Plasticity of Verbal Memory in the Blind

Blindness

United States
National Institute of Diabetes and Digestive and...

Completed

The Effect of Thyroid Hormone on Drug Elimination in Cancer Patients

Thyroid Cancer

United States
National Institute of Neurological Disorders and...

Completed

Spinal Reflexes in Motor Skill Learning

Healthy

United States
National Cancer Institute (NCI)

Completed

Randomized, Double Blind, Placebo-Controlled, Phase IIB Trial of Ketorolac Mouth Rinse Evaluating the Effect of Cyclooxygenase Inhibition on Oropharyngeal Leukoplakia: Collaborative Study of the NCI, NIDCD and the NIDCR

Leukoplakia | Periodontal Disease

United States
National Cancer Institute (NCI)

Completed

Micellar Paclitaxel to Treat Severe Psoriasis

Psoriasis

United States
National Institute of Neurological Disorders and...

Completed

Brain Excitability During Self-Paced Voluntary Movements

Healthy | Movement Disorder

United States
National Institute of Neurological Disorders and...

Completed

Transcranial Magnetic Stimulation to Study Imagination of Movement

Healthy

United States
National Institute of Neurological Disorders and...

Completed

Transcranial Magnetic Stimulation (TMS) Studies of Dystonia

Healthy | Dystonic Disorder

United States
National Institute of Neurological Disorders and...

Completed

Mechanisms of Human Plasticity in the Human System

Blindness | Cerebrovascular Accident | Spinal Cord Injury

United States
National Institute of Neurological Disorders and...

Completed

Brain Encoding for Memory

Healthy

United States
Universidade Federal do Ceara

Completed

The Use of Antimicrobial Agents in the Inhibition of Mutans Streptococci in Children With Dental Caries

Dental Caries

Brazil
Novartis

Completed

Effects of Aliskiren, Irbesartan, and the Combination in Hypertensive Patients With Type 2 Diabetes and Diabetic Nephropathy

Diabetes Type 2

Denmark
Novartis

Completed

Effects of Imatinib in Subjects With Seasonal Allergic Rhinitis and Who Are Sensitive to Timothy Grass Pollen

Seasonal Allergic Rhinitis

United Kingdom
Kantonsspital Graubünden

Completed

Platelet Inhibition by Aspirin, Acetaminophen and NSAID

Hemostasis

Switzerland
Intarcia Therapeutics

Terminated

Treatment and Survival Continuation Study of Atamestane Plus Toremifene vs Letrozole in Advanced Breast Cancer

Breast Neoplasms | Neoplasms, Hormone-Dependent

United States, Ukraine, Canada, Russian Federation
Intarcia Therapeutics

Terminated

The CAT Study: Atamestane Plus Toremifene Versus Letrozole in Advanced Breast Cancer

Breast Neoplasms | Neoplasms, Hormone-Dependent

United States, Romania, Russian Federation, Ukraine, Bulgaria
Innovative Medical

Completed

Aqueous Concentrations and PGE2 Inhibition of Ketorolac 0.4% vs. Bromfenac 0.09% in Cataract Patients

Cataract

United States
Klinikum Ludwigshafen

Completed

Effects of Beta-Blocker Therapy and Phosphodiesterase Inhibition on Cardiac Neurohormonal Activation

Coronary Artery Disease

Germany
IRCCS San Raffaele

Completed

Effect of Chronic PDE5-Inhibition on Endothelial Function in Diabetics

Diabetes

Italy
KU Leuven

Completed

Long-Term Pharmacokinetics of Tacrolimus in Renal Recipients

Renal Transplantation

Belgium
University of Milan

Completed

PDE5-Inhibition With Sildenafil in Chronic Heart Failure

Heart Failure

Italy
Inotek Pharmaceuticals Corporation

Completed

A Study of INO-1001, an Intravenous PARP (Poly [ADP Ribose] Polymerase) Inhibitor in Acute Heart Attack Patients Undergoing Primary Percutaneous Coronary Intervention

Acute Myocardial Infarction

United States, Israel
Boston Scientific Corporation

Completed

INTRINSIC RV - Inhibition of Unnecessary RV Pacing With AV Search Hysteresis in ICDs

Tachycardia
University Health Network, Toronto
Abbott Medical Devices; Dr. Douglas Cameron

Completed

Assessment of Prepulse Inhibition for Shock Pain Reduction

Pain Awareness From ICD Shocks

Canada
Hospital Britanico

Completed

Inhibition of the Renin Angiotensin System Plus Corticosteroids for the Treatment of Proteinuria in IGA Nephropathy

IGA Nephropathy

Argentina
University Heart Center Freiburg - Bad Krozingen

Completed

Efficacy of Adjusted Clopidogrel Dose in Patients With Insufficient Platelet Inhibition

Coronary Artery Disease | Drug Resistance

Germany
Regional Hospital Holstebro

Completed

Effects of Inhibition of NO-Synthesis on Renal Hemodynamics and Sodium Excretion in Patients With Essential Hypertension and Healthy Controls

Hypertension
Regional Hospital Holstebro

Completed

Effects of Systemic NO-Inhibition on Renal Hemodynamics in Patiens With Polycystic Kidney Disease and Chronic Glomerulonephritis

Glomerulonephritis | ADPKD
AZ-VUB
Hoffmann-La Roche

Unknown

First-Line EGFR-1 Tyrosine Kinase Inhibition in Patients With NSCLC With Mutant EGFR Gene

Lung Neoplasms | Non-Small Cell Lung Cancer | Adenocarcinoma, Bronchiolo-Alveolar

Belgium
Tobinick, Edward Lewis, M.D.

Completed

TNF-Alpha Inhibition for Treatment of Alzheimer's Disease

Alzheimer's Disease

United States
Tobinick, Edward Lewis, M.D.

Completed

TNF-Alpha Inhibition for Treatment of Alzheimer's Disease

Alzheimer's Disease

United States
Leiden University Medical Center
The Netherlands Asthma Foundation

Unknown

Towards Restoring the Physiological Inhibition of Airway Narrowing in Asthma

Chronic Obstructive Pulmonary Disease | Asthma

Netherlands
Eunice Kennedy Shriver National Institute of Child...
National Center for Medical Rehabilitation Research (NCMRR)

Unknown

Electrical Stimulation After Total Knee Arthroplasty

Osteoarthritis | Total Knee Arthroplasty

United States
National Center for Research Resources (NCRR)

Unknown

The Inhibition of Platelet Antiaggregating Activity of Clopidogrel by Atorvastatin Detected by Erythromycin Breath Test: a Metabolic Inhibition of Hepatic Cytochrome P450-3A

Thrombosis | Hypercholesterolemia

United States

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