Search clinical trials for: Neoantigen

Total 137 results

Jaime Leandro Foundation for Therapeutic Cancer...

Enrolling by invitation

Basket Trial of Neoantigen Synthetic Long Peptide Vaccines in Patients With Advanced Malignancy

Cancer | Solid Tumor

United States
Gritstone bio, Inc.

Terminated

Study of an Individualized Vaccine Targeting Neoantigens in Combination With Immune Checkpoint Blockade for Patients With Colon Cancer

Colorectal Neoplasms | Colonic Neoplasms

United States
BGI, China
Sun Yat-sen University

Completed

Treatment of Advanced Solid Tumor With TSA-CTL(Tumor Specific Antigen-Induced Cytotoxic T Lymphocytes)

Solid Cancer

China
Gritstone bio, Inc.

Completed

A Screening Study Targeting Tumor-specific Antigens

Metastatic Colorectal Cancer | Stage II/III Colon Cancer

United States
PACT Pharma, Inc.

Suspended

A Study of Gene Edited Autologous Neoantigen Targeted TCR T Cells With or Without Anti-PD-1 in Patients With Solid Tumors

Solid Tumor

United States
Washington University School of Medicine
Bristol-Myers Squibb; The Foundation for Barnes-Jewish Hospital; Bavarian Nordic and other collaborators

Completed

Neoantigen DNA Vaccine in Combination With Nivolumab/Ipilimumab and PROSTVAC in Metastatic Hormone-Sensitive Prostate Cancer

Metastatic Hormone-Sensitive Prostate Cancer

United States
Genocea Biosciences, Inc.

Terminated

TiTAN-1: Safety, Proliferation and Persistence of GEN-011 Autologous Cell Therapy

Melanoma | Renal Cell Carcinoma | Squamous Cell Carcinoma of Head and Neck | Non-small Cell Lung Cancer | Small-cell Lung Cancer | Urothelial Carcinoma | Anal Squamous Cell Carcinoma | Merkel Cell Carcinoma | Cutaneous Squamous Cell Carcinoma

United States
Universidad Nacional de Colombia
Fundación Salud de los Andes

Completed

Breast Cancer Neoantigen Vaccination With Autologous Dendritic Cells

Breast Cancer | Triple Negative Breast Cancer

Colombia
Sir Run Run Shaw Hospital
Hangzhou Neoantigen Therapeutics Co., Ltd.

Active, not recruiting

Clinical Study of a Personalized Neoantigen Cancer Vaccine in Treating Patients With Advanced Malignant Tumor

Advanced Malignant Solid Tumor

China
Zhejiang Provincial People's Hospital
Hangzhou Neoantigen Therapeutics Co., Ltd.

Completed

Clinical Study of a Personalized Neoantigen Cancer Vaccine in Treating Patients With Advanced Pancreatic Cancer

Pancreatic Cancer | Pancreatic Carcinoma

China
Washington University School of Medicine
Bristol-Myers Squibb

Terminated

Neoantigen-based Personalized Vaccine Combined With Immune Checkpoint Blockade Therapy in Patients With Newly Diagnosed, Unmethylated Glioblastoma

Glioblastoma

United States
BioNTech US Inc.
Merck Sharp & Dohme LLC

Completed

A Personal Cancer Vaccine (NEO-PV-01) With Pembrolizumab and Chemotherapy for Patients With Lung Cancer

Carcinoma, Non-Small-Cell Lung | Lung Cancer | Nonsquamous Nonsmall Cell Neoplasm of Lung

United States
BioNTech US Inc.
Bristol-Myers Squibb

Completed

A Personal Cancer Vaccine (NEO-PV-01) w/ Nivolumab for Patients With Melanoma, Lung Cancer or Bladder Cancer

Melanoma | Carcinoma, Non-Small-Cell Lung | Lung Cancer | Urinary Bladder Cancer | Skin Cancer | Transitional Cell Carcinoma of the Bladder | Malignant Melanoma | Bladder Tumors

United States
Hoffmann-La Roche

Withdrawn

A Study of the Efficacy and Safety of RO7198457 in Combination With Atezolizumab Versus Atezolizumab Alone Following Adjuvant Platinum-Doublet Chemotherapy in Participants Who Are ctDNA Positive After Surgical Resection of Stage II-III Non-Small Cell Lung Cancer

Non-small Cell Lung Cancer (NSCLC)
National Cancer Institute (NCI)

Withdrawn

Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Mutated or Viral Neoantigens in a Patient With Metastatic Cancer Plus the Administration of Pembrolizumab

Metastatic HPV-16 Positive Squamous Cell Anal Cancer

United States
Patrick Ott, MD

Completed

A Phase I Study With a Personalized NeoAntigen Cancer Vaccine in Melanoma

Melanoma

United States
Gritstone bio, Inc.

Completed

A Study of Personalized Neoantigen Cancer Vaccines

Colorectal Cancer | Non Small Cell Lung Cancer | Gastroesophageal Adenocarcinoma | Pancreatic Ductal Adenocarcinoma | Urothelial Carcinoma

United States
National Institutes of Health Clinical Center (CC)

No longer available

Single Patient Protocol: A Phase II Study Using the Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Mutated Neoantigens in a Patient With Metastatic Cancer Plus the Administration of Pembrolizumab
BioNTech US Inc.
Apexigen, Inc.

Terminated

A Personal Cancer Vaccine (NEO-PV-01) and APX005M or Ipilimumab With Nivolumab in Patients With Advanced Melanoma

Metastatic Melanoma

United States
Washington University School of Medicine
MedImmune LLC

Withdrawn

PolyImmune {Durvalumab (MEDI4736) and Tremelimumab} & Vaccine Orchestrated Treatment for Patients With Advanced/Metastatic Renal Cell Carcinoma (PIVOT-RCC)

Renal Cell Carcinoma
Ardigen
Małopolskie Centre of Entrepreneurship

Unknown

AImmune - Artificial Intelligence Algorithm for Identification of Immunogenic Neoepitopes of Cancer to Predict and Boost Patient's Response to Immunotherapies.

Non Small Cell Lung Cancer | Immunotherapy | Neoantigens | Neoepitopes | Next Generation Sequencing (NGS) | Personalized Neoantigen Cancer Vaccine

Poland
First Hospital of Shijiazhuang City
Tianjin Hengjia Biotechnology Development co., LTD

Unknown

Clinical Study of Neoantigen Vaccine Combined With Targeted Drugs in the Treatment of Non-small Cell Lung Cancer

Non Small Cell Lung Cancer

China
Peking University Cancer Hospital & Institute

Unknown

Total Neoadjuvant Treatment Plus SHR1210 for High-risk Rectal Cancer and Biomarker Screening Base on Neoantigen

Rectal Cancer

China
Shenzhen Geno-Immune Medical Institute
Shenzhen Children's Hospital; Shenzhen Hospital of Southern Medical University

Unknown

Immune Modulatory DC Vaccine Against Brain Tumor

Diffuse Intrinsic Pontine Glioma or Glioblastoma

China
National Cancer Institute (NCI)

Terminated

Messenger RNA (mRNA)-Based, Personalized Cancer Vaccine Against Neoantigens Expressed by the Autologous Cancer

Melanoma | Colon Cancer | Gastrointestinal Cancer | Hepatocellular Cancer | Genitourinary Cancer

United States
Agenus Inc.

Terminated

Safety and Tolerability Study of AutoSynVax™ Vaccine in Subjects With Advanced Cancer

Advanced Cancer

United States
Xiangya Hospital of Central South University

Unknown

A Personalized NeoAntigen Cancer Vaccine Combined With Anti-PD-1 in Melanoma

Melanoma (Skin)

China
Henan Cancer Hospital

Unknown

An Immunogenic Personal Neoantigen Vaccine for Cancer Treatment

Cancer

China
PersImmune, Inc
University of California, San Diego

Unknown

Personalized Adoptive Cellular Therapy Targeting MDS Stem Cell Neoantigens (PACTN)

Myelodysplastic Syndromes

United States
National Cancer Institute (NCI)

Terminated

Ability of a Dendritic Cell Vaccine to Immunize Melanoma or Epithelial Cancer Patients Against Defined Mutated Neoantigens Expressed by the Autologous Cancer

Melanoma | Breast Cancer | Pancreatic Cancer | Ovarian Cancer | Gastrointestinal Cancer

United States
Shenzhen People's Hospital

Unknown

Neoantigen-primed DC Vaccines Therapy for Refractory Lung Cancer

Carcinoma, Non-Small Cell Lung | Carcinoma, Small Cell Lung

China
Changhai Hospital
Stemirna Therapeutics

Unknown

Clinical Study of Personalized mRNA Vaccine Encoding Neoantigen in Patients With Advanced Digestive System Neoplasms

Pancreatic Adenocarcinoma | Gastric Adenocarcinoma | Colorectal Adenocarcinoma | Advanced Esophageal Squamous Carcinoma

China
Chinese PLA General Hospital
Likang Life Sciences Holdings Limited

Unknown

A Study Combining Personalized Neoantigen-based Dendritic Cell Vaccine With Microwave Ablation for the Treatment of Hepatocellular Carcinoma

Hepatocellular Carcinoma | Liver Cancer, Adult

China
S.C.B. Medical College and Hospital

Completed

The Effects of OCP and Metformin on Clinical, Hormonal, Metabolic and Ultrasonographic Characteristics in PCOS

Polycystic Ovary Syndrome

India
The Affiliated Nanjing Drum Tower Hospital of Nanjing...

Unknown

Neoantigen Reactive T Cells Combined With SHR-1210 for Chinese Patients With Advanced Refractory Solid Tumors (NRT-01)

Advanced Malignant Solid Tumor

China
Chongqing Medical University

Completed

Efficacy of Metformin and Diane-35 on PCOS Patients,a Randomized, Controlled, Prospective Clinical Trial

Polycystic Ovary Syndrome | Insulin Resistance

China
Brooke Army Medical Center
T.R.U.E. Research Foundation

Completed

Does Induction PEG-Intron in Combination With Rebetol Enhance the Sustained Response Rates in Patients With CHC

Hepatitis C

United States

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