Clinical Trials Sponsored by Shire

Total 697 results

Shire

Completed

Open Label Extension (TRES)

Osteoporosis

United States, Argentina
Shire

Completed

Maribavir for Prevention of CMV After Stem Cell Transplants

Cytomegalovirus Infection

United States
Shire

Completed

Safety, Efficacy and Pharmacokinetic Study of Teduglutide in Infants 4 to 12 Months of Age With Short Bowel Syndrome

Short Bowel Syndrome

Finland, Italy, United Kingdom, France
Shire

Terminated

Efficacy and Safety Study of Ontamalimab as Induction Therapy in Participants With Moderate to Severe Crohn's Disease (CARMEN CD 305) (CARMEN CD 305)

Crohn's Disease

United States, Australia, Romania, Israel, Italy, Croatia, South Africa, Germany, Poland, United Kingdom, Austria, Japan, Lithuania, Netherlands, Russian Federation, Serbia
Shire

Terminated

Mucopolysaccharidosis (MPS) I, II, and VI Screening in a High-Risk Population With Previous Surgical Repair or Presence of Inguinal and/or Umbilical Hernia in Combination With Pediatric ENT Surgery (The HATT Project)

Mucopolysaccharidosis (MPS)

United States, Canada, United Kingdom, Turkey, Italy, Mexico, Spain
Shire

Completed

Pediatric Disease Registry in Essential Thrombocythaemia (ET)

Essential Thrombocythemia (ET)

United Kingdom, Italy, Czechia, France, Germany, Greece, Spain, Switzerland
Shire

Completed

Home Therapy With Replagal in Fabry Disease

Fabry Disease

Austria, Germany
Shire

Terminated

Natural History Study of Children With Metachromatic Leukodystrophy

Metabolic Diseases | Brain Diseases | Central Nervous System Diseases | Nervous System Diseases | Demyelinating Diseases | Genetic Diseases, Inborn | Metabolism, Inborn Errors | Lysosomal Storage Diseases | Lipid Metabolism Disorders | Sphingolipidoses | Hereditary Central Nervous System Demyelinating Diseases and other conditions

United States, Denmark, France, Argentina, Belgium, Brazil, Canada, Germany, Japan, Turkey
Shire

Completed

An Extension Study to Evaluate Maintenance of Efficacy and Long-term Treatment Effect of Oral Budesonide Suspension (OBS) in Adults and Adolescents With Eosinophilic Esophagitis (EoE) (ORBIT2)

Eosinophilic Esophagitis (EoE)

United States
Shire

Completed

Study of Teduglutide in Japanese Participants With Short Bowel Syndrome

Short Bowel Syndrome

Japan
Bayer
Shire

Completed

Long-term Study in Chronic Kidney Disease (Extension From Study 14817)

Hyperphosphatemia

Japan
Shire

Completed

Study of Long Term Safety and Clinical Outcomes of Idursulfase IT and Elaprase Treatment in Pediatric Participants Who Have Completed Study HGT-HIT-094

Hunter Syndrome

United States, Spain, Canada, United Kingdom, Mexico, Australia, France
Shire
Takeda

Completed

FIRAZYR General Drug Use-Results Survey (Japan)

Hereditary Angioedema (HAE)

Japan
Shire

Completed

Drug Use Study With Intuniv® in European Countries

Attention Deficit Hyperactivity Disorder (ADHD)

Germany
Shire

Completed

Post Marketing Surveillance (PMS) Study for Velaglucerase Alfa (VPRIV) in India

Gaucher Disease

India
Shire

Terminated

A Study of Replagal in Treatment-naïve Adults With Fabry Disease

Fabry Disease

Spain, Greece, Germany, Portugal, Canada, Finland, Poland, Sweden
Shire

Withdrawn

A Clinical Study of rhPTH(1-84) Treatment in Japanese Participants With Chronic Hypoparathyroidism

Chronic Hypoparathyroidism

Japan
Shire

Completed

A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of a Single Oral Dose of Maribavir Administered in Healthy Japanese Participants Compared With Matched, Healthy, Non-Hispanic, Caucasian Participants and to Assess Dose-Proportionality of 3 Doses of Maribavir in Japanese Participants

Healthy Volunteers

United States
Shire

Completed

Study in Japanese Pediatric Subjects With Short Bowel Syndrome (SBS) Who Are Dependent on Parenteral Support

Short Bowel Syndrome

Japan
Shire

Completed

Study of the Effect of Velaglucerase Alfa (VPRIV®) on Bone-related Pathology in Treatment-naïve Participants With Type 1 Gaucher Disease

Gaucher Disease

United States, Spain, United Kingdom, Israel
Shire

Completed

Drug Use Study With VYVANSE® in Australia for Binge Eating Disorder

Binge-eating Disorder

Australia
Shire

Completed

Retrospective, Observational Chart Review Study Conducted in Poland to Document the Management and Clinical Outcome of CUVITRU and HYQVIA in Pediatric Participants (< 18 Years) With Primary Immunodeficiency (PID) (IG-TATRY)

Primary Immunodeficiencies (PID)

Poland
Shire

Completed

Long-term Safety and Efficacy Study of Teduglutide in Pediatric Participants With Short Bowel Syndrome (SBS)

Short Bowel Syndrome

United States, Canada, Finland, Italy, United Kingdom, Belgium
Shire

Terminated

FST-100 Ophthalmic Suspension in Acute Adenoviral Conjunctivitis

Acute Adenoviral Conjunctivitis

United States
Shire

Completed

Study of SSP-004184 (SPD602) in Healthy Adults and Subjects With Impaired Liver Function

Healthy | Hepatic Impairment

United States
Shire

Completed

This Study is Designed to Evaluate PD/PK and Safety of Replagal Manufactured by Two Different Processes.

Fabry Disease

Canada
Shire

Completed

Efficacy and Safety of SPD465 in Adults With Moderately Symptomatic ADHD.

Attention Deficit Disorder With Hyperactivity
Shire

Terminated

Dynepo Long-Term Safety Study

Anemia | Kidney Failure, Chronic

Belgium
Shire

Completed

A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Subcutaneous CINRYZE Administration

Hereditary Angioedema

United States
Shire

Completed

Efficacy and Safety of Fosrenol in Treating Elevated Serum Phosphate Levels in Adults With End Stage Renal Disease

Kidney Failure, Chronic
Shire

Completed

Efficacy and Safety of SPD465 in Adults With ADHD

Attention Deficit Disorder With Hyperactivity
Shire

Terminated

Pharmacokinetics of SSP-004184 in the Treatment of Chronic Iron Overload Requiring Chelation Therapy

Iron Overload Due to Repeated Red Blood Cell Transfusions

United States, Canada, Lebanon, Italy, Egypt
Shire

Completed

Effect of Lanthanum Carbonate in Patients Previously Treated With Calcium-based Phosphate Binder Therapy

End Stage Renal Disease

Germany
Shire

Completed

Metazym for the Treatment of Patients With Late Infantile Metachromatic Leukodystrophy (MLD)

Metachromatic Leukodystrophy (MLD)

Denmark
Shire

Completed

A Phase 3 Study to Evaluate the Efficacy of Lifitegrast in Subjects With Dry Eye

Dry Eye Disease

United States
Shire

Completed

Open-Label Extension Study Evaluating Long Term Safety in Patients With Type 1 Gaucher Disease Receiving DRX008A (ERT)

Gaucher Disease

Israel, Romania, Serbia
Shire

Terminated

SPD489 Low Dose and High Dose Ranges When Added to Stable Doses of Antipsychotic Medications in Clinically Stable Adults With Negative Symptoms of Schizophrenia

Schizophrenia

United States
Shire

Completed

Access to Extended Release Guanfacine HCl for Subjects Who Participated in Studies SPD503-315 or SPD503-316 in Europe

Attention Deficit Hyperactivity Disorder (ADHD)

Spain, Germany, Ukraine, France, Italy, Austria, Belgium, Ireland, Netherlands, Poland, Romania, Sweden, United Kingdom
Shire

Completed

Study to Evaluate the Effect of Omeprazole on the Pharmacokinetics of SPD422 (Anagrelide Hydrochloride) in Healthy Adult Participants

Healthy Volunteers

United States
Shire

Completed

Exploratory Study of SPD489 in Adults With Major Depressive Disorder (MDD) as Augmentation Therapy to an Antidepressant

Major Depressive Disorder

United States
Shire

Completed

Safety and Pharmacokinetics of MMX Mesalamine in Children and Adolescents With Ulcerative Colitis

Ulcerative Colitis

United States, United Kingdom, Australia, Poland, Slovakia
Shire

Completed

FST-201 in the Treatment of Acute Otitis Externa

Acute Otitis Externa

American Samoa
Shire

Completed

Efficacy and Safety of SPD476 in Maintaining Remission in Patients With Ulcerative Colitis

Ulcerative Colitis

United States, Spain, Denmark, Korea, Republic of, Australia, Taiwan, Singapore, Sweden, Belgium, France, United Kingdom, Romania, New Zealand, India, Canada, South Africa, Brazil, Germany, Mexico, Hungary, Portugal, Chile, Netherlands and more
Shire

Completed

Prevention of Recurrence of Diverticulitis (PREVENT1)

Diverticulitis

New Zealand, United States, United Kingdom, Sweden, Australia, Israel, India, Spain, Colombia, Argentina, France
Shire

Terminated

Dynepo Infrequent Dosing Study

Anemia | Kidney Failure

Spain, United Kingdom, Austria, Belgium, France, Germany, Italy
Shire

Completed

Long-term Metazym Treatment of Patients With Late Infantile Metachromatic Leukodystrophy (MLD)

Late Infantile Metachromatic Leukodystrophy

Denmark
Shire

Terminated

SPD489 Adult Major Depressive Disorder (MDD) Open-label Safety and Tolerability Rollover Extension Study

Major Depressive Disorder

United States, Spain, Germany, Puerto Rico, Canada, Estonia, South Africa, Czechia, Finland, Chile, Hungary, Mexico, Poland, Romania
Shire

Completed

IGF-1/IGFBP3 Prevention of Retinopathy of Prematurity

Retinopathy of Prematurity (ROP)

United States, Italy, Netherlands, United Kingdom, Sweden, Poland
Shire

Terminated

Treatment of Adenoviral Conjunctivitis With SHP640 Compared to Povidone-iodine (PVP-I) and Placebo

Adenoviral Conjunctivitis

United States, Israel, France, India, Australia, Austria, Spain, Estonia, Hungary, Poland, South Africa, Canada, Germany, Italy, Peru, United Kingdom
Shire

Terminated

Efficacy and Safety Study of SHP647 as Induction Therapy in Participants With Moderate to Severe Ulcerative Colitis (FIGARO UC 301)

Ulcerative Colitis

United States, Australia, Russian Federation, Romania, Brazil, Israel, Germany, Italy, Croatia, Netherlands, Poland, United Kingdom, Austria, Japan, Lithuania, Serbia, South Africa, Czechia

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