Search clinical trials for: CYP3A4 inhibitor

Total 68213 results

Gerd Mikus

Completed

Influence of Cytochrome CYP3A4-induction by St. John's Wort on the Steady State Pharmacokinetics of Ambrisentan

Drug Interactions

Germany
KU Leuven

Completed

Long-Term Pharmacokinetics of Tacrolimus in Renal Recipients

Renal Transplantation

Belgium
CTI BioPharma
Covance

Completed

Drug-Interaction Study to Evaluate the Effect of Rifampin, a Potent CYP3A4 Inducer, on the Systemic Exposure of Pacritinib in Healthy Subjects

Healthy Subjects

United States
Cyclerion Therapeutics

Completed

A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of Praliciguat (IW-1973) in Healthy Volunteers

Healthy

United States
Millennium Pharmaceuticals, Inc.

Completed

A Study to Evaluate the Effect of the Potent CYP3A4 Inhibitor Itraconazole on the Pharmacokinetics (PK) of TAK-906 in Healthy Participants

Healthy Participants

United States
Pfizer

Completed

A Study to Estimate the Effect of CYP3A4 Inhibitors (Itraconazole, Diltiazem or Verapamil) on the Pharmacokinetics of Single Dose PF- 00489791 in Healthy Volunteers

Healthy Volunteers

Belgium
Novartis Pharmaceuticals

Withdrawn

HDM201 Added to CT in R/R or Newly Diagnosed AML

Leukemia, Myeloid, Acute
University Hospital, Clermont-Ferrand

Completed

Dextromethorphan Effect on Central Sensitization to Pain in Healthy Volunteers (Hydex)

Hyperalgesia | Experimental Pain

France
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Effect of Ibrutinib on the Pharmacokinetics of Oral Contraceptives, CYP2B6, and CYP3A4 Substrates in Female Participants With B Cell Malignancy

Leukemia, Lymphocytic, Chronic, B-Cell

Spain, Poland
Bayer
Orion Corporation, Orion Pharma

Completed

Drug-drug-interaction Study to Assess the Effect of Darolutamide on the Pharmacokinetics of Probe Substrates of CYP3A4 and P-gp in Healthy Male Volunteers

Prostatic Neoplasms

Germany
Eisai Inc.

Completed

A Study to Evaluate the Effects of Diltiazem, a Moderate CYP3A4/A5 Inhibitor, on the Pharmacokinetics and Pharmacodynamics of E5555 and Its Metabolites in Healthy Subjects

Healthy Subjects

Netherlands
Vanda Pharmaceuticals
Cross Research S.A.

Completed

Study to Assess the Effect of Multiple Doses of Tradipitant on CYP3A4 Using Midazolam as a Substrate in Healthy Subjects

Healthy Volunteers

Switzerland
R-Pharm International, LLC
IQVIA RDS Ireland Ltd; Thermo Fisher Scientific FS

Completed

Study in Subjects With Rheumatoid Arthritis to Evaluate the Effect of a Single Dose of Olokizumab on the Pharmacokinetics of Substrates for CYP1A2, CYP2C9, CYP2C19 and CYP3A4

Rheumatoid Arthritis

Bulgaria, Moldova, Republic of
Cyclerion Therapeutics

Completed

A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of the Soluble Guanylate Cyclase Stimulator, Olinciguat (IW-1701), in Healthy Volunteers

Healthy

United States
Takeda

Completed

A Study to Evaluate the Effect of the Potent Cytochrome P-450 3A4 (CYP3A4) Inhibitor Itraconazole on the Pharmacokinetics (PK) of TAK-954 in Healthy Adult Participants

Healthy Participants

United States
Thomas Jefferson University
Bristol-Myers Squibb

Completed

Drug Interaction Study of Apixaban With Cyclosporine and Tacrolimus (ACT)

Healthy | Venous Thromboembolism | Pharmacokinetics

United States
Eisai Inc.

Completed

A Pharmacokinetic Study to Assess the Influence of Simultaneous CYP3A4 and P-glycoprotein Inhibition on E7080 Pharmacokinetics Following Single Dose Oral Administration of 5 mg E7080 to Healthy Volunteers

Healthy Volunteers

United States
Memorial Sloan Kettering Cancer Center
Pfizer; Dana-Farber Cancer Institute; University of Pittsburgh; University of Virginia

Completed

Phase II Trial of Sunitinib (SU011248) in Patients With Recurrent or Inoperable Meningioma

Neurofibromatosis | Meningioma | CNS Cancer | Hemangioblastoma | Intracranial Hemangiopericytoma

United States
AHEPA University Hospital
Skylitseio General Hospital

Completed

Beta Blockers Plus Intravenous Flecainide for Paroxysmal Atrial Fibrillation: a Real-world Chios Registry (BETAFLEC-CHIOS) (BETAFLEC-CHIOS)

Atrial Fibrillation | Arrhythmias, Cardiac

Greece
University Medicine Greifswald

Completed

Pharmacokinetic and Pharmacodynamic Interactions Between the Cholesterol-lowering Ezetimibe and the Non-nucleoside Reverse Transcriptase Inhibitor Efavirenz During Chronic Treatment in Healthy Volunteers With Reference to Intestinal Expression of CYP3A4, UGT1A1, ABCB1 and ABCC2

Pharmacokinetics | Pharmacodynamics | Drug Interactions | Intestinal Transporter Expression

Germany
Eisai Inc.

Completed

A Pharmacokinetic Study to Assess the Influence of P-glycoprotein Inhibition and Simultaneous CYP3A4 and P-glycoprotein Induction on E7080 Pharmacokinetics Following Single Dose Oral Administration of 24 mg E7080 to Healthy Volunteers

Healthy Volunteers | P-glycoprotein

United States
AstraZeneca

Completed

To Assess the Effect of Itraconazole (a CYP3A4 Inhibitor) on the Pharmacokinetics of Olaparib, and the Effect of Olaparib on QT Interval Following Oral Dosing of a Tablet Formulation to Patients With Advanced Solid Tumours

Solid Tumours

Belgium, Denmark, United Kingdom, Netherlands
Dizal Pharmaceuticals

Recruiting

Assessing the Effect of DZD9008 on the Pharmacokinetics of the Cocktail Probes Representative for CYP3A4, P-gp, BCRP and OATP1B1 in Patients With EGFR or HER2 Mutant Advanced Non-small Cell Lung Cancer (WU-KONG19)

Non-small Cell Lung Cancer

China
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Effect of Oral Doses of JNJ-54175446 on the Inhibition of Cytochrome P450 CYP3A4, CYP2C9, CYP1A2 and CYP2D6 Activity and the Induction of CYP2B6 and CYP2C19 Activity Using a Multiple Probe Substrate Cocktail in Healthy Subjects

Healthy

Belgium
Daiichi Sankyo, Inc.

Completed

A PHASE 1, OPEN-LABEL, CROSS-OVER, FIXED SEQUENCE STUDY TO EVALUATE THE EFFECT OF MULTIPLE DOSES OF DS-1971A ON THE SINGLE DOSE PHARMACOKINETICS OF PROBE SUBSTRATES FOR CYP2B6, CYP2C8, CYP2C9, CYP2C19 AND CYP3A4 ENZYMES IN HEALTHY MALE AND FEMALE SUBJECTS

Healthy

United Kingdom
Clementia Pharmaceuticals Inc.

Completed

Study Evaluating the Effect of Food on the Pharmacokinetics of Palovarotene and the Effect of Palovarotene on the Pharmacokinetics of the CYP3A4 Substrate Midazolam in Two Cohorts of Healthy Adult Subjects

Fibrodysplasia Ossificans Progressiva

United States
AstraZeneca

Completed

Study to Assess the Effect of Itraconazole (a CYP3A4 Inhibitor) on the Pharmacokinetics of AZD9291, in Patients With EGFR Positive Non-small Cell Lung Cancer. Patients Will be Chosen From Those Who Have Already Been Prescribed an EGFR TKI Medicine (Such as Iressa or Tarceva)

Advanced Non Small Cell Lung Cancer | Advanced (Inoperable) Non Small Cell Lung Cancer

Belgium, United States, Korea, Republic of, Taiwan, United Kingdom, Netherlands
Boehringer Ingelheim

Completed

Evaluation of the Effect of Multiple Dosing With BI 201335 on CYP2B6 Metabolism and Effect of Multiple Dosing With Efavirenz on the Steady-state Pharmacokinetics of BI 201335 and on CYP3A4/5 Metabolism in Healthy Volunteers

Healthy

Switzerland
University of Illinois at Chicago
Oregon State University

Completed

Licorice Botanical Dietary Supplements - Metabolism and Safety in Women

Food-drug Interaction

United States
Repros Therapeutics Inc.

Completed

Open-Label, Multiple-Dose, Non-Randomized Study to Assess Drug-Drug Interactions of Proellex® in Female Subjects

Drug Interactions

United States
First Affiliated Hospital Xi'an Jiaotong University

Not yet recruiting

Irinotecan Liposomes for the Treatment of Neuroendocrine Carcinoma

Neuroendocrine Tumors
Hunan Cancer Hospital

Not yet recruiting

Liposomal Irinotecan Combination Regimen for Second-line Treatment of Advanced Gastric Cancer

Advanced Gastric Cancer
Tang-Du Hospital

Recruiting

Neoadjuvant Adebrelimab in Resectable SCLC: A Randomized Trial

Small Cell Lung Cancer (SCLC)

China
Swissmed Hospital

Recruiting

The Effects of Preoperative Botulinum Toxin A Injection on Respiratory System Function

Hernia | Botulinum Toxins, Type A

Poland
Ain Shams University

Recruiting

Effect of Captopril on GLS in Duchenne Myodystrophy

Effect of Drug

Egypt
Changzhi People's Hospital Affiliated to Changzhi...

Recruiting

A Real-world Study of Camrelizumab Alone or in Combination With Apatinib/Chemotherapy for Advanced Gastric Cancer

Gastric Cancer | PD-1 Immunotherapy | RWS

China
ZimVie

Not yet recruiting

Evaluation of Safety and Effectiveness of Primary Hybrid Construct of Mobi-C and ACDF in the Treatment of Two-level Symptomatic Degenerative Disc Disease in the Cervical Spine.

Degenerative Disc Disease
St. Olavs Hospital
Ullevaal University Hospital; Oslo University Hospital; University Hospital of... and other collaborators

Recruiting

Prophylactic Treatment With Atorvastatin for Chronic Migraine (ChronicStatinMig)

Chronic Migraine

Norway
Guohui Xu

Recruiting

TACE Plus Camrelizumab and Apatinib for Unresectable Hepatocellular Carcinoma

Unresectable Hepatocellular Carcinoma | Apatinib | Camrelizumab | Transarterial Chemoembolization

China
Gilead Sciences
GOG Foundation; European Network of Gynaecological Oncological Trial Groups...

Not yet recruiting

Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Participants With Endometrial Cancer After Platinum-Based Chemotherapy and Immunotherapy (ASCENT-GYN-01)

Endometrial Cancer
Zagazig University

Not yet recruiting

Isotretinoin Versus Excimer Light an Adjuvant in Treating Onychomycosis

Onychomycosis
Kafrelsheikh University

Recruiting

Valproate Versus Propranolol in Migraine

Migraine Disorders

Egypt
Boehringer Ingelheim

Not yet recruiting

Real-life-persistence to Antifibrotic Treatments (REPEAT)

Idiopathic Pulmonary Fibrosis

France
Assistance Publique Hopitaux De Marseille

Not yet recruiting

Axitinib and Oral Metronomic Etoposide for Pediatric Children and AYA Refractory/Relapsing Medulloblastoma and Ependymoma (MEPENDAX)

Ependymoma | Medulloblastoma
Region Skane
Swedish Lung Cancer Study Group

Recruiting

EGFR-mutated Lung Cancer in Randomized Investigator-Initiated Study (ERIS)

Non-Small Cell Lung Cancer

Sweden
The Affiliated Nanjing Drum Tower Hospital of Nanjing...

Not yet recruiting

Comparison of the Antiplatelet Efficacy of Aspirin Combined With Clopidogrel and Aspirin Combined With Half-dose Ticagrelor in Patients With Unruptured Intracranial Aneurysms With Normal CYP2C19 Metabolizer Phenotype

Intracranial Aneurysms | Antiplatelet Drugs
Second Affiliated Hospital of Guangzhou Medical...

Recruiting

Checkpoint Inhibitor Combinations Therapy as First Line for Inoperable Lung Cancer Via IT

Lung Cancer | Inoperable Disease

China
Merck Sharp & Dohme LLC

Not yet recruiting

A Study of Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Plus Enfortumab Vedotin (EV) With Pembrolizumab in Advanced Urothelial Carcinoma (MK-3475-04C/KEYMAKER-U04)

Metastatic Urothelial Carcinoma | Locally Advanced Urothelial Carcinoma
Wuhan Union Hospital, China

Not yet recruiting

Fruquintinib and Pirfenidone in Combination With Anti-PD-1 Antibody in Advanced or Metastatic pMMR/MSS Colorectal Carcinoma

To Evaluate the Efficacy of Fruquintinib and Pirfenidone in Combination With Anti-PD-1 Antibody in Colorectal Carcinoma | To Evaluate Whether Pirfenidone Can Reshape the Tumor Microenvironment in Colorectal Cancer | Combination of Fruquintinib and Anti-PD-1 Antibody Was Reported to...
Shanghai General Hospital, Shanghai Jiao Tong University...

Recruiting

Venetoclax and Azacitidine Combined With Homoharringtonine, Followed by Allo-HSCT for Intermediate and High-risk AML.

Acute Myeloid Leukemia

China

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