Clinical Trials Sponsored by Serco Group Plc

Total 236 results

TcLand Expression S.A.
Premier Research Group plc; Theradis pharma; Medpharmgene, Inc.

Terminated

Validation Study of RA-INF-Dx, a Multigene Molecular Test Used to Predict Non-Response to INfliximab Therapy (PRINT)

Rheumatoid Arthritis

Canada, France, Hungary, Italy, Lithuania, Romania, Slovakia, Spain
Canadian Myeloma Research Group
Merck Sharp & Dohme LLC

Withdrawn

A Study of Pembrolizumab Added to the Standard First-Line Therapy of Cyclophosphamide, Bortezomib, and Dexamethasone (CyBorD) for NDMM NTE

Multiple Myeloma

Canada
Canadian Cancer Trials Group
Merck Sharp & Dohme LLC

Terminated

Response to Pembrolizumab in Metastatic Melanoma: Computed Tomography Texture Analysis as a Predictive Biomarker

Metastatic Melanoma

Canada
Stoparkinson Healthcare Systems LLC
The Parkinson Study Group

Completed

Auricular Muscle Zone Stimulation for Parkinson Disease (Earstim-PD)

Parkinson Disease

United States
Rocky Mountain MS Research Group, LLC
Abreos Biosciences

Completed

Validation of a Laboratory Test Measuring Natalizumab (Tysabri®) Serum Levels in MS (IIT12)

Multiple Sclerosis

United States
KGK Science Inc.
Joint Health Wellness Group, LLC.

Completed

A Study on the Efficacy of Glucosamine Sulfate Potassium Chloride/Standardized Ginkgo Biloba Leaf Extract in Adults With Osteoarthritis of the Knee. (13GOHJ)

Osteoarthritis of the Knee

Canada
Texas A&M University
Anderson Global Group, LLC

Completed

Anderson Study 1 - Tart Cherry Study (AS1)

Health Services Research

United States
Ascentage Pharma Group Inc.
Merck Sharp & Dohme LLC

Recruiting

A Study of APG-115 in Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid Tumors

Melanoma | P53 Mutation | Uveal Melanoma | Cutaneous Melanoma | Mucosal Melanoma | Malignant Peripheral Nerve Sheath Tumors | MPNST | Unresectable or Metastatic Melanoma or Advanced Solid Tumors | MDM2 Gene Mutation

United States, Australia
Merck Sharp & Dohme LLC
Novartis; Integrated Therapeutics Group

Completed

Tiotropium Bromide Alone vs Tiotropium Bromide and Formoterol Fumarate in Subjects With COPD (Study P04272)

Pulmonary Disease, Chronic Obstructive
Cellular Biomedicine Group Ltd.
Chinese PLA General Hospital

Unknown

A Phase I Study Evaluating Safety and Efficacy of C-CAR011 Treatment in Adult Subjects With r/r CD19+B-ALL

Relapsed or Refractory Acute Lymphoblastic Leukemia

China
Spanish Lung Cancer Group
Merck Sharp & Dohme LLC

Terminated

Phase I/II of Oral Vorinostat Combination With Erlotinib in NSCLC Patients With EGFR Mutations With DP After Erlotinib.

Non-small Cell Lung Cancer

Spain
Alliance Foundation Trials, LLC.
Pfizer; Breast International Group; NSABP Foundation Inc; Austrian Breast & Colorectal... and other collaborators

Active, not recruiting

PALbociclib CoLlaborative Adjuvant Study (PALLAS)

Breast Cancer

United States, Spain, Italy, Ireland, United Kingdom, Australia, Germany, Japan, Portugal, Taiwan, Canada, Israel, Netherlands, Switzerland, Belgium, Austria, Hungary, Korea, Republic of, Mexico, Poland, Sweden
Region Stockholm
Karolinska Institutet; Uppsala University; Universidade do Porto; Niox Group Plc

Enrolling by invitation

Cluster-Randomized Asthma FeNO Trial (CRAFT)

Asthma

Sweden
Children's Oncology Group
National Cancer Institute (NCI); Incuron LLC

Recruiting

CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma

Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Recurrent Lymphoma | Recurrent Malignant Solid Neoplasm | Recurrent Osteosarcoma | Refractory Osteosarcoma | Diffuse Midline Glioma, H3 K27M-Mutant | Recurrent Diffuse Intrinsic Pontine Glioma | Metastatic Malignant Neoplasm in the Central... and other conditions

United States
ARCAGY/ GINECO GROUP
Merck Sharp & Dohme LLC; OSE Immunotherapeutics

Recruiting

OSE2101 Alone or in Combination With Pembrolizumab vs BSC in Patient With Platinum-sensitive Recurrent OC (TEDOVA)

Relapsed Ovarian Cancer | Platinum-sensitive Ovarian Cancer

Belgium, France, Germany
Spanish Breast Cancer Research Group
Merck Sharp & Dohme LLC

Completed

Incidence of Chemotherapy-Induced Nausea and Vomiting Associated With Docetaxel-Cyclophosphamide in Early Breast Cancer.

Breast Cancer

Spain
Chinese PLA General Hospital
Tianjin TongRenTang Group Co., Ltd.

Unknown

Efficacy and Safety of Shenyankangfu Tablets for Primary Glomerulonephritis

Proteinuria | Glomerulonephritis

China
Retina Research Institute, LLC
Retina-Vitreous Associates Medical Group; West Coast Retina Medical Group,...

Terminated

Ozurdex Implant for Macular Edema After Treatment Failure With Anti-VEGF

Macular Edema | Retinal Vein Occlusion (RVO)

United States
SOLTI Breast Cancer Research Group
Merck Sharp & Dohme LLC

Terminated

Pembrolizumab + Paclitaxel in Hormone Receptor-positive (HR+)/Human Epidermal Growth Factor Receptor 2-negative (HER2-) Non-luminal (by PAM50) Advanced Breast Cancer After Cyclin-dependent Kinase 4/6 (CDK4/6) Inhibitors Progression (TATEN)

Metastatic Breast Cancer

Spain
ESM Technologies, LLC
QPS Bio-Kinetic; KD Pharma Group

Completed

NEM® + KD PUR® Fish Oil Versus Placebo in Exercised-induced Joint Pain, Stiffness, & Cartilage Turnover in Healthy Men & Women (Move3)

Exercise-induced Joint Pain | Exercise-induced Joint Stiffness | Exercise-induced Joint Cartilage Turnover

United States
Latin American Cooperative Oncology Group
Merck Sharp & Dohme LLC

Completed

Pembrolizumab Combined With Cisplatin-based Chemotherapy as First-line Systemic Therapy in Advanced Penile Cancer (HERCULES)

Penile Carcinoma

Brazil
Cancer Insight, LLC
Genentech, Inc.; Sellas Life Sciences Group

Completed

Phase II Trial of Combination Immunotherapy With NeuVax and Trastuzumab in High-risk HER2+ Breast Cancer Patients (HER3+)

Breast Cancer

United States
Latin American Cooperative Oncology Group
Merck Sharp & Dohme LLC

Active, not recruiting

Study of a Pembrolizumab-based Organ Preservation Strategy for Locally Advanced Larynx Cancers (SMART-KEY)

Squamous Cell Carcinoma of Larynx

Brazil
Spanish Breast Cancer Research Group
Merck Sharp & Dohme LLC

Completed

Trial to Evaluate Efficacy and Safety of Pembrolizumab and Gemcitabine in HER2-negative ABC (PANGEA)

Advanced Breast Cancer

Spain
MedImmune LLC
Thrombolysis in Myocardial Infarction (TIMI) Study Group

Completed

A Study to Evaluate the Safety and Efficacy of MEDI6012 in Acute ST Elevation Myocardial Infarction (REAL-TIMI 63B)

ST Elevation Myocardial Infarction

Netherlands, United Kingdom, Brazil, Spain, Slovakia, Israel, Czechia, Hungary, Poland, Russian Federation
Larimar Therapeutics, Inc.
Veristat, Inc.; Metrum Research Group, LLC

Completed

Single Ascending Dose Study of CTI-1601 Versus Placebo in Subjects With Friedreich's Ataxia

Friedreich Ataxia

United States
Australasian Leukaemia and Lymphoma Group
Merck Sharp & Dohme LLC

Unknown

Emesis Control Study in Non-Hodgkin Lymphoma Patients Receiving R-CHOP

Lymphoma, Non-Hodgkin
Ruimin Wang
Sinotau Pharmaceutical Group

Recruiting

A Clinical Study of [177Lu]Lu-XT117 Injection in Patients With Advanced Solid Tumors

Advanced Solid Tumor

China
Naima Health LLC
University of Pittsburgh; Obstetrix Medical Group

Recruiting

Evaluation of MHP 3.0 in Two Clinical Settings

Telemedicine

United States
Rochester Skin Lymphoma Medical Group, PLLC
Rochester General Hospital

Completed

Mechlorethamine Induced Contact Dermatitis Avoidance Study (MIDAS)

Mycosis Fungoides | Cutaneous T-cell Lymphoma | Transformed Mycosis Fungoides | Cutaneous T-cell Lymphoma Stage I | Folliculotropic Mycosis Fungoides | Granulomatous Slack Skin | Syringotropic Mycosis Fungoides | Mycosis Fungoides Variant

United States
Larimar Therapeutics, Inc.
Veristat, Inc.; Metrum Research Group, LLC

Completed

Multiple Ascending Dose Study of CTI-1601 Versus Placebo in Subjects With Friedreich's Ataxia

Friedreich Ataxia

United States
Canadian Cancer Trials Group
Merck Sharp & Dohme LLC; Seagen Inc.

Recruiting

Pembrolizumab and Brentuximab Vedotin vs GDP and Stem Cell Transplant for Relapsed/Refractory Hodgkin Lymphoma

Hodgkin Lymphoma

Canada
University of Colorado, Denver
Rocky Mountain MS Research Group, LLC

Completed

Comparison of Rituximab Induction Therapy Followed by Glatiramer Acetate (GATEWAYII)

Multiple Sclerosis

United States
West German Study Group
Merck Sharp & Dohme LLC; Gilead Sciences

Not yet recruiting

NeoAdj. Therapy Comparing Sacituzumab Govitecan (SG) vs. SG+Pembrolizumab in Low-risk, Triple-neg. EBC (ADAPT-TN-III) (ADAPT-TN-III)

Triple Negative Breast Cancer
Oslo University Hospital
Merck Sharp & Dohme LLC; Italian Sarcoma Group

Terminated

A Study of Pembrolizumab in Patients With Relapsed Or Metastatic Osteosarcoma Not Eligible for Curative Surgery (PROMO)

Osteosarcoma

Norway, Italy
Applied Biologics, LLC
Fondren Orthopedic Group L.L.P.; Texas Orthopedic Hospital

Unknown

Efficacy of an Amniotic Fluid Derived Allograft, (FlōGraft®) in Rotator Cuff Repairs: A Prospective Study

Rotator Cuff Tear | Fatty Atrophy

United States
SOLTI Breast Cancer Research Group
Novartis; Alliance Foundation Trials, LLC.

Recruiting

Ribociclib vs. Palbociclib in Patients With Advanced Breast Cancer Within the HER2-Enriched Intrinsic Subtype (HARMONIA)

Metastatic Breast Cancer

United States, Spain, Portugal
Cochlear
Analytical Solutions Group, Inc.; R. P. Chiacchierini Consulting, LLC

Completed

Osia 2 Pediatric Expansion Study

Conductive Hearing Loss | Single-Sided Deafness | Mixed Hearing Loss

United States
Johns Hopkins University
National Eye Institute (NEI); Results Group LLC

Terminated

Tools to Optimize Patient Presentation After Onset of Exudative Age-Related Macular Degeneration (AMD)

Age-related Macular Degeneration

United States
Chinese PLA General Hospital
Jiangsu Suzhong Pharmaceutical Group Co., Ltd.

Unknown

Efficacy and Safety of Abelmoschus Manihot for Chronic Kidney Disease

Chronic Kidney Disease

China
IRCCS Policlinico S. Matteo
Merck Sharp & Dohme LLC; Menarini Group

Unknown

Nebivolol Versus Losartan Versus Nebivolol+Losartan Against Aortic Root Dilation in Genotyped Marfan Patients (MaNeLo)

Marfan Syndrome

Italy
Groupe Francophone des Myelodysplasies
Merck Sharp & Dohme LLC

Terminated

Addition of Vorinostat to Azacitidine in Higher Risk MDS a Phase II add-on Study in Patients With Azacitidine Failure (GFM-AZA-VOR)

Myelodysplastic Syndrome

France
Groupe Francophone des Myelodysplasies
Merck Sharp & Dohme LLC

Completed

Vorinostat and Low Dose Cytarabine for High Risk Myelodysplasia (GFMVOR2007)

Myelodysplastic Syndromes

France
Australasian Leukaemia and Lymphoma Group
Merck Sharp & Dohme LLC; Novartis Pharmaceuticals

Unknown

Pegylated Interferon Alfa-2b and Nilotinib for Augmentation of Complete Molecular Response in Chronic Myeloid Leukaemia (PInNACLe)

Chronic Myeloid Leukaemia

Australia
Seagen Inc.
Merck Sharp & Dohme LLC; GOG Foundation; European Network of Gynaecological Oncological... and other collaborators

Active, not recruiting

Safety and Efficacy of Tisotumab Vedotin Monotherapy & in Combination With Other Cancer Agents in Subjects With Cervical Cancer

Cervical Cancer

United States, Belgium, Netherlands, Czechia, Spain, Turkey, Ireland, United Kingdom, Italy, Denmark
National Cancer Institute (NCI)
Childrens Oncology Group (COG); LLS PedAL LLC

Recruiting

Highest Dose of Uproleselan in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Mixed Phenotype Acute Leukemia Relapsed or Refractory and That Expresses E-selectin Ligand on the Cell Membrane

Down Syndrome | Recurrent Acute Myeloid Leukemia | Recurrent Myelodysplastic Syndrome | Refractory Acute Myeloid Leukemia | Refractory Myelodysplastic Syndrome | Recurrent Mixed Phenotype Acute Leukemia | Refractory Mixed Phenotype Acute Leukemia | Acute Myeloid Leukemia Post Cytotoxic Therapy | Myelodysplastic...

United States
Greater Houston Retina Research
Regeneron Pharmaceuticals; Clinical Trials Resource Group, LLC

Active, not recruiting

Long-Term Efficacy and Safety of Intravitreal Aflibercept Injections for the Treatment of Diabetic Retinopathy for Subjects Who Completed the 2-Year PANORAMA Trial (VOYAGE)

Diabetic Retinopathy

United States, Puerto Rico
Fresenius Medical Care Deutschland GmbH
acromion GmbH; Vector Psychometric Group, LLC

Completed

Development, Feasibility Testing and Validation of a Survey Set to Measure Patient-Reported Outcomes Among Hemodialysis Patients in Turkey (DOPRO)

Renal Failure | End Stage Renal Disease

Turkey
John F. Foley, MD
Biogen

Completed

Pharmacokinetic, Immunological and Biochemical Sample Collection and Analysis of a Tysabri Patient Cohort

Multiple Sclerosis | Relapse

United States
John F. Foley, MD
Biogen

Completed

Longitudinal Pharmacokinetic, Pharmacodynamic, Immunological, and Biochemical

Multiple Sclerosis

United States

Clinical Trials Sponsored by Serco Group Plc

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